| 730918 | Adm | adrenomedullin | Predicted to enable adrenomedullin receptor binding activity. Involved in several processes, including circulatory system development; negative regulation of vascular permeability; and positive regulation of vasculogenesis. Acts upstream of or within chordate embryonic development; developmental gro wth; and positive regulation of cell population proliferation. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; extraembryonic component; gut; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in brain infarction; breast cancer; pancreatic cancer; and pulmonary hypertension. Orthologous to human ADM (adrenomedullin). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 110226864 | 110229027 | Mouse | 554 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1622982 | Adm2 | adrenomedullin 2 | This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. Intravenous injection of the active peptide was found to protect mouse lungs from ischemia/reperfusion injury. [provided by RefSeq, Aug 2015] | 15 | 89206923 | 89208934 | Mouse | 132 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 62196 | Gpr182 | G protein-coupled receptor 182 | Predicted to enable adrenomedullin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in several structures, including central nervous system; gut; heart; reproductive system; and retina. Orthologous t o human GPR182 (G protein-coupled receptor 182). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 127585471 | 127587667 | Mouse | 85 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1615120 | Sptssb | serine palmitoyltransferase, small subunit B | Contributes to serine C-palmitoyltransferase activity. Acts upstream of or within ceramide biosynthetic process; endoplasmic reticulum organization; and regulation of serine C-palmitoyltransferase activity. Part of serine palmitoyltransferase complex. Is expressed in central nervous system; eye; gen itourinary system; and gut. Orthologous to human SPTSSB (serine palmitoyltransferase small subunit B). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 69726871 | 69768697 | Mouse | 89 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1550099 | Adamts4 | ADAM metallopeptidase with thrombospondin type 1 motif 4 | This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encod ed preproprotein undergoes proteolytic processing to generate an active zinc-dependent aggrecanase enzyme that degrades cartilage. [provided by RefSeq, Jul 2016] | 1 | 171077698 | 171089836 | Mouse | 168 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1552871 | Adamts5 | ADAM metallopeptidase with thrombospondin type 1 motif 5 | This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encod ed preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. Mice lacking the encoded protein are protected from surgery-induced osteoarthritis and antigen-induced arthritis. [provided by RefSeq, May 2016] | 16 | 85655045 | 85698013 | Mouse | 205 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1313884 | Catsper3 | cation channel, sperm associated 3 | Enables voltage-gated calcium channel activity. Acts upstream of or within several processes, including flagellated sperm motility; sodium ion transport; and sperm capacitation. Located in acrosomal vesicle and endoplasmic reticulum. Part of CatSper complex. Is expressed in ductus deferens; epididym is; ileum; prostate gland; and testis. Orthologous to human CATSPER3 (cation channel sperm associated 3). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 55932313 | 55971861 | Mouse | 64 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1553335 | Cngb1 | cyclic nucleotide gated channel beta 1 | Enables cyclic nucleotide-activated monoatomic ion channel activity. Acts upstream of or within several processes, including photoreceptor cell maintenance; photoreceptor cell outer segment organization; and sensory perception of smell. Located in membrane and photoreceptor outer segment. Is express ed in several structures, including head mesenchyme; incisor; limb; sensory organ; and skeleton. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 45. Orthologous to human CNGB1 (cyclic nucleotide gated channel subunit beta 1). [provided by Alliance of Genome Resources, Apr 2025] | 8 | 95965671 | 96033213 | Mouse | 185 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 5144849 | Ighv7-3 | immunoglobulin heavy variable 7-3 | Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Orthologous to several human genes including IGHV3-72 (immunoglobulin heavy variable 3-72). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 114116800 | 114117264 | Mouse | 14 | GenBank Protein | gene, pseudo, VALIDATED [RefSeq] |
| 69124 | Lep | leptin | Enables DNA binding activity and hormone activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within several processes, including determination of ad ult lifespan; regulation of protein localization; and steroid metabolic process. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and reproductive system. Used to study abdominal obesity-metabolic syndrome (multiple); obesity; steatotic liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 29060220 | 29073875 | Mouse | 1743 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 149735866 | LOC102642252 | uncharacterized LOC102642252 | | | | | Mouse | | GenBank Protein | gene, protein-coding |
| 10691 | Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | Enables several functions, including identical protein binding activity; nuclear glucocorticoid receptor activity; and promoter-specific chromatin binding activity. Involved in several processes, including glial cell differentiation; nuclear receptor-mediated glucocorticoid signaling pathway; and po sitive regulation of miRNA transcription. Acts upstream of or within several processes, including maternal behavior; regulation of primary metabolic process; and response to cortisol. Located in cytosol; membrane; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and leg muscle. Used to study primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anorexia nervosa; cocaine abuse; heroin dependence; and lung disease (multiple). Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 39543598 | 39652485 | Mouse | 1273 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1615632 | Ovch2 | ovochymase 2 | Predicted to enable serine-type endopeptidase activity. Involved in fertilization. Predicted to be located in extracellular region. Is expressed in epididymis; large intestine; ovary; and testis. Orthologous to human OVCH2 (ovochymase 2). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 107380751 | 107400386 | Mouse | 33 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1332483 | Slc4a4 | solute carrier family 4 (anion exchanger), member 4 | Enables sodium:bicarbonate symporter activity. Acts upstream of or within bicarbonate transport; establishment of localization in cell; and sodium ion transport. Located in basolateral plasma membrane. Is expressed in several structures, including brain; metanephros; spinal cord floor plate; and thy roid primordium. Used to study renal tubular acidosis. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 88941717 | 89387515 | Mouse | 307 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1623908 | Syce3 | synaptonemal complex central element protein 3 | Involved in reciprocal meiotic recombination; spermatogenesis; and synaptonemal complex assembly. Acts upstream of or within positive regulation of apoptotic process; positive regulation of developmental process; and positive regulation of reproductive process. Located in central element. Is express ed in embryo; ovary; and testis. Orthologous to human SYCE3 (synaptonemal complex central element protein 3). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 89274377 | 89294706 | Mouse | 51 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1550062 | Ddah2 | DDAH family member 2, ADMA independent | Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human DDAH2 (DDAH family member 2, ADMA-independent). [provided by A lliance of Genome Resources, Apr 2025] | 17 | 35278011 | 35281075 | Mouse | 147 | name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1314519 | Itih1 | inter-alpha trypsin inhibitor, heavy chain 1 | This gene encodes a heavy chain of inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors. IaI proteins are protein-glycosaminoglycan-protein complexes comprised of two heavy chains and a light chain. The encoded protein covalently associates with the light chain via a chond roitin sulfate moiety. Intravenous administration of the encoded protein improved survival of mice after infection with Escherichia coli. This gene is located adjacent to two other IaI heavy chain genes. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature protein. [provided by RefSeq, Oct 2015] | 14 | 30651137 | 30665246 | Mouse | 128 | description | gene, protein-coding, REVIEWED [RefSeq] |
