Ca5a (carbonic anhydrase 5A) - Rat Genome Database

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Gene: Ca5a (carbonic anhydrase 5A) Heterocephalus glaber
Analyze
Symbol: Ca5a
Name: carbonic anhydrase 5A
RGD ID: 18913190
Description: ENCODES a protein that exhibits carbonate dehydratase activity (ortholog); ASSOCIATED WITH CARBONIC ANHYDRASE VA DEFICIENCY, HYPERAMMONEMIA DUE TO (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: carbonic anhydrase 5A, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247461,293,875 - 1,315,890 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247461,293,619 - 1,323,067 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
mitochondrion  (IEA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ca5a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247461,293,875 - 1,315,890 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247461,293,619 - 1,323,067 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
CA5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381687,881,549 - 87,936,529 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1687,881,546 - 87,936,580 (-)Ensemblhg38GRCh38
GRCh371687,915,155 - 87,970,135 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361686,479,126 - 86,527,613 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341686,479,125 - 86,527,613NCBI
Celera1672,219,173 - 72,267,375 (-)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1673,662,132 - 73,710,650 (-)NCBIHuRef
CHM1_11689,333,043 - 89,381,480 (-)NCBICHM1_1
T2T-CHM13v2.01693,954,203 - 94,009,111 (-)NCBIT2T-CHM13v2.0
Car5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398122,642,874 - 122,671,651 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8122,642,865 - 122,671,643 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388121,916,135 - 121,944,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,916,126 - 121,944,904 (-)Ensemblmm10GRCm38
MGSCv378124,440,035 - 124,468,812 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368121,987,915 - 122,017,051 (-)NCBIMGSCv36mm8
MGSCv368124,802,236 - 124,830,994 (-)NCBIMGSCv36mm8
Celera8126,138,230 - 126,172,629 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.81NCBI
Ca5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81966,881,678 - 66,911,486 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1966,881,693 - 66,911,486 (-)EnsemblGRCr8
mRatBN7.21949,973,092 - 50,002,948 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1949,973,107 - 50,002,906 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1956,765,427 - 56,795,202 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,448,040 - 57,477,851 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01959,664,027 - 59,693,795 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1960,677,977 - 60,707,764 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1958,802,646 - 58,832,453 (-)NCBILyon_Normotensive
Lyon_Hypertensive1960,675,902 - 60,705,685 (-)NCBILyon_Hypertensive
F344_StmMcwi1958,408,709 - 58,438,487 (-)NCBIF344_StmMcwi
Rnor_6.01954,731,829 - 54,761,697 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1954,731,859 - 54,761,670 (-)Ensemblrn6Rnor6.0
Rnor_5.01965,451,126 - 65,480,815 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41952,158,607 - 52,188,664 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1949,218,046 - 49,247,995 (-)NCBICelera
RGSC_v3.11952,163,493 - 52,193,545 (-)NCBI
Cytogenetic Map19q12NCBI
Ca5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555412,139,920 - 2,160,597 (-)Ensembl
ChiLan1.0NW_0049555412,141,450 - 2,159,955 (-)NCBIChiLan1.0ChiLan1.0
CA5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21897,653,307 - 97,706,766 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116103,574,183 - 103,588,635 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01668,564,400 - 68,618,614 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11687,887,288 - 87,903,159 (-)NCBIPanPan1.1PanPan1.1panPan2
CA5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1565,269,855 - 65,297,593 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl565,269,635 - 65,296,777 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha565,280,118 - 65,307,768 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0565,489,652 - 65,517,389 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl565,489,538 - 65,516,573 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1565,515,185 - 65,542,854 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0565,346,901 - 65,374,559 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0565,753,935 - 65,781,642 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ca5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,719,672 - 25,742,042 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366411,480,325 - 1,495,490 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366411,478,285 - 1,495,490 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,506,042 - 1,538,777 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.161,495,615 - 1,539,390 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CA5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1573,284,536 - 73,333,629 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660472,374,418 - 2,429,386 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ca5a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11741,560,357 - 41,589,343 (-)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000016256   ⟹   ENSHGLP00000016087
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247461,293,875 - 1,315,890 (+)Ensembl
RefSeq Acc Id: XM_004842707   ⟹   XP_004842764
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247461,293,792 - 1,323,067 (+)NCBI
RefSeq Acc Id: XM_021256588   ⟹   XP_021112247
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247461,293,792 - 1,313,778 (+)NCBI
RefSeq Acc Id: XM_021256589   ⟹   XP_021112248
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247461,293,619 - 1,313,778 (+)NCBI
RefSeq Acc Id: XM_021256590   ⟹   XP_021112249
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247461,293,792 - 1,313,778 (+)NCBI
RefSeq Acc Id: XM_021256591   ⟹   XP_021112250
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247461,295,203 - 1,313,778 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004842764 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112247 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112248 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112249 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112250 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000016087
GenBank Protein JAO01494 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021112248   ⟸   XM_021256589
- Peptide Label: isoform X1
- UniProtKB: A0AAX6ST18 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004842764   ⟸   XM_004842707
- Peptide Label: isoform X3
- UniProtKB: A0A0N8EUA3 (UniProtKB/TrEMBL),   A0AAX6P315 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112247   ⟸   XM_021256588
- Peptide Label: isoform X1
- UniProtKB: A0AAX6ST18 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112249   ⟸   XM_021256590
- Peptide Label: isoform X2
- UniProtKB: A0AAX6SU13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112250   ⟸   XM_021256591
- Peptide Label: isoform X4
- UniProtKB: A0AAX6SUT3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000016087   ⟸   ENSHGLT00000016256


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011507 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000016256 ENTREZGENE
Gene3D-CATH 3.10.200.10 UniProtKB/TrEMBL
InterPro CA_dom UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/TrEMBL
NCBI Gene Ca5a ENTREZGENE
PANTHER CARBONIC ANHYDRASE 5A, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR18952 UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/TrEMBL
PROSITE ALPHA_CA_1 UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/TrEMBL
UniProt A0A0N8EUA3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6P315 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6ST18 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SU13 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SUT3 ENTREZGENE, UniProtKB/TrEMBL