| 620091 | Upb1 | beta-ureidopropionase 1 | ENCODES a protein that exhibits beta-ureidopropionase activity; zinc ion binding; protein homodimerization activity (ortholog); INVOLVED IN beta-alanine metabolic process; in utero embryonic development; liver development; PARTICIPATES IN pyrimidine metabolic pathway; beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; ASSOCIATED WITH autistic disorder (ortholog); Beta-Ureidopropionase Deficiency (ortholog); celiac disease (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene | 20 | 13216693 | 13243016 | Rat | 163 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734439 | UPB1 | beta-ureidopropionase 1 | This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (D HP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008] | 22 | 24495332 | 24528390 | Human | 204 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 734440 | Upb1 | ureidopropionase, beta | This gene encodes an enzyme that catalyzes the conversion of N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid or beta-alanine. Mutations in the related gene in human have been associated with beta-ureidopropionase deficiency. [provided by RefSeq, Dec 2013 ] | 10 | 75242745 | 75277513 | Mouse | 169 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 9005974 | Upb1 | beta-ureidopropionase 1 | ENCODES a protein that exhibits beta-ureidopropionase activity (ortholog); protein homodimerization activity (ortholog); zinc ion binding (ortholog); INVOLVED IN beta-alanine biosynthetic process via 3-ureidopropionate (ortholog); beta-alanine metabolic process (ortholog); in utero embryonic develop ment (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; ASSOCIATED WITH autistic disorder (ortholog); Beta-Ureidopropionase Deficiency (ortholog); celiac disease (ortholog); FOUND IN cytosol (ortholog) | NW_004955455 | 7961296 | 7992235 | Chinchilla | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11824944 | UPB1 | beta-ureidopropionase 1 | ENCODES a protein that exhibits beta-ureidopropionase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN beta-alanine metabolic process (ortholog); in utero embryonic development (ortholog); liver development (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionas e deficiency pathway; carnosinemia pathway; ASSOCIATED WITH autistic disorder (ortholog); Beta-Ureidopropionase Deficiency (ortholog); celiac disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 22 | 5300686 | 5332735 | Bonobo | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12390517 | UPB1 | beta-ureidopropionase 1 | ENCODES a protein that exhibits beta-ureidopropionase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN beta-alanine metabolic process (ortholog); in utero embryonic development (ortholog); liver development (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionas e deficiency pathway; carnosinemia pathway; ASSOCIATED WITH autistic disorder (ortholog); Beta-Ureidopropionase Deficiency (ortholog); celiac disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 26 | 28194968 | 28225977 | Dog | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12681056 | Upb1 | beta-ureidopropionase 1 | ENCODES a protein that exhibits beta-ureidopropionase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN beta-alanine metabolic process (ortholog); in utero embryonic development (ortholog); liver development (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionas e deficiency pathway; carnosinemia pathway; ASSOCIATED WITH autistic disorder (ortholog); Beta-Ureidopropionase Deficiency (ortholog); celiac disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | NW_004936619 | 668380 | 713720 | Squirrel | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920052 | Upb1 | beta-ureidopropionase 1 | ENCODES a protein that exhibits beta-ureidopropionase activity (ortholog); protein homodimerization activity (ortholog); zinc ion binding (ortholog); INVOLVED IN beta-alanine metabolic process (ortholog); in utero embryonic development (ortholog); liver development (ortholog); PARTICIPATES IN beta-a lanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; ASSOCIATED WITH autistic disorder (ortholog); Beta-Ureidopropionase Deficiency (ortholog); celiac disease (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626057189 | Upb1 | beta-ureidopropionase 1 | ENCODES a protein that exhibits beta-ureidopropionase activity (ortholog); protein homodimerization activity (ortholog); zinc ion binding (ortholog); INVOLVED IN beta-alanine biosynthetic process via 3-ureidopropionate (ortholog); beta-alanine metabolic process (ortholog); in utero embryonic develop ment (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; ASSOCIATED WITH autistic disorder (ortholog); Beta-Ureidopropionase Deficiency (ortholog); celiac disease (ortholog); FOUND IN cytosol (ortholog) | | | | Black Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18491381 | UPB1 | beta-ureidopropionase 1 | ENCODES a protein that exhibits beta-ureidopropionase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN beta-alanine metabolic process (ortholog); in utero embryonic development (ortholog); liver development (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionas e deficiency pathway; carnosinemia pathway; ASSOCIATED WITH autistic disorder (ortholog); Beta-Ureidopropionase Deficiency (ortholog); celiac disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243516 | upb1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14150251 | UPB1 | beta-ureidopropionase 1 | ENCODES a protein that exhibits beta-ureidopropionase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN beta-alanine metabolic process (ortholog); in utero embryonic development (ortholog); liver development (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionas e deficiency pathway; carnosinemia pathway; ASSOCIATED WITH autistic disorder (ortholog); Beta-Ureidopropionase Deficiency (ortholog); celiac disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Pig | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254780 | upb1.S | | | | | | African Clawed Frog | | symbol | gene, null |