Zc3h12b (zinc finger CCCH-type containing 12B)

Gene: Zc3h12b (zinc finger CCCH-type containing 12B) Rattus norvegicus

Analyze

Symbol:

Zc3h12b

Name:

zinc finger CCCH-type containing 12B

RGD ID:

1560891

Description:

Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human ZC3H12B (zinc finger CCCH-type containing 12B); INTERACTS WITH bisphenol A; cyclophosphamide; gentamycin.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC296864; probable ribonuclease ZC3H12B; RGD1560891; similar to hypothetical protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ZC3H12B (zinc finger CCCH-type containing 12B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Zc3h12b (zinc finger CCCH-type containing 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Zc3h12b (zinc finger CCCH-type containing 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ZC3H12B (zinc finger CCCH-type containing 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ZC3H12B (zinc finger CCCH-type containing 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Zc3h12b (zinc finger CCCH-type containing 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ZC3H12B (zinc finger CCCH-type containing 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ZC3H12B (zinc finger CCCH-type containing 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Zc3h12b (zinc finger CCCH-type containing 12B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CDSN (corneodesmosin)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ZC3H12B (zinc finger CCCH-type containing 12B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Zc3h12b (zinc finger CCCH-type containing 12B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zc3h12b (zinc finger CCCH-type containing 12B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10889	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rege-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	zc3h12b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	64,625,479 - 64,858,634 (+)	NCBI		GRCr8
mRatBN7.2	X	60,615,616 - 60,849,278 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	60,615,682 - 60,844,832 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	65,040,032 - 65,074,857 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	65,040,104 - 65,074,712 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	65,882,161 - 65,916,894 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	83,528,345 - 83,561,515 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	61,034,060 - 61,259,514 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

osteopathia striata with cranial sclerosis (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

WIEACKER-WOLFF SYNDROME, FEMALE-RESTRICTED (ISO)

Wilson-Turner syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

aflatoxin M1 (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

CGP 52608 (ISO)

choline (ISO)

cisplatin (ISO)

cyclophosphamide (EXP)

dorsomorphin (ISO)

entinostat (ISO)

folic acid (ISO)

gentamycin (EXP)

L-methionine (ISO)

methylmercury chloride (ISO)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

SB 431542 (ISO)

sunitinib (ISO)

temozolomide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasmic ribonucleoprotein granule (IBA)

nucleus (IBA)

Molecular Function

metal ion binding (IEA)

mRNA binding (IBA)

RNA endonuclease activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Zc3h12b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	64,625,479 - 64,858,634 (+)	NCBI		GRCr8
mRatBN7.2	X	60,615,616 - 60,849,278 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	60,615,682 - 60,844,832 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	65,040,032 - 65,074,857 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	65,040,104 - 65,074,712 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	65,882,161 - 65,916,894 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	83,528,345 - 83,561,515 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	61,034,060 - 61,259,514 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

ZC3H12B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	65,034,826 - 65,507,887 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	65,034,788 - 65,507,887 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	64,254,706 - 64,727,767 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	64,625,431 - 64,644,492 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	65,055,755 - 65,074,911 (+)	NCBI		Celera
Cytogenetic Map	X	q11.2-q12	NCBI
HuRef	X	58,536,997 - 58,555,927 (+)	NCBI		HuRef
CHM1_1	X	64,601,682 - 64,620,833 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	63,460,180 - 63,934,332 (+)	NCBI		T2T-CHM13v2.0

Zc3h12b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	94,755,206 - 94,976,262 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	94,755,284 - 94,976,243 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	95,711,583 - 95,932,656 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	95,711,678 - 95,932,637 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	92,907,017 - 93,123,309 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	91,914,397 - 92,127,477 (+)	NCBI		MGSCv36	mm8
Celera	X	82,732,867 - 82,942,791 (+)	NCBI		Celera
Cytogenetic Map	X	C3	NCBI
cM Map	X	42.14	NCBI

Zc3h12b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955475	5,126,158 - 5,162,108 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955475	4,676,190 - 5,162,108 (+)	NCBI	ChiLan1.0	ChiLan1.0

ZC3H12B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	64,570,892 - 65,032,083 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	64,574,426 - 65,035,687 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	54,162,659 - 54,623,859 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	64,680,085 - 64,699,055 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	64,563,916 - 64,699,055 (+)	Ensembl	panpan1.1		panPan2

ZC3H12B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	50,295,906 - 50,507,290 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	50,296,114 - 50,503,019 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	40,751,760 - 41,346,169 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	51,271,151 - 51,466,110 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	X	48,844,047 - 49,437,341 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	50,184,370 - 50,783,525 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	50,090,364 - 50,693,773 (+)	NCBI		UU_Cfam_GSD_1.0

Zc3h12b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	51,818,609 - 52,114,221 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936635	2,588,510 - 2,641,616 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936635	2,580,693 - 2,690,297 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZC3H12B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	51,502,732 - 51,749,625 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	51,231,526 - 51,749,627 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	58,099,740 - 58,372,807 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZC3H12B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	55,152,447 - 55,498,218 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666083	2,365,607 - 2,794,233 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Zc3h12b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624898	1,750,494 - 1,802,364 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624898	1,750,550 - 1,802,233 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Zc3h12b
1011 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	26
Count of miRNA genes:	22
Interacting mature miRNAs:	25
Transcripts:	ENSRNOT00000044006
Prediction methods:	Miranda, Pita, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	41304447	112935181	Rat
70221	Bp56	Blood pressure QTL 56	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	57042141	65612192	Rat

Markers in Region

D9Mit122

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	X	68,320,928 - 68,321,026	NCBI	Rnor5.0
Rnor_5.0	X	65,760,087 - 65,760,185	NCBI	Rnor5.0
Rnor_5.0	2	219,200,997 - 219,201,091	NCBI	Rnor5.0
RGSC_v3.4	X	83,377,299 - 83,377,396	UniSTS	RGSC3.4
RGSC_v3.4	2	192,387,219 - 192,387,312	UniSTS	RGSC3.4
Celera	X	61,103,479 - 61,103,576	UniSTS
Celera	2	177,638,960 - 177,639,053	UniSTS
Cytogenetic Map	2	q34	UniSTS
Cytogenetic Map	X	q31	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low			11	4	9	4			74	24	34	7
Below cutoff	1	38	13	4	10	4	8	8		11	6	4	8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_002730248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008758446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039100436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280452	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000044006 ⟹ ENSRNOP00000045289

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	60,615,682 - 60,844,832 (+)	Ensembl
Rnor_6.0 Ensembl	X	65,040,934 - 65,074,712 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000076903

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	65,040,104 - 65,071,253 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000077012

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	65,068,682 - 65,073,115 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000081354 ⟹ ENSRNOP00000071926

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	65,040,775 - 65,071,290 (+)	Ensembl

RefSeq Acc Id:

XM_002730248 ⟹ XP_002730294

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	64,625,479 - 64,858,634 (+)	NCBI
mRatBN7.2	X	60,615,616 - 60,849,278 (+)	NCBI
Rnor_6.0	X	65,040,032 - 65,074,857 (+)	NCBI
Rnor_5.0	X	65,882,161 - 65,916,894 (+)	NCBI
RGSC_v3.4	X	83,528,345 - 83,561,515 (+)	RGD

Sequence:

show sequence

AATCCTTTTCTGTAATTAATATTTTAATGTTCATCAATCAAGTTGACTTGATATTTTTTCTCTA
TTTTACAGGGTCTCCCTCTGTTGCCTATGGGGAGGGGTATCTCTCCCAAGGCTCAAGGGAACCT
CCTGTCTTGGCCTCCTGAATTAATGGGACTTGAGAGACTGCTAACATCTGAACATACAAAATCA
AACAGACAAACTCTTGCACAATTGCTCCCCCAGCATTCTACTCTAGAGGAATGCCACTGCACAT
GGATTCCAAGCAGGTTAAAAAGAAAAGTAGTTGATTAGATCTCAGAGCACCCAGTGAACGGGAT
GACGGCCACAGCTGCAGTGGAGACACCAAAAATGGAGAAGAGTGCTTCCAAGGAAGAGAAGCAC
CAGCCAAAGCAGAAAGGCAGCACAGACCGAGACAATGCTGATCCTGAGGAATGGGTGAACTCTG
AGAGTGACCCTGAACCGATGAGCTTTAAGAGTGGCCACAACAGCAACCAATCTGCAGATATTCA
GTTGAAGAAGAAAGAGATGCCCTCCAAGCCACATCGCCCGCTCTGTCGGTCACCCTGCCTGGAC
CGGCCAAGCTTCTCTCAGAGCAGCATTTTACAGGATGGGAAGCTAGACTTGGAGAAAGAATACC
AAGCCAAGATGGATTTCGCTCTAAAGTTGGGCTATGCAGAAGAACAAATTCAATCAGTGCTTAA
TAAACTAGGCCCAGAATCACTTATTAATGATGTATTAGCAGAGCTTGTGAGACTTGGAAACAAA
GGTGATTCCGAAGCACAAGTCAACTTGAGTCTGTTATTGCCCCGAGGAGCTAGTTCCAGAGAGA
TTGCGAGCCCTGAATTGTCTCTTGAAGATGAAATAGACAATAGTGATAATTTAAGACCAGTTGT
TATTGATGGAAGTAATGTGGCAATGAGCCATGGGAATAAAGAAGAATTCTCCTGCAGAGGAATA
CAGCTCGCTGTGGATTGGTTTCTAGACAAAGGCCATAAAGACATCACTGTATTTGTACCAGCAT
GGAGAAAGGAGCAATCCCGCCCTGATGCGCCGATTACAGATCAAGATATTCTGCGTAAACTGGA
GAAGGAAAAGATTCTCGTCTTCACACCATCCCGAAGAGTCCAAGGCAGAAGGGTGGTCTGCTAT
GATGATCGGTTCATAGTCAAATTGGCTTTTGATTCTGATGGCATCATTGTGTCCAATGATAACT
ACCGAGACCTTCAAGTTGAAAAGCCAGAATGGAAGAAGTTTATAGAGGAACGGTTGCTGATGTA
TTCTTTTGTGAATGATAAGTTTATGCCACCAGATGATCCTCTTGGACGCCATGGTCCAAGCCTT
GAGAATTTCTTAAGAAAGAGACCTGTGGTTCCTGAGCATAAAAAGCAACCGTGTCCGTATGGCA
AAAAATGTACCTACGGCCACAAGTGCAAATACTATCATCCGGAGCGGGCCAACCAACCCCAGCG
TTCGGTGGCTGATGAGCTCCGCATCAGTGCCAAACTGTCCACAGTGAAAATAATGAGTGAAGAC
ACCCTGGCCAAATGTGGTACAGGGATGTCTACTGCCAAAGGTGAGATAACCTCAGAGATCAAAC
GTGTGGCCTCCAAGCGCCAATCAGATCCCAGCATCCGGTCTGTGGCTGTGGAGCCTGAGGAGTG
GCTGTCCATTGCCCGTAAACCTGAGGCCAGTTCTGTCCCTTCACTTGTGACCGCTTTAAGTGTC
CCTACAATCCCTCCCCCCAAAAGCCATGCAGTGGGTGCACTCAACACCCGTTCAGCCAGCAGCC
CAGTGCCAGGGTCCTCCCATTTTCCCCATCAAAAGGCCTCTTTGGAACACATGGTCAGCATGCA
ATATCCACCTATCCTGGTTACCAACAGCCATGGCACCCCTATTAACTACACTGAGCAATACCCA
AAGTTTGAGACCATGGGGGACCATGACTACTATTCAGTGTTAAGCGACTTCTCCAAGCTGAGCA
TCAACAACATGCATAATCATGAATATTATATGGCTGAGGCAAACCAAGGGGTATATGTTCGGAA
TCCTGGCCTATGTACCGACAGTCACATGAGCCATACCAGGAATGACAACTATTCCTCTTACAAC
AACTTGTACTTGGCTGTAGCTGATGCCCATCCTGAAGGCACGTTGAAGCTGCACCGCGCAGCAT
CCCATAACCATCTTCAGCCTTTCTCCCATGGTTACCATGAAGCCTTAGCGAGAGTTCAAAGTTA
TGGTTCAGAAGATTCCAAGCAAGCACCCCACAAGCAGTCAGTCCCTCACTTAGCTCTGCATACC
CAGAATCCAGCAACTGGAGCACACTCTAGCTGTCCTGGAGACTACACCATGCCTCCCAATATCC
ATCCCGTGGGACCCTCCCAGCCAGGCCGTGCTCTGGTGATGACTCGGATGGACAGCATTTCTGA
CTCCCGCCTCTATGACAGCAACCCTATGAGGCAAAGGCGGCCTCCTCTGTGCAGGGAACAGCAT
GCTAGCTGGGACCCATTGCCTTGTACAGCCGACTCCTACGGATACCACTCCTACCCCTTAGGTA
ACAGCCTCATGCAACCATGTTATGAACCAGTCATGGTAAGGAGCATGCCTGAAAAAATGGAGCA
GCTTTGGAGGAATCCTTGGGTCGGAATGTGCAATGATTCTAGGGAGCATATGATACCAGAGCAT
CAATATCAGACGTACAAGAACCTCTGCAACATCTTCCCTTCTAACATTGTTCTCGCAGTGATGG
AGAAGAATCCCCACACAGCAGATGCTCAACAACTGGCAGCCTTGATTGTTGCCAAGCTTAGGGC
TGCACGTTGACATGACATAGGACTTATTCCTTTACATAAATATGAATACTATTAATACATTGAG
ACTATAATTCTAGTAAGTAATAATTTGTGTTGTGCTTTTCAAATTAGAGTACTTCTATCTTTTA
AGTACATAACAACTCTGTGAGGTAGATCTCAGTAACATTCGATTTTATAGAGAAGGAAACAAAG
CGTGATGCTCGAAAATGACAGCAAGACACCCACCTAAGTTCTCTGGCCCAATGTCCCATGCCCT
TTCCCACTAAAGTGTGGAGATAATGGGGGACAAAACCCAGGAGGCCTACGTGCACAAGAAACCC
CAAGGGAACTCATTACTATACCTTTCTTTCAATTTTCTTTTTTTAATTTTTTGAGACAGTTTTT
GAGACCTTGTAACCCTGGCTTTCCTGAA

hide sequence

RefSeq Acc Id:

XM_039100436 ⟹ XP_038956364

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	64,625,479 - 64,858,634 (+)	NCBI
mRatBN7.2	X	60,615,616 - 60,849,278 (+)	NCBI

RefSeq Acc Id:

XM_063280452 ⟹ XP_063136522

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	64,625,479 - 64,858,634 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_002730294	(Get FASTA)	NCBI Sequence Viewer
	XP_038956364	(Get FASTA)	NCBI Sequence Viewer
	XP_063136522	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL95981	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000045289
	ENSRNOP00000045289.3

RefSeq Acc Id:	XP_002730294 ⟸ XM_002730248
- Peptide Label:	isoform X1
- UniProtKB:	D4ACQ4 (UniProtKB/TrEMBL), A6IQ32 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTATAAVETPKMEKSASKEEKHQPKQKGSTDRDNADPEEWVNSESDPEPMSFKSGHNSNQSADI QLKKKEMPSKPHRPLCRSPCLDRPSFSQSSILQDGKLDLEKEYQAKMDFALKLGYAEEQIQSVL NKLGPESLINDVLAELVRLGNKGDSEAQVNLSLLLPRGASSREIASPELSLEDEIDNSDNLRPV VIDGSNVAMSHGNKEEFSCRGIQLAVDWFLDKGHKDITVFVPAWRKEQSRPDAPITDQDILRKL EKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFDSDGIIVSNDNYRDLQVEKPEWKKFIEERLLM YSFVNDKFMPPDDPLGRHGPSLENFLRKRPVVPEHKKQPCPYGKKCTYGHKCKYYHPERANQPQ RSVADELRISAKLSTVKIMSEDTLAKCGTGMSTAKGEITSEIKRVASKRQSDPSIRSVAVEPEE WLSIARKPEASSVPSLVTALSVPTIPPPKSHAVGALNTRSASSPVPGSSHFPHQKASLEHMVSM QYPPILVTNSHGTPINYTEQYPKFETMGDHDYYSVLSDFSKLSINNMHNHEYYMAEANQGVYVR NPGLCTDSHMSHTRNDNYSSYNNLYLAVADAHPEGTLKLHRAASHNHLQPFSHGYHEALARVQS YGSEDSKQAPHKQSVPHLALHTQNPATGAHSSCPGDYTMPPNIHPVGPSQPGRALVMTRMDSIS DSRLYDSNPMRQRRPPLCREQHASWDPLPCTADSYGYHSYPLGNSLMQPCYEPVMVRSMPEKME QLWRNPWVGMCNDSREHMIPEHQYQTYKNLCNIFPSNIVLAVMEKNPHTADAQQLAALIVAKLR AAR hide sequence

RefSeq Acc Id:

ENSRNOP00000071926 ⟸ ENSRNOT00000081354

RefSeq Acc Id:

ENSRNOP00000045289 ⟸ ENSRNOT00000044006

RefSeq Acc Id:	XP_038956364 ⟸ XM_039100436
- Peptide Label:	isoform X1
- UniProtKB:	D4ACQ4 (UniProtKB/TrEMBL), A6IQ32 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136522 ⟸ XM_063280452
- Peptide Label:	isoform X2

Protein Domains

C3H1-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ACQ4-F1-model_v2	AlphaFold	D4ACQ4	1-835	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560891	AgrOrtholog
BioCyc Gene	G2FUF-2201	BioCyc
Ensembl Genes	ENSRNOG00000011508	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000044006.5	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.11980	UniProtKB/TrEMBL
InterPro	Rege-1_UBA-like	UniProtKB/TrEMBL
	Regnase_1/ZC3H12_C	UniProtKB/TrEMBL
	RNase_Zc3h12	UniProtKB/TrEMBL
	Znf_CCCH	UniProtKB/TrEMBL
KEGG Report	rno:296864	UniProtKB/TrEMBL
NCBI Gene	296864	ENTREZGENE
PANTHER	N4BP1-RELATED	UniProtKB/TrEMBL
	RIBONUCLEASE ZC3H12B-RELATED	UniProtKB/TrEMBL
Pfam	Regnase_1_C	UniProtKB/TrEMBL
	RNase_Zc3h12a	UniProtKB/TrEMBL
	UBA_6	UniProtKB/TrEMBL
PhenoGen	Zc3h12b	PhenoGen
PROSITE	ZF_C3H1	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011508	RatGTEx
UniProt	A6IQ32	ENTREZGENE, UniProtKB/TrEMBL
	D4ACQ4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-11	Zc3h12b	zinc finger CCCH-type containing 12B	RGD1560891	similar to hypothetical protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1560891	similar to hypothetical protein	RGD1560891_predicted	similar to hypothetical protein (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1560891_predicted	similar to hypothetical protein (predicted)	LOC296864	similar to hypothetical protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC296864	similar to hypothetical protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar