| 621623 | Tpt1 | tumor protein, translationally-controlled 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN spermatogenesis; negative regulation of ectoderm development (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); ASSOCIATED WITH Kidney Neoplasms (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic microtubule (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3,4,5,3',4',5'-Hexachlorobiphenyl | 15 | 57562217 | 57568968 | Rat | 161 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732860 | Tpt1 | tumor protein, translationally-controlled 1 | Enables DNA-binding transcription factor binding activity. Involved in negative regulation of ectoderm development and stem cell population maintenance. Located in nucleoplasm. Is expressed in cerebral cortex ventricular layer; cortical plate; sciatic nerve; and testis. Orthologous to several human genes including TPT1 (tumor protein, translationally-controlled 1). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 76082771 | 76085743 | Mouse | 186 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 735250 | TPT1 | tumor protein, translationally-controlled 1 | This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] | 13 | 45333471 | 45341183 | Human | 170 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 12025055 | TPT1 | tumor protein, translationally-controlled 1 | ENCODES a protein that exhibits calcium ion binding (inferred); DNA-binding transcription factor binding (inferred); INVOLVED IN negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Kidney Neoplasms (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic microtubule (inferred); cytosol (inferred) | 13 | 26504747 | 26509160 | Bonobo | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12214333 | TPT1 | tumor protein, translationally-controlled 1 | ENCODES a protein that exhibits DNA-binding transcription factor binding (inferred); INVOLVED IN negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); response to virus (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Kidney Neoplasms (ortholog); P rostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic microtubule (ortholog); cytosol (ortholog) | 22 | 5711076 | 5715254 | Dog | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12607646 | Tpt1 | tumor protein, translationally-controlled 1 | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); INVOLVED IN negative regulation of ectoderm development (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Kidn ey Neoplasms (ortholog); Prostatic Neoplasms (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004936791 | 1439997 | 1443959 | Squirrel | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13884234 | TPT1 | tumor protein, translationally-controlled 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Kidney Neoplasms (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm ( ortholog); cytoplasmic microtubule (ortholog); extracellular space (ortholog) | | | | Pig | 35 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14387562 | TPT1 | | | | | | Yeast | | symbol | gene, null |
| 18698229 | TPT1 | tumor protein, translationally-controlled 1 | ENCODES a protein that exhibits calcium ion binding (inferred); DNA-binding transcription factor binding (inferred); INVOLVED IN negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH Kidney Neoplasms (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic microtubule (inferred); cytosol (inferred) | | | | Green Monkey | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917973 | Tpt1 | tumor protein, translationally-controlled 1 | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); INVOLVED IN negative regulation of ectoderm development (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); response to virus (ortholog); ASSOCIATED WITH Ki dney Neoplasms (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasmic microtubule (ortholog); cytosol (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155247321 | tpt1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625929918 | Tpt1 | tumor protein, translationally-controlled 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN negative regulation of ectoderm development (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); response to viru s (ortholog); ASSOCIATED WITH Kidney Neoplasms (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic microtubule (ortholog); cytosol (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247320 | tpt1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 5687516 | TPT1-AS1 | TPT1 antisense RNA 1 | Biomarker of malignant astrocytoma. [provided by Alliance of Genome Resources, Jul 2025] | 13 | 45341345 | 45391483 | Human | 20 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1565260 | Tpt1-ps1 | tumor protein, translationally-controlled 1, pseudogene 1 | | 13 | 34674494 | 34675172 | Rat | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 2311986 | Tpt1-ps1 | tumor protein, translationally-controlled, pseudogene 1 | | 3 | 101140804 | 101141439 | Mouse | | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1563739 | Tpt1-ps2 | tumor protein, translationally-controlled 1 pseudogene 2 | | 15 | 16230762 | 16231508 | Rat | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 2311792 | Tpt1-ps2 | tumor protein, translationally-controlled, pseudogene 2 | | 4 | 54564566 | 54565337 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1591786 | Tpt1-ps3 | tumor protein, translationally-controlled 1 pseudogene 3 | | 13 | 23880033 | 23883678 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 2294082 | Tpt1-ps3 | tumor protein, translationally-controlled, pseudogene 3 | INTERACTS WITH (1->4)-beta-D-glucan; perfluorooctane-1-sulfonic acid | 6 | 99854572 | 99855394 | Mouse | 2 | symbol , PhenoGen | gene, pseudo, VALIDATED [RefSeq] |
| 1562068 | Tpt1-ps4 | tumor protein, translationally-controlled 1 pseudogene 4 | | 8 | 92571019 | 92571665 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 2310056 | Tpt1-ps4 | tumor protein, translationally-controlled, pseudogene 4 | | 7 | 11649756 | 11650619 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1614620 | Tpt1-ps5 | tumor protein, translationally-controlled, pseudogene 5 | | 9 | 37607702 | 37608537 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1589682 | Tpt1-ps6 | tumor protein, translationally-controlled 1 pseudogene 6 | | 9 | 105321843 | 105322395 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1623327 | Tpt1-ps6 | tumor protein, translationally-controlled, pseudogene 6 | | X | 100812096 | 100812865 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 2311992 | Tpt1-ps7 | tumor protein, translationally-controlled, pseudogene 7 | | 17 | 53773486 | 53774331 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1564783 | Tpt1-ps8 | tumor protein, translationally-controlled 1 pseudogene 8 | | 15 | 23086107 | 23090340 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1597752 | Tpt1-ps9 | tumor protein, translationally-controlled 1 pseudogene 9 | | 7 | 67007092 | 67007755 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41086840 | Tpt1-ps10 | tumor protein, translationally-controlled 1 pseudogene 10 | | 6 | 17030303 | 17032149 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1618243 | Trpt1 | tRNA phosphotransferase 1 | Enables tRNA 2'-phosphotransferase activity. Acts upstream of or within regulation of protein kinase activity and tRNA splicing, via endonucleolytic cleavage and ligation. Is expressed in several structures, including gonad; intestine; liver; lung; and spleen. Orthologous to human TRPT1 (tRNA phosph otransferase 1). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 6970046 | 6977689 | Mouse | 70 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 127284977 | LOC121627959 | TPT1-like | | X | 72159845 | 72160349 | Human | | old_gene_name , name , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 11741247 | LOC100990752 | TPT1-like protein | | X | 61394706 | 61397080 | Bonobo | | name | gene, protein-coding, MODEL [RefSeq] |
| 18371467 | LOC103232174 | TPT1-like protein | | | | | Green Monkey | | name | gene, protein-coding, MODEL [RefSeq] |
| 18919334 | LOC106009608 | TPT1-like protein | ENCODES a protein that exhibits calcium ion binding (inferred); FOUND IN cytoplasm (inferred) | | | | Naked Mole-Rat | 2 | name | gene, protein-coding, MODEL [RefSeq] |
| 18908918 | LOC110349529 | TPT1-like protein | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 1348535 | TPT1P1 | TPT1 pseudogene 1 | | 21 | 31840226 | 31841064 | Human | | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 7366196 | TPT1P2 | TPT1 pseudogene 2 | | 2 | 208214724 | 208222625 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, MODEL [RefSeq] |
| 7381294 | TPT1P3 | TPT1 pseudogene 3 | | 3 | 141709010 | 141709727 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 7385924 | TPT1P4 | TPT1 pseudogene 4 | INTERACTS WITH chloropicrin | 6 | 144200238 | 144201079 | Human | 2 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7365837 | TPT1P5 | TPT1 pseudogene 5 | | 5 | 31908361 | 31909183 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 7365571 | TPT1P6 | TPT1 pseudogene 6 | | 6 | 85427251 | 85428080 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 10402018 | TPT1P7 | TPT1 pseudogene 7 | | 7 | 23811239 | 23811642 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1602215 | TPT1P8 | TPT1 pseudogene 8 | Predicted to enable calcium ion binding activity. Predicted to be involved in apoptotic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 36888370 | 36889530 | Human | 12 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7378831 | TPT1P9 | TPT1 pseudogene 9 | INTERACTS WITH chloropicrin; zoledronic acid | 9 | 118082693 | 118083496 | Human | 3 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7375266 | TPT1P10 | TPT1 pseudogene 10 | | 10 | 58212325 | 58213456 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, MODEL [RefSeq] |
| 10450701 | TPT1P11 | TPT1 pseudogene 11 | | 2 | 48632680 | 48633469 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7367148 | TPT1P12 | TPT1 pseudogene 12 | | 12 | 9155511 | 9156538 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7368625 | TPT1P13 | TPT1 pseudogene 13 | | X | 121863284 | 121864310 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 7385671 | TPT1P14 | TPT1 pseudogene 14 | | X | 14977566 | 14978580 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 151954013 | TPT1P15 | TPT1 pseudogene 15 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo |
| 16566722 | AL138963.3 | novel transcript, antisense to TPT1 | | | | | Human | | name | gene, lncrna |
| 16566051 | AC067959.1 | tumor protein, translationally-controlled 1 (TPT1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16558964 | AC114781.3 | tumor protein, translationally-controlled 1 (TPT1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16555180 | AC024082.2 | pseudogene similiar to part of tumor protein, translationally-controlled 1 (TPT1) | | | | | Human | | name | gene, processed_pseudogene |
| 1603499 | NHSL2 | NHS like 2 | Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | X | 71910845 | 72153286 | Human | 64 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1565798 | Tpt1l1 | tumor protein, translationally-controlled 1 like 1 | INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine | 7 | 130456035 | 130461611 | Rat | 3 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 15003240 | Tpt1l1 | tumor protein, translationally-controlled 1 like 1 | | | | | Rat | | symbol , PhenoGen | gene, processed_pseudogene |
| 1590250 | Tpt1l2 | tumor protein, translationally-controlled 1 like 2 | | 16 | 12496929 | 12497533 | Rat | 2 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 2321467 | Tpt1l3 | tumor protein, translationally-controlled 1 like 3 | | 1 | 20926845 | 20927580 | Rat | 2 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11798566 | LOC100973098 | translationally-controlled tumor protein | ENCODES a protein that exhibits calcium ion binding (inferred); DNA-binding transcription factor binding (inferred); INVOLVED IN negative regulation of ectoderm development (inferred); response to virus (inferred); stem cell population maintenance (inferred); FOUND IN cytoplasm (inferred); cytoplasm ic microtubule (inferred); cytosol (inferred) | 1 | 85710290 | 85710998 | Bonobo | 15 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1310831 | Trpt1 | tRNA phosphotransferase 1 | ENCODES a protein that exhibits tRNA 2'-phosphotransferase activity (ortholog); INVOLVED IN regulation of protein kinase activity (ortholog); tRNA splicing, via endonucleolytic cleavage and ligation (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A | 1 | 213615503 | 213620502 | Rat | 65 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |