Sptssb (serine palmitoyltransferase, small subunit B) - Rat Genome Database

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Gene: Sptssb (serine palmitoyltransferase, small subunit B) Mus musculus
Analyze
Symbol: Sptssb
Name: serine palmitoyltransferase, small subunit B
RGD ID: 1615120
MGI Page MGI
Description: Contributes to serine C-palmitoyltransferase activity. Acts upstream of or within ceramide biosynthetic process; endoplasmic reticulum organization; and regulation of serine C-palmitoyltransferase activity. Part of serine C-palmitoyltransferase complex. Is expressed in central nervous system; eye; genitourinary system; and gut. Orthologous to human SPTSSB (serine palmitoyltransferase small subunit B); INTERACTS WITH bisphenol A; chlordecone; chloroprene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110032A04Rik; AD; ADMP; androgen down regulated in mouse prostate; serine palmitoyltransferase small subunit B; small subunit of serine palmitoyltransferase B; Sssptb
RGD Orthologs
Human
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39369,726,871 - 69,768,697 (-)NCBIGRCm39mm39
GRCm39 Ensembl369,726,875 - 69,767,273 (-)Ensembl
GRCm38369,819,538 - 69,861,363 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl369,819,542 - 69,859,940 (-)EnsemblGRCm38mm10GRCm38
MGSCv37369,623,460 - 69,663,818 (-)NCBIGRCm37mm9NCBIm37
MGSCv36369,907,467 - 69,947,803 (-)NCBImm8
Celera369,927,513 - 69,961,175 (-)NCBICelera
Cytogenetic Map3E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:15777716   PMID:16141072   PMID:16141073   PMID:19416851  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:24194600   PMID:25269881   PMID:26438849   PMID:27626380  


Genomics

Comparative Map Data
Sptssb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39369,726,871 - 69,768,697 (-)NCBIGRCm39mm39
GRCm39 Ensembl369,726,875 - 69,767,273 (-)Ensembl
GRCm38369,819,538 - 69,861,363 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl369,819,542 - 69,859,940 (-)EnsemblGRCm38mm10GRCm38
MGSCv37369,623,460 - 69,663,818 (-)NCBIGRCm37mm9NCBIm37
MGSCv36369,907,467 - 69,947,803 (-)NCBImm8
Celera369,927,513 - 69,961,175 (-)NCBICelera
Cytogenetic Map3E2NCBI
SPTSSB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3161,344,792 - 161,372,880 (-)EnsemblGRCh38hg38GRCh38
GRCh383161,344,784 - 161,373,228 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373161,062,586 - 161,089,305 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363162,545,274 - 162,572,565 (-)NCBINCBI36hg18NCBI36
Celera3159,484,918 - 159,512,206 (-)NCBI
Cytogenetic Map3q26.1NCBI
HuRef3158,461,562 - 158,488,796 (-)NCBIHuRef
CHM1_13161,025,525 - 161,052,774 (-)NCBICHM1_1
Sptssb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22154,133,728 - 154,162,127 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2154,133,733 - 154,163,120 (-)Ensembl
Rnor_6.02166,654,036 - 166,682,325 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2166,654,043 - 166,682,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02186,020,417 - 186,049,284 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42159,961,911 - 159,962,141 (-)NCBIRGSC3.4rn4RGSC3.4
Celera2148,466,971 - 148,495,254 (-)NCBICelera
Cytogenetic Map2q32NCBI
Sptssb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544811,756,766 - 11,790,368 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544811,756,766 - 11,791,418 (-)NCBIChiLan1.0ChiLan1.0
SPTSSB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13427,321,108 - 27,350,436 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3427,322,405 - 27,322,635 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3431,362,455 - 31,391,555 (-)NCBI
ROS_Cfam_1.03427,378,927 - 27,408,084 (-)NCBI
UMICH_Zoey_3.13427,307,650 - 27,336,776 (-)NCBI
UNSW_CanFamBas_1.03427,270,394 - 27,300,935 (-)NCBI
UU_Cfam_GSD_1.03427,540,651 - 27,569,750 (-)NCBI
Sptssb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560293,232,255 - 93,264,730 (-)NCBI
SpeTri2.0NW_0049367081,270,720 - 1,301,493 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPTSSB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13101,023,812 - 101,059,885 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113101,023,238 - 101,059,917 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213109,530,942 - 109,566,575 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPTSSB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11529,468,155 - 29,502,387 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660411,970,118 - 2,010,779 (+)NCBIVero_WHO_p1.0
Sptssb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473039,280,846 - 39,324,174 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
BF406676  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38369,860,223 - 69,860,359UniSTSGRCm38
MGSCv37369,664,145 - 69,664,281UniSTSGRCm37
Celera369,961,502 - 69,961,638UniSTS
Cytogenetic Map3E3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1018416183277639Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31018416183277639Mouse
1357857Lvrq5_mliver weight QTL 5 (mouse)Not determined31018416183277639Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31018416183277639Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1018416183277639Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1018416183277639Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31018416183277639Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
14746977Manh53_mmandible shape 53 (mouse)33601785970017859Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
1301585Cd4ts1_mCD4 T cell subset 1 (mouse)Not determined33979668173796810Mouse
10755516Amzn1_manatomical modifier of Zfp423 1 (mouse)33979668173796810Mouse
11039513Ltpr3a_mLeishmania tropica response 3a (mouse)33979668173796810Mouse
11041901Lmr11b_mleishmaniasis resistance 11b (mouse)33979668173796810Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)344000000101700000Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4945016083450160Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34958758483587697Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34958758483587697Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)352000000102400000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35271817686718412Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35271817686718412Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35271817686718412Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35301585087015850Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356796681100556821Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35900000093000000Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36183275495832934Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366139351100139488Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369661247103661247Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369718176100747974Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:664
Count of miRNA genes:261
Interacting mature miRNAs:284
Transcripts:ENSMUST00000051239, ENSMUST00000171529
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000051239   ⟹   ENSMUSP00000062794
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl369,726,875 - 69,767,273 (-)Ensembl
GRCm38.p6 Ensembl369,819,542 - 69,859,940 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171529   ⟹   ENSMUSP00000131241
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl369,727,911 - 69,767,255 (-)Ensembl
GRCm38.p6 Ensembl369,820,578 - 69,859,922 (-)Ensembl
RefSeq Acc Id: NM_001164210   ⟹   NP_001157682
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39369,726,871 - 69,767,227 (-)NCBI
GRCm38369,819,538 - 69,859,894 (-)NCBI
MGSCv37369,623,460 - 69,663,818 (-)RGD
Celera369,927,513 - 69,961,173 (-)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001286959   ⟹   NP_001273888
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39369,726,871 - 69,767,227 (-)NCBI
GRCm38369,819,538 - 69,859,894 (-)NCBI
Celera369,927,513 - 69,961,173 (-)NCBI
Sequence:
RefSeq Acc Id: NM_133675   ⟹   NP_598436
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39369,726,871 - 69,767,227 (-)NCBI
GRCm38369,819,538 - 69,859,894 (-)NCBI
MGSCv37369,623,460 - 69,663,818 (-)RGD
Celera369,927,513 - 69,961,173 (-)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030252751   ⟹   XP_030108611
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39369,726,871 - 69,768,697 (-)NCBI
GRCm38369,819,538 - 69,861,363 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598436   ⟸   NM_133675
- Peptide Label: isoform a
- UniProtKB: Q925E8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001157682   ⟸   NM_001164210
- Peptide Label: isoform a
- UniProtKB: Q925E8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001273888   ⟸   NM_001286959
- Peptide Label: isoform b
- Sequence:
RefSeq Acc Id: XP_030108611   ⟸   XM_030252751
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000062794   ⟸   ENSMUST00000051239
RefSeq Acc Id: ENSMUSP00000131241   ⟸   ENSMUST00000171529

Promoters
RGD ID:6833156
Promoter ID:MM_KWN:34586
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:NM_133675_1110032A04RIK,   UC008PMN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36369,663,616 - 69,664,116 (-)MPROMDB
RGD ID:6880880
Promoter ID:EPDNEW_M3891
Type:initiation region
Name:Sptssb_1
Description:Mus musculus serine palmitoyltransferase, small subunit B , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38369,859,894 - 69,859,954EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913433 AgrOrtholog
Ensembl Genes ENSMUSG00000043461 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000062794 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000131241 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000051239 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000171529 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Ser_palmitoyltrfase_ssu-like UniProtKB/Swiss-Prot
KEGG Report mmu:66183 UniProtKB/Swiss-Prot
MGD MGI:1913433 ENTREZGENE
NCBI Gene 66183 ENTREZGENE
Pfam SPT_ssu-like UniProtKB/Swiss-Prot
PhenoGen Sptssb PhenoGen
UniProt Q925E8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-25 Sptssb  serine palmitoyltransferase, small subunit B  1110032A04Rik  RIKEN cDNA 1110032A04 gene  Symbol and/or name change 5135510 APPROVED