Slc22a16 (solute carrier family 22 member 16) - Rat Genome Database

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Gene: Slc22a16 (solute carrier family 22 member 16) Rattus norvegicus
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Symbol: Slc22a16
Name: solute carrier family 22 member 16
RGD ID: 1592810
Description: Predicted to enable amine transmembrane transporter activity; carnitine transmembrane transporter activity; and spermidine transmembrane transporter activity. Predicted to be involved in several processes, including carnitine transmembrane transport; flagellated sperm motility; and spermidine transmembrane transport. Predicted to act upstream of or within carnitine transport. Predicted to be located in cytosol and plasma membrane. Orthologous to human SLC22A16 (solute carrier family 22 member 16); PARTICIPATES IN doxorubicin pharmacokinetics pathway; INTERACTS WITH 1,2-dimethylhydrazine (ortholog); 1-methylnicotinamide (ortholog); 2-palmitoylglycerol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC682934; similar to solute carrier family 22, member 16; solute carrier family 22 (organic cation/carnitine transporter), member 16
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82045,527,275 - 45,647,675 (+)NCBIGRCr8
mRatBN7.22043,972,808 - 44,068,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,972,836 - 44,065,019 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02045,658,398 - 45,669,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02047,377,218 - 47,389,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2044,675,285 - 44,692,225 (+)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
membrane  (ISO)
plasma membrane  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
5. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
Additional References at PubMed
PMID:12089149   PMID:15963465  


Genomics

Comparative Map Data
Slc22a16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82045,527,275 - 45,647,675 (+)NCBIGRCr8
mRatBN7.22043,972,808 - 44,068,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,972,836 - 44,065,019 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02045,658,398 - 45,669,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02047,377,218 - 47,389,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2044,675,285 - 44,692,225 (+)NCBICelera
Cytogenetic Map20q12NCBI
SLC22A16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386110,424,687 - 110,476,613 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6110,424,687 - 110,476,641 (-)EnsemblGRCh38hg38GRCh38
GRCh376110,745,890 - 110,797,816 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366110,852,599 - 110,904,537 (-)NCBINCBI36Build 36hg18NCBI36
Build 346110,852,602 - 110,904,537NCBI
Celera6111,492,526 - 111,544,454 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6108,312,812 - 108,364,722 (-)NCBIHuRef
CHM1_16111,009,079 - 111,061,055 (-)NCBICHM1_1
T2T-CHM13v2.06111,603,183 - 111,655,121 (-)NCBIT2T-CHM13v2.0
Slc22a16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391040,446,317 - 40,480,128 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1040,446,332 - 40,480,128 (+)EnsemblGRCm39 Ensembl
GRCm381040,570,321 - 40,604,132 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1040,570,336 - 40,604,132 (+)EnsemblGRCm38mm10GRCm38
MGSCv371040,290,168 - 40,323,938 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361040,259,752 - 40,293,557 (+)NCBIMGSCv36mm8
Celera1041,459,880 - 41,493,899 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1021.99NCBI
SLC22A16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25130,438,134 - 130,490,825 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16128,324,168 - 128,376,849 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06108,232,950 - 108,332,469 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16112,302,079 - 112,354,629 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6112,302,265 - 112,354,829 (-)Ensemblpanpan1.1panPan2
SLC22A16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11267,110,606 - 67,167,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1267,110,606 - 67,149,880 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1266,930,237 - 66,986,909 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01267,995,002 - 68,050,363 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1267,995,015 - 68,037,024 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11267,346,263 - 67,401,153 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01267,192,304 - 67,247,319 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01267,464,534 - 67,521,660 (-)NCBIUU_Cfam_GSD_1.0
Slc22a16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946102,036,912 - 102,078,052 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365646,311,934 - 6,352,759 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl176,423,355 - 76,467,575 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1176,423,386 - 76,468,267 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,021,436 - 86,064,197 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11363,422,540 - 63,474,920 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1363,442,867 - 63,474,874 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604035,665,444 - 35,767,647 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Slc22a16
1605 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat

Markers in Region
RH144435  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22043,975,691 - 43,975,830 (+)MAPPERmRatBN7.2
Rnor_6.02045,661,271 - 45,661,409NCBIRnor6.0
Rnor_5.02047,380,106 - 47,380,244UniSTSRnor5.0
Celera2044,678,158 - 44,678,296UniSTS
RH 3.4 Map20474.4UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000109258   ⟹   ENSRNOP00000079293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2043,972,836 - 44,065,019 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115027   ⟹   ENSRNOP00000082507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2043,972,836 - 44,065,019 (+)Ensembl
RefSeq Acc Id: XM_039099170   ⟹   XP_038955098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,527,275 - 45,647,675 (+)NCBI
mRatBN7.22043,972,808 - 44,068,447 (+)NCBI
RefSeq Acc Id: XM_063279637   ⟹   XP_063135707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82045,527,306 - 45,647,675 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001419271 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955098 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135707 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079293.1
  ENSRNOP00000082507.1
RefSeq Acc Id: XP_038955098   ⟸   XM_039099170
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000082507   ⟸   ENSRNOT00000115027
Ensembl Acc Id: ENSRNOP00000079293   ⟸   ENSRNOT00000109258
RefSeq Acc Id: XP_063135707   ⟸   XM_063279637
- Peptide Label: isoform X2
Protein Domains
Major facilitator superfamily (MFS) profile

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592810 AgrOrtholog
BioCyc Gene G2FUF-3421 BioCyc
Ensembl Genes ENSRNOG00000063767 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000109258.1 UniProtKB/TrEMBL
  ENSRNOT00000115027.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_dom UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
NCBI Gene 682934 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 22 MEMBER 16 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PhenoGen Slc22a16 PhenoGen
PROSITE MFS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000063767 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/TrEMBL
UniProt A0A8I5ZMN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUN0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Slc22a16  solute carrier family 22 member 16  Slc22a16  solute carrier family 22 member 16  Data merged from RGD:149736491 737654 PROVISIONAL
2021-08-09 Slc22a16  solute carrier family 22 member 16      Symbol and Name status set to provisional 45752 PROVISIONAL
2016-02-25 Slc22a16  solute carrier family 22 member 16  Slc22a16  solute carrier family 22 (organic cation/carnitine transporter), member 16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-10-03 Slc22a16  solute carrier family 22 (organic cation/carnitine transporter), member 16  LOC682934  similar to solute carrier family 22, member 16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC682934  similar to solute carrier family 22, member 16      Symbol and Name status set to provisional 70820 PROVISIONAL