Arhgef16 (Rho guanine nucleotide exchange factor 16)

Gene: Arhgef16 (Rho guanine nucleotide exchange factor 16) Rattus norvegicus

Analyze

Symbol:

Arhgef16

Name:

Rho guanine nucleotide exchange factor 16

RGD ID:

1588981

Description:

Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in cell chemotaxis and positive regulation of protein localization to plasma membrane. Orthologous to human ARHGEF16 (Rho guanine nucleotide exchange factor 16); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hypothetical protein LOC687105; LOC687105; MGC187446; Rho guanine nucleotide exchange factor; Rho guanine nucleotide exchange factor (GEF) 16

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	170,126,573 - 170,148,624 (-)	NCBI		GRCr8
mRatBN7.2	5	164,843,656 - 164,866,212 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	164,844,161 - 164,866,212 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	167,548,321 - 167,570,389 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	169,369,735 - 169,391,803 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	169,332,254 - 169,354,323 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	171,626,450 - 171,649,124 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	171,624,796 - 171,648,563 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	175,097,644 - 175,120,197 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	5	163,054,279 - 163,076,331 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 1p36 deletion syndrome (ISO)

Ehlers-Danlos syndrome spondylodysplastic type 2 (ISO)

immunodeficiency 16 (ISO)

immunodeficiency 38 (ISO)

Joubert syndrome 25 (ISO)

Neurodevelopmental Disorders (ISO)

Peroxisome Biogenesis Disorder, Complementation Group 7 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acetamide (EXP)

acrolein (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroethene (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

diazinon (ISO)

ethanol (ISO)

folic acid (ISO)

fonofos (ISO)

FR900359 (ISO)

gentamycin (EXP)

isobutanol (ISO)

ivermectin (ISO)

kojic acid (ISO)

manganese(II) chloride (EXP)

N,N-diethyl-m-toluamide (EXP)

N-methyl-4-phenylpyridinium (EXP)

ozone (ISO)

paracetamol (ISO)

parathion (ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quercetin (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

terbufos (ISO)

titanium dioxide (ISO)

tributylstannane (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

Triptolide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell chemotaxis (ISO)

positive regulation of protein localization to plasma membrane (ISO)

Molecular Function

guanyl-nucleotide exchange factor activity (ISO)

PDZ domain binding (ISO)

protein binding (ISO)

receptor tyrosine kinase binding (ISO)

small GTPase binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:20679435	PMID:21139582	PMID:25468996

Genomics

Comparative Map Data

Arhgef16
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	170,126,573 - 170,148,624 (-)	NCBI		GRCr8
mRatBN7.2	5	164,843,656 - 164,866,212 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	164,844,161 - 164,866,212 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	167,548,321 - 167,570,389 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	169,369,735 - 169,391,803 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	169,332,254 - 169,354,323 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	171,626,450 - 171,649,124 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	171,624,796 - 171,648,563 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	175,097,644 - 175,120,197 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	5	163,054,279 - 163,076,331 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

ARHGEF16
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	3,454,665 - 3,481,113 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	3,454,665 - 3,481,113 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	3,371,229 - 3,397,677 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	3,369,982 - 3,387,537 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	3,403,278 - 3,420,832	NCBI
Celera	1	2,624,447 - 2,650,733 (+)	NCBI		Celera
Cytogenetic Map	1	p36.32	NCBI
HuRef	1	2,663,841 - 2,692,412 (+)	NCBI		HuRef
CHM1_1	1	3,357,218 - 3,384,706 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	2,959,327 - 2,988,135 (+)	NCBI		T2T-CHM13v2.0

Arhgef16
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	154,362,926 - 154,384,535 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	154,362,943 - 154,386,133 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	154,278,469 - 154,300,107 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	154,278,486 - 154,301,676 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	153,652,579 - 153,674,004 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	153,122,270 - 153,144,133 (-)	NCBI		MGSCv36	mm8
Celera	4	156,565,792 - 156,575,315 (-)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	83.96	NCBI

Arhgef16
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	8,109,291 - 8,123,404 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	8,109,291 - 8,128,184 (-)	NCBI	ChiLan1.0	ChiLan1.0

ARHGEF16
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	224,832,003 - 224,859,350 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	223,477,657 - 223,505,186 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	2,121,058 - 2,148,391 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	3,258,189 - 3,276,337 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	3,258,664 - 3,275,809 (+)	Ensembl	panpan1.1		panPan2

ARHGEF16
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	58,031,246 - 58,051,936 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	58,030,459 - 58,051,936 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	58,042,558 - 58,063,422 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	58,232,977 - 58,253,909 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	58,233,018 - 58,253,905 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	58,247,674 - 58,268,510 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	58,116,370 - 58,137,240 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	58,506,497 - 58,527,429 (+)	NCBI		UU_Cfam_GSD_1.0

Arhgef16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	29,067,527 - 29,096,097 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936737	369,852 - 383,719 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936737	369,872 - 383,671 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARHGEF16
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	65,027,442 - 65,048,542 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	65,026,490 - 65,048,545 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	59,773,558 - 59,794,924 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ARHGEF16
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	128,204,517 - 128,229,866 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666054	32,483,595 - 32,510,575 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Arhgef16
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	6,949,484 - 6,966,237 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	6,949,484 - 6,966,195 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Arhgef16
50 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	93
Count of miRNA genes:	75
Interacting mature miRNAs:	89
Transcripts:	ENSRNOT00000072786
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	151113452	166875058	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	154828214	166875058	Rat

Markers in Region

RH144516

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	164,880,499 - 164,880,755 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	171,662,913 - 171,663,168	NCBI	Rnor6.0
Rnor_5.0	5	175,134,120 - 175,134,375	UniSTS	Rnor5.0
Celera	5	163,090,563 - 163,090,818	UniSTS
RH 3.4 Map	5	1160.6	UniSTS

BI285850

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	164,844,226 - 164,844,402 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	171,626,518 - 171,626,693	NCBI	Rnor6.0
Rnor_5.0	5	175,098,214 - 175,098,389	UniSTS	Rnor5.0
Celera	5	163,054,347 - 163,054,522	UniSTS
RH 3.4 Map	5	1159.9	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3									21		1
Low		19	13	4	10	4	1	1	24	14	33	10	1
Below cutoff		24	42	35	9	35	7	10	50		8		7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127591	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764385	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764386	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000072786 ⟹ ENSRNOP00000066478

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	164,844,161 - 164,866,212 (-)	Ensembl
Rnor_6.0 Ensembl	5	171,624,796 - 171,648,563 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000082847 ⟹ ENSRNOP00000072293

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	164,846,602 - 164,866,212 (-)	Ensembl
Rnor_6.0 Ensembl	5	171,624,796 - 171,648,327 (-)	Ensembl

RefSeq Acc Id:

NM_001127591 ⟹ NP_001121063

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	170,126,573 - 170,148,624 (-)	NCBI
mRatBN7.2	5	164,844,159 - 164,866,212 (-)	NCBI
Rnor_6.0	5	171,626,450 - 171,648,501 (-)	NCBI
Rnor_5.0	5	175,097,644 - 175,120,197 (-)	NCBI
Celera	5	163,054,279 - 163,076,331 (-)	RGD

Sequence:

show sequence

GCCGCCCTTCCGCGGCGCGCACAGATTTGAAGATTGAAACCGAGAGGTGGCGTCTTTAATCATT
GAGGACACCAGGTTTCCAGCCCCCCAACAGGGCAGCTCCTGACAAGTGTGGAGGACCCCCAGTC
ACGGAGGCCTCCTCTGTCACCAGCATGTCCCAGAGGCATTCTGACAGCTCCCTGGATGAGAAAC
TACTGGAGTACCGCTTCCACGCGGAGCTGCGACTCGACGCCAACGGGAACCCCGTGCCTGGACT
CCCCATGGTCCGGGGTTCCTTAAAAGCCAGAGCCAACGCTGCCTTTGAGCCCGATGCCCCAGAA
TCCTTACAGCCGCCACCGCCTGGAGATGAGGAGCCTCGGCCCATCATCCTCAGCACACAAAGCC
CTGCGGCCCTCAAGATGGGCACGCAGCAGCTCATCCCCAAGAGCTTGGCGGTGGCCAGCAAGGC
CAAGACCAAGTCGCCCGCCCGCCACCAGAGCTTTGGGGCAGCTGTGCTCAGTAAGGAGGCCGCG
AGGCGGACTCCTCAGCTCCTCCCAGCCCCCAGTTTCTCTCTGGATGATATGGACATGGACGCCG
TCACAGGTGGGAACCTGAAACGCAACCTGAGGAACCAATCCTACAGGGCAGCCATGAAGGGCCT
GGGGCCACCCAGTAGCAAGGAAGACTCAGTCCGCCTCGGCCCCAAGCTCCAGGCCCTCGCTGAG
GAGGCTGCTCAGCCTCCTGCCCGGCACCCAGCCAAAAATAAGAAAACTTGGAAACGCGCAAACA
AGGGCTCGTTCAAAGATGACCCCCAACTTTACCAGGAGATCCGAGAGCGGGGTTTGAATACTAG
TCACGAGTCTGATGATGACATACTGGACGAGCCCTCCAGCTCTGGGGGCACTCAGAGAGGGGAC
ACCACCATTGTGGTTAAGACCTATCGCCCTGCTCAGCTCACCTGGAGCCAGCTCCCAGAGGTGC
TGGAGTCAGGTATCCTGGACACACTGTCAGTGGAAGAGCGGAAGAGACAGGAGGCCATCTTCGA
GATCCTCACGTCTGAGTTCTCCTATCTGCACAGCCTGAAGATCCTGGTGAATGAATTCCTACAG
TCCCAAGAGCTGAAGACCACCATGACGCAGACAGAACACCACCACCTCTTCTCCAACATCTCGG
ATGTGCTGGCTGCCAGTCAGAAGTTCTTTGAATCCCTGGAGCAGCGGCACAAAGCTCAGGTGTG
TGTGGAGGACATCAGCGACATCTTGGAGGACCATGCCGAGAACCACTTCCACCCTTACATCGCC
TACTGCTCCAACGAGGTCTATCAGCAGCGCACCCTGCAGAAGCTGTCGAACAGCAACACAGCCT
TCCGGGAAGTTCTGAGGGAGATAGAGAAACTGCCTGCGTGTGGGGGCCTGCCCATGATCTCCTT
CCTGATTCTCCCCATGCAGAGGGTGACCCGGCTGCCTCTGTTGACGGATACACTCTGCCTGAAG
ACACAAGGCCATCCCGAACGGTATAAAGCCGCCAGCCGCGCCCTGAAGGCCATCAGCAAGCTGG
TGAAACAATGTAACGAGGGGGCCCACAAAATGGAGCGCACAGAGCAGATGTACACACTGCACAT
GCAGCTGGACTTCGGTAAGGTCAAGTCCCTCCCACTCATCTCTGCCTCTCGCTGGTTACTGAAA
CGTGGAGAGCTCCTCCTCTTGGAAGAATCCAGTATCTTTAGGAAAATTGCTAGCCGACCCACGT
GCTACCTGTTCCTATTCAATGACGTCCTGGTTGTCACCAAGAAGAAAAGTGAGGAAAGTTACTT
GGTCCAAGACTACGCGCAGCTAGACCACGTGCAGGTCAGGAAGGTGGAACCCTCGGAGCTCCCA
CTGCCAGGAGGCAGCAGCCGCAGCTCTTCCGTGCCCTACCCTTTCCAAGTGAACCTGCTACACA
ACAGCGAGGGCCGCCAGGAGCAGATACTGCTGTCTTCTGACTCCGCGAGTGACCGGGCCCGGTG
GATCACAGCACTCAGCTACAAGGAGAGACAGTGGCAGGGCATCAGCAACAAAGGAGAACTGCCC
CAGGTGGAGGTCACCAAGGCATACTTTGCCAAGCAGGCTGATGAGATCACACTGCAACAGGCAG
ACGTCGTCCTGGTCCTGCAGGAAGAGGATGGCTGGCTTTATGGTGAGCGGCTTCGGGACGGAGA
GACCGGCTGGTTTCCCGAGAGCTTTGCTCACTGCATCACCAGCCGTGTGGCCGTGGAAGGCAAT
GTGCGCAGGATGGAGCGGCTGCGGGTGGAGACAGATGTGTAGCTGGACAGCTCGGAAGCCAAGC
TGTGGCAGACACACCTTCAATCCTCCAACCAGCAAGCCGAGCGGTCCTGCCTGCCCCCAGGAGT
GGGCGGGGTTCATCATGGGACGCAGATCCTTCTCATGGGCTCACGGTTGAGTGCAGAACACTGA
ACTTGTATACATTCGCTTGCCTAAACACCTCTGAGGCAAGCTCCAGGGGCCCACATTCTGGAAA
GAGCCTTAGCCTGGCCTCTCACTGGACACCTGAGCTACACCAGCTAACAGTGATACAGGACTGT
TGCCTTCATTGAAGACACCATAGGGCCACCTGACAGCTGCACCCCTCCATCCCAGGTGGGACCA
AAAGGGGCCGGTGCTCTGAGAGGACAGTGCTGGTGACAGGTGACCTGAGGTACCAGCAGGGATG
TTGTGATTTACAGAGTTCAATAACATTAAAATATTTCTTTTAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001121063	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66429	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000066478
	ENSRNOP00000066478.1
	ENSRNOP00000072293.2

RefSeq Acc Id:

NP_001121063 ⟸ NM_001127591

- UniProtKB:

B2GUW2 (UniProtKB/TrEMBL), A0A0G2K2L6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSQRHSDSSLDEKLLEYRFHAELRLDANGNPVPGLPMVRGSLKARANAAFEPDAPESLQPPPPG
DEEPRPIILSTQSPAALKMGTQQLIPKSLAVASKAKTKSPARHQSFGAAVLSKEAARRTPQLLP
APSFSLDDMDMDAVTGGNLKRNLRNQSYRAAMKGLGPPSSKEDSVRLGPKLQALAEEAAQPPAR
HPAKNKKTWKRANKGSFKDDPQLYQEIRERGLNTSHESDDDILDEPSSSGGTQRGDTTIVVKTY
RPAQLTWSQLPEVLESGILDTLSVEERKRQEAIFEILTSEFSYLHSLKILVNEFLQSQELKTTM
TQTEHHHLFSNISDVLAASQKFFESLEQRHKAQVCVEDISDILEDHAENHFHPYIAYCSNEVYQ
QRTLQKLSNSNTAFREVLREIEKLPACGGLPMISFLILPMQRVTRLPLLTDTLCLKTQGHPERY
KAASRALKAISKLVKQCNEGAHKMERTEQMYTLHMQLDFGKVKSLPLISASRWLLKRGELLLLE
ESSIFRKIASRPTCYLFLFNDVLVVTKKKSEESYLVQDYAQLDHVQVRKVEPSELPLPGGSSRS
SSVPYPFQVNLLHNSEGRQEQILLSSDSASDRARWITALSYKERQWQGISNKGELPQVEVTKAY
FAKQADEITLQQADVVLVLQEEDGWLYGERLRDGETGWFPESFAHCITSRVAVEGNVRRMERLR
VETDV

hide sequence

RefSeq Acc Id:

ENSRNOP00000072293 ⟸ ENSRNOT00000082847

RefSeq Acc Id:

ENSRNOP00000066478 ⟸ ENSRNOT00000072786

Protein Domains

DH PH SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2GUW2-F1-model_v2	AlphaFold	B2GUW2	1-709	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1588981	AgrOrtholog
BioCyc Gene	G2FUF-38959	BioCyc
Ensembl Genes	ENSRNOG00000046803	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000072786	ENTREZGENE
	ENSRNOT00000072786.3	UniProtKB/TrEMBL
	ENSRNOT00000082847.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.900.10	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7128351	IMAGE-MGC_LOAD
InterPro	ARHGEF16/ARHGEF26_SH3	UniProtKB/TrEMBL
	DBL_dom_sf	UniProtKB/TrEMBL
	DH-domain	UniProtKB/TrEMBL
	Ephexin-like	UniProtKB/TrEMBL
	PH_ephexin	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
KEGG Report	rno:687105	UniProtKB/TrEMBL
MGC_CLONE	MGC:187446	IMAGE-MGC_LOAD
NCBI Gene	687105	ENTREZGENE
PANTHER	GUANINE NUCLEOTIDE EXCHANGE FACTOR	UniProtKB/TrEMBL
	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 16	UniProtKB/TrEMBL
Pfam	PF00169	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
	SH3_9	UniProtKB/TrEMBL
PhenoGen	Arhgef16	PhenoGen
PROSITE	DH_2	UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000046803	RatGTEx
SMART	RhoGEF	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	DH-domain	UniProtKB/TrEMBL
	PH domain-like	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
UniProt	A0A0G2K2L6	ENTREZGENE, UniProtKB/TrEMBL
	B2GUW2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-19	Arhgef16	Rho guanine nucleotide exchange factor 16	Arhgef16	Rho guanine nucleotide exchange factor (GEF) 16	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-16	Arhgef16	Rho guanine nucleotide exchange factor (GEF) 16	LOC687105	hypothetical protein LOC687105	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC687105	hypothetical protein LOC687105			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar