Mospd2 (motile sperm domain containing 2) - Rat Genome Database

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Gene: Mospd2 (motile sperm domain containing 2) Rattus norvegicus
Analyze
Symbol: Mospd2
Name: motile sperm domain containing 2
RGD ID: 1563952
Description: Predicted to enable FFAT motif binding activity. Predicted to be involved in lipid droplet formation; positive regulation of leukocyte chemotaxis; and protein homooligomerization. Predicted to be located in endoplasmic reticulum membrane; organelle membrane contact site; and plasma membrane. Predicted to be active in endomembrane system and endoplasmic reticulum-endosome membrane contact site. Orthologous to human MOSPD2 (motile sperm domain containing 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC363463; LOC363463; motile sperm domain-containing protein 2; RGD1563952; similar to Mospd2 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,052,063 - 33,105,550 (+)NCBIGRCr8
mRatBN7.2X29,420,485 - 29,472,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX29,420,586 - 29,462,398 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX30,466,543 - 30,508,388 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X33,890,184 - 33,932,013 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,090,847 - 30,132,698 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X31,140,967 - 31,182,823 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX31,140,960 - 31,182,816 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X31,520,477 - 31,562,135 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X50,160,231 - 50,202,085 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX29,778,938 - 29,819,862 (+)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19946888   PMID:28137892  


Genomics

Comparative Map Data
Mospd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,052,063 - 33,105,550 (+)NCBIGRCr8
mRatBN7.2X29,420,485 - 29,472,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX29,420,586 - 29,462,398 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX30,466,543 - 30,508,388 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X33,890,184 - 33,932,013 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,090,847 - 30,132,698 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X31,140,967 - 31,182,823 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX31,140,960 - 31,182,816 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X31,520,477 - 31,562,135 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X50,160,231 - 50,202,085 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX29,778,938 - 29,819,862 (+)NCBICelera
Cytogenetic MapXq14NCBI
MOSPD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X14,873,421 - 14,922,327 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX14,873,421 - 14,922,327 (+)EnsemblGRCh38hg38GRCh38
GRCh37X14,891,543 - 14,940,449 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X14,801,484 - 14,849,378 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X14,651,219 - 14,699,113NCBI
CeleraX19,006,911 - 19,054,670 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX12,649,660 - 12,698,200 (+)NCBIHuRef
CHM1_1X14,921,937 - 14,969,882 (+)NCBICHM1_1
T2T-CHM13v2.0X14,453,939 - 14,503,195 (+)NCBIT2T-CHM13v2.0
Mospd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X163,719,165 - 163,763,501 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX163,719,165 - 163,763,371 (-)EnsemblGRCm39 Ensembl
GRCm38X164,936,169 - 164,980,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,936,169 - 164,980,375 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X161,376,141 - 161,418,267 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X160,280,274 - 160,324,480 (-)NCBIMGSCv36mm8
CeleraX148,140,317 - 148,182,431 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.75NCBI
Mospd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555193,286,847 - 3,337,286 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555193,290,137 - 3,336,817 (-)NCBIChiLan1.0ChiLan1.0
MOSPD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X16,673,598 - 16,722,124 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X16,677,263 - 16,726,363 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X7,501,222 - 7,549,523 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X14,786,183 - 14,834,408 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX14,785,436 - 14,828,978 (+)Ensemblpanpan1.1panPan2
MOSPD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,147,782 - 11,200,838 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,147,958 - 11,200,117 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,055,567 - 11,108,667 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,109,941 - 11,163,021 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX11,109,927 - 11,163,175 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X11,173,144 - 11,226,167 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,164,536 - 11,217,230 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,192,117 - 11,245,390 (+)NCBIUU_Cfam_GSD_1.0
Mospd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,330,321 - 4,374,033 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364704,330,323 - 4,374,755 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364704,330,400 - 4,373,790 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOSPD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX11,409,107 - 11,473,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X11,409,157 - 11,473,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X12,362,232 - 12,428,379 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOSPD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X13,350,639 - 13,399,157 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX13,350,639 - 13,399,311 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605615,186,784 - 15,235,301 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mospd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624944314,638 - 359,085 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624944314,787 - 358,570 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mospd2
124 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:105
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000004494
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004494   ⟹   ENSRNOP00000004494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX29,420,588 - 29,461,460 (+)Ensembl
Rnor_6.0 EnsemblX31,140,978 - 31,182,816 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084395   ⟹   ENSRNOP00000074561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX29,420,588 - 29,462,398 (+)Ensembl
Rnor_6.0 EnsemblX31,140,960 - 31,180,594 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116700   ⟹   ENSRNOP00000081484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX29,420,586 - 29,461,460 (+)Ensembl
RefSeq Acc Id: NM_001398727   ⟹   NP_001385656
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,052,187 - 33,094,032 (+)NCBI
mRatBN7.2X29,420,571 - 29,462,415 (+)NCBI
RefSeq Acc Id: XM_006256866   ⟹   XP_006256928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,052,063 - 33,093,858 (+)NCBI
mRatBN7.2X29,420,485 - 29,462,415 (+)NCBI
Rnor_6.0X31,140,967 - 31,182,823 (+)NCBI
Rnor_5.0X31,520,477 - 31,562,135 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099873   ⟹   XP_038955801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,052,063 - 33,105,550 (+)NCBI
mRatBN7.2X29,420,485 - 29,472,099 (+)NCBI
RefSeq Acc Id: XP_006256928   ⟸   XM_006256866
- Peptide Label: isoform X1
- UniProtKB: A6K2K0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004494   ⟸   ENSRNOT00000004494
Ensembl Acc Id: ENSRNOP00000074561   ⟸   ENSRNOT00000084395
RefSeq Acc Id: XP_038955801   ⟸   XM_039099873
- Peptide Label: isoform X2
- UniProtKB: D4A4X7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081484   ⟸   ENSRNOT00000116700
RefSeq Acc Id: NP_001385656   ⟸   NM_001398727
- UniProtKB: A0A0G2K8D1 (UniProtKB/TrEMBL),   A6K2K2 (UniProtKB/TrEMBL)
Protein Domains
CRAL-TRIO   MSP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K8D1-F1-model_v2 AlphaFold A0A0G2K8D1 1-518 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701793
Promoter ID:EPDNEW_R12317
Type:initiation region
Name:Mospd2_1
Description:motile sperm domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X31,141,007 - 31,141,067EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563952 AgrOrtholog
BioCyc Gene G2FUF-2600 BioCyc
Ensembl Genes ENSRNOG00000003350 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004494.6 UniProtKB/TrEMBL
  ENSRNOT00000084395.2 UniProtKB/TrEMBL
  ENSRNOT00000116700.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.40.525.10 UniProtKB/TrEMBL
InterPro CRAL-bd_TRIO_C UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/TrEMBL
  CRAL/TRIO_N_dom_sf UniProtKB/TrEMBL
  ER-organelle_contact UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Major_sperm UniProtKB/TrEMBL
  PapD-like UniProtKB/TrEMBL
NCBI Gene 363463 ENTREZGENE
PANTHER MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam CRAL_TRIO UniProtKB/TrEMBL
  Motile_Sperm UniProtKB/TrEMBL
PhenoGen Mospd2 PhenoGen
PROSITE CRAL_TRIO UniProtKB/TrEMBL
  MSP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003350 RatGTEx
SMART SEC14 UniProtKB/TrEMBL
Superfamily-SCOP CRAL_TRIO_C UniProtKB/TrEMBL
  PapD-like UniProtKB/TrEMBL
  Sec14p_like_N UniProtKB/TrEMBL
UniProt A0A0G2K8D1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZT29_RAT UniProtKB/TrEMBL
  A6K2K0 ENTREZGENE, UniProtKB/TrEMBL
  A6K2K2 ENTREZGENE, UniProtKB/TrEMBL
  D4A4X7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-05 Mospd2  motile sperm domain containing 2  RGD1563952  similar to Mospd2 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563952  similar to Mospd2 protein   RGD1563952_predicted  similar to Mospd2 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563952_predicted  similar to Mospd2 protein (predicted)  LOC363463  similar to Mospd2 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363463  similar to Mospd2 protein      Symbol and Name status set to provisional 70820 PROVISIONAL