Upb1 (beta-ureidopropionase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Upb1 (beta-ureidopropionase 1) Heterocephalus glaber
Analyze
Symbol: Upb1
Name: beta-ureidopropionase 1
RGD ID: 18920052
Description: ENCODES a protein that exhibits beta-ureidopropionase activity (ortholog); protein homodimerization activity (ortholog); zinc ion binding (ortholog); INVOLVED IN beta-alanine metabolic process (ortholog); CMP catabolic process (ortholog); dCMP catabolic process (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; ASSOCIATED WITH autistic disorder (ortholog); Beta-Ureidopropionase Deficiency (ortholog); celiac disease (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: beta-ureidopropionase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247479,911,448 - 9,940,537 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247479,911,323 - 9,940,770 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Upb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247479,911,448 - 9,940,537 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247479,911,323 - 9,940,770 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
UPB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,495,332 - 24,528,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,494,107 - 24,528,390 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,891,300 - 24,924,358 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,221,251 - 23,252,553 (+)NCBINCBI36Build 36hg18NCBI36
Build 342223,215,804 - 23,247,106NCBI
Celera228,690,987 - 8,722,274 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,840,918 - 7,872,203 (+)NCBIHuRef
CHM1_12224,849,971 - 24,881,302 (+)NCBICHM1_1
T2T-CHM13v2.02224,956,949 - 24,989,995 (+)NCBIT2T-CHM13v2.0
Upb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,242,745 - 75,277,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,236,949 - 75,277,513 (+)EnsemblGRCm39 Ensembl
GRCm381075,406,911 - 75,441,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,401,115 - 75,441,679 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,869,779 - 74,902,942 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361074,846,181 - 74,883,913 (+)NCBIMGSCv36mm8
Celera1076,453,987 - 76,488,021 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.53NCBI
Upb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,216,693 - 13,243,016 (-)NCBIGRCr8
mRatBN7.22013,217,252 - 13,243,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,217,258 - 13,243,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,923,828 - 13,950,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,284,776 - 13,311,090 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,757,287 - 13,783,611 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,167,383 - 14,193,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,167,586 - 14,193,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,352,599 - 16,378,743 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,715,995 - 13,743,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,716,221 - 13,743,488 (-)NCBI
Celera2014,703,097 - 14,729,538 (-)NCBICelera
Cytogenetic Map20p12NCBI
Upb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554557,961,264 - 7,995,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554557,961,296 - 7,992,235 (+)NCBIChiLan1.0ChiLan1.0
UPB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22334,283,288 - 34,320,118 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12237,013,937 - 37,053,257 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0225,300,686 - 5,332,735 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12222,138,989 - 22,197,360 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,166,370 - 22,197,360 (+)Ensemblpanpan1.1panPan2
UPB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,194,968 - 28,225,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,195,081 - 28,225,567 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,269,282 - 27,301,115 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02629,598,247 - 29,630,273 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,599,300 - 29,630,269 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12627,681,607 - 27,713,443 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,298,626 - 27,330,446 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,288,066 - 28,320,106 (+)NCBIUU_Cfam_GSD_1.0
Upb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118142,039,199 - 142,085,682 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619668,351 - 696,306 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936619668,380 - 713,720 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UPB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,533,231 - 49,565,075 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,533,208 - 49,561,518 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,975,014 - 53,003,329 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UPB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,605,999 - 7,639,339 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,605,537 - 7,639,017 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660854,807,773 - 4,841,973 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000020820   ⟹   ENSHGLP00000020618
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247479,911,448 - 9,940,537 (+)Ensembl
RefSeq Acc Id: XM_004843542   ⟹   XP_004843599
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247479,911,372 - 9,940,770 (+)NCBI
RefSeq Acc Id: XM_004843544   ⟹   XP_004843601
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247479,918,561 - 9,940,770 (+)NCBI
RefSeq Acc Id: XM_013071693   ⟹   XP_012927147
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247479,918,677 - 9,940,770 (+)NCBI
RefSeq Acc Id: XM_021257269   ⟹   XP_021112928
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247479,911,323 - 9,940,770 (+)NCBI
RefSeq Acc Id: XM_021257270   ⟹   XP_021112929
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247479,911,372 - 9,940,770 (+)NCBI
RefSeq Acc Id: XM_021257271   ⟹   XP_021112930
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247479,911,323 - 9,940,770 (+)NCBI
RefSeq Acc Id: XM_021257272   ⟹   XP_021112931
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247479,911,373 - 9,940,770 (+)NCBI
RefSeq Acc Id: XM_021257273   ⟹   XP_021112932
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247479,911,393 - 9,940,770 (+)NCBI
RefSeq Acc Id: XP_021112928   ⟸   XM_021257269
- Peptide Label: isoform X1
- UniProtKB: A0AAX6SX66 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112930   ⟸   XM_021257271
- Peptide Label: isoform X4
- UniProtKB: G5B628 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004843599   ⟸   XM_004843542
- Peptide Label: isoform X2
- UniProtKB: A0AAX6P4Y6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112929   ⟸   XM_021257270
- Peptide Label: isoform X3
- UniProtKB: A0AAX6SVH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112931   ⟸   XM_021257272
- Peptide Label: isoform X5
- UniProtKB: A0AAX6SU68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112932   ⟸   XM_021257273
- Peptide Label: isoform X7
- UniProtKB: A0AAX6ST87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004843601   ⟸   XM_004843544
- Peptide Label: isoform X7
- UniProtKB: A0AAX6ST87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927147   ⟸   XM_013071693
- Peptide Label: isoform X6
- UniProtKB: A0AAX6QTK6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000020618   ⟸   ENSHGLT00000020820


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014750 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000020820 ENTREZGENE
Gene3D-CATH 3.60.110.10 UniProtKB/TrEMBL
InterPro Aliph_Amidase/BUP UniProtKB/TrEMBL
  C-N_Hydrolase UniProtKB/TrEMBL
  C-N_Hydrolase_sf UniProtKB/TrEMBL
NCBI Gene Upb1 ENTREZGENE
PANTHER BETA-UREIDOPROPIONASE UniProtKB/TrEMBL
  NITRILASE C965.09-RELATED UniProtKB/TrEMBL
Pfam CN_hydrolase UniProtKB/TrEMBL
PROSITE CN_HYDROLASE UniProtKB/TrEMBL
Superfamily-SCOP SSF56317 UniProtKB/TrEMBL
UniProt A0AAX6P4Y6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QTK6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6ST87 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SU68 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SVH6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SX66 ENTREZGENE, UniProtKB/TrEMBL
  G5B628 ENTREZGENE, UniProtKB/TrEMBL