Upb1 (ureidopropionase, beta) - Rat Genome Database
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Gene: Upb1 (ureidopropionase, beta) Mus musculus
Analyze
Symbol: Upb1
Name: ureidopropionase, beta
RGD ID: 734440
MGI Page MGI
Description: Predicted to have beta-ureidopropionase activity; protein homodimerization activity; and zinc ion binding activity. Predicted to be involved in several processes, including beta-alanine biosynthetic process via 3-ureidopropionate; protein homotetramerization; and pyrimidine nucleoside catabolic process. Predicted to localize to cytoplasm. Is expressed in liver. Orthologous to human UPB1 (beta-ureidopropionase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI195023; beta-alanine synthase; beta-ureidopropionase; N-carbamoyl-beta-alanine amidohydrolase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,242,745 - 75,277,513 (+)NCBIGRCm39mm39
GRCm381075,406,911 - 75,441,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,401,115 - 75,441,679 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,869,779 - 74,902,942 (+)NCBIGRCm37mm9NCBIm37
MGSCv361074,846,181 - 74,883,913 (+)NCBImm8
Celera1076,453,987 - 76,488,021 (+)NCBICelera
Cytogenetic Map10C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:5472365   PMID:8449931   PMID:10349636   PMID:10989448   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15489334  
PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635   PMID:25857663  


Genomics

Comparative Map Data
Upb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,242,745 - 75,277,513 (+)NCBIGRCm39mm39
GRCm381075,406,911 - 75,441,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,401,115 - 75,441,679 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,869,779 - 74,902,942 (+)NCBIGRCm37mm9NCBIm37
MGSCv361074,846,181 - 74,883,913 (+)NCBImm8
Celera1076,453,987 - 76,488,021 (+)NCBICelera
Cytogenetic Map10C1NCBI
UPB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2224,494,107 - 24,528,390 (+)EnsemblGRCh38hg38GRCh38
GRCh382224,495,060 - 24,528,681 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,891,300 - 24,924,358 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh372224,863,344 - 24,922,553 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,221,251 - 23,252,553 (+)NCBINCBI36hg18NCBI36
Build 342223,215,804 - 23,247,106NCBI
Celera228,690,987 - 8,722,274 (+)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,840,918 - 7,872,203 (+)NCBIHuRef
CHM1_12224,849,971 - 24,881,302 (+)NCBICHM1_1
Upb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22013,217,252 - 13,243,590 (-)NCBI
Rnor_6.0 Ensembl2014,167,586 - 14,193,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02014,167,383 - 14,193,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02016,352,599 - 16,378,743 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,715,995 - 13,743,261 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12013,716,221 - 13,743,488 (-)NCBI
Celera2014,703,097 - 14,729,538 (-)NCBICelera
Cytogenetic Map20p12NCBI
Upb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554557,961,264 - 7,995,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554557,961,296 - 7,992,235 (+)NCBIChiLan1.0ChiLan1.0
UPB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12222,138,989 - 22,197,360 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,166,370 - 22,197,360 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0225,300,686 - 5,332,735 (+)NCBIMhudiblu_PPA_v0panPan3
UPB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2628,195,081 - 28,225,567 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12628,194,968 - 28,225,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Upb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936619668,380 - 713,720 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UPB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,533,226 - 49,565,100 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,533,208 - 49,561,518 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,975,014 - 53,003,329 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UPB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,605,999 - 7,639,339 (-)NCBI
ChlSab1.1 Ensembl197,605,537 - 7,639,017 (-)Ensembl
Upb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247479,911,323 - 9,940,770 (+)NCBI

Position Markers
AI195023  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381075,440,033 - 75,440,128UniSTSGRCm38
MGSCv371074,902,778 - 74,902,873UniSTSGRCm37
Celera1076,487,857 - 76,487,952UniSTS
Cytogenetic Map10C1UniSTS
Whitehead/MRC_RH10858.61UniSTS
px-31f3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B5UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map16C3.3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map10A3-A4UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map16B5UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map10C3UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map5C3.1UniSTS
Cytogenetic Map10B5.1UniSTS
Cytogenetic Map18E4UniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map18D1UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map17B3UniSTS
Cytogenetic Map12C2UniSTS
Cytogenetic Map13B2UniSTS
Cytogenetic Map15A1UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map10D1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map18D3UniSTS
cM Map1060.0UniSTS
cM Map154.6UniSTS
cM Map439.4UniSTS
cM Map1170.0UniSTS
cM Map1336.0UniSTS
cM Map518.2UniSTS
cM Map1229.0UniSTS
cM MapX42.0UniSTS
cM Map1347.01UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1045000000116100000Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045600000120800000Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4684430782655287Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104950223383502378Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined105001240884012633Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined105001240884012633Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined105001240884012633Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined105001244384012618Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined105001244384012618Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105125566085255809Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105125566085255809Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105161730482655287Mouse
14746991Manh68_mmandible shape 68 (mouse)105244466786444667Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105868113592681262Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059500000122500000Mouse
13208560Wght9_mweight 9 (mouse)1060000000121000000Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1064100000116100000Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106565510499655287Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106565510499655287Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106565510499655287Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106701240892422811Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067500000111900000Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1068000000125000000Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069900000132500000Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073671039107671185Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7415138482655287Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1074151384125680038Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1074151384125680038Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:866
Count of miRNA genes:541
Interacting mature miRNAs:648
Transcripts:ENSMUST00000039925, ENSMUST00000129946, ENSMUST00000132629, ENSMUST00000138058
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000039925   ⟹   ENSMUSP00000049342
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1075,406,911 - 75,441,679 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129946
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1075,428,181 - 75,430,319 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132629
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1075,410,043 - 75,427,777 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138058
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1075,406,958 - 75,424,777 (+)Ensembl
RefSeq Acc Id: ENSMUST00000219052   ⟹   ENSMUSP00000151804
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1075,401,115 - 75,424,564 (+)Ensembl
RefSeq Acc Id: NM_133995   ⟹   NP_598756
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391075,242,745 - 75,277,513 (+)NCBI
GRCm381075,406,911 - 75,441,679 (+)NCBI
MGSCv371074,869,779 - 74,902,942 (+)RGD
Celera1076,453,864 - 76,489,503 (+)NCBI
cM Map10 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598756   ⟸   NM_133995
- UniProtKB: Q8VC97 (UniProtKB/Swiss-Prot),   Q3UEK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000151804   ⟸   ENSMUST00000219052
RefSeq Acc Id: ENSMUSP00000049342   ⟸   ENSMUST00000039925
Protein Domains
CN hydrolase

Promoters
RGD ID:6820075
Promoter ID:MM_KWN:4542
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000078814,   OTTMUST00000078816
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361074,869,456 - 74,869,956 (+)MPROMDB
RGD ID:6820076
Promoter ID:MM_KWN:4543
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000078815
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361074,872,456 - 74,872,956 (+)MPROMDB
RGD ID:6820077
Promoter ID:MM_KWN:4544
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000078817
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361074,890,591 - 74,891,091 (+)MPROMDB
RGD ID:8672306
Promoter ID:EPDNEW_M14183
Type:single initiation site
Name:Upb1_2
Description:Mus musculus ureidopropionase, beta , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14184  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381075,406,819 - 75,406,879EPDNEW
RGD ID:8672308
Promoter ID:EPDNEW_M14184
Type:initiation region
Name:Upb1_1
Description:Mus musculus ureidopropionase, beta , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14183  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381075,407,016 - 75,407,076EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2143535 AgrOrtholog
Ensembl Genes ENSMUSG00000033427 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000049342 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000151804 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000039925 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000219052 UniProtKB/TrEMBL
Gene3D-CATH 3.60.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-N_Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-N_Hydrolase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:103149 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2143535 ENTREZGENE
NCBI Gene 103149 ENTREZGENE
Pfam CN_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB UPB1 RGD
PhenoGen Upb1 PhenoGen
PROSITE CN_HYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2P7X7_MOUSE UniProtKB/TrEMBL
  BUP1_MOUSE UniProtKB/Swiss-Prot
  Q3UEK4 ENTREZGENE, UniProtKB/TrEMBL
  Q8VC97 ENTREZGENE
UniProt Secondary Q8R1K8 UniProtKB/Swiss-Prot