| 12380019 | CALY | calcyon neuron specific vesicular protein | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); positive regulation of clathrin coat assembly (ortholog); positive regulation of endocytosis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); attention def icit hyperactivity disorder (ortholog); essential hypertension (ortholog); FOUND IN axon (ortholog); glutamatergic synapse (ortholog); plasma membrane (ortholog) | 28 | 40918341 | 40925161 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12403550 | AAK1 | AP2 associated kinase 1 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); ATP binding (inferred); kinase activity (inferred); INVOLVED IN protein phosphorylation (ortholog); ASSOCIATED WITH tooth agenesis (ortholog); FOUND IN calyx of Held (ortholog); cell leadin g edge (ortholog); clathrin complex (ortholog) | 10 | 68181584 | 68336266 | Dog | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 12393741 | ATP1A3 | ATPase Na+/K+ transporting subunit alpha 3 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); D1 dopamine receptor binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); blood circulation (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ort holog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | 1 | 112325988 | 112346056 | Dog | 267 | description | gene, protein-coding, MODEL [RefSeq] |
| 12383950 | CACNA1A | calcium voltage-gated channel subunit alpha1 A | ENCODES a protein that exhibits calmodulin binding (ortholog); high voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Alternating Hemiplegia of Childhood 1 (ortholog); amyotrophic lateral sclerosis (ortholog); Ataxia (ortholog); FOUND IN calyx of Held (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | 20 | 48747087 | 49036627 | Dog | 242 | description | gene, protein-coding, MODEL [RefSeq] |
| 12176425 | CALB1 | calbindin 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cochlea development (ortholog); learning or memory (ortholog); locomotory behavior (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); bilirubin metabolic disorder (ortholog); gestational diabetes (ortholog); FOUND IN calyx of Held (ortholog); cuticular plate (ortholog); neuronal cell body (ortholog) | 29 | 35551836 | 35572985 | Dog | 64 | description | gene, protein-coding, MODEL [RefSeq] |
| 12359409 | CALM1 | calmodulin 1 | ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); calcineurin-mediated signaling (ortholog); cellular response to interferon-beta (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN calcium channel complex (ortholog); calyx of Held (ortholog); catalytic complex (ortholog) | 8 | 61398231 | 61408874 | Dog | 164 | description | gene, protein-coding, MODEL [RefSeq] |
| 12283682 | CALM3 | calmodulin 3 | ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); calcineurin-mediated signaling (ortholog); cellular response to interferon-beta (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Cardiac Arrhythmias (ortholog); FOUND IN calcium channel complex (ortholog); calyx of Held (ortholog); catalytic complex (ortholog) | 1 | 109284729 | 109294491 | Dog | 109 | description | gene, protein-coding, MODEL [RefSeq] |
| 12301895 | CCIN | calicin | INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH spermatogenic failure 91 (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog); sperm glycocalyx (ortholog) | 11 | 52637580 | 52640121 | Dog | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 12420241 | CPLX1 | complexin 1 | ENCODES a protein that exhibits lipid binding (ortholog); SNARE binding (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN insulin secretion (ortholog); regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane (ortholog); synaptic vesicle exocytosis (ortholog); ASSO CIATED WITH Ataxia (ortholog); bipolar disorder (ortholog); developmental and epileptic encephalopathy 63 (ortholog); FOUND IN calyx of Held (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | 3 | 91635953 | 91658084 | Dog | 45 | description | gene, protein-coding, MODEL [RefSeq] |
| 150657537 | CPLX2 | histamine receptor H2 | ENCODES a protein that exhibits syntaxin binding (inferred); INVOLVED IN exocytosis (inferred); neurotransmitter transport (inferred); positive regulation of synaptic plasticity (inferred); FOUND IN calyx of Held (inferred); cytosol (inferred); glutamatergic syn apse (inferred) | | | | Dog | 13 | description | gene, protein-coding |
| 12160116 | GIT2 | GIT ArfGAP 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH inflammatory bowel disease (ortholog); FOUND IN calyx of Held (ortholog); presynapse (ortholog) | 26 | 17170651 | 17217634 | Dog | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 12304129 | GLRA1 | glycine receptor alpha 1 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity (ortholog); extracellularly glycine-gated ion channel activity (ortholog); glycine binding (ortholog); INVOLVED IN acrosome reaction (ortholog); action potential (ortholog); adult walking behavior (ortholog); PAR TICIPATES IN Inhibitory synaptic transmission pathway; ASSOCIATED WITH dystonia (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); endoplasmic reticulum (ortholog); postsynaptic specialization membrane (ortholog); INTERACTS WITH digoxin; Doramectin; ivermectin | 4 | 57443094 | 57541494 | Dog | 106 | description | gene, protein-coding, MODEL [RefSeq] |
| 12408957 | HTR1B | 5-hydroxytryptamine receptor 1B | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); heterocyclic compound binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN adenylate cyclase-inhibiting serotonin rec eptor signaling pathway (ortholog); bone remodeling (ortholog); cellular response to alkaloid (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amphetamine abuse (ortholog); FOUND IN calyx of Held (ortholog); plasma membrane (ortholog); INTERACTS WITH capsaicin | 12 | 38659088 | 38659546 | Dog | 98 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12224546 | ITSN1 | intersectin 1 | ENCODES a protein that exhibits kinase activator activity (ortholog); molecular adaptor activity (ortholog); proline-rich region binding (ortholog); INVOLVED IN cell-cell signaling (ortholog); endocytosis (ortholog); intracellular protein localization (ortholog); PARTICIPATES IN clathrin-dependent s ynaptic vesicle endocytosis; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); esophageal atresia/tracheoesophageal fistula (ortholog); FOUND IN apical dendrite (ortholog); calyx of Held (ortholog); clathrin-coated pit (ortholog) | 31 | 29144754 | 29360134 | Dog | 88 | description | gene, protein-coding, MODEL [RefSeq] |
| 12105823 | KCNA1 | potassium voltage-gated channel subfamily A member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane po tential (ortholog); INVOLVED IN axon development (ortholog); cell communication by electrical coupling (ortholog); cerebral cortex development (ortholog); ASSOCIATED WITH epilepsy (ortholog); epilepsy with generalized tonic-clonic seizures (ortholog); episodic ataxia (ortholog); FOUND IN apical plasma membrane (ortholog); calyx of Held (ortholog); cell surface (ortholog) | 27 | 39928347 | 39936753 | Dog | 100 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12235737 | KCNA2 | potassium voltage-gated channel subfamily A member 2 | ENCODES a protein that exhibits voltage-gated potassium channel activity; delayed rectifier potassium channel activity (ortholog); kinesin binding (ortholog); INVOLVED IN cerebral cortex development (ortholog); corpus callosum development (ortholog); neuronal action potential (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 1 (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | 6 | 41405453 | 41415727 | Dog | 102 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12193857 | KCNA3 | potassium voltage-gated channel subfamily A member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); ASSOCIATED WI TH developmental and epileptic encephalopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); membrane raft (ortholog) | 6 | 41343613 | 41363076 | Dog | 51 | description | gene, protein-coding, MODEL [RefSeq] |
| 12378292 | KCNC1 | potassium voltage-gated channel subfamily C member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); cerebellum development (ortholo g); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); cell surface (ortholog); dendrite (ortholog) | 21 | 40273366 | 40315189 | Dog | 69 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12249363 | KCNC3 | potassium voltage-gated channel subfamily C member 3 | ENCODES a protein that exhibits monoatomic ion channel activity (inferred); potassium channel activity (inferred); voltage-gated potassium channel activity (inferred); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); regulation of neurotransmitter secretion (or tholog); ASSOCIATED WITH genetic disease (ortholog); spinocerebellar ataxia 13 (ortholog); FOUND IN axolemma (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | 1 | 106366657 | 106371062 | Dog | 49 | description | gene, protein-coding, MODEL [RefSeq] |
| 12056086 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | 6 | 41743214 | 41764572 | Dog | 58 | description | gene, protein-coding, MODEL [RefSeq] |
| 12309802 | KCNQ5 | potassium voltage-gated channel subfamily Q member 5 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual deve lopmental disorder (ortholog); autosomal dominant intellectual developmental disorder 46 (ortholog); congenital diaphragmatic hernia (ortholog); FOUND IN calyx of Held (ortholog); presynaptic membrane (ortholog) | 12 | 34872514 | 35364794 | Dog | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 12088742 | NCS1 | neuronal calcium sensor 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); magnesium ion binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of calcium-mediated signaling (ortholog); positive regulation of exocytosis (ortholog); regulation of neuron projection development (or tholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; FOUND IN axon (ortholog); calyx of Held (ortholog); cytoplasm (ortholog) | 9 | 53661361 | 53676925 | Dog | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 12138247 | RIMBP2 | RIMS binding protein 2 | ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); structural constituent of presynaptic active zone (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of calcium-depende nt activation of synaptic vesicle fusion (ortholog); regulation of presynaptic membrane potential (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); presynaptic active zone cytoplasmic component (ortholog) | 26 | 1519489 | 1744011 | Dog | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 12330700 | SEPTIN5 | septin 5 | ENCODES a protein that exhibits GDP binding (ortholog); phosphatidylinositol binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN adult behavior (ortholog); negative regulation of regulated secretory pathway (ortholog); regulation of synaptic vesicle docking (ortholog); ASSO CIATED WITH adult respiratory distress syndrome (ortholog); Polyarteritis Nodosa, Childhood-Onset (ortholog); FOUND IN axon terminus (ortholog); calyx of Held (ortholog); cell cortex (ortholog) | 26 | 29568776 | 29573837 | Dog | 64 | description | gene, protein-coding, MODEL [RefSeq] |
| 12223499 | TPRG1L | tumor protein p63 regulated 1 like | ENCODES a protein that exhibits calmodulin binding (inferred); identical protein binding (inferred); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); negative regulation of synaptic transmission (ortholog); regulation of synaptic transmission, glutamatergic (ortholog); FOUND IN caly ='font-weight:700;'>calyx of Held (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | 5 | 58155178 | 58159880 | Dog | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 12345272 | TSPOAP1 | TSPO associated protein 1 | ENCODES a protein that exhibits benzodiazepine receptor binding (inferred); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (inferred); INVOLVED IN regulation of neurotransmitter secretion (inferred); regulation of presynaptic cytosolic calcium i on concentration (inferred); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); COVID-19 (ortholog); dystonia (ortholog); FOUND IN calyx of Held (inferred); cytoplasm (inferred); glutamatergic synapse (inferred) | 9 | 32949912 | 32972830 | Dog | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 12057537 | UNC13A | unc-13 homolog A | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); dense core granule docking (ortholog); innervation (ortholog); PARTICIPATES IN insul in secretion pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autistic disorder (ortholog); cerebellar ataxia (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); excitatory synapse (ortholog) | 20 | 45179275 | 45237544 | Dog | 84 | description | gene, protein-coding, MODEL [RefSeq] |
| 12093093 | UNC13B | unc-13 homolog B | ENCODES a protein that exhibits GTP-dependent protein binding (ortholog); syntaxin binding (ortholog); INVOLVED IN acrosomal vesicle exocytosis (ortholog); cellular response to glucose stimulus (ortholog); chemical synaptic transmission (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN caly style='font-weight:700;'>calyx of Held (ortholog); cytosol (ortholog); early phagosome (ortholog) | 11 | 51707968 | 51941148 | Dog | 73 | description | gene, protein-coding, MODEL [RefSeq] |
| 12318442 | UNC13C | unc-13 homolog C | ENCODES a protein that exhibits syntaxin binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); ASSOCIATED WITH clubfoot (ortholog); FOUND IN calyx of Held (ortholog); presynapse (ortholog); synaptic vesicle membrane (ortholog) | 30 | 19519177 | 20096633 | Dog | 33 | description | gene, protein-coding, MODEL [RefSeq] |