MOSPD2 (motile sperm domain containing 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MOSPD2 (motile sperm domain containing 2) Canis lupus familiaris
Analyze
Symbol: MOSPD2
Name: motile sperm domain containing 2
RGD ID: 12217964
Description: ENCODES a protein that exhibits FFAT motif binding (inferred); INVOLVED IN lipid droplet formation (inferred); positive regulation of monocyte chemotaxis (inferred); positive regulation of neutrophil chemotaxis (inferred); ASSOCIATED WITH autistic disorder (ortholog); Fanconi anemia (ortholog); multiple congenital anomalies-hypotonia-seizures syndrome 2 (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); endoplasmic reticulum-endosome membrane contact site (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: motile sperm domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,147,782 - 11,200,838 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,147,958 - 11,200,117 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,055,567 - 11,108,667 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,109,941 - 11,163,021 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX11,109,927 - 11,163,175 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X11,173,144 - 11,226,167 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,164,536 - 11,217,230 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,192,117 - 11,245,390 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MOSPD2Dogautistic disorder  ISOMOSPD2 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
MOSPD2DogFanconi anemia  ISOMOSPD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Fanconi anemiaClinVarPMID:28492532
MOSPD2Dogmultiple congenital anomalies-hypotonia-seizures syndrome 2  ISOMOSPD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Multiple congenital anomalies-hypotonia-seizures syndrome 2ClinVarPMID:24706016 more ...
MOSPD2DogNeurodevelopmental Disorders  ISOMOSPD2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MOSPD2Doglipid droplet formation involved_inIEAUniProtKB:Q8NHP6 and ensembl:ENSP00000369860150520179 EnsemblGO_REF:0000107
MOSPD2Dogpositive regulation of monocyte chemotaxis involved_inIEAUniProtKB:Q8NHP6 and ensembl:ENSP00000369860150520179 EnsemblGO_REF:0000107
MOSPD2Dogpositive regulation of neutrophil chemotaxis involved_inIEAUniProtKB:Q8NHP6 and ensembl:ENSP00000369860150520179 EnsemblGO_REF:0000107
MOSPD2Dogprotein homooligomerization involved_inIEAUniProtKB:Q8NHP6 and ensembl:ENSP00000369860150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MOSPD2Dogendomembrane system is_active_inIBAPANTHER:PTN005301323 and UniProtKB:Q8NHP6150520179 GO_CentralGO_REF:0000033
MOSPD2Dogendoplasmic reticulum located_inIEAUniProtKB:Q8NHP6 and ensembl:ENSP00000369860150520179 EnsemblGO_REF:0000107
MOSPD2Dogendoplasmic reticulum membrane located_inIEAUniProtKB:Q8NHP6 and ensembl:ENSP00000369860150520179 EnsemblGO_REF:0000107
MOSPD2Dogendoplasmic reticulum-endosome membrane contact site located_inIEAUniProtKB:Q8NHP6 and ensembl:ENSP00000369860150520179 EnsemblGO_REF:0000107
MOSPD2Dogendoplasmic reticulum-endosome membrane contact site is_active_inIBAPANTHER:PTN005301323 and UniProtKB:Q8NHP6150520179 GO_CentralGO_REF:0000033
MOSPD2Dogmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
MOSPD2Dogorganelle membrane contact site located_inIEAUniProtKB:Q8NHP6 and ensembl:ENSP00000369860150520179 EnsemblGO_REF:0000107
MOSPD2Dogplasma membrane located_inIEAUniProtKB:Q8NHP6 and ensembl:ENSP00000369860150520179 EnsemblGO_REF:0000107

Molecular Function

  

PMID:30404858  



MOSPD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,147,782 - 11,200,838 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,147,958 - 11,200,117 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,055,567 - 11,108,667 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,109,941 - 11,163,021 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX11,109,927 - 11,163,175 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X11,173,144 - 11,226,167 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,164,536 - 11,217,230 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,192,117 - 11,245,390 (+)NCBIUU_Cfam_GSD_1.0
MOSPD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X14,873,421 - 14,922,327 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX14,873,421 - 14,922,327 (+)EnsemblGRCh38hg38GRCh38
GRCh37X14,891,543 - 14,940,449 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X14,801,484 - 14,849,378 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X14,651,219 - 14,699,113NCBI
CeleraX19,006,911 - 19,054,670 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX12,649,660 - 12,698,200 (+)NCBIHuRef
CHM1_1X14,921,937 - 14,969,882 (+)NCBICHM1_1
T2T-CHM13v2.0X14,453,939 - 14,503,195 (+)NCBIT2T-CHM13v2.0
Mospd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X163,719,165 - 163,763,501 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX163,719,165 - 163,763,371 (-)EnsemblGRCm39 Ensembl
GRCm38X164,936,169 - 164,980,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,936,169 - 164,980,375 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X161,376,141 - 161,418,267 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X160,280,274 - 160,324,480 (-)NCBIMGSCv36mm8
CeleraX148,140,317 - 148,182,431 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.75NCBI
Mospd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,052,063 - 33,105,550 (+)NCBIGRCr8
mRatBN7.2X29,420,485 - 29,472,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX29,420,586 - 29,462,398 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX30,466,543 - 30,508,388 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X33,890,184 - 33,932,013 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,090,847 - 30,132,698 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X31,140,967 - 31,182,823 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX31,140,960 - 31,182,816 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X31,520,477 - 31,562,135 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X50,160,231 - 50,202,085 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX29,778,938 - 29,819,862 (+)NCBICelera
Cytogenetic MapXq14NCBI
Mospd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555193,286,847 - 3,337,286 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555193,290,137 - 3,336,817 (-)NCBIChiLan1.0ChiLan1.0
MOSPD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X16,673,598 - 16,722,124 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X16,677,263 - 16,726,363 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X7,501,222 - 7,549,523 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X14,786,183 - 14,834,408 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX14,785,436 - 14,828,978 (+)Ensemblpanpan1.1panPan2
Mospd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,330,321 - 4,374,033 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364704,330,323 - 4,374,755 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364704,330,400 - 4,373,790 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOSPD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX11,409,107 - 11,473,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X11,409,157 - 11,473,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X12,362,232 - 12,428,379 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOSPD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X13,350,639 - 13,399,157 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX13,350,639 - 13,399,311 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605615,186,784 - 15,235,301 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mospd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624944314,638 - 359,085 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624944314,787 - 358,570 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in MOSPD2
376 total Variants



adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10



Ensembl Acc Id: ENSCAFT00000018876   ⟹   ENSCAFP00000017492
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX11,147,958 - 11,198,605 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000049785   ⟹   ENSCAFP00000042205
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX11,147,958 - 11,200,117 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845051894   ⟹   ENSCAFP00845040714
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX11,109,927 - 11,161,740 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845051918   ⟹   ENSCAFP00845040732
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX11,110,165 - 11,163,175 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845051944   ⟹   ENSCAFP00845040754
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX11,110,182 - 11,161,757 (+)Ensembl
RefSeq Acc Id: XM_005641128   ⟹   XP_005641185
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X11,147,782 - 11,200,838 (+)NCBI
Dog10K_Boxer_TashaX11,055,567 - 11,108,667 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038449447   ⟹   XP_038305375
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X11,109,941 - 11,163,010 (+)NCBI
RefSeq Acc Id: XM_038449448   ⟹   XP_038305376
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X11,109,941 - 11,163,021 (+)NCBI
RefSeq Acc Id: XM_038522869   ⟹   XP_038378797
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X11,173,144 - 11,226,156 (+)NCBI
RefSeq Acc Id: XM_038522870   ⟹   XP_038378798
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X11,173,144 - 11,226,167 (+)NCBI
RefSeq Acc Id: XM_038586861   ⟹   XP_038442789
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X11,192,117 - 11,245,379 (+)NCBI
RefSeq Acc Id: XM_038586862   ⟹   XP_038442790
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X11,192,117 - 11,245,390 (+)NCBI
RefSeq Acc Id: XM_038651376   ⟹   XP_038507304
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X11,164,536 - 11,217,219 (+)NCBI
RefSeq Acc Id: XM_038651377   ⟹   XP_038507305
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X11,164,536 - 11,217,230 (+)NCBI
RefSeq Acc Id: XM_548867   ⟹   XP_548867
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X11,147,782 - 11,200,031 (+)NCBI
Dog10K_Boxer_TashaX11,055,567 - 11,108,656 (+)NCBI
Sequence:
1 to 5 of 15 rows
1 to 5 of 15 rows
RefSeq Acc Id: XP_548867   ⟸   XM_548867
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N2D3 (UniProtKB/TrEMBL),   A0A8I3Q7W6 (UniProtKB/TrEMBL),   A0A8C0QUJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005641185   ⟸   XM_005641128
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SE91 (UniProtKB/TrEMBL),   A0A8I3Q0I2 (UniProtKB/TrEMBL),   A0A8C0JQ65 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000042205   ⟸   ENSCAFT00000049785
Ensembl Acc Id: ENSCAFP00000017492   ⟸   ENSCAFT00000018876
RefSeq Acc Id: XP_038378798   ⟸   XM_038522870
- Peptide Label: isoform X2
CRAL-TRIO   MSP



1 to 40 of 49 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCAFG00000011879 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012622 UniProtKB/TrEMBL
  ENSCAFG00040012549 UniProtKB/TrEMBL
  ENSCAFG00845029311 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018876.5 UniProtKB/TrEMBL
  ENSCAFT00000049785.4 UniProtKB/TrEMBL
  ENSCAFT00000099056.1 UniProtKB/TrEMBL
  ENSCAFT00030023435.1 UniProtKB/TrEMBL
  ENSCAFT00030023583.1 UniProtKB/TrEMBL
  ENSCAFT00030023709.1 UniProtKB/TrEMBL
  ENSCAFT00040023126.1 UniProtKB/TrEMBL
  ENSCAFT00040023226.1 UniProtKB/TrEMBL
  ENSCAFT00845051894 ENTREZGENE
  ENSCAFT00845051894.1 UniProtKB/TrEMBL
  ENSCAFT00845051918 ENTREZGENE
  ENSCAFT00845051918.1 UniProtKB/TrEMBL
  ENSCAFT00845051944.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.40.525.10 UniProtKB/TrEMBL
InterPro CRAL-TRIO_dom UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/TrEMBL
  CRAL/TRIO_N_dom_sf UniProtKB/TrEMBL
  ER-organelle_contact UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  MSP_dom UniProtKB/TrEMBL
  PapD-like_sf UniProtKB/TrEMBL
KEGG Report cfa:491747 UniProtKB/TrEMBL
NCBI Gene MOSPD2 ENTREZGENE
PANTHER MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam CRAL_TRIO UniProtKB/TrEMBL
  Motile_Sperm UniProtKB/TrEMBL
PROSITE CRAL_TRIO UniProtKB/TrEMBL
  MSP UniProtKB/TrEMBL
SMART SEC14 UniProtKB/TrEMBL
Superfamily-SCOP SSF46938 UniProtKB/TrEMBL
  SSF49354 UniProtKB/TrEMBL
  SSF52087 UniProtKB/TrEMBL
UniProt A0A8C0JQ65 ENTREZGENE
  A0A8C0N2D3 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 49 rows