SUFU (SUFU negative regulator of hedgehog signaling) - Rat Genome Database

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Pathways
Gene: SUFU (SUFU negative regulator of hedgehog signaling) Canis lupus familiaris
Analyze
Symbol: SUFU
Name: SUFU negative regulator of hedgehog signaling
RGD ID: 12422745
Description: ENCODES a protein that exhibits beta-catenin binding (inferred); protein kinase binding (inferred); protein sequestering activity (inferred); INVOLVED IN aorta development (ortholog); coronary vasculature development (ortholog); determination of left/right symmetry (ortholog); PARTICIPATES IN Hedgehog signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); basal cell carcinoma (ortholog); brain glioblastoma multiforme (ortholog); FOUND IN cilium (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: suppressor of fused homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,992,989 - 15,115,499 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,992,618 - 15,112,389 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2815,165,295 - 15,287,811 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02815,467,025 - 15,589,735 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,466,996 - 15,589,728 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12815,011,961 - 15,134,129 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02815,051,335 - 15,173,877 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,183,706 - 15,305,945 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SUFU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,992,989 - 15,115,499 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,992,618 - 15,112,389 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2815,165,295 - 15,287,811 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02815,467,025 - 15,589,735 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,466,996 - 15,589,728 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12815,011,961 - 15,134,129 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02815,051,335 - 15,173,877 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,183,706 - 15,305,945 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SUFU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,502,819 - 102,633,535 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,503,952 - 102,633,535 (+)Ensemblhg38GRCh38
GRCh3710104,263,729 - 104,393,292 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,253,754 - 104,383,199 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3410104,253,753 - 104,383,199NCBI
Celera1098,004,628 - 98,134,149 (+)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,897,496 - 98,026,978 (+)NCBIHuRef
CHM1_110104,547,179 - 104,677,032 (+)NCBICHM1_1
T2T-CHM13v2.010103,387,806 - 103,518,575 (+)NCBIT2T-CHM13v2.0
Sufu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,385,335 - 46,477,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,385,335 - 46,477,243 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381946,396,896 - 46,488,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,396,896 - 46,488,804 (+)Ensemblmm10GRCm38
MGSCv371946,471,408 - 46,561,150 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361946,450,229 - 46,539,971 (+)NCBIMGSCv36mm8
Celera1947,160,488 - 47,250,442 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.85NCBI
Sufu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,199,108 - 255,296,983 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1255,199,164 - 255,296,981 (+)EnsemblGRCr8
mRatBN7.21245,257,725 - 245,355,576 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,257,768 - 245,355,577 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1253,379,193 - 253,479,376 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01260,073,830 - 260,172,100 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,725,633 - 252,823,412 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,143,766 - 266,241,742 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,143,818 - 266,239,016 (+)Ensemblrn6Rnor6.0
Rnor_5.01273,574,697 - 273,672,663 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41251,612,377 - 251,708,109 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1241,040,495 - 241,135,358 (+)NCBICelera
Cytogenetic Map1q54NCBI
Sufu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554857,808,131 - 7,925,677 (-)Ensembl
ChiLan1.0NW_0049554857,805,244 - 7,925,414 (-)NCBIChiLan1.0ChiLan1.0
SUFU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28114,389,841 - 114,515,759 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110114,395,163 - 114,521,085 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01099,107,516 - 99,231,761 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110102,571,886 - 102,696,472 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10102,571,886 - 102,696,472 (+)EnsemblpanPan2panpan1.1
Sufu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721331,665,075 - 31,778,513 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,268,260 - 3,381,781 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366003,270,662 - 3,381,722 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SUFU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,500,842 - 113,626,003 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114113,500,001 - 113,628,064 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,356,101 - 123,481,988 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SUFU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,532,228 - 95,660,594 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl995,532,242 - 95,657,290 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604856,639,722 - 56,772,532 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sufu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,882,077 - 2,012,341 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248311,882,114 - 2,012,341 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sufu
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1245,856,918 - 45,952,094 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in SUFU
791 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000016234   ⟹   ENSCAFP00000015018
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2814,992,618 - 15,112,389 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845044187   ⟹   ENSCAFP00845034628
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2815,466,996 - 15,589,728 (+)Ensembl
RefSeq Acc Id: XM_005637674   ⟹   XP_005637731
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12814,992,989 - 15,115,499 (+)NCBI
Dog10K_Boxer_Tasha2815,165,295 - 15,287,811 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038440420   ⟹   XP_038296348
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02815,467,025 - 15,589,735 (+)NCBI
RefSeq Acc Id: XM_038440421   ⟹   XP_038296349
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02815,467,026 - 15,589,735 (+)NCBI
RefSeq Acc Id: XM_038515042   ⟹   XP_038370970
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12815,011,961 - 15,134,129 (+)NCBI
RefSeq Acc Id: XM_038515043   ⟹   XP_038370971
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12815,011,962 - 15,134,129 (+)NCBI
RefSeq Acc Id: XM_038578647   ⟹   XP_038434575
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02815,183,706 - 15,305,945 (+)NCBI
RefSeq Acc Id: XM_038578648   ⟹   XP_038434576
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02815,183,707 - 15,305,945 (+)NCBI
RefSeq Acc Id: XM_038642831   ⟹   XP_038498759
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02815,051,335 - 15,173,877 (+)NCBI
RefSeq Acc Id: XM_038642832   ⟹   XP_038498760
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02815,051,336 - 15,173,877 (+)NCBI
RefSeq Acc Id: XM_846083   ⟹   XP_851176
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12814,992,990 - 15,115,499 (+)NCBI
Dog10K_Boxer_Tasha2815,165,296 - 15,287,811 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005637731   ⟸   XM_005637674
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QYQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_851176   ⟸   XM_846083
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PCL8 (UniProtKB/TrEMBL),   A0A8I3PTN7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000015018   ⟸   ENSCAFT00000016234
RefSeq Acc Id: XP_038370970   ⟸   XM_038515042
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038370971   ⟸   XM_038515043
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038498759   ⟸   XM_038642831
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038498760   ⟸   XM_038642832
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038296348   ⟸   XM_038440420
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QYQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038296349   ⟸   XM_038440421
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PCL8 (UniProtKB/TrEMBL),   A0A8I3PTN7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038434575   ⟸   XM_038578647
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QYQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038434576   ⟸   XM_038578648
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PCL8 (UniProtKB/TrEMBL),   A0A8I3PTN7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845034628   ⟸   ENSCAFT00845044187

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010221 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024635 UniProtKB/TrEMBL
  ENSCAFG00040023489 UniProtKB/TrEMBL
  ENSCAFG00845025024 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016234.5 UniProtKB/TrEMBL
  ENSCAFT00030045324.1 UniProtKB/TrEMBL
  ENSCAFT00040043765.1 UniProtKB/TrEMBL
  ENSCAFT00845044187 ENTREZGENE
  ENSCAFT00845044187.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1360.230 UniProtKB/TrEMBL
InterPro SUFU-like_domain UniProtKB/TrEMBL
  SUFU_C UniProtKB/TrEMBL
  SUFU_C_sf UniProtKB/TrEMBL
  SUFU_N UniProtKB/TrEMBL
  Suppressor_of_fused UniProtKB/TrEMBL
  Suppressor_of_fused_euk UniProtKB/TrEMBL
NCBI Gene SUFU ENTREZGENE
PANTHER PTHR10928 UniProtKB/TrEMBL
  SUPPRESSOR OF FUSED HOMOLOG UniProtKB/TrEMBL
Pfam SUFU UniProtKB/TrEMBL
  SUFU_C UniProtKB/TrEMBL
PIRSF Suppressor_of_fused_protein UniProtKB/TrEMBL
Superfamily-SCOP SSF103359 UniProtKB/TrEMBL
UniProt A0A8C0PCL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QYQ4 ENTREZGENE
  A0A8I3PTN7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46971 ENTREZGENE