Pdia2 (protein disulfide isomerase family A, member 2)

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Gene: Pdia2 (protein disulfide isomerase family A, member 2) Rattus norvegicus

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Symbol:

Pdia2

Name:

protein disulfide isomerase family A, member 2

RGD ID:

1305164

Description:

Predicted to enable protein-disulfide reductase activity. Predicted to act upstream of or within platelet aggregation. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human PDIA2 (protein disulfide isomerase family A member 2); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; INTERACTS WITH 6-propyl-2-thiouracil; bis(2-ethylhexyl) phthalate; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC287164; Pdip; protein disulfide isomerase A2; protein disulfide isomerase associated 2; protein disulfide isomerase, pancreatic; protein disulfide-isomerase A2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	15,720,301 - 15,723,386 (-)	NCBI		GRCr8
mRatBN7.2	10	15,215,824 - 15,218,937 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	15,215,824 - 15,220,931 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	19,955,596 - 19,958,670 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	19,444,475 - 19,447,549 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	14,943,755 - 14,946,829 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_5.0	10	15,376,461 - 15,379,606 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	15,462,935 - 15,466,009 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	15,463,985 - 15,467,059 (-)	NCBI
Celera	10	14,883,630 - 14,886,704 (-)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

bicuspid aortic valve disease (ISO)

epilepsy (ISO)

idiopathic generalized epilepsy (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chlorpromazine (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

ellagic acid (EXP)

furan (EXP)

ketamine (EXP)

L-ascorbic acid (ISO)

lactacystin (ISO)

lipopolysaccharide (ISO)

malathion (ISO)

N-methyl-4-phenylpyridinium (ISO)

potassium dichromate (ISO)

resveratrol (ISO)

rotenone (EXP)

senecionine (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

tetraphene (ISO)

titanium dioxide (ISO)

triclosan (ISO)

tunicamycin (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

platelet aggregation (ISO)

Cellular Component

endoplasmic reticulum lumen (IEA)

Molecular Function

protein binding (ISO)

protein disulfide isomerase activity (IEA)

protein-disulfide reductase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

codeine and morphine pharmacodynamics pathway (ISO)

codeine and morphine pharmacokinetics pathway (ISO)

etoposide pharmacodynamics pathway (ISO)

etoposide pharmacokinetics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacokinetics pathway (ISO)

irinotecan pharmacodynamics pathway (ISO)

irinotecan pharmacokinetics pathway (ISO)

paracetamol pharmacokinetics pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

retinol metabolic pathway (ISO)

sorafenib pharmacokinetics pathway (ISO)

vitamin A deficiency pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
2.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:16677074	PMID:19103594	PMID:19429457	PMID:25122773

Genomics

Comparative Map Data

Pdia2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	15,720,301 - 15,723,386 (-)	NCBI		GRCr8
mRatBN7.2	10	15,215,824 - 15,218,937 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	15,215,824 - 15,220,931 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	19,955,596 - 19,958,670 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	19,444,475 - 19,447,549 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	14,943,755 - 14,946,829 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_5.0	10	15,376,461 - 15,379,606 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	15,462,935 - 15,466,009 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	15,463,985 - 15,467,059 (-)	NCBI
Celera	10	14,883,630 - 14,886,704 (-)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

PDIA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	283,164 - 287,215 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	283,164 - 287,215 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	333,164 - 337,215 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	273,119 - 277,210 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	273,208 - 277,210	NCBI
Celera	16	533,017 - 537,108 (+)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	251,360 - 255,512 (+)	NCBI		HuRef
CHM1_1	16	333,055 - 337,171 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	278,036 - 282,088 (+)	NCBI		T2T-CHM13v2.0

Pdia2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	26,414,973 - 26,418,108 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	26,414,973 - 26,418,061 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	26,195,999 - 26,199,134 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	26,195,999 - 26,199,087 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	26,332,944 - 26,336,032 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	25,923,599 - 25,926,687 (-)	NCBI		MGSCv36	mm8
Celera	17	26,729,757 - 26,732,844 (-)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	13.07	NCBI

Pdia2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	16,898,635 - 16,901,799 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	16,898,563 - 16,901,867 (-)	NCBI	ChiLan1.0	ChiLan1.0

PDIA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	501,336 - 506,685 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	4,294,232 - 4,298,939 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	273,692 - 278,014 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	273,764 - 277,914 (+)	Ensembl	panpan1.1		panPan2

PDIA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	40,218,566 - 40,221,924 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	40,218,550 - 40,231,402 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	41,482,205 - 41,485,425 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	40,560,945 - 40,564,168 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	40,560,945 - 40,564,149 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	40,249,209 - 40,252,422 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	40,210,283 - 40,213,487 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	40,688,729 - 40,691,944 (-)	NCBI		UU_Cfam_GSD_1.0

Pdia2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	112,536,174 - 112,539,335 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	634,118 - 637,000 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	634,034 - 637,177 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDIA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	41,394,058 - 41,397,687 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	41,394,267 - 41,397,547 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	41,030,474 - 41,033,683 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDIA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	229,523 - 233,298 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	229,607 - 233,200 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	30,943,512 - 30,947,245 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pdia2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624913	1,135,536 - 1,138,819 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624913	1,135,498 - 1,138,900 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pdia2
5 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	99
Count of miRNA genes:	87
Interacting mature miRNAs:	94
Transcripts:	ENSRNOT00000027726
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
7387235	Uae41	Urinary albumin excretion QTL 41	5.26	0.1874	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	1	29497586	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	19233348	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	17245662	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6154182	15990232	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085369	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005489718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000099303 ⟹ ENSRNOP00000085020

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	15,215,824 - 15,220,931 (-)	Ensembl

RefSeq Acc Id:

NM_001105775 ⟹ NP_001099245

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	15,720,301 - 15,723,375 (-)	NCBI
mRatBN7.2	10	15,215,824 - 15,218,899 (-)	NCBI
Rnor_5.0	10	15,376,461 - 15,379,606 (-)	NCBI
RGSC_v3.4	10	15,462,935 - 15,466,009 (-)	RGD
Celera	10	14,883,630 - 14,886,704 (-)	RGD

Sequence:

show sequence

ATGGATGATCGGTTTCTGCCAGTGTTGCTGCTCCTGCTGGGTGTCTCAGGCTCATGGGGACAGG
GAGAGGAGCCGGGGGGTCCCCCAGAGGTGCTCTCTGAGGAGTCCATTGGGGAAGAAGTCCCCGA
GGAGGATGGAATCTTGGTTTTGAACAACCAAACCCTGAGCCTGGCACTGCAGGAGCATTCAGCC
CTGATGGTGGAGTTTTATGCCCCATGGTGTGGTCACTGCAAGGCACTAGCTCCTGAGTACAGCA
AGGCAGCTGCCCTGCTGGCAGCTGAGTCAGCTGCGGTCACCTTGGCCAAGGTGGATGGGCCTGC
GGAACCAGAGCTGACCAAGGAGTTTGGAGTGGTAGGGTACCCTACACTCAAGTTCTTCCAGAAT
GGAAACCGCACAAACCCAGAAGAATACATAGGGCCCAAGACAGCTGAGGGCATTGCTGAGTGGC
TGAGGCGGCGAGTGGGGCCCAGCGCCACACGTCTGGAGGATGAGGAAGGTGTCCAGGCACTGAT
GGCCAAATGGGATATGGTGGTCATTGGCTTCTTTCAGGATCTACAGGAAGAGGATGTGGCAACT
TTCCTGGCCTTGGCCAGGGATGCTCTGGACATGGCCTTTGGCTTCACTGACCAGCCACAGCTTT
TTGAGAAGTTTGGCCTCACCAAGGACACTGTGGTCCTTTTCAAGAAGTTTGATGAGGGTCGGGC
CGACTTCCCGGTAGACAAGGAGGCTGGCCTGGACCTGGGGGACCTGTCCCGCTTCCTCATCACA
CACAGCATGCACCTGGTCACAGAATTCAACAGCCAGACATCACCTAAGATCTTTGCAGCCAGGA
TCCTCAACCACCTGCTGCTGTTTGTGAACCAGACACTAGCTCAGCACAGGGAGCTACTGACAGG
CTTCAGGGAGGCAGCTCCTCCATTCCGGGGACAGGTGTTGTTTGTGATGGTGGATGTGGCCGCT
GACAACAGCCATGTGCTAAATTATTTTGGCCTCAAGGCTGAGGAAGCCCCCACCCTGCGTCTGA
TTAATGTTGAGACTACCAAGAAGTATGCACCTGCAGGGGTGATACCCATCACTGCAGCTTCTGT
GGCTGCATTCTGCCAGGCAGTCCTCCATGGGGAAGTCAAGCACTATCTCCTGAGCCAGGAGATA
CCCCCCGACTGGGACCAGCGGCCAGTCAAGACTCTTGTGAGCAAGAATTTTGAGCAGGTTGCCT
TTGATGAAACCAAGAATGTGTTTGTCAAGTTCTATGCCCCATGGTGCAGCCACTGCAAGGAGAT
GGCTCCAGCCTGGGAGGCACTGGCAGAGAAGTACAGGGATCGTGAGGACATTGTCATTGCTGAG
ATGGATGCTACAGCTAACGAGCTGGAGGCCTTCTCTGTGCATGGCTATCCCACTCTCAAGTTCT
TCCCTGCAGGACCTGACCGAAAGATTATAGAATACAAAAGCACCAGGGACCTAGAGACATTCTC
CAAGTTCCTGGACAGAGGAGGTGACCTGCCTGAGGAAGAATCCAAGGAGCCTGCAGTCTCTGCC
CCAGAAGCACAACCCAATTCCACCTTGGGTCCCAAGGAGGAGCTGTAGCCATTGGGACACTGTA
TTCCAGAGAGTGGTGTCCTCACTCAGGTGCAGGAGGGAGCTGTGCACTATGAATAAACATGCTG
TCCCAGA

hide sequence

RefSeq Acc Id:

XM_039085368 ⟹ XP_038941296

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	15,720,301 - 15,723,386 (-)	NCBI
mRatBN7.2	10	15,215,826 - 15,218,937 (-)	NCBI

RefSeq Acc Id:

XM_039085369 ⟹ XP_038941297

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	15,720,301 - 15,723,308 (-)	NCBI
mRatBN7.2	10	15,215,826 - 15,218,835 (-)	NCBI

RefSeq Acc Id:

XR_005489718

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	15,720,301 - 15,723,386 (-)	NCBI
mRatBN7.2	10	15,215,824 - 15,218,937 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099245	(Get FASTA)	NCBI Sequence Viewer
	XP_038941296	(Get FASTA)	NCBI Sequence Viewer
	XP_038941297	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM03998	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000085020.1

RefSeq Acc Id:	NP_001099245 ⟸ NM_001105775
- Peptide Label:	precursor
- UniProtKB:	A0A8I6A0T0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDDRFLPVLLLLLGVSGSWGQGEEPGGPPEVLSEESIGEEVPEEDGILVLNNQTLSLALQEHSA LMVEFYAPWCGHCKALAPEYSKAAALLAAESAAVTLAKVDGPAEPELTKEFGVVGYPTLKFFQN GNRTNPEEYIGPKTAEGIAEWLRRRVGPSATRLEDEEGVQALMAKWDMVVIGFFQDLQEEDVAT FLALARDALDMAFGFTDQPQLFEKFGLTKDTVVLFKKFDEGRADFPVDKEAGLDLGDLSRFLIT HSMHLVTEFNSQTSPKIFAARILNHLLLFVNQTLAQHRELLTGFREAAPPFRGQVLFVMVDVAA DNSHVLNYFGLKAEEAPTLRLINVETTKKYAPAGVIPITAASVAAFCQAVLHGEVKHYLLSQEI PPDWDQRPVKTLVSKNFEQVAFDETKNVFVKFYAPWCSHCKEMAPAWEALAEKYRDREDIVIAE MDATANELEAFSVHGYPTLKFFPAGPDRKIIEYKSTRDLETFSKFLDRGGDLPEEESKEPAVSA PEAQPNSTLGPKEEL hide sequence

RefSeq Acc Id:	XP_038941296 ⟸ XM_039085368
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941297 ⟸ XM_039085369
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000085020 ⟸ ENSRNOT00000099303

Protein Domains

Thioredoxin

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305164	AgrOrtholog
BioCyc Gene	G2FUF-25724	BioCyc
Ensembl Genes	ENSRNOG00000063310	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000099303.1	UniProtKB/TrEMBL
Gene3D-CATH	Glutaredoxin	UniProtKB/TrEMBL
InterPro	Prot_disulphide_isomerase	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
	Thioredoxin_CS	UniProtKB/TrEMBL
	Thioredoxin_domain	UniProtKB/TrEMBL
KEGG Report	rno:287164	UniProtKB/TrEMBL
NCBI Gene	287164	ENTREZGENE
PANTHER	PROTEIN DISULFIDE ISOMERASE	UniProtKB/TrEMBL
	PROTEIN DISULFIDE-ISOMERASE A2	UniProtKB/TrEMBL
Pfam	Thioredoxin	UniProtKB/TrEMBL
	Thioredoxin_6	UniProtKB/TrEMBL
PhenoGen	Pdia2	PhenoGen
PRINTS	THIOREDOXIN	UniProtKB/TrEMBL
PROSITE	THIOREDOXIN_1	UniProtKB/TrEMBL
	THIOREDOXIN_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000063310	RatGTEx
Superfamily-SCOP	SSF52833	UniProtKB/TrEMBL
UniProt	A0A8I6A0T0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-10	Pdia2	protein disulfide isomerase family A, member 2	Pdia2	protein disulfide isomerase associated 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Pdia2	protein disulfide isomerase associated 2	Pdia2_predicted	protein disulfide isomerase associated 2 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Pdia2_predicted	protein disulfide isomerase associated 2 (predicted)	Pdip_predicted	protein disulfide isomerase, pancreatic (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Pdip_predicted	protein disulfide isomerase, pancreatic (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB