Macir (macrophage immunometabolism regulator) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Macir (macrophage immunometabolism regulator) Rattus norvegicus
Analyze
Symbol: Macir
Name: macrophage immunometabolism regulator
RGD ID: 1562136
Description: Predicted to be involved in negative regulation of cytokine production involved in inflammatory response; negative regulation of fibroblast migration; and negative regulation of inflammatory response. Predicted to act upstream of or within negative regulation of epithelial cell migration. Predicted to be located in ciliary transition zone and cytoplasm. Orthologous to human MACIR (macrophage immunometabolism regulator); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC501195; LOC501195; RGD1562136; similar to D1Ertd622e protein; UNC119-binding protein C5orf30 homolog; uncharacterized protein LOC501195
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89105,868,072 - 105,888,128 (+)NCBIGRCr8
mRatBN7.2998,420,760 - 98,440,818 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl998,420,376 - 98,441,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9106,834,539 - 106,854,561 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09111,962,313 - 111,982,335 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09110,305,924 - 110,325,948 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09111,327,333 - 111,347,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9111,327,402 - 111,347,430 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09110,878,815 - 110,898,589 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4997,216,277 - 97,236,238 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera995,862,440 - 95,882,884 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090   PMID:22085962   PMID:26316022   PMID:30659109  


Genomics

Comparative Map Data
Macir
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89105,868,072 - 105,888,128 (+)NCBIGRCr8
mRatBN7.2998,420,760 - 98,440,818 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl998,420,376 - 98,441,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9106,834,539 - 106,854,561 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09111,962,313 - 111,982,335 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09110,305,924 - 110,325,948 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09111,327,333 - 111,347,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9111,327,402 - 111,347,430 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09110,878,815 - 110,898,589 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4997,216,277 - 97,236,238 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera995,862,440 - 95,882,884 (+)NCBICelera
Cytogenetic Map9q36NCBI
MACIR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385103,258,374 - 103,278,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5103,258,763 - 103,278,660 (+)EnsemblGRCh38hg38GRCh38
GRCh375102,594,075 - 102,614,361 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365102,622,341 - 102,642,260 (+)NCBINCBI36Build 36hg18NCBI36
Celera598,542,288 - 98,562,209 (+)NCBICelera
Cytogenetic Map5q21.1NCBI
HuRef597,775,822 - 97,795,742 (+)NCBIHuRef
CHM1_15102,027,108 - 102,047,027 (+)NCBICHM1_1
T2T-CHM13v2.05103,766,495 - 103,786,818 (+)NCBIT2T-CHM13v2.0
Macir
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39197,571,627 - 97,589,743 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl197,534,043 - 97,589,799 (-)EnsemblGRCm39 Ensembl
GRCm38197,643,902 - 97,662,018 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl197,606,318 - 97,662,074 (-)EnsemblGRCm38mm10GRCm38
MGSCv37199,540,479 - 99,558,595 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36199,474,309 - 99,492,382 (-)NCBIMGSCv36mm8
Celera1100,523,076 - 100,541,194 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.76NCBI
Macir
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541810,752,250 - 10,767,791 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541810,752,250 - 10,767,791 (-)NCBIChiLan1.0ChiLan1.0
MACIR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2498,541,893 - 98,561,641 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1596,695,534 - 96,715,289 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0598,612,892 - 98,632,854 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15104,313,494 - 104,332,681 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5104,330,232 - 104,330,852 (+)Ensemblpanpan1.1panPan2
MACIR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137,956,865 - 7,968,964 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha39,358,340 - 9,377,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.037,844,435 - 7,863,767 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl37,844,463 - 7,862,952 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137,785,357 - 7,804,615 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037,805,599 - 7,823,519 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.037,964,146 - 7,983,424 (-)NCBIUU_Cfam_GSD_1.0
Macir
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213163,088,172 - 163,107,524 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365231,275,214 - 1,292,854 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365231,273,812 - 1,292,837 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MACIR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2108,733,357 - 108,753,275 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12108,733,347 - 108,753,276 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22112,804,239 - 112,822,920 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MACIR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,695,131 - 6,714,925 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,712,171 - 6,712,791 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660367,609,545 - 7,629,192 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Macir
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474321,372,278 - 21,387,871 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474321,372,253 - 21,389,202 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Macir
73 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:234
Count of miRNA genes:142
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000045749
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)992491589100929786Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat

Markers in Region
RH118244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2998,440,174 - 98,440,337 (+)MAPPERmRatBN7.2
Rnor_6.09111,346,785 - 111,346,947NCBIRnor6.0
Rnor_5.09110,897,946 - 110,898,108UniSTSRnor5.0
RGSC_v3.4997,235,595 - 97,235,757UniSTSRGSC3.4
Celera995,882,241 - 95,882,403UniSTS
Cytogenetic Map9q36UniSTS
RH130451  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2998,440,539 - 98,440,719 (+)MAPPERmRatBN7.2
Rnor_6.09111,347,150 - 111,347,329NCBIRnor6.0
Rnor_5.09110,898,311 - 110,898,490UniSTSRnor5.0
RGSC_v3.4997,235,960 - 97,236,139UniSTSRGSC3.4
Celera995,882,606 - 95,882,785UniSTS
Cytogenetic Map9q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 22 37 23 17 23 8 11 74 35 27 11 8
Low 21 20 18 2 18 12
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045749   ⟹   ENSRNOP00000041389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl998,420,376 - 98,441,733 (+)Ensembl
Rnor_6.0 Ensembl9111,327,402 - 111,347,430 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101908   ⟹   ENSRNOP00000093274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl998,421,582 - 98,441,733 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101977   ⟹   ENSRNOP00000083706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl998,421,130 - 98,441,733 (+)Ensembl
RefSeq Acc Id: NM_001109086   ⟹   NP_001102556
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,868,072 - 105,888,128 (+)NCBI
mRatBN7.2998,420,760 - 98,440,818 (+)NCBI
Rnor_6.09111,327,333 - 111,347,428 (+)NCBI
Rnor_5.09110,878,815 - 110,898,589 (+)NCBI
RGSC_v3.4997,216,277 - 97,236,238 (+)RGD
Celera995,862,440 - 95,882,884 (+)RGD
Sequence:
RefSeq Acc Id: XM_017596608   ⟹   XP_017452097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,868,459 - 105,888,128 (+)NCBI
mRatBN7.2998,421,149 - 98,440,818 (+)NCBI
Rnor_6.09111,327,642 - 111,347,428 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596609   ⟹   XP_017452098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,869,582 - 105,888,128 (+)NCBI
mRatBN7.2998,422,271 - 98,440,818 (+)NCBI
Rnor_6.09111,328,823 - 111,347,428 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084127   ⟹   XP_038940055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,869,260 - 105,888,128 (+)NCBI
mRatBN7.2998,421,994 - 98,440,818 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001102556   ⟸   NM_001109086
- UniProtKB: D3ZPS9 (UniProtKB/TrEMBL),   A6JR86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452097   ⟸   XM_017596608
- Peptide Label: isoform X1
- UniProtKB: D3ZPS9 (UniProtKB/TrEMBL),   A6JR86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452098   ⟸   XM_017596609
- Peptide Label: isoform X1
- UniProtKB: D3ZPS9 (UniProtKB/TrEMBL),   A6JR86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000041389   ⟸   ENSRNOT00000045749
RefSeq Acc Id: XP_038940055   ⟸   XM_039084127
- Peptide Label: isoform X1
- UniProtKB: D3ZPS9 (UniProtKB/TrEMBL),   A6JR86 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083706   ⟸   ENSRNOT00000101977
RefSeq Acc Id: ENSRNOP00000093274   ⟸   ENSRNOT00000101908

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZPS9-F1-model_v2 AlphaFold D3ZPS9 1-207 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696900
Promoter ID:EPDNEW_R7424
Type:initiation region
Name:RGD1562136_1
Description:similar to D1Ertd622e protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09111,327,444 - 111,327,504EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562136 AgrOrtholog
BioCyc Gene G2FUF-26579 BioCyc
Ensembl Genes ENSRNOG00000032398 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045749 ENTREZGENE
  ENSRNOT00000045749.5 UniProtKB/TrEMBL
  ENSRNOT00000101908.1 UniProtKB/TrEMBL
  ENSRNOT00000101977.1 UniProtKB/TrEMBL
InterPro UNC119_bd_prot UniProtKB/TrEMBL
KEGG Report rno:501195 UniProtKB/TrEMBL
NCBI Gene 501195 ENTREZGENE
PANTHER MACROPHAGE IMMUNOMETABOLISM REGULATOR UniProtKB/TrEMBL
  PTHR31224 UniProtKB/TrEMBL
Pfam UNC119_bdg UniProtKB/TrEMBL
PhenoGen Macir PhenoGen
RatGTEx ENSRNOG00000032398 RatGTEx
UniProt A6JR86 ENTREZGENE, UniProtKB/TrEMBL
  D3ZPS9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Macir  macrophage immunometabolism regulator  RGD1562136  similar to D1Ertd622e protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562136  similar to D1Ertd622e protein   RGD1562136_predicted  similar to D1Ertd622e protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562136_predicted  similar to D1Ertd622e protein (predicted)  LOC501195  similar to D1Ertd622e protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501195  similar to D1Ertd622e protein      Symbol and Name status set to provisional 70820 PROVISIONAL