Rit1 (Ras-like without CAAX 1) - Rat Genome Database

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Gene: Rit1 (Ras-like without CAAX 1) Rattus norvegicus
Analyze
Symbol: Rit1
Name: Ras-like without CAAX 1
RGD ID: 1559874
Description: Predicted to enable GTPase activity; calmodulin binding activity; and guanyl ribonucleotide binding activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 8; RASopathy; and hepatocellular carcinoma. Orthologous to human RIT1 (Ras like without CAAX 1); INTERACTS WITH bisphenol A; cadmium dichloride; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GTP-binding protein Rit1; LOC499652; RGD1559874; similar to rit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,478,616 - 176,493,269 (+)NCBIGRCr8
mRatBN7.22174,180,742 - 174,195,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,180,848 - 174,195,455 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,327,175 - 181,341,949 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,349,534 - 179,364,308 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,949,437 - 173,964,131 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,087,486 - 188,099,444 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,087,486 - 188,099,444 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,487,476 - 207,498,920 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,846,683 - 180,859,135 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2168,125,309 - 168,137,930 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
cadmium dichloride  (EXP,ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
formaldehyde  (ISO)
gadodiamide hydrate  (ISO)
ifosfamide  (ISO)
inulin  (ISO)
lead diacetate  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
N(6)-dimethylallyladenine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chloride  (ISO)
quercetin  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. RIT1 oncoproteins escape LZTR1-mediated proteolysis. Castel P, etal., Science. 2019 Mar 15;363(6432):1226-1230. doi: 10.1126/science.aav1444.
2. Mutations in RIT1 cause Noonan syndrome with possible juvenile myelomonocytic leukemia but are not involved in acute lymphoblastic leukemia. Cave H, etal., Eur J Hum Genet. 2016 Jan 13. doi: 10.1038/ejhg.2015.273.
3. Next-generation sequencing identifies rare variants associated with Noonan syndrome. Chen PC, etal., Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11473-8. doi: 10.1073/pnas.1324128111. Epub 2014 Jul 21.
4. RIT1 suppresses esophageal squamous cell carcinoma growth and metastasis and predicts good prognosis. Feng YF, etal., Cell Death Dis. 2018 Oct 22;9(11):1085. doi: 10.1038/s41419-018-0979-x.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. HIF-1α-induced RIT1 promotes liver cancer growth and metastasis and its deficiency increases sensitivity to sorafenib. Song Z, etal., Cancer Lett. 2019 Sep 28;460:96-107. doi: 10.1016/j.canlet.2019.06.016. Epub 2019 Jun 24.
10. New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis. Takahara S, etal., EBioMedicine. 2019 Apr;42:43-53. doi: 10.1016/j.ebiom.2019.03.014. Epub 2019 Mar 18.
11. Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations. Yaoita M, etal., Hum Genet. 2016 Feb;135(2):209-22. doi: 10.1007/s00439-015-1627-5. Epub 2015 Dec 29.
Additional References at PubMed
PMID:8824319   PMID:10545207   PMID:23791108  


Genomics

Comparative Map Data
Rit1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,478,616 - 176,493,269 (+)NCBIGRCr8
mRatBN7.22174,180,742 - 174,195,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,180,848 - 174,195,455 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,327,175 - 181,341,949 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,349,534 - 179,364,308 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,949,437 - 173,964,131 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,087,486 - 188,099,444 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,087,486 - 188,099,444 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,487,476 - 207,498,920 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,846,683 - 180,859,135 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2168,125,309 - 168,137,930 (+)NCBICelera
Cytogenetic Map2q34NCBI
RIT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,897,808 - 155,911,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,897,808 - 155,911,404 (-)EnsemblGRCh38hg38GRCh38
GRCh371155,867,599 - 155,881,140 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,134,225 - 154,147,801 (-)NCBINCBI36Build 36hg18NCBI36
Build 341152,682,962 - 152,694,199NCBI
Celera1128,940,503 - 128,954,081 (-)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,228,453 - 127,242,067 (-)NCBIHuRef
CHM1_11157,263,378 - 157,276,968 (-)NCBICHM1_1
T2T-CHM13v2.01155,035,925 - 155,049,482 (-)NCBIT2T-CHM13v2.0
Rit1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,624,154 - 88,638,354 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,624,145 - 88,638,356 (+)EnsemblGRCm39 Ensembl
GRCm38388,716,842 - 88,731,048 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,716,838 - 88,731,049 (+)EnsemblGRCm38mm10GRCm38
MGSCv37388,520,776 - 88,534,970 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,802,791 - 88,815,654 (+)NCBIMGSCv36mm8
Celera388,758,569 - 88,772,478 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.95NCBI
Rit1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,089,536 - 2,099,404 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,089,530 - 2,099,404 (-)NCBIChiLan1.0ChiLan1.0
RIT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,943,872 - 93,973,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,674,831 - 93,704,667 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,232,277 - 131,245,437 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,062,994 - 135,075,183 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,063,000 - 135,074,942 (-)Ensemblpanpan1.1panPan2
RIT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,894,726 - 41,903,450 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,895,330 - 41,901,173 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,384,004 - 41,392,704 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,761,662 - 41,770,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,762,237 - 41,770,224 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,542,190 - 41,550,885 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,595,838 - 41,604,533 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,880,003 - 41,888,698 (+)NCBIUU_Cfam_GSD_1.0
Rit1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,126,969 - 26,136,903 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,156,565 - 5,167,040 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,157,351 - 5,166,790 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,117,882 - 94,127,384 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,117,721 - 94,127,882 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,860,735 - 102,869,029 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RIT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,965,944 - 7,979,396 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,966,057 - 7,976,819 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660387,270,415 - 7,284,182 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rit1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248851,275,765 - 1,284,613 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rit1
114 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:302
Count of miRNA genes:187
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000027455
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
RH131731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,193,523 - 174,193,707 (+)MAPPERmRatBN7.2
Rnor_6.02188,099,724 - 188,099,907NCBIRnor6.0
Rnor_5.02207,499,200 - 207,499,383UniSTSRnor5.0
RGSC_v3.42180,859,415 - 180,859,598UniSTSRGSC3.4
Celera2168,138,210 - 168,138,393UniSTS
RH 3.4 Map21152.51UniSTS
Cytogenetic Map2q34UniSTS
BE102808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,192,957 - 174,193,131 (+)MAPPERmRatBN7.2
Rnor_6.02188,099,158 - 188,099,331NCBIRnor6.0
Rnor_5.02207,498,634 - 207,498,807UniSTSRnor5.0
RGSC_v3.42180,858,849 - 180,859,022UniSTSRGSC3.4
Celera2168,137,644 - 168,137,817UniSTS
RH 3.4 Map21156.0UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000027455   ⟹   ENSRNOP00000027455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2188,087,486 - 188,099,444 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099308   ⟹   ENSRNOP00000090769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,180,848 - 174,195,455 (+)Ensembl
RefSeq Acc Id: NM_001396541   ⟹   NP_001383470
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,478,616 - 176,493,269 (+)NCBI
mRatBN7.22174,180,800 - 174,195,455 (+)NCBI
RefSeq Acc Id: NM_001396542   ⟹   NP_001383471
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,478,616 - 176,493,269 (+)NCBI
mRatBN7.22174,180,800 - 174,195,455 (+)NCBI
RefSeq Acc Id: NM_001396548   ⟹   NP_001383477
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,478,616 - 176,493,269 (+)NCBI
mRatBN7.22174,180,800 - 174,195,455 (+)NCBI
Ensembl Acc Id: ENSRNOP00000027455   ⟸   ENSRNOT00000027455
Ensembl Acc Id: ENSRNOP00000090769   ⟸   ENSRNOT00000099308
RefSeq Acc Id: NP_001383470   ⟸   NM_001396541
- Peptide Label: isoform 1
- UniProtKB: A0A8I6ABM0 (UniProtKB/TrEMBL),   A6J699 (UniProtKB/TrEMBL),   A6J6A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001383471   ⟸   NM_001396542
- Peptide Label: isoform 1
- UniProtKB: A0A8I6ABM0 (UniProtKB/TrEMBL),   A6J699 (UniProtKB/TrEMBL),   A6J6A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001383477   ⟸   NM_001396548
- Peptide Label: isoform 1
- UniProtKB: A0A8I6ABM0 (UniProtKB/TrEMBL),   A6J699 (UniProtKB/TrEMBL),   A6J6A2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJH4-F1-model_v2 AlphaFold D3ZJH4 1-192 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559874 AgrOrtholog
BioCyc Gene G2FUF-52465 BioCyc
Ensembl Genes ENSRNOG00000020232 Ensembl
  ENSRNOG00000064584 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000099308.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/TrEMBL
NCBI Gene 499652 ENTREZGENE
PANTHER GTP-BINDING PROTEIN RIT1 UniProtKB/TrEMBL
  PTHR24070 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PhenoGen Rit1 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020232 RatGTEx
  ENSRNOG00000064584 RatGTEx
SMART RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6ABM0 ENTREZGENE, UniProtKB/TrEMBL
  A6J699 ENTREZGENE, UniProtKB/TrEMBL
  A6J6A2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Rit1  Ras-like without CAAX 1   Rit1_predicted  Ras-like without CAAX 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-04-05 Rit1_predicted    Rit1  Ras-like without CAAX 1 (predicted)  Symbol updated 1299863 APPROVED
2006-04-05 Rit1  Ras-like without CAAX 1 (predicted)  RGD1559874_predicted  similar to rit (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559874_predicted  similar to rit (predicted)  LOC499652  similar to rit  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499652  similar to rit      Symbol and Name status set to provisional 70820 PROVISIONAL