Fermt2 (FERM domain containing kindlin 2) - Rat Genome Database

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Pathways
Gene: Fermt2 (FERM domain containing kindlin 2) Ictidomys tridecemlineatus
Analyze
Symbol: Fermt2
Name: FERM domain containing kindlin 2
RGD ID: 12683352
Description: ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); integrin binding (inferred); INVOLVED IN cell adhesion (ortholog); protein localization to cell junction (ortholog); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); angle-closure glaucoma (ortholog); urinary bladder cancer (ortholog); FOUND IN adherens junction (inferred); anchoring junction (inferred); cell junction (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fermitin family homolog 2; fermitin family member 2; fermitin family member 2, transcript variant X1; fermitin family member 2, transcript variant X2; fermitin family member 2, transcript variant X3; fermitin family member 2, transcript variant X4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864076,153,793 - 76,234,113 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366971,927,812 - 2,008,268 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366971,927,817 - 2,008,268 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fermt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864076,153,793 - 76,234,113 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366971,927,812 - 2,008,268 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366971,927,817 - 2,008,268 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FERMT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381452,857,273 - 52,951,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1452,857,267 - 52,952,435 (-)Ensemblhg38GRCh38
GRCh371453,323,991 - 53,417,768 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361452,393,743 - 52,487,460 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341452,393,742 - 52,487,460NCBI
Celera1433,373,704 - 33,467,553 (-)NCBICelera
Cytogenetic Map14q22.1NCBI
HuRef1433,486,674 - 33,581,054 (-)NCBIHuRef
CHM1_11453,262,863 - 53,356,715 (-)NCBICHM1_1
T2T-CHM13v2.01447,065,165 - 47,158,990 (-)NCBIT2T-CHM13v2.0
Fermt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391445,696,252 - 45,767,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1445,696,252 - 45,767,575 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381445,458,792 - 45,530,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1445,458,795 - 45,530,118 (-)Ensemblmm10GRCm38
MGSCv371446,078,467 - 46,149,740 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361444,380,669 - 44,451,942 (-)NCBIMGSCv36mm8
Celera1441,642,480 - 41,713,283 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1422.97NCBI
Fermt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81521,162,603 - 21,257,995 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1521,162,605 - 21,258,115 (-)EnsemblGRCr8
mRatBN7.21518,682,927 - 18,751,959 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1518,682,927 - 18,751,811 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1521,475,374 - 21,544,137 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01522,432,342 - 22,501,106 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01520,688,917 - 20,757,681 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1519,902,750 - 19,971,584 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1519,808,525 - 19,877,359 (-)NCBILyon_Normotensive
Lyon_Hypertensive1519,891,269 - 19,960,116 (-)NCBILyon_Hypertensive
F344_StmMcwi1520,490,856 - 20,559,709 (-)NCBIF344_StmMcwi
Rnor_6.01519,807,806 - 19,876,557 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1519,807,808 - 19,876,408 (-)Ensemblrn6Rnor6.0
Rnor_5.01523,771,816 - 23,840,554 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41521,358,411 - 21,427,264 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1519,110,289 - 19,178,605 (-)NCBICelera
RGSC_v3.11521,358,412 - 21,427,264 (-)NCBI
Cytogenetic Map15p14NCBI
Fermt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540910,285,793 - 10,327,468 (+)Ensembl
ChiLan1.0NW_00495540910,285,780 - 10,327,286 (+)NCBIChiLan1.0ChiLan1.0
FERMT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21553,988,488 - 54,082,373 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11453,205,000 - 53,298,842 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01433,453,983 - 33,547,721 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11451,737,188 - 51,830,109 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1451,737,188 - 51,829,766 (-)EnsemblpanPan2panpan1.1
FERMT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1829,083,538 - 29,135,915 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl829,084,531 - 29,133,391 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha828,829,003 - 28,907,889 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0829,250,020 - 29,326,046 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl829,250,010 - 29,395,871 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1828,924,206 - 29,004,100 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0828,996,473 - 29,076,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0829,325,136 - 29,405,152 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
FERMT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1182,519,684 - 182,606,869 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11182,519,681 - 182,606,890 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21202,790,224 - 202,816,460 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FERMT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12429,954,706 - 30,053,012 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605318,220,669 - 18,321,976 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fermt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473116,168,207 - 16,246,778 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473116,168,179 - 16,247,747 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fermt2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11277,507,364 - 77,575,160 (+)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000008577   ⟹   ENSSTOP00000007688
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366971,927,812 - 2,008,268 (+)Ensembl
RefSeq Acc Id: XM_005337972   ⟹   XP_005338029
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864076,153,793 - 76,234,113 (+)NCBI
SpeTri2.0NW_0049366971,927,817 - 2,008,268 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013364108   ⟹   XP_013219562
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864076,153,816 - 76,234,113 (+)NCBI
SpeTri2.0NW_0049366971,927,817 - 2,008,268 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021735066   ⟹   XP_021590741
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864076,153,815 - 76,234,113 (+)NCBI
SpeTri2.0NW_0049366971,927,817 - 2,008,266 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021735067   ⟹   XP_021590742
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864076,153,816 - 76,234,113 (+)NCBI
SpeTri2.0NW_0049366971,927,817 - 2,008,268 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040274145   ⟹   XP_040130079
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864076,153,815 - 76,234,113 (+)NCBI
RefSeq Acc Id: XM_040274146   ⟹   XP_040130080
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864076,153,816 - 76,234,113 (+)NCBI
RefSeq Acc Id: XM_040274147   ⟹   XP_040130081
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864076,153,835 - 76,234,113 (+)NCBI
RefSeq Acc Id: XP_013219562   ⟸   XM_013364108
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005338029   ⟸   XM_005337972
- Peptide Label: isoform X6
- UniProtKB: I3MBW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021590742   ⟸   XM_021735067
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_021590741   ⟸   XM_021735066
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040130079   ⟸   XM_040274145
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040130080   ⟸   XM_040274146
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040130081   ⟸   XM_040274147
- Peptide Label: isoform X7
Ensembl Acc Id: ENSSTOP00000007688   ⟸   ENSSTOT00000008577
Protein Domains
PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008563 Ensembl, UniProtKB/TrEMBL
  ENSSTOG00015014407 ENTREZGENE
Ensembl Transcript ENSSTOT00000008577.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  Kindlin/fermitin UniProtKB/TrEMBL
  Kindlin_2_N UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_Kindlin/fermitin UniProtKB/TrEMBL
KEGG Report iti:101968773 UniProtKB/TrEMBL
NCBI Gene Fermt2 ENTREZGENE
PANTHER FERMITIN FAMILY HOMOLOG 2 UniProtKB/TrEMBL
  PTHR16160 UniProtKB/TrEMBL
Pfam FERM_M UniProtKB/TrEMBL
  Kindlin_2_N UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
UniProt I3MBW2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-16 Fermt2  FERM domain containing kindlin 2  Fermt2  fermitin family member 2  Symbol and/or name change 5135510 APPROVED