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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Tmem50b | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Tmem50b (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of TMEM50B mRNA | CTD | PMID:22206623 | Tmem50b | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of TMEM50B mRNA | CTD | PMID:32145629 | Tmem50b | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:19095052 | Tmem50b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Tmem50b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TMEM50B mRNA | CTD | PMID:20819909 | Tmem50b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TMEM50B mRNA | CTD | PMID:33387578 | Tmem50b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Tmem50b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TMEM50B mRNA | CTD | PMID:21570461 | Tmem50b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TMEM50B mRNA | CTD | PMID:18796159 more ... | Tmem50b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Tmem50b (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of TMEM50B mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TMEM50B gene] | CTD | PMID:20819909 and PMID:25975270 | Tmem50b | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TMEM50B mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TMEM50B mRNA | CTD | PMID:28628672 | Tmem50b | Rat | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of TMEM50B mRNA | CTD | PMID:36041667 | Tmem50b | Rat | acrolein | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of TMEM50B mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of TMEM50B mRNA | CTD | PMID:32699268 | Tmem50b | Rat | all-trans-retinoic acid | increases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Tretinoin results in increased expression of TMEM50B mRNA | CTD | PMID:21934132 | Tmem50b | Rat | alpha-pinene | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of TMEM50B mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of TMEM50B mRNA | CTD | PMID:32699268 | Tmem50b | Rat | arsane | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of TMEM50B mRNA | CTD | PMID:32525701 | Tmem50b | Rat | arsenic atom | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of TMEM50B mRNA | CTD | PMID:32525701 | Tmem50b | Rat | atrazine | increases expression | EXP | | 6480464 | Atrazine results in increased expression of TMEM50B mRNA | CTD | PMID:36841081 | Tmem50b | Rat | benzo[a]pyrene | multiple interactions | ISO | Tmem50b (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of TMEM50B mRNA] | CTD | PMID:22228805 | Tmem50b | Rat | benzo[a]pyrene | decreases methylation | ISO | TMEM50B (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of TMEM50B 5' UTR | CTD | PMID:27901495 | Tmem50b | Rat | benzo[a]pyrene | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of TMEM50B mRNA | CTD | PMID:26238291 | Tmem50b | Rat | benzo[a]pyrene | increases expression | ISO | Tmem50b (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of TMEM50B mRNA | CTD | PMID:22228805 | Tmem50b | Rat | Benzo[k]fluoranthene | decreases expression | ISO | Tmem50b (Mus musculus) | 6480464 | benzo(k)fluoranthene results in decreased expression of TMEM50B mRNA | CTD | PMID:26377693 | Tmem50b | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of TMEM50B mRNA | CTD | PMID:25181051 | Tmem50b | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of TMEM50B mRNA | CTD | PMID:36041667 | Tmem50b | Rat | bisphenol A | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of TMEM50B gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TMEM50B mRNA | CTD | PMID:28628672 and PMID:31601247 | Tmem50b | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TMEM50B mRNA | CTD | PMID:30816183 more ... | Tmem50b | Rat | bisphenol F | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TMEM50B mRNA | CTD | PMID:28628672 | Tmem50b | Rat | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of TMEM50B mRNA | CTD | PMID:36041667 | Tmem50b | Rat | butan-1-ol | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of TMEM50B mRNA | CTD | PMID:29432896 | Tmem50b | Rat | carbon nanotube | decreases expression | ISO | Tmem50b (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Tmem50b | Rat | carbon nanotube | increases expression | ISO | Tmem50b (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of TMEM50B mRNA | CTD | PMID:25620056 | Tmem50b | Rat | CGP 52608 | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to TMEM50B gene] | CTD | PMID:28238834 | Tmem50b | Rat | ciguatoxin CTX1B | affects expression | ISO | Tmem50b (Mus musculus) | 6480464 | Ciguatoxins affects the expression of TMEM50B mRNA | CTD | PMID:18353800 | Tmem50b | Rat | cisplatin | increases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Cisplatin results in increased expression of TMEM50B mRNA | CTD | PMID:19561079 | Tmem50b | Rat | clobetasol | increases expression | ISO | Tmem50b (Mus musculus) | 6480464 | Clobetasol results in increased expression of TMEM50B mRNA | CTD | PMID:27462272 | Tmem50b | Rat | copper atom | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of TMEM50B mRNA | CTD | PMID:20971185 | Tmem50b | Rat | copper(0) | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of TMEM50B mRNA | CTD | PMID:20971185 | Tmem50b | Rat | copper(II) sulfate | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of TMEM50B mRNA | CTD | PMID:19549813 | Tmem50b | Rat | cyclosporin A | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of TMEM50B mRNA | CTD | PMID:25562108 | Tmem50b | Rat | dexamethasone | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TMEM50B mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TMEM50B mRNA | CTD | PMID:28628672 | Tmem50b | Rat | dibutyl phthalate | decreases expression | ISO | Tmem50b (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of TMEM50B mRNA | CTD | PMID:21266533 | Tmem50b | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of TMEM50B mRNA | CTD | PMID:21266533 | Tmem50b | Rat | dicrotophos | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of TMEM50B mRNA | CTD | PMID:28302478 | Tmem50b | Rat | dimethylarsinous acid | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | dimethylarsinous acid results in decreased expression of TMEM50B mRNA | CTD | PMID:16507463 | Tmem50b | Rat | dioxygen | multiple interactions | ISO | Tmem50b (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of TMEM50B mRNA | CTD | PMID:30529165 | Tmem50b | Rat | doxorubicin | affects expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Doxorubicin affects the expression of TMEM50B mRNA | CTD | PMID:29803840 | Tmem50b | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of TMEM50B mRNA | CTD | PMID:24793618 | Tmem50b | Rat | formaldehyde | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of TMEM50B mRNA | CTD | PMID:23649840 | Tmem50b | Rat | fulvestrant | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of TMEM50B gene | CTD | PMID:31601247 | Tmem50b | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of TMEM50B mRNA | CTD | PMID:33387578 | Tmem50b | Rat | hydrogen peroxide | increases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Hydrogen Peroxide results in increased expression of TMEM50B mRNA | CTD | PMID:18951874 | Tmem50b | Rat | indometacin | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TMEM50B mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TMEM50B mRNA | CTD | PMID:28628672 | Tmem50b | Rat | isobutanol | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of TMEM50B mRNA | CTD | PMID:29432896 | Tmem50b | Rat | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of TMEM50B mRNA | CTD | PMID:24136188 | Tmem50b | Rat | methyl methanesulfonate | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of TMEM50B mRNA | CTD | PMID:23649840 | Tmem50b | Rat | niclosamide | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Niclosamide results in decreased expression of TMEM50B mRNA | CTD | PMID:36318118 | Tmem50b | Rat | ochratoxin A | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | ochratoxin A results in decreased expression of TMEM50B mRNA | CTD | PMID:22124623 | Tmem50b | Rat | ozone | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of TMEM50B mRNA more ... | CTD | PMID:32699268 | Tmem50b | Rat | paracetamol | increases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of TMEM50B mRNA | CTD | PMID:21420995 | Tmem50b | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of TMEM50B mRNA | CTD | PMID:33387578 | Tmem50b | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of TMEM50B mRNA | CTD | PMID:32680482 | Tmem50b | Rat | quercetin | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Quercetin results in decreased expression of TMEM50B mRNA | CTD | PMID:21632981 | Tmem50b | Rat | resveratrol | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of TMEM50B mRNA | CTD | PMID:23557933 | Tmem50b | Rat | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of TMEM50B mRNA | CTD | PMID:28374803 | Tmem50b | Rat | rotenone | increases expression | ISO | Tmem50b (Mus musculus) | 6480464 | Rotenone results in increased expression of TMEM50B mRNA | CTD | PMID:32937126 | Tmem50b | Rat | silicon dioxide | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of TMEM50B mRNA | CTD | PMID:25895662 | Tmem50b | Rat | sodium arsenate | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of TMEM50B mRNA | CTD | PMID:32525701 | Tmem50b | Rat | sodium arsenite | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of TMEM50B mRNA | CTD | PMID:28595984 and PMID:34032870 | Tmem50b | Rat | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of TMEM50B mRNA | CTD | PMID:19281266 | Tmem50b | Rat | sunitinib | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of TMEM50B mRNA | CTD | PMID:31533062 | Tmem50b | Rat | T-2 toxin | decreases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | T-2 Toxin results in decreased expression of TMEM50B mRNA | CTD | PMID:31863870 | Tmem50b | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of TMEM50B mRNA | CTD | PMID:34492290 | Tmem50b | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of TMEM50B mRNA | CTD | PMID:33387578 | Tmem50b | Rat | triphenyl phosphate | increases expression | EXP | | 6480464 | triphenyl phosphate results in increased expression of TMEM50B mRNA | CTD | PMID:30589522 | Tmem50b | Rat | tunicamycin | increases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of TMEM50B mRNA | CTD | PMID:22378314 and PMID:29453283 | Tmem50b | Rat | valproic acid | increases expression | ISO | TMEM50B (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of TMEM50B mRNA | CTD | PMID:19101580 more ... | Tmem50b | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of TMEM50B mRNA | CTD | PMID:23034163 | Tmem50b | Rat | zinc atom | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of TMEM50B mRNA | CTD | PMID:18593933 | Tmem50b | Rat | zinc(0) | multiple interactions | ISO | TMEM50B (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of TMEM50B mRNA | CTD | PMID:18593933 | |