Upb1 (ureidopropionase, beta) - Rat Genome Database

Name: Upb1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Upb1 (ureidopropionase, beta) Mus musculus

Analyze

Symbol:

Upb1

Name:

ureidopropionase, beta

RGD ID:

734440

MGI Page

MGI

Description:

Predicted to have beta-ureidopropionase activity; protein homodimerization activity; and zinc ion binding activity. Predicted to be involved in several processes, including beta-alanine biosynthetic process via 3-ureidopropionate; protein homotetramerization; and pyrimidine nucleoside catabolic process. Predicted to localize to cytoplasm. Is expressed in liver. Orthologous to human UPB1 (beta-ureidopropionase 1).

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

AI195023; beta-alanine synthase; beta-ureidopropionase; N-carbamoyl-beta-alanine amidohydrolase

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UPB1 (beta-ureidopropionase 1)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Upb1 (beta-ureidopropionase 1)	HGNC	Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Upb1 (beta-ureidopropionase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	UPB1 (beta-ureidopropionase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	UPB1 (beta-ureidopropionase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Upb1 (beta-ureidopropionase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UPB1 (beta-ureidopropionase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	UPB1 (beta-ureidopropionase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Upb1 (beta-ureidopropionase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Upb1 (beta-ureidopropionase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Homo sapiens (human):	UPB1 (beta-ureidopropionase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	upb1 (ureidopropionase, beta)	Alliance	DIOPT (PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	upb-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup)
Drosophila melanogaster (fruit fly):	pyd3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	75,242,745 - 75,277,513 (+)	NCBI	GRCm39		mm39
GRCm38	10	75,406,911 - 75,441,679 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	75,401,115 - 75,441,679 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	74,869,779 - 74,902,942 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	74,846,181 - 74,883,913 (+)	NCBI			mm8
Celera	10	76,453,987 - 76,488,021 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Beta-Ureidopropionase Deficiency (ISO)

celiac disease (ISO)

disease of metabolism (ISO)

schizophrenia (ISO)

West syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (EXP)

1,2-dimethylhydrazine (EXP)

1-chloro-2,4-dinitrobenzene (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (ISO)

2,4-dinitrotoluene (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3-chloropropane-1,2-diol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (EXP)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

aflatoxin B1 (EXP,ISO)

ammonium chloride (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (EXP)

bisphenol A (ISO)

bromobenzene (ISO)

buta-1,3-diene (EXP)

C60 fullerene (ISO)

carbon nanotube (EXP)

chromium(6+) (EXP)

cyclosporin A (ISO)

dextran sulfate (EXP)

dioxygen (ISO)

flavonoids (ISO)

furan (ISO)

gentamycin (ISO)

gliotoxin (ISO)

glycidol (ISO)

isotretinoin (ISO)

methapyrilene (ISO)

methotrexate (ISO)

N-nitrosodiethylamine (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nimesulide (ISO)

O-methyleugenol (ISO)

obeticholic acid (ISO)

ochratoxin A (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (EXP)

progesterone (EXP)

Propiverine (ISO)

rotenone (ISO)

sodium arsenite (ISO)

tauroursodeoxycholic acid (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (ISO)

titanium dioxide (EXP)

toluene 2,4-diisocyanate (EXP)

toxaphene (ISO)

triclosan (ISO)

troglitazone (ISO)

tunicamycin (EXP)

urethane (ISO)

valproic acid (ISO)

vancomycin (EXP)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

beta-alanine biosynthetic process via 3-ureidopropionate (IBA,ISO)

beta-alanine metabolic process (ISO)

CMP catabolic process (IDA)

dCMP catabolic process (IDA)

dTMP catabolic process (ISO)

dUMP catabolic process (IDA)

in utero embryonic development (ISO)

liver development (ISO)

nitrogen compound metabolic process (IEA)

protein homooligomerization (ISO)

protein homotetramerization (ISO)

pyrimidine nucleoside catabolic process (ISO)

UMP catabolic process (IDA)

Cellular Component

cytoplasm (IEA)

cytosol (IDA)

Molecular Function

beta-ureidopropionase activity (IBA,IDA,ISO)

catalytic activity (IEA)

hydrolase activity (IEA)

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IBA)

protein homodimerization activity (ISO)

zinc ion binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

beta-alanine metabolic pathway (IEA,ISO)

beta-ureidopropionase deficiency pathway (ISO)

carnosinemia pathway (ISO)

dihydropyrimidinase deficiency pathway (ISO)

GABA aminotransferase deficiency pathway (ISO)

mitochondrial neurogastrointestinal encephalopathy syndrome pathway (ISO)

orotic aciduria 1 pathway (ISO)

pantothenic acid metabolic pathway (IEA)

pyrimidine metabolic pathway (IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased body length (IEA)

decreased circulating creatinine level (IEA)

decreased lean body mass (IEA)

increased total body fat amount (IEA)

References

References - curated


1.	MGD data from the GO Consortium
2.	OMIM Disease Annotation Pipeline
3.	Pipeline to import KEGG annotations from KEGG into RGD
4.	Pipeline to import SMPDB annotations from SMPDB into RGD
5.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	RGD automated import pipeline for gene-chemical interactions
7.	Tamaki N, etal., Br J Nutr. 1995 May;73(5):711-22.

Additional References at PubMed

PMID:5472365	PMID:8449931	PMID:10349636	PMID:10989448	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12466851	PMID:12477932	PMID:14610273	PMID:14681479	PMID:15489334
PMID:16141072	PMID:16141073	PMID:21267068	PMID:21677750	PMID:21873635	PMID:25857663

Genomics

Comparative Map Data

Upb1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	75,242,745 - 75,277,513 (+)	NCBI	GRCm39		mm39
GRCm38	10	75,406,911 - 75,441,679 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	75,401,115 - 75,441,679 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	74,869,779 - 74,902,942 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	74,846,181 - 74,883,913 (+)	NCBI			mm8
Celera	10	76,453,987 - 76,488,021 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI

UPB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	22	24,494,107 - 24,528,390 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	22	24,495,060 - 24,528,681 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	22	24,891,300 - 24,924,358 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	22	24,863,344 - 24,922,553 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	23,221,251 - 23,252,553 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	22	23,215,804 - 23,247,106	NCBI
Celera	22	8,690,987 - 8,722,274 (+)	NCBI
Cytogenetic Map	22	q11.23	NCBI
HuRef	22	7,840,918 - 7,872,203 (+)	NCBI		HuRef
CHM1_1	22	24,849,971 - 24,881,302 (+)	NCBI		CHM1_1

Upb1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	13,217,252 - 13,243,590 (-)	NCBI
Rnor_6.0 Ensembl	20	14,167,586 - 14,193,690 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	20	14,167,383 - 14,193,724 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	20	16,352,599 - 16,378,743 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	13,715,995 - 13,743,261 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	13,716,221 - 13,743,488 (-)	NCBI
Celera	20	14,703,097 - 14,729,538 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

Upb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	7,961,264 - 7,995,946 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	7,961,296 - 7,992,235 (+)	NCBI	ChiLan1.0	ChiLan1.0

UPB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	22	22,138,989 - 22,197,360 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	22,166,370 - 22,197,360 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	22	5,300,686 - 5,332,735 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

UPB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	26	28,195,081 - 28,225,567 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	26	28,194,968 - 28,225,977 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Upb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936619	668,380 - 713,720 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UPB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	49,533,226 - 49,565,100 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	49,533,208 - 49,561,518 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	52,975,014 - 53,003,329 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UPB1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	7,605,999 - 7,639,339 (-)	NCBI
ChlSab1.1 Ensembl	19	7,605,537 - 7,639,017 (-)	Ensembl

Upb1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624747	9,911,323 - 9,940,770 (+)	NCBI

Position Markers

AI195023

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	10	75,440,033 - 75,440,128	UniSTS	GRCm38
MGSCv37	10	74,902,778 - 74,902,873	UniSTS	GRCm37
Celera	10	76,487,857 - 76,487,952	UniSTS
Cytogenetic Map	10	C1	UniSTS
Whitehead/MRC_RH	10	858.61	UniSTS

px-31f3

Mouse Assembly	Chr	Position (strand)	Source
Cytogenetic Map	11	B5	UniSTS
Cytogenetic Map	7	A1	UniSTS
Cytogenetic Map	16	C3.3	UniSTS
Cytogenetic Map	10	A4	UniSTS
Cytogenetic Map	10	A3-A4	UniSTS
Cytogenetic Map	18	B3	UniSTS
Cytogenetic Map	7	C	UniSTS
Cytogenetic Map	9	E3.1	UniSTS
Cytogenetic Map	10	A1	UniSTS
Cytogenetic Map	17	C	UniSTS
Cytogenetic Map	15	F1	UniSTS
Cytogenetic Map	7	F3	UniSTS
Cytogenetic Map	16	B5	UniSTS
Cytogenetic Map	15	D3	UniSTS
Cytogenetic Map	7	F1	UniSTS
Cytogenetic Map	10	C3	UniSTS
Cytogenetic Map	3	F1	UniSTS
Cytogenetic Map	14	B	UniSTS
Cytogenetic Map	5	C3.1	UniSTS
Cytogenetic Map	10	B5.1	UniSTS
Cytogenetic Map	18	E4	UniSTS
Cytogenetic Map	1	A2	UniSTS
Cytogenetic Map	18	D1	UniSTS
Cytogenetic Map	8	A2	UniSTS
Cytogenetic Map	5	A3	UniSTS
Cytogenetic Map	2	A3	UniSTS
Cytogenetic Map	14	D2	UniSTS
Cytogenetic Map	3	F2.2	UniSTS
Cytogenetic Map	13	C1	UniSTS
Cytogenetic Map	5	G2	UniSTS
Cytogenetic Map	10	C1	UniSTS
Cytogenetic Map	11	C	UniSTS
Cytogenetic Map	17	B3	UniSTS
Cytogenetic Map	12	C2	UniSTS
Cytogenetic Map	13	B2	UniSTS
Cytogenetic Map	15	A1	UniSTS
Cytogenetic Map	11	E1	UniSTS
Cytogenetic Map	5	B1	UniSTS
Cytogenetic Map	10	D1	UniSTS
Cytogenetic Map	13	D1	UniSTS
Cytogenetic Map	4	C3	UniSTS
Cytogenetic Map	X	D	UniSTS
Cytogenetic Map	18	D3	UniSTS
cM Map	10	60.0	UniSTS
cM Map	15	4.6	UniSTS
cM Map	4	39.4	UniSTS
cM Map	11	70.0	UniSTS
cM Map	13	36.0	UniSTS
cM Map	5	18.2	UniSTS
cM Map	12	29.0	UniSTS
cM Map	X	42.0	UniSTS
cM Map	13	47.01	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357740	Obsty3_m	obesity 3 (mouse)			Not determined		10	8359714	116355075	Mouse
1301386	Sysbp1_m	systolic blood pressure 1 (mouse)			Not determined		10	10232521	87565233	Mouse
1357825	Kidpq2_m	kidney weight percentage QTL 2 (mouse)			Not determined		10	12828307	84243920	Mouse
1357656	Hrtq3_m	heart weight QTL 3 (mouse)			Not determined		10	12828307	84243920	Mouse
1357864	Scfpq1_m	subcutaneous fat pad percentage QTL 1 (mouse)			Not determined		10	12828307	84243920	Mouse
1357893	Lvrq4_m	liver weight QTL 4 (mouse)			Not determined		10	12828307	84243920	Mouse
4142380	W3q11_m	weight 3 weeks QTL 11 (mouse)			Not determined			12828307	84243920	Mouse
4141943	W6q6_m	weight 6 weeks QTL 6 (mouse)			Not determined			12828307	84243920	Mouse
4141956	Egq7_m	early growth QTL 7 (mouse)			Not determined			12828307	84243920	Mouse
4142272	W10q5_m	weight 10 weeks QTL 5 (mouse)			Not determined			12828307	84243920	Mouse
39128215	Lwq17_m	liver weight QTL 17 (mouse)					10	12828307	84243920	Mouse
1302067	Scc9_m	colon tumor susceptibility 9 (mouse)			Not determined		10	18383585	125739363	Mouse
27226772	Tibl13_m	tibia length 13, 10 week (mouse)					10	19000000	129800000	Mouse
1558757	Eae34_m	experimental allergic encephalomyelitis susceptibility 34 (mouse)			Not determined		10	21532255	114381325	Mouse
26884403	Cvht8_m	cranial vault height 8, 16 week (mouse)					10	23000000	91200000	Mouse
26884426	Cvht1_m	cranial vault height 1, 5 week (mouse)					10	24800000	121200000	Mouse
27095911	Pglq15_m	pelvic girdle length QTL 15, 16 week (mouse)					10	39300000	129800000	Mouse
27226764	Tibl19_m	tibia length 19, 16 week (mouse)					10	39300000	129800000	Mouse
26884411	Bzwq8_m	bi-zygomatic width QTL 8, 10 week (mouse)					10	45000000	116100000	Mouse
26884407	Bzwq14_m	bi-zygomatic width QTL 14, 16 wee (mouse)					10	45600000	120800000	Mouse
4142313	Angvq1_m	angiogenesis by VEGF QTL 1 (mouse)			Not determined			46844307	82655287	Mouse
1302150	Bbaa18_m	B.burgdorferi-associated arthritis 18 (mouse)			Not determined		10	49502233	83502378	Mouse
4142169	Pbwg16_m	postnatal body weight growth 16 (mouse)			Not determined		10	50012408	84012633	Mouse
1300597	Skull14_m	skull morphology 14 (mouse)			Not determined		10	50012408	84012633	Mouse
10045641	Jckm3_m	juvenile cystic kidney modifier 3 (mouse)			Not determined		10	50012408	84012633	Mouse
1301966	Lifespan2_m	life span 2 (mouse)			Not determined		10	50012443	84012618	Mouse
1357737	Hpcr2_m	hepatocarcinogen resistance 2 (mouse)			Not determined		10	50012443	84012618	Mouse
1300882	Ath17_m	atherosclerosis 17 (mouse)			Not determined		10	51255660	85255809	Mouse
1301502	Eae17_m	susceptibility to experimental allergic encephalomyelitis 17 (mouse)			Not determined		10	51255660	85255809	Mouse
1301380	Cia8_m	collagen induced arthritis QTL 8 (mouse)			Not determined		10	51617304	82655287	Mouse
14746991	Manh68_m	mandible shape 68 (mouse)					10	52444667	86444667	Mouse
1301787	Bsc1_m	brain size control 1 (mouse)			Not determined		10	58681135	92681262	Mouse
26884450	Sklq15_m	skull length QTL 15, 16 week (mouse)					10	59500000	122500000	Mouse
13208560	Wght9_m	weight 9 (mouse)					10	60000000	121000000	Mouse
26884424	Zlq9_m	zygomatic length QTL 9, 16 week (mouse)					10	64100000	116100000	Mouse
1302060	El3_m	epilepsy 3 (mouse)			Not determined		10	65655104	99655287	Mouse
1300533	Aem3_m	anti-erythrocyte autoantibody modifier 3 (mouse)			Not determined		10	65655104	99655287	Mouse
1301737	Insq9_m	insulin QTL 9 (mouse)			Not determined		10	65655104	99655287	Mouse
1302035	Lmb4_m	lupus in MRL and B6 F2 cross (mouse)			Not determined		10	67012408	92422811	Mouse
26884447	Sklq9_m	skull length QTL 9, 10 week (mouse)					10	67500000	111900000	Mouse
26884430	Zlq5_m	zygomatic length QTL 5, 10 week (mouse)					10	68000000	125000000	Mouse
26884405	Huml2_m	humerus length 2, 5 week (mouse)					10	69900000	132500000	Mouse
11039497	Ltpr5a_m	Leishmania tropica response 5a (mouse)					10	73671039	107671185	Mouse
4142107	Obrq12_m	obesity resistance QTL 12 (mouse)			Not determined			74151384	82655287	Mouse
11353832	Pcholq4_m	plasma cholesterol QTL 4 (mouse)					10	74151384	125680038	Mouse
11353843	Gluq1_m	blood glucose QTL 1 (mouse)					10	74151384	125680038	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	866
Count of miRNA genes:	541
Interacting mature miRNAs:	648
Transcripts:	ENSMUST00000039925, ENSMUST00000129946, ENSMUST00000132629, ENSMUST00000138058
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133995	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC137067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC144461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK149373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK149480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK165429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC021388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC024447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466553	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000039925 ⟹ ENSMUSP00000049342

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	10	75,406,911 - 75,441,679 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000129946

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	10	75,428,181 - 75,430,319 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000132629

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	10	75,410,043 - 75,427,777 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000138058

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	10	75,406,958 - 75,424,777 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000219052 ⟹ ENSMUSP00000151804

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	10	75,401,115 - 75,424,564 (+)	Ensembl

RefSeq Acc Id:

NM_133995 ⟹ NP_598756

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	10	75,242,745 - 75,277,513 (+)	NCBI
GRCm38	10	75,406,911 - 75,441,679 (+)	NCBI
MGSCv37	10	74,869,779 - 74,902,942 (+)	RGD
Celera	10	76,453,864 - 76,489,503 (+)	NCBI
cM Map	10		ENTREZGENE

Sequence:

show sequence

GTTGCCAGCATGTGAACCCTCCTCACAGAGCACCAAATCCCGTGCCTCTGGAGACCTGCCAGGC
TGCTGCCTCCTTCTCCCCATACTCCAGGCCGAGGGCAGGCCATTCGTGTGGGACATCAGTCCCT
GCAACCAGCTTCTGGCCATGGCGGGACCGGAGTGGCAGTCCCTGGAGCAGTGCCTGGAAAAACA
TCTGCCGCCTGACGATTTGGCCCAGGTGAAGCGAATTCTCTACGGCAAGCAGACTAGGAATCTC
GATCTGCCCAGAGAAGCTTTAAAAGCTGCCTCAGAAAGGAACTTTGAACTGAAGGGATATGCCT
TCGGGGCAGCCAAGGAGCAGCAGAGATGCCCCCAGATCGTGCGCGTGGGGCTCGTTCAGAACAG
AATCCCGCTCCCCACTTCTGCCCCCGTGGCAGAACAGGTCTCTGCGCTCCACAAGAGCATAGAG
GAGATTGCTGAGGTGGCCGCAATGTGTGGAGTCAATATCATCTGTTTCCAGGAAGCATGGAATA
TGCCGTTCGCTTTTTGTACACGAGAGAAACTTCCTTGGACAGAATTTGCTGAGTCGGCCGAGGA
TGGGCTCACCACCAGGTTCTGTCAGAAGCTGGCAAAGAAGCACAACATGGTGGTGGTGTCTCCA
ATCTTGGAGCGTGATAGAGAGCATGGGGGAGTTCTGTGGAACACAGCTGTGGTGATCTCCAATT
CAGGGCTGGTCATGGGGAAGACCAGAAAGAACCACATCCCCAGAGTGGGAGACTTCAACGAGTC
CACTTACTACATGGAGGGAAACCTGGGCCACCCCGTGTTCCAGACCCAGTTTGGCAGGATTGCA
GTGAACATTTGCTATGGGCGGCACCACCCCCTCAACTGGCTCATGTACAGCATCAACGGAGCTG
AAATCATCTTCAACCCTTCGGCCACCATTGGAGAACTCAGTGAGTCCTTGTGGCCGATCGAAGC
CAGAAATGCAGCCATTGCCAATCACTGCTTCACCTGTGCTCTCAACCGTGTGGGTCAGGAACAC
TTCCCCAATGAGTTTACTTCTGGAGATGGAAAGAAAGCTCACCATGACCTCGGCTACTTCTATG
GTTCGAGCTATGTGGCAGCTCCCGATGGCAGCCGGACCCCCGGCCTCTCCCGTAATCAGGATGG
GCTGCTGGTCACGGAGCTCAACCTCAATCTCTGCCAGCAGATCAATGATTTCTGGACTTTCAAG
ATGACGGGACGACTTGAGATGTATGCCCGGGAACTTGCCGAAGCGGTCAAACCCAACTACAGTC
CCAACATTGTGAAGGAAGACCTGGTACTAGCCCCTAGCTCGGGTTAGGTTTGGGGACATATCCG
GCCCCAGTGGATAAGTTTTAAAATGTATACAAGGCGGAGTTTTTAATACTCAGGCAGGAGGAGG
GTAGAATAGGCACTTAACTGCGTATGTGTGATAATTGTTAATGATGAATATGAGAACTTTCTTC
TGGGGACTTGGAAATGTTTGGGGATTCAAAAGATGATTCAACATCATTGAAATTTTATTAAATG
TGACTGGATCGGTATACTTCAAAAGTGTTTTGTGTAGTGTAGATTCTACCCCAGGATAAGATGC
TGTAGGATCATATTAAGGCCATGGAAAGGAGCTGGTCCGGAGGAGAATGGGATGTGGTAATACC
TGGGCGTGGGCAGCTTTGATAGACTTCCCAGCTTCCCACCCTGGTCTCCATTTGTGTCTATAAT
GAGATGCTACGTGGACCAGGCCGACCTTCTCTGCTCCTCTACCTGGTGTCCTGTTCCTCAGCTC
CATTCCGACCCCATCTCAAGGTTCCATCAGCTCCTCAAGGGGCAATCTGGGAAACTGTGTACTA
GCAGGAAGACAGTAAGAGCAGATGAGAGTCACAGAGACCATAGCATCTCTGTGAGCAGATGGAC
TGTTCATAGGATAAGCTGAGTCAACTTAGCTATGGCCCAATTATTCAGGCAGGCACAAACCTAG
GTGTCTTAGTTAGGACTTTACTGAACAGACACCATTACCAAAGCAAAATTATAAGGACGATATT
TAATTGGGGCTGCTTACGGGTTCAGAGGTTCAGTCCATTATCATCTAGGTGGGAACATGGCAGC
ATCCAAGCCGACCTGGTGCAGAAGAAGCTGAGAGTTCTACATCTTCATTTGAAGGCAGTCAGGA
GAAGACTGGCTTCCAGACAGCTAGGATGAGGGTCTTAAAGCCCACGCCCACAGTGACACACCTA
CTCTAGCAAAGCCACCAAATAGTGCCACTCCCTGGGCCAAGCATATTACAAACCATCACACTAG
GTGATGCAGAGAATTTGAGGTGGGAGACATGGTCCCATTGTCTTGCCGGTCTTGAACTCAGGAT
CAAAGCACCATCCTGCCTTCTAAGTAGCTAGGACTACAGGTATGTGCCACCATGCCCAGCACTG
TGCAAAGGTATCTTACAAATGTGATCAAAGTTTACAGCCTGTTGACTGATCATGCCATAAAACT
AAGGTGAACCTCACTCAGTCTGCTTACAGCGCTAACAAGCATCCTTGAGCCTTCCATGAGGAAG
AAGGAATTCTGTGTAGACAACAGTTCCAGCCCCTGGCAAGACAGTCAGCCTGCCTCCTTGACAT
CTCTCCCTGGAGTTATTAGACTGACCTAGCCAACTGCCCCACCCCACCCCCTTCACCTCCTCAT
AATATCTCCTAACATGTTGCCTGTGAGTACTGCCTCTGGTTGGGCTAACTGATACAGGCTTTGA
TGCCCAAAGGAACAGAAGCTTAGGGGATGAGTTTCCCTCTCTGGGTCTGGGTTTCTGGAATGTT
TTCCATTTGATTTGGTTTAAAGGCACCAATGACTCTGTTTCCTGTGGTAAACACAGAAGTGGTT
GCTCGTGGCACGATGGGTGCCACCATTAACATCTACGTGTGGGGCCGATCGCAGCCAGGGCCCA
AGTGCACCAGCCTGCCTGCCCTTCCTGGTGGCCTTCCCTGTGGGTCTCAGGCTTGTGTAATCAG
GCTTCCTATCGTCCCATCAGGAAGTTCTTTGTAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_598756	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH21388	(Get FASTA)	NCBI Sequence Viewer
	AAH24447	(Get FASTA)	NCBI Sequence Viewer
	BAE28841	(Get FASTA)	NCBI Sequence Viewer
	BAE28907	(Get FASTA)	NCBI Sequence Viewer
	EDL31923	(Get FASTA)	NCBI Sequence Viewer
	EDL31924	(Get FASTA)	NCBI Sequence Viewer
	Q8VC97	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_598756 ⟸ NM_133995

- UniProtKB:

Q8VC97 (UniProtKB/Swiss-Prot), Q3UEK4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGPEWQSLEQCLEKHLPPDDLAQVKRILYGKQTRNLDLPREALKAASERNFELKGYAFGAAKE
QQRCPQIVRVGLVQNRIPLPTSAPVAEQVSALHKSIEEIAEVAAMCGVNIICFQEAWNMPFAFC
TREKLPWTEFAESAEDGLTTRFCQKLAKKHNMVVVSPILERDREHGGVLWNTAVVISNSGLVMG
KTRKNHIPRVGDFNESTYYMEGNLGHPVFQTQFGRIAVNICYGRHHPLNWLMYSINGAEIIFNP
SATIGELSESLWPIEARNAAIANHCFTCALNRVGQEHFPNEFTSGDGKKAHHDLGYFYGSSYVA
APDGSRTPGLSRNQDGLLVTELNLNLCQQINDFWTFKMTGRLEMYARELAEAVKPNYSPNIVKE
DLVLAPSSG

hide sequence

RefSeq Acc Id:

ENSMUSP00000151804 ⟸ ENSMUST00000219052

RefSeq Acc Id:

ENSMUSP00000049342 ⟸ ENSMUST00000039925

Protein Domains

CN hydrolase

Promoters

RGD ID:

6820075

Promoter ID:

MM_KWN:4542

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Kidney, Liver

Transcripts:

OTTMUST00000078814, OTTMUST00000078816

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	10	74,869,456 - 74,869,956 (+)	MPROMDB

RGD ID:

6820076

Promoter ID:

MM_KWN:4543

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Kidney, Liver

Transcripts:

OTTMUST00000078815

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	10	74,872,456 - 74,872,956 (+)	MPROMDB

RGD ID:

6820077

Promoter ID:

MM_KWN:4544

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Kidney

Transcripts:

OTTMUST00000078817

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	10	74,890,591 - 74,891,091 (+)	MPROMDB

RGD ID:

8672306

Promoter ID:

EPDNEW_M14183

Type:

single initiation site

Name:

Upb1_2

Description:

Mus musculus ureidopropionase, beta , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M14184

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	10	75,406,819 - 75,406,879	EPDNEW

RGD ID:

8672308

Promoter ID:

EPDNEW_M14184

Type:

initiation region

Name:

Upb1_1

Description:

Mus musculus ureidopropionase, beta , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M14183

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	10	75,407,016 - 75,407,076	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2143535	AgrOrtholog
Ensembl Genes	ENSMUSG00000033427	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000049342	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000151804	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000039925	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000219052	UniProtKB/TrEMBL
Gene3D-CATH	3.60.110.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	C-N_Hydrolase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	C-N_Hydrolase_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:103149	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:2143535	ENTREZGENE
NCBI Gene	103149	ENTREZGENE
Pfam	CN_hydrolase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	UPB1	RGD
PhenoGen	Upb1	PhenoGen
PROSITE	CN_HYDROLASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56317	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A1W2P7X7_MOUSE	UniProtKB/TrEMBL
	BUP1_MOUSE	UniProtKB/Swiss-Prot
	Q3UEK4	ENTREZGENE, UniProtKB/TrEMBL
	Q8VC97	ENTREZGENE
UniProt Secondary	Q8R1K8	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)