UPB1 (beta-ureidopropionase 1) - Rat Genome Database
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Gene: UPB1 (beta-ureidopropionase 1) Canis lupus familiaris
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Symbol: UPB1
Name: beta-ureidopropionase 1
RGD ID: 12390517
Description: ENCODES a protein that exhibits beta-ureidopropionase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN beta-alanine metabolic process (ortholog); CMP catabolic process (ortholog); dCMP catabolic process (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; ASSOCIATED WITH autistic disorder (ortholog); Beta-Ureidopropionase Deficiency (ortholog); celiac disease (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: beta-ureidopropionase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2628,195,081 - 28,225,567 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12628,194,968 - 28,225,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)

References

Genomics

Comparative Map Data
UPB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2628,195,081 - 28,225,567 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12628,194,968 - 28,225,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
UPB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2224,494,107 - 24,528,390 (+)EnsemblGRCh38hg38GRCh38
GRCh382224,495,060 - 24,528,681 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,891,300 - 24,924,358 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,221,251 - 23,252,553 (+)NCBINCBI36hg18NCBI36
Build 342223,215,804 - 23,247,106NCBI
Celera228,690,987 - 8,722,274 (+)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,840,918 - 7,872,203 (+)NCBIHuRef
CHM1_12224,849,971 - 24,881,302 (+)NCBICHM1_1
Upb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,242,745 - 75,277,513 (+)NCBIGRCm39mm39
GRCm39 Ensembl1075,236,949 - 75,277,513 (+)Ensembl
GRCm381075,406,911 - 75,441,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,401,115 - 75,441,679 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,869,779 - 74,902,942 (+)NCBIGRCm37mm9NCBIm37
MGSCv361074,846,181 - 74,883,913 (+)NCBImm8
Celera1076,453,987 - 76,488,021 (+)NCBICelera
Cytogenetic Map10C1NCBI
Upb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22013,217,252 - 13,243,590 (-)NCBI
Rnor_6.0 Ensembl2014,167,586 - 14,193,690 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02014,167,383 - 14,193,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02016,352,599 - 16,378,743 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,715,995 - 13,743,261 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12013,716,221 - 13,743,488 (-)NCBI
Celera2014,703,097 - 14,729,538 (-)NCBICelera
Cytogenetic Map20p12NCBI
Upb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554557,961,264 - 7,995,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554557,961,296 - 7,992,235 (+)NCBIChiLan1.0ChiLan1.0
UPB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12222,138,989 - 22,197,360 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,166,370 - 22,197,360 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0225,300,686 - 5,332,735 (+)NCBIMhudiblu_PPA_v0panPan3
Upb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936619668,380 - 713,720 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UPB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,533,226 - 49,565,100 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,533,208 - 49,561,518 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,975,014 - 53,003,329 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UPB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,605,999 - 7,639,339 (-)NCBI
ChlSab1.1 Ensembl197,605,537 - 7,639,017 (-)Ensembl
Upb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247479,911,323 - 9,940,770 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 2 6 4
Low 5 5 15 4 5 3 8 8 9 2
Below cutoff 1 1 3 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038437418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038459201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038459202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038512289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038512290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038512291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038575789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038575790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038575791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_543524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000021967   ⟹   ENSCAFP00000020398
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2628,195,081 - 28,225,567 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000049172   ⟹   ENSCAFP00000042140
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2628,201,903 - 28,225,567 (+)Ensembl
RefSeq Acc Id: XM_022410326   ⟹   XP_022266034
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12628,194,968 - 28,225,977 (+)NCBI
Sequence:
RefSeq Acc Id: XM_543524   ⟹   XP_543524
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12628,194,974 - 28,225,977 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_543524   ⟸   XM_543524
- Peptide Label: isoform X2
- UniProtKB: E2QT84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022266034   ⟸   XM_022410326
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000042140   ⟸   ENSCAFT00000049172
RefSeq Acc Id: ENSCAFP00000020398   ⟸   ENSCAFT00000021967
Protein Domains
CN hydrolase

Promoters
RGD ID:13688017
Promoter ID:EPDNEW_C6085
Type:initiation region
Name:UPB1_1
Description:beta-ureidopropionase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12628,195,038 - 28,195,098EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013843 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000020398 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000042140 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000021967 UniProtKB/TrEMBL
  ENSCAFT00000049172 UniProtKB/TrEMBL
Gene3D-CATH 3.60.110.10 UniProtKB/TrEMBL
InterPro C-N_Hydrolase UniProtKB/TrEMBL
  C-N_Hydrolase_sf UniProtKB/TrEMBL
NCBI Gene UPB1 ENTREZGENE
Pfam CN_hydrolase UniProtKB/TrEMBL
PROSITE CN_HYDROLASE UniProtKB/TrEMBL
Superfamily-SCOP SSF56317 UniProtKB/TrEMBL
UniProt E2QT84 ENTREZGENE, UniProtKB/TrEMBL
  J9P8R1_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:48149 ENTREZGENE