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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307561
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tmem50b
Name: transmembrane protein 50B
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of TMEM50B mRNA

PMID:18796159, PMID:21215274
affects expressionISORGD:15529866480464CTDTetrachlorodibenzodioxin affects the expression of TMEM50B mRNA

PMID:21570461
increases expressionISORGD:15529866480464CTDTetrachlorodibenzodioxin results in increased expression of TMEM50B mRNA

PMID:20819909
multiple interactionsISORGD:15529866480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of TMEM50B mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TMEM50B gene]

PMID:20819909, PMID:25975270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.