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Gene: Nfxl1 (nuclear transcription factor, X-box binding-like 1) Rattus norvegicus

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Symbol:

Nfxl1

Name:

nuclear transcription factor, X-box binding-like 1

RGD ID:

1359201

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in membrane. Predicted to be active in nucleus. Orthologous to human NFXL1 (nuclear transcription factor, X-box binding like 1); INTERACTS WITH (+)-schisandrin B; amitrole; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC289595; NF-X1-type zinc finger protein NFXL1; RGD1359201; similar to CG15011-PA; similar to nuclear transcription factor, X-box binding-like 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	35,980,058 - 36,021,478 (+)	NCBI		GRCr8
mRatBN7.2	14	35,626,086 - 35,667,505 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	35,626,066 - 35,667,498 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	35,991,372 - 36,032,388 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	37,296,126 - 37,337,142 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	35,784,495 - 35,825,508 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	38,192,462 - 38,233,852 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	38,192,446 - 38,233,852 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	38,003,494 - 38,044,774 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	38,054,861 - 38,095,844 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	38,082,031 - 38,099,193 (+)	NCBI
Celera	14	34,878,053 - 34,918,828 (+)	NCBI		Celera
Cytogenetic Map	14	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

cholestasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

aflatoxin B1 (ISO)

amitrole (EXP)

atazanavir sulfate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chenodeoxycholic acid (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

coumarin (ISO)

cyclosporin A (ISO)

deoxycholic acid (ISO)

Dibutyl phosphate (ISO)

formaldehyde (ISO)

FR900359 (ISO)

gallic acid (ISO)

glycochenodeoxycholic acid (ISO)

glycocholic acid (ISO)

glycodeoxycholic acid (ISO)

heptanal (ISO)

hexanal (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

N-methyl-4-phenylpyridinium (EXP)

nefazodone (ISO)

nonanal (ISO)

octanal (ISO)

paracetamol (ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

propanal (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

triticonazole (EXP)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of DNA-templated transcription (IBA)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

membrane (IEA)

nucleus (IBA)

Molecular Function

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:19946888

Genomics

Comparative Map Data

Nfxl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	35,980,058 - 36,021,478 (+)	NCBI		GRCr8
mRatBN7.2	14	35,626,086 - 35,667,505 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	35,626,066 - 35,667,498 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	35,991,372 - 36,032,388 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	37,296,126 - 37,337,142 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	35,784,495 - 35,825,508 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	38,192,462 - 38,233,852 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	38,192,446 - 38,233,852 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	38,003,494 - 38,044,774 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	38,054,861 - 38,095,844 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	38,082,031 - 38,099,193 (+)	NCBI
Celera	14	34,878,053 - 34,918,828 (+)	NCBI		Celera
Cytogenetic Map	14	p11	NCBI

NFXL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	47,847,233 - 47,914,667 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	47,847,233 - 47,914,667 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	47,849,250 - 47,916,684 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	47,544,014 - 47,611,390 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	48,298,135 - 48,365,585 (-)	NCBI		Celera
Cytogenetic Map	4	p12	NCBI
HuRef	4	47,168,755 - 47,236,269 (-)	NCBI		HuRef
CHM1_1	4	47,848,204 - 47,915,792 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	47,814,565 - 47,881,968 (-)	NCBI		T2T-CHM13v2.0

Nfxl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	72,670,647 - 72,717,078 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	72,670,644 - 72,717,027 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	72,513,304 - 72,559,735 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	72,513,301 - 72,559,684 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	72,904,543 - 72,950,884 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	72,835,570 - 72,838,148 (-)	NCBI		MGSCv36	mm8
Celera	5	69,767,855 - 69,808,087 (-)	NCBI		Celera
Cytogenetic Map	5	C3.2	NCBI
cM Map	5	38.44	NCBI

Nfxl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955443	668,031 - 713,481 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955443	665,235 - 714,627 (+)	NCBI	ChiLan1.0	ChiLan1.0

NFXL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	79,944,440 - 80,013,688 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	80,207,453 - 80,274,861 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	74,234,523 - 74,301,966 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	84,966,959 - 85,034,154 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	84,967,076 - 85,034,154 (+)	Ensembl	panpan1.1		panPan2

NFXL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	43,743,271 - 43,814,899 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	43,744,181 - 43,814,520 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	43,695,854 - 43,767,093 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	44,342,939 - 44,414,377 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	44,342,946 - 44,414,375 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	44,020,805 - 44,091,824 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	43,552,949 - 43,623,828 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	44,435,784 - 44,507,011 (-)	NCBI		UU_Cfam_GSD_1.0

Nfxl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	32,235,545 - 32,289,403 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936482	14,009,724 - 14,062,207 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936482	14,008,825 - 14,062,654 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NFXL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	37,812,911 - 37,875,540 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	37,812,378 - 37,875,582 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	39,788,607 - 39,845,909 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NFXL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	2,333,158 - 2,401,008 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	2,333,809 - 2,400,084 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	48,351,769 - 48,419,293 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nfxl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	19,029,434 - 19,084,307 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624761	19,029,537 - 19,084,156 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nfxl1
179 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	382
Count of miRNA genes:	229
Interacting mature miRNAs:	283
Transcripts:	ENSRNOT00000003131
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9088978	39057237	Rat
10755459	Coatc15	Coat color QTL 15		0.01681	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	14	19836944	64836944	Rat
1300154	Bp189	Blood pressure QTL 189	3.04		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	14	30883777	68757901	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30320092	80829842	Rat
2324617	Coatc2	Coat color QTL 2		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	14	30767025	39153750	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
71117	Niddm17	Non-insulin dependent diabetes mellitus QTL 17	2.35		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	17593761	42336881	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	18631345	42337007	Rat
7387267	Uae42	Urinary albumin excretion QTL 42		0.61	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	14	22167967	67167967	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18541332	63541332	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	17622561	42337007	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat

Markers in Region

RH141380

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	35,627,844 - 35,628,044 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	38,194,221 - 38,194,420	NCBI	Rnor6.0
Rnor_5.0	14	38,005,239 - 38,005,438	UniSTS	Rnor5.0
RGSC_v3.4	14	38,056,212 - 38,056,411	UniSTS	RGSC3.4
Celera	14	34,879,812 - 34,880,011	UniSTS
Cytogenetic Map	14	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001170438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091704	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC121481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000077080 ⟹ ENSRNOP00000074217

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	35,626,086 - 35,667,498 (+)	Ensembl
Rnor_6.0 Ensembl	14	38,192,870 - 38,233,852 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090242 ⟹ ENSRNOP00000075378

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	35,626,066 - 35,667,498 (+)	Ensembl
Rnor_6.0 Ensembl	14	38,192,446 - 38,233,534 (+)	Ensembl

RefSeq Acc Id:

NM_001170438 ⟹ NP_001163909

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	35,980,083 - 36,021,478 (+)	NCBI
mRatBN7.2	14	35,626,086 - 35,667,498 (+)	NCBI
Rnor_6.0	14	38,192,462 - 38,233,852 (+)	NCBI
Rnor_5.0	14	38,003,494 - 38,044,774 (+)	NCBI
RGSC_v3.4	14	38,054,861 - 38,095,844 (+)	RGD
Celera	14	34,878,053 - 34,918,828 (+)	NCBI

Sequence:

show sequence

CGCGGGCAGAGGCTTCTGGGAGTTGTAGTCGCTGGCGGTGGGCGCCGTCGGTAAGGAGACGTAG
CTTTCGGTGCGGTCCACTTCAGCAGTTGGTTCCCGGCCGCGGCGTCACGGGATGGACGCTTCCT
GGCGCCAGGTGGCCGCTGGCCGAGGCCGAGCCCGAGGAAGGGGTACCGCAGTGCCCCTCTCAGG
AAATGGAGTCCCTCTTAGCGGCGCAGGGGGAGGGCGAGCCAAAGGGTCTGGGGGCGCGGTGCCC
TCGGCCCCCGGCCCGAGGAGAGCAGCAACTCCGGGCCCTGCGGGTCACAAGCAGCGCTCTGCTG
GAGGCGAAGCCCCGCAGCCCCTGTGGGTCGGCGGTGAGGATGGCTCAGAGCTAATATCTCAGAG
GAAATTTGAGGAGATCAAGAAGGCCAATCAAGCTGCAGCCAGAAAGCTCGTGGAGGAACACTGC
AGCTCTTCCTCTGAAGAAGAAGAAGGGGATGAAGACTTTGAAGGAAAACAGGGGAAAATTGTTG
CTAATACATTCATAACATACACCACTCACACAGATGGAGATGTACATGAATTGGAGAAAACAAA
ACAGTATCTGAATGAGGCTTTCCAAGCAGGGGCTATGACGTGCCTGATTTGTATTGCTTCAGTG
AAGAGAAACCAGGCAGTTTGGAGCTGTTCAGGATGTTTCTGTATATTCCACATGCCCTGTATTC
AGAAGTGGGCTAAGGACAGCCAGTTTCTTGTATCTTCTGTGACAGACGATGATTTTGGAAAGAA
AGATTATCCCTGGCCATGTCCAAAATGTAGATTTGAATACAAAAGGTCGGAAACACCTAGTCGA
TATTATTGCTACTGTGGAAAAGTAGAAGACCCACCTTTAGATCCCTGGCTTGTTCCTCATTCGT
GTGGCCAAGTGTGTGAGAGAGAATTTAAACCTTCCTGTGGTCATAAATGTCTACTACTCTGCCA
TCCAGGTCCCTGCCCTCCTTGTCCAAAGATGGTCACAACTACTTGCTACTGTAAGAAAGCAAAA
CCTATCCCTCGTAGGTGCAGTGCCAAGCAGTGGTCCTGTCAGCTGCCATGTGGGCGAAAGCTGC
TTTGTGGGCAGCATTCGTGTGAAAATCCTTGCCATGCAGGAAACTGTCAGCCTTGTCCAAGAGT
TAGTAGACAAAAATGTGTATGTGGCAAAAAAGTAGCAGAAAGAAGTTGTGCGAGTCCAGTGTGG
CACTGTGACCAAGTATGTAGAAAGACACTGCCGTGTGGTAATCATACATGTGAGCAAGTTTGTC
ATGTTGGTGCTTGTGGAGAATGTCCTCGCTCTGGGAAGAGGTCTTGTCCCTGTCAGAAATCAAA
GTTTTCTTTGCCTTGTACAGAAGATGTACCAACTTGTGGAGACAGCTGTGACAAAATACTCGAA
TGTGGAATCCACAGGTGTTCACAGCGTTGCCATCGAGGTCCTTGTGAAACGTGCAGACAAGAAG
TGGAAAAGCAGTGTCGTTGTGGAAAACATACAAAGCGAATGCCTTGTCACAAGACTTACCTTTG
TGAAACGAAGTGTGTAAAAATGCGGGACTGTCAAAAGCATCAGTGTAGGAGAAAGTGTTGCCCT
GGAAACTGTCCACCTTGTGATCAAAATTGTGGACGGACTTTAGGATGTAGAAACCATAAGTGTC
CGTCTGTCTGCCACAGAGGCAGCTGCTATCCATGCCCAGAAACGGTAGATGTGAAGTGCAACTG
TGGTAACGCAAAGGTGACAGTACCCTGTGGCCGAGAGCGGACTACAAGGCCACCTAAGTGCAAA
GAGCTGTGCAGTCGACCACCAACATGTCATCATTCAAGTCAAGAAAAACACCGCTGTCACTTTG
GCCCATGCCCACCATGTCATCAGCCTTGCCAAAAAGTTCTGGAGAAATGTGGGCACTTGTGTCC
CATTTCATGTCATGATCAAGCATTAGTAAAGCAGACCGGCAGGCATCAGCTGTCAGGCCCTTGG
GAGCAGCCAGCCGAGCCAGCGTTTATTCAGACTGCGTTGCCTTGTCCTCCGTGTCAAGTTCCCA
TTCCTGTGGAATGTCTGGGGAAGCATGAGGTAAGCCCACTACCATGCCATGCTGTAGGACCCTA
TTCATGCAAGAGACTTTGTGGAAGAATGTTGAACTGTCAGAATCATACGTGTACGAAAGAATGC
CACAAAGTGACTGAAGTTGATGGCTGTCCTGGCAGACATAAGGCTGGCCCAGAATGCCTTCAGT
GTGAAGAAGGGTGTTCTAAGTCACGGCCTGCAGGTTGTCCTCACCCTTGTGTTTTGCCATGTCA
CCCTGGAAAATGCCCTCCTTGTGTCCAGATGCTTAGAATAAAATGTCACTGCAAGATCACAAAC
CTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTGAGTGAGAAGAACCTCCTCAGTTGTT
GCAAAAACCAGTGCCCCAAAGAGCTTCCTTGTGGCCATAGATGCAAAGAGATGTGTCATCCTGG
TGAATGCCCCTATAATTGCAACCAGAAGGTAAAACTTAGATGCCCTTGTAAAAGAATAAAACGG
GAATTGCCTTGCAATAAAATCCGTGGGAATCAGGTTTCAGTGGAATGCGATGCGGCGTGCAAGG
AGATGAAGCGGAAAGCATCTGAGATTAAAGAAGCGGAAGCCAACGCTGCTCTGGAAGAAGAAAA
GCGAAGGCAGCAGGCTGAGCTGGAGGCTTTTGAGAACAGACTGAAGGGCCGGCGGAAGAAGAAC
AGGAAACGCGATGAAGTGGCCGTGCAGCTCTCGCCTTGGCAGAAGTACAAGTCCTACCTCTTTC
CGGTGTGTGGAGTTGTGGTGGCGGTGCTTGTGTGGTACATCTGCCATCATGCGGATTAATGATC
CTTTAGATCTCACTTACCTCAGACTGGAGTTATATAAACGTTGACTCTAGGACGTTAGAACGTG
CGCTGTAGCATATGATACACATTCACATTCCTCTCTGTGTCCTTGTCTGGCTGTAGGTAGGACA
GGATGTTTTAGTGTTCTCTGAACCAGCAGTTCCCGGGCCTGTGAGATACTGTACAGTCATCATG
GCTGCAGGTAGAAACAGGTCAGGAAGCTTCGTCAGGAGCACTGTGCCCCTGTGTATTAAGTTAG
TCTTTGTCCTCAGATGTGTCCACGTCCAACACTTCATCCTGTGAATTCAGATAGAACTGAGCCA
TATGTGCAGCCACAAGGATATTTCTCTGTGATATTTCACTTACTGGGTACTTTTCTTGATCATG
TAACTTTCTACTTTTTTAAAGAAATGATTCTGTAACAGAATCTTAAATTCTAACAGGAAGTTTT
ATAGTTAGATTTCAGATTATCAGAGAGGAATTTTTATTGGTAATTGAAGCAAATTTTACACTGC
GTATTCCTCGGATATATAAACAAGTGCCAGACGAGGTTCCTTTTAGGACGTTGTTGGGTTGGGT
TTTTTTTTTTTTTTTTTTTTTTTTTGGTGTAAGAAGCTTTAATTGATGTTGGCATGTTTTGTAA
AACTTGTGTGTATCTTTTTATGATCATAATAAAGGAAAACTAATATTTATGAGCAATATGTGCA
GAGCACAGGGCTGGTGGGTGTAATGTACTTGATTCCATTTTTTTTTTACTGTAATTTTTGATAT
AGCTGAGAATAATCCATTTTGTGAAATCAAACTGATAGAGAAATAATAAGCCAAATTGCATAGA
TTTGTAAGTCATTTAAAGTAGTTTTGCTATTTAATTTTATGATTGTTTTCATTAAAAGTTTTCA
TACCAAA

hide sequence

RefSeq Acc Id:

XM_039091704 ⟹ XP_038947632

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	35,980,139 - 36,021,478 (+)	NCBI
mRatBN7.2	14	35,626,139 - 35,667,505 (+)	NCBI

RefSeq Acc Id:

XM_039091705 ⟹ XP_038947633

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	35,987,691 - 36,021,478 (+)	NCBI
mRatBN7.2	14	35,633,694 - 35,667,505 (+)	NCBI

RefSeq Acc Id:

XM_063272918 ⟹ XP_063128988

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	35,980,058 - 36,021,478 (+)	NCBI

RefSeq Acc Id:

XM_063272919 ⟹ XP_063128989

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	35,980,137 - 36,021,478 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001163909	(Get FASTA)	NCBI Sequence Viewer
	XP_038947632	(Get FASTA)	NCBI Sequence Viewer
	XP_038947633	(Get FASTA)	NCBI Sequence Viewer
	XP_063128988	(Get FASTA)	NCBI Sequence Viewer
	XP_063128989	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88853	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000074217.2
	ENSRNOP00000075378.2

RefSeq Acc Id:

NP_001163909 ⟸ NM_001170438

- UniProtKB:

F1LNF3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDASWRQVAAGRGRARGRGTAVPLSGNGVPLSGAGGGRAKGSGGAVPSAPGPRRAATPGPAGHK
QRSAGGEAPQPLWVGGEDGSELISQRKFEEIKKANQAAARKLVEEHCSSSSEEEEGDEDFEGKQ
GKIVANTFITYTTHTDGDVHELEKTKQYLNEAFQAGAMTCLICIASVKRNQAVWSCSGCFCIFH
MPCIQKWAKDSQFLVSSVTDDDFGKKDYPWPCPKCRFEYKRSETPSRYYCYCGKVEDPPLDPWL
VPHSCGQVCEREFKPSCGHKCLLLCHPGPCPPCPKMVTTTCYCKKAKPIPRRCSAKQWSCQLPC
GRKLLCGQHSCENPCHAGNCQPCPRVSRQKCVCGKKVAERSCASPVWHCDQVCRKTLPCGNHTC
EQVCHVGACGECPRSGKRSCPCQKSKFSLPCTEDVPTCGDSCDKILECGIHRCSQRCHRGPCET
CRQEVEKQCRCGKHTKRMPCHKTYLCETKCVKMRDCQKHQCRRKCCPGNCPPCDQNCGRTLGCR
NHKCPSVCHRGSCYPCPETVDVKCNCGNAKVTVPCGRERTTRPPKCKELCSRPPTCHHSSQEKH
RCHFGPCPPCHQPCQKVLEKCGHLCPISCHDQALVKQTGRHQLSGPWEQPAEPAFIQTALPCPP
CQVPIPVECLGKHEVSPLPCHAVGPYSCKRLCGRMLNCQNHTCTKECHKVTEVDGCPGRHKAGP
ECLQCEEGCSKSRPAGCPHPCVLPCHPGKCPPCVQMLRIKCHCKITNLYVECRKITTADVSEKN
LLSCCKNQCPKELPCGHRCKEMCHPGECPYNCNQKVKLRCPCKRIKRELPCNKIRGNQVSVECD
AACKEMKRKASEIKEAEANAALEEEKRRQQAELEAFENRLKGRRKKNRKRDEVAVQLSPWQKYK
SYLFPVCGVVVAVLVWYICHHAD

hide sequence

Ensembl Acc Id:

ENSRNOP00000074217 ⟸ ENSRNOT00000077080

Ensembl Acc Id:

ENSRNOP00000075378 ⟸ ENSRNOT00000090242

RefSeq Acc Id:	XP_038947632 ⟸ XM_039091704
- Peptide Label:	isoform X2
- UniProtKB:	F1LNF3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038947633 ⟸ XM_039091705
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063128988 ⟸ XM_063272918
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAF4 (UniProtKB/TrEMBL), F1LNF3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128989 ⟸ XM_063272919
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAF4 (UniProtKB/TrEMBL), F1LNF3 (UniProtKB/TrEMBL)

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LNF3-F1-model_v2	AlphaFold	F1LNF3	1-919	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699308

Promoter ID:

EPDNEW_R9825

Type:

initiation region

Name:

Nfxl1_1

Description:

nuclear transcription factor, X-box binding-like 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	38,192,541 - 38,192,601	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359201	AgrOrtholog
BioCyc Gene	G2FUF-15850	BioCyc
Ensembl Genes	ENSRNOG00000058588	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000077080.2	UniProtKB/TrEMBL
	ENSRNOT00000090242.2	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7317845	IMAGE-MGC_LOAD
InterPro	NFX1_fam	UniProtKB/TrEMBL
	Znf_NFX1	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
MGC_CLONE	MGC:105619	IMAGE-MGC_LOAD
NCBI Gene	289595	ENTREZGENE
PANTHER	NF-X1-TYPE ZINC FINGER PROTEIN NFXL1	UniProtKB/TrEMBL
	PTHR12360	UniProtKB/TrEMBL
Pfam	zf-NF-X1	UniProtKB/TrEMBL
PhenoGen	Nfxl1	PhenoGen
PROSITE	ZF_RING_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000058588	RatGTEx
SMART	ZnF_NFX	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
UniProt	A0A0G2KAF4	ENTREZGENE, UniProtKB/TrEMBL
	F1LNF3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-04-23	Nfxl1	nuclear transcription factor, X-box binding-like 1	RGD1359201	similar to nuclear transcription factor, X-box binding-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	RGD1359201	similar to nuclear transcription factor, X-box binding-like 1			Symbol and Name updated	1299863	APPROVED
2005-07-29	LOC289595	similar to CG15011-PA			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD