Fermt2 (FERM domain containing kindlin 2) - Rat Genome Database

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Gene: Fermt2 (FERM domain containing kindlin 2) Chinchilla lanigera
Analyze
Symbol: Fermt2
Name: FERM domain containing kindlin 2
RGD ID: 8866316
Description: ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); INVOLVED IN adherens junction maintenance (ortholog); cell adhesion (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); angle-closure glaucoma (ortholog); urinary bladder cancer (ortholog); FOUND IN adherens junction (ortholog); cell junction (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fermitin family homolog 2; fermitin family member 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540910,285,793 - 10,327,468 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540910,285,780 - 10,327,286 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fermt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540910,285,793 - 10,327,468 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540910,285,780 - 10,327,286 (+)NCBIChiLan1.0ChiLan1.0
FERMT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381452,857,273 - 52,951,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1452,857,268 - 52,952,435 (-)EnsemblGRCh38hg38GRCh38
GRCh371453,323,991 - 53,417,768 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361452,393,743 - 52,487,460 (-)NCBINCBI36Build 36hg18NCBI36
Build 341452,393,742 - 52,487,460NCBI
Celera1433,373,704 - 33,467,553 (-)NCBICelera
Cytogenetic Map14q22.1NCBI
HuRef1433,486,674 - 33,581,054 (-)NCBIHuRef
CHM1_11453,262,863 - 53,356,715 (-)NCBICHM1_1
T2T-CHM13v2.01447,065,165 - 47,158,990 (-)NCBIT2T-CHM13v2.0
Fermt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391445,696,252 - 45,767,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1445,696,252 - 45,767,575 (-)EnsemblGRCm39 Ensembl
GRCm381445,458,792 - 45,530,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1445,458,795 - 45,530,118 (-)EnsemblGRCm38mm10GRCm38
MGSCv371446,078,467 - 46,149,740 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361444,380,669 - 44,451,942 (-)NCBIMGSCv36mm8
Celera1441,642,480 - 41,713,283 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1422.97NCBI
Fermt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81521,162,603 - 21,257,995 (-)NCBIGRCr8
mRatBN7.21518,682,927 - 18,751,959 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1518,682,927 - 18,751,811 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1521,475,374 - 21,544,137 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01522,432,342 - 22,501,106 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01520,688,917 - 20,757,681 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01519,807,806 - 19,876,557 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1519,807,808 - 19,876,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01523,771,816 - 23,840,554 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41521,358,411 - 21,427,264 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11521,358,412 - 21,427,264 (-)NCBI
Celera1519,110,289 - 19,178,605 (-)NCBICelera
Cytogenetic Map15p14NCBI
FERMT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21553,988,488 - 54,082,373 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11453,205,000 - 53,298,842 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01433,453,983 - 33,547,721 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11451,737,188 - 51,830,109 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1451,737,188 - 51,829,766 (-)Ensemblpanpan1.1panPan2
FERMT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1829,083,538 - 29,135,915 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl829,084,531 - 29,133,391 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha828,829,003 - 28,907,889 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0829,250,020 - 29,326,046 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl829,250,010 - 29,395,871 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1828,924,206 - 29,004,100 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0828,996,473 - 29,076,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0829,325,136 - 29,405,152 (-)NCBIUU_Cfam_GSD_1.0
Fermt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864076,153,793 - 76,234,113 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366971,927,812 - 2,008,268 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366971,927,817 - 2,008,268 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FERMT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1182,519,684 - 182,606,869 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11182,519,681 - 182,606,890 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21202,790,224 - 202,816,460 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FERMT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12429,954,706 - 30,053,012 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605318,220,669 - 18,321,976 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fermt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473116,168,207 - 16,246,778 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473116,168,179 - 16,247,747 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000017034   ⟹   ENSCLAP00000016869
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540910,285,793 - 10,327,468 (+)Ensembl
RefSeq Acc Id: XM_005376773   ⟹   XP_005376830
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540910,285,780 - 10,327,286 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005376830 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000016869
  ENSCLAP00000016869.1
RefSeq Acc Id: XP_005376830   ⟸   XM_005376773
- UniProtKB: A0A8C2VPB4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000016869   ⟸   ENSCLAT00000017034
Protein Domains
PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011575 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017034 ENTREZGENE
  ENSCLAT00000017034.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  Kindlin/fermitin UniProtKB/TrEMBL
  Kindlin_2_N UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_Kindlin/fermitin UniProtKB/TrEMBL
NCBI Gene Fermt2 ENTREZGENE
PANTHER FERMITIN FAMILY HOMOLOG 2 UniProtKB/TrEMBL
  PTHR16160 UniProtKB/TrEMBL
Pfam FERM_M UniProtKB/TrEMBL
  Kindlin_2_N UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
UniProt A0A8C2VPB4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-16 Fermt2  FERM domain containing kindlin 2  Fermt2  fermitin family member 2  Symbol and/or name change 5135510 APPROVED