TPT1 (tumor protein, translationally-controlled 1) - Rat Genome Database

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Gene: TPT1 (tumor protein, translationally-controlled 1) Homo sapiens
Analyze
Symbol: TPT1
Name: tumor protein, translationally-controlled 1
RGD ID: 735250
HGNC Page HGNC
Description: Exhibits calcium ion binding activity. Involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage and response to virus. Localizes to several cellular components, including extracellular space; microtubule cytoskeleton; and multivesicular body.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ27337; fortilin; histamine-releasing factor; HRF; p02; p23; TCTP; translationally-controlled tumor protein
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: TPT1P1   TPT1P11   TPT1P12   TPT1P13   TPT1P14   TPT1P3   TPT1P4   TPT1P5   TPT1P6   TPT1P7   TPT1P8   TPT1P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1345,333,471 - 45,341,284 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1345,333,471 - 45,341,370 (-)EnsemblGRCh38hg38GRCh38
GRCh381345,333,471 - 45,341,183 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371345,907,606 - 45,915,318 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361344,809,304 - 44,813,297 (-)NCBINCBI36hg18NCBI36
Build 341344,809,303 - 44,813,297NCBI
Celera1326,967,432 - 26,971,425 (-)NCBI
Cytogenetic Map13q14.13NCBI
HuRef1326,712,445 - 26,716,438 (-)NCBIHuRef
CHM1_11345,875,181 - 45,882,993 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1286667   PMID:1286669   PMID:2813067   PMID:7542803   PMID:7821789   PMID:9059837   PMID:9150946   PMID:10343127   PMID:11368327   PMID:11598139   PMID:11790298   PMID:11991642  
PMID:12149273   PMID:12167714   PMID:12399545   PMID:12477932   PMID:12487227   PMID:12876410   PMID:12948934   PMID:14499622   PMID:14500674   PMID:14623968   PMID:15057823   PMID:15062873  
PMID:15162379   PMID:15262975   PMID:15319436   PMID:15342556   PMID:15383549   PMID:15489334   PMID:15840729   PMID:15870695   PMID:15958728   PMID:16130169   PMID:16193335   PMID:16548883  
PMID:16730713   PMID:16859841   PMID:17301792   PMID:17353931   PMID:17549383   PMID:17645945   PMID:17897616   PMID:18042794   PMID:18274553   PMID:18325344   PMID:18345488   PMID:18504434  
PMID:18624398   PMID:18676370   PMID:18816836   PMID:18976975   PMID:19271148   PMID:19299420   PMID:19360337   PMID:19484128   PMID:19523440   PMID:19570981   PMID:19605695   PMID:19621893  
PMID:19815065   PMID:20098747   PMID:20237496   PMID:20966960   PMID:21081126   PMID:21278788   PMID:21319273   PMID:21795694   PMID:21801721   PMID:21832049   PMID:21873635   PMID:21900206  
PMID:21953552   PMID:22157679   PMID:22340241   PMID:22451927   PMID:22658674   PMID:22779921   PMID:22853445   PMID:22898364   PMID:22902387   PMID:22912717   PMID:22939629   PMID:22990118  
PMID:23042265   PMID:23387829   PMID:23533145   PMID:23749504   PMID:23824909   PMID:23894469   PMID:24106833   PMID:24165482   PMID:24311645   PMID:24465583   PMID:24583282   PMID:24606760  
PMID:24657995   PMID:25092287   PMID:25103245   PMID:25263704   PMID:25270224   PMID:25277244   PMID:25356737   PMID:25363345   PMID:25396429   PMID:25416956   PMID:25423047   PMID:25635048  
PMID:25779659   PMID:25936523   PMID:26328748   PMID:26344197   PMID:26425551   PMID:27367023   PMID:27607350   PMID:27813490   PMID:27926873   PMID:28143584   PMID:28219065   PMID:28409693  
PMID:28472637   PMID:28514442   PMID:28536478   PMID:28550308   PMID:28700943   PMID:28846114   PMID:28958626   PMID:28986522   PMID:29130935   PMID:29149401   PMID:29149402   PMID:29149403  
PMID:29149404   PMID:29149405   PMID:29149406   PMID:29149410   PMID:29149412   PMID:29149413   PMID:29149414   PMID:29149416   PMID:29150431   PMID:29216544   PMID:29676587   PMID:29719201  
PMID:29791485   PMID:29867020   PMID:30066846   PMID:30381327   PMID:30563768   PMID:30575818   PMID:30721952   PMID:30835870   PMID:30941821   PMID:31046837   PMID:31180492   PMID:31536960  
PMID:31980649   PMID:32416067   PMID:32694731   PMID:33122078  


Genomics

Comparative Map Data
TPT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1345,333,471 - 45,341,284 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1345,333,471 - 45,341,370 (-)EnsemblGRCh38hg38GRCh38
GRCh381345,333,471 - 45,341,183 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371345,907,606 - 45,915,318 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361344,809,304 - 44,813,297 (-)NCBINCBI36hg18NCBI36
Build 341344,809,303 - 44,813,297NCBI
Celera1326,967,432 - 26,971,425 (-)NCBI
Cytogenetic Map13q14.13NCBI
HuRef1326,712,445 - 26,716,438 (-)NCBIHuRef
CHM1_11345,875,181 - 45,882,993 (-)NCBICHM1_1
Tpt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391476,082,472 - 76,085,743 (+)NCBIGRCm39mm39
GRCm39 Ensembl1476,082,533 - 76,085,965 (+)Ensembl
GRCm381475,845,256 - 75,848,303 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1475,845,093 - 75,848,525 (+)EnsemblGRCm38mm10GRCm38
MGSCv371476,245,063 - 76,248,110 (+)NCBIGRCm37mm9NCBIm37
MGSCv361474,579,486 - 74,582,453 (+)NCBImm8
Celera1473,346,596 - 73,349,642 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1440.29NCBI
Tpt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21551,156,728 - 51,159,629 (+)NCBI
Rnor_6.0 Ensembl1557,891,680 - 57,894,504 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01557,891,680 - 57,894,504 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01561,598,787 - 61,601,611 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41556,752,464 - 56,755,288 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11556,768,246 - 56,771,068 (+)NCBI
Celera1550,783,471 - 50,786,295 (+)NCBICelera
Cytogenetic Map15q11NCBI
TPT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13197,562,788 - 197,567,290 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3197,562,788 - 197,567,290 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01326,504,747 - 26,509,160 (-)NCBIMhudiblu_PPA_v0panPan3
TPT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1225,711,076 - 5,715,254 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl225,711,071 - 5,715,069 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha225,700,382 - 5,704,539 (+)NCBI
ROS_Cfam_1.0225,829,066 - 5,833,209 (+)NCBI
UMICH_Zoey_3.1225,611,060 - 5,615,216 (+)NCBI
UNSW_CanFamBas_1.0225,674,049 - 5,678,187 (+)NCBI
UU_Cfam_GSD_1.0225,679,693 - 5,683,850 (+)NCBI
Tpt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945155,519,429 - 155,523,389 (-)NCBI
SpeTri2.0NW_0049367911,439,997 - 1,443,959 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,929,176 - 21,933,786 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11121,929,294 - 21,932,905 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TPT1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1323,428,523 - 23,432,846 (-)NCBI
ChlSab1.1 Ensembl323,429,044 - 23,433,108 (-)Ensembl
Tpt1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247489,657,041 - 9,660,924 (+)NCBI

Position Markers
G26329  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371345,911,409 - 45,911,522UniSTSGRCh37
Build 361344,809,409 - 44,809,522RGDNCBI36
Celera1326,967,537 - 26,967,650RGD
Cytogenetic Map13q14.13UniSTS
Cytogenetic Map13q14UniSTS
HuRef1326,712,550 - 26,712,663UniSTS
RH41035  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X71,380,133 - 71,380,254UniSTSGRCh37
GRCh371345,911,466 - 45,912,858UniSTSGRCh37
Build 36X71,296,858 - 71,296,979RGDNCBI36
Celera1326,967,594 - 26,968,986UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map13q14.13UniSTS
Cytogenetic MapXq13.1UniSTS
HuRef1326,712,607 - 26,713,999UniSTS
HuRefX65,135,544 - 65,135,665UniSTS
D17S1473E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37MT3,740 - 3,834UniSTSGRCh37
Cytogenetic Map17p12UniSTS
Cytogenetic Map13q14UniSTS
GDB:554914  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371345,911,062 - 45,911,264UniSTSGRCh37
Build 361344,809,062 - 44,809,264RGDNCBI36
Celera1326,967,190 - 26,967,392RGD
Cytogenetic Map13q14UniSTS
HuRef1326,712,203 - 26,712,405UniSTS
HUM000S635  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371345,911,063 - 45,911,266UniSTSGRCh37
Build 361344,809,063 - 44,809,266RGDNCBI36
Celera1326,967,191 - 26,967,394RGD
Cytogenetic Map13q14UniSTS
HuRef1326,712,204 - 26,712,407UniSTS
Stanford-G3 RH Map131126.0UniSTS
NCBI RH Map13405.2UniSTS
GeneMap99-G3 RH Map131122.0UniSTS
RH68285  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371345,911,464 - 45,912,867UniSTSGRCh37
Celera1326,967,592 - 26,968,995UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map13q14.13UniSTS
HuRef1326,712,605 - 26,714,008UniSTS
GeneMap99-GB4 RH Map1247.75UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1431
Count of miRNA genes:495
Interacting mature miRNAs:552
Transcripts:ENST00000309246, ENST00000379055, ENST00000379056, ENST00000379060, ENST00000442760, ENST00000484604, ENST00000490277, ENST00000527226, ENST00000528619, ENST00000529421, ENST00000530245, ENST00000530705, ENST00000533567
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 262 338 324 162 568 149 1163 829 64 205 561 388 15 424 932 3
Medium 2170 2646 1399 460 1380 315 3192 1364 3644 213 887 1220 156 780 1856 1
Low 5 5 2 2 3 1 1 4 14 1 8 4 3 1 1 2
Below cutoff 2 1 10 3 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001286272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF072098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ400717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL138963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX405763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY117678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY334563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP215975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000309246   ⟹   ENSP00000339051
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,338,185 - 45,341,086 (-)Ensembl
RefSeq Acc Id: ENST00000379055   ⟹   ENSP00000368344
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,337,302 - 45,341,158 (-)Ensembl
RefSeq Acc Id: ENST00000379056   ⟹   ENSP00000368345
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,336,873 - 45,341,212 (-)Ensembl
RefSeq Acc Id: ENST00000379060   ⟹   ENSP00000368350
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,337,198 - 45,341,122 (-)Ensembl
RefSeq Acc Id: ENST00000442760
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,340,026 - 45,341,183 (-)Ensembl
RefSeq Acc Id: ENST00000484604
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,337,064 - 45,339,848 (-)Ensembl
RefSeq Acc Id: ENST00000490277
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,337,177 - 45,341,155 (-)Ensembl
RefSeq Acc Id: ENST00000527226   ⟹   ENSP00000433738
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,338,687 - 45,341,158 (-)Ensembl
RefSeq Acc Id: ENST00000528619   ⟹   ENSP00000433091
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,336,899 - 45,339,533 (-)Ensembl
RefSeq Acc Id: ENST00000529421
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,337,053 - 45,340,402 (-)Ensembl
RefSeq Acc Id: ENST00000530245   ⟹   ENSP00000432457
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,337,178 - 45,339,533 (-)Ensembl
RefSeq Acc Id: ENST00000530705   ⟹   ENSP00000431872
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,333,471 - 45,341,183 (-)Ensembl
RefSeq Acc Id: ENST00000533567
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,337,177 - 45,340,258 (-)Ensembl
RefSeq Acc Id: ENST00000616577   ⟹   ENSP00000477781
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1345,333,471 - 45,341,284 (-)Ensembl
RefSeq Acc Id: NM_001286272   ⟹   NP_001273201
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381345,333,471 - 45,341,183 (-)NCBI
HuRef1326,708,748 - 26,716,560 (-)NCBI
CHM1_11345,875,181 - 45,882,993 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286273   ⟹   NP_001273202
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381345,333,471 - 45,341,183 (-)NCBI
HuRef1326,708,748 - 26,716,560 (-)NCBI
CHM1_11345,875,181 - 45,882,993 (-)NCBI
Sequence:
RefSeq Acc Id: NM_003295   ⟹   NP_003286
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381345,333,471 - 45,341,183 (-)NCBI
GRCh371345,911,005 - 45,915,505 (-)NCBI
Build 361344,809,304 - 44,813,297 (-)NCBI Archive
HuRef1326,708,748 - 26,716,560 (-)NCBI
CHM1_11345,875,181 - 45,882,993 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003286   ⟸   NM_003295
- Peptide Label: isoform 2
- UniProtKB: P13693 (UniProtKB/Swiss-Prot),   A0A0P1J1R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273202   ⟸   NM_001286273
- Peptide Label: isoform 3
- UniProtKB: P13693 (UniProtKB/Swiss-Prot),   A0A024RDY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273201   ⟸   NM_001286272
- Peptide Label: isoform 1
- UniProtKB: A0A0B4J2C3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000431872   ⟸   ENST00000530705
RefSeq Acc Id: ENSP00000339051   ⟸   ENST00000309246
RefSeq Acc Id: ENSP00000432457   ⟸   ENST00000530245
RefSeq Acc Id: ENSP00000368344   ⟸   ENST00000379055
RefSeq Acc Id: ENSP00000368345   ⟸   ENST00000379056
RefSeq Acc Id: ENSP00000368350   ⟸   ENST00000379060
RefSeq Acc Id: ENSP00000477781   ⟸   ENST00000616577
RefSeq Acc Id: ENSP00000433738   ⟸   ENST00000527226
RefSeq Acc Id: ENSP00000433091   ⟸   ENST00000528619
Protein Domains
TCTP

Promoters
RGD ID:6791169
Promoter ID:HG_KWN:17745
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_2Hour,   Jurkat,   Lymphoblastoid
Transcripts:OTTHUMT00000044762
Position:
Human AssemblyChrPosition (strand)Source
Build 361344,812,069 - 44,812,569 (-)MPROMDB
RGD ID:6791192
Promoter ID:HG_KWN:17746
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000309246,   ENST00000379055,   ENST00000379056,   ENST00000379060,   ENST00000400416,   NR_024458,   OTTHUMT00000044763,   UC001VAC.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361344,812,861 - 44,813,837 (-)MPROMDB
RGD ID:6851762
Promoter ID:EP73686
Type:single initiation site
Name:HS_TPT1
Description:Tumor protein, translationally-controlled 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361344,813,318 - 44,813,378EPD
RGD ID:7226349
Promoter ID:EPDNEW_H18921
Type:initiation region
Name:TPT1_1
Description:tumor protein, translationally-controlled 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381345,341,183 - 45,341,243EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 13q12.3-31.3(chr13:31363472-90575292)x3 copy number gain See cases [RCV000050293] Chr13:31363472..90575292 [GRCh38]
Chr13:31937609..91227546 [GRCh37]
Chr13:30835609..90025547 [NCBI36]
Chr13:13q12.3-31.3
pathogenic
GRCh38/hg38 13q14.12-31.3(chr13:44967523-92738168)x1 copy number loss See cases [RCV000050891] Chr13:44967523..92738168 [GRCh38]
Chr13:45541658..93390421 [GRCh37]
Chr13:44439658..92188422 [NCBI36]
Chr13:13q14.12-31.3
pathogenic
GRCh38/hg38 13q12.3-21.33(chr13:30697728-69471973)x1 copy number loss See cases [RCV000051373] Chr13:30697728..69471973 [GRCh38]
Chr13:31271865..70046105 [GRCh37]
Chr13:30169865..68944106 [NCBI36]
Chr13:13q12.3-21.33
pathogenic
GRCh38/hg38 13q13.3-14.2(chr13:38558617-47502862)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051377]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051377]|See cases [RCV000051377] Chr13:38558617..47502862 [GRCh38]
Chr13:39132754..48076997 [GRCh37]
Chr13:38030754..46974998 [NCBI36]
Chr13:13q13.3-14.2
pathogenic
GRCh38/hg38 13q14.11-14.2(chr13:43505396-49983668)x1 copy number loss See cases [RCV000051378] Chr13:43505396..49983668 [GRCh38]
Chr13:44079532..50557804 [GRCh37]
Chr13:42977532..49455805 [NCBI36]
Chr13:13q14.11-14.2
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000053731] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q12.3-31.1(chr13:30318913-83610426)x3 copy number gain See cases [RCV000053737] Chr13:30318913..83610426 [GRCh38]
Chr13:30893050..84184561 [GRCh37]
Chr13:29791050..83082562 [NCBI36]
Chr13:13q12.3-31.1
pathogenic
GRCh38/hg38 13q11-34(chr13:18565048-114327173)x3 copy number gain See cases [RCV000053719] Chr13:18565048..114327173 [GRCh38]
Chr13:19139188..115085141 [GRCh37]
Chr13:18037188..114110750 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q11-34(chr13:18850545-114327173)x3 copy number gain See cases [RCV000053723] Chr13:18850545..114327173 [GRCh38]
Chr13:19296527..115085141 [GRCh37]
Chr13:18194527..114110750 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q12.11-34(chr13:18946182-114304628)x3 copy number gain See cases [RCV000053726] Chr13:18946182..114304628 [GRCh38]
Chr13:19520322..115070103 [GRCh37]
Chr13:18418322..114088205 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q13.2-34(chr13:33528097-114327173)x3 copy number gain See cases [RCV000053759] Chr13:33528097..114327173 [GRCh38]
Chr13:34102234..115085141 [GRCh37]
Chr13:33000234..114110750 [NCBI36]
Chr13:13q13.2-34
pathogenic
GRCh38/hg38 13q14.11-34(chr13:43219125-114327314)x3 copy number gain See cases [RCV000053762] Chr13:43219125..114327314 [GRCh38]
Chr13:43793261..115085141 [GRCh37]
Chr13:42691261..114110891 [NCBI36]
Chr13:13q14.11-34
pathogenic
GRCh38/hg38 13q14.11-34(chr13:44164751-114327173)x3 copy number gain See cases [RCV000053764] Chr13:44164751..114327173 [GRCh38]
Chr13:44738887..115085141 [GRCh37]
Chr13:43636887..114110750 [NCBI36]
Chr13:13q14.11-34
pathogenic
GRCh38/hg38 13q14.12-34(chr13:44733046-114327173)x3 copy number gain See cases [RCV000053767] Chr13:44733046..114327173 [GRCh38]
Chr13:45307182..115085141 [GRCh37]
Chr13:44205182..114110750 [NCBI36]
Chr13:13q14.12-34
pathogenic
GRCh38/hg38 13q13.3-21.31(chr13:36777318-62955876)x1 copy number loss See cases [RCV000133696] Chr13:36777318..62955876 [GRCh38]
Chr13:37351455..63530009 [GRCh37]
Chr13:36249455..62428010 [NCBI36]
Chr13:13q13.3-21.31
pathogenic
GRCh38/hg38 13q14.11-31.1(chr13:41288493-85137552)x3 copy number gain See cases [RCV000133944] Chr13:41288493..85137552 [GRCh38]
Chr13:41862629..85711687 [GRCh37]
Chr13:40760629..84609688 [NCBI36]
Chr13:13q14.11-31.1
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19833130-114298614)x3 copy number gain See cases [RCV000134104] Chr13:19833130..114298614 [GRCh38]
Chr13:20407270..115064089 [GRCh37]
Chr13:19305270..114082191 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q12.3-21.32(chr13:31553608-65470367)x3 copy number gain See cases [RCV000135808] Chr13:31553608..65470367 [GRCh38]
Chr13:32127745..66044499 [GRCh37]
Chr13:31025745..64942500 [NCBI36]
Chr13:13q12.3-21.32
pathogenic
GRCh38/hg38 13q11-34(chr13:18445862-114327173)x1 copy number loss See cases [RCV000135610] Chr13:18445862..114327173 [GRCh38]
Chr13:19020001..115085141 [GRCh37]
Chr13:10098739..114110750 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q14.11-31.1(chr13:41143820-85137552)x1 copy number loss See cases [RCV000136526] Chr13:41143820..85137552 [GRCh38]
Chr13:41717956..85711687 [GRCh37]
Chr13:40615956..84609688 [NCBI36]
Chr13:13q14.11-31.1
pathogenic
GRCh38/hg38 13q14.11-34(chr13:40942298-114340331)x1 copy number loss See cases [RCV000137893] Chr13:40942298..114340331 [GRCh38]
Chr13:41516434..115085141 [GRCh37]
Chr13:40414434..114123908 [NCBI36]
Chr13:13q14.11-34
pathogenic
GRCh38/hg38 13q12.3-14.2(chr13:31018160-48491204)x1 copy number loss See cases [RCV000138723] Chr13:31018160..48491204 [GRCh38]
Chr13:31592297..49065340 [GRCh37]
Chr13:30490297..47963341 [NCBI36]
Chr13:13q12.3-14.2
pathogenic
GRCh38/hg38 13q13.1-31.1(chr13:32531486-86757044)x3 copy number gain See cases [RCV000138339] Chr13:32531486..86757044 [GRCh38]
Chr13:33105623..87409299 [GRCh37]
Chr13:32003623..86207300 [NCBI36]
Chr13:13q13.1-31.1
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19833130-114327106)x3 copy number gain See cases [RCV000139078] Chr13:19833130..114327106 [GRCh38]
Chr13:20407270..115085141 [GRCh37]
Chr13:19305270..114110683 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q11-34(chr13:18456040-114340285)x3 copy number gain See cases [RCV000140004] Chr13:18456040..114340285 [GRCh38]
Chr13:19030180..115105760 [GRCh37]
Chr13:17928180..114123862 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q13.3-21.32(chr13:37864226-67963788)x1 copy number loss See cases [RCV000140744] Chr13:37864226..67963788 [GRCh38]
Chr13:38438363..68537920 [GRCh37]
Chr13:37336363..67435921 [NCBI36]
Chr13:13q13.3-21.32
pathogenic
GRCh38/hg38 13q13.3-14.3(chr13:38514177-51425214)x1 copy number loss See cases [RCV000140788] Chr13:38514177..51425214 [GRCh38]
Chr13:39088314..51999350 [GRCh37]
Chr13:37986314..50897351 [NCBI36]
Chr13:13q13.3-14.3
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19671934-114340331)x3 copy number gain See cases [RCV000142924] Chr13:19671934..114340331 [GRCh38]
Chr13:20246074..115085141 [GRCh37]
Chr13:19144074..114123908 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q11-34(chr13:18862146-114342258)x3 copy number gain See cases [RCV000143462] Chr13:18862146..114342258 [GRCh38]
Chr13:19436286..115107733 [GRCh37]
Chr13:18334286..114125835 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q12.3-31.3(chr13:31363472-90575292)x3 copy number gain See cases [RCV000148244] Chr13:31363472..90575292 [GRCh38]
Chr13:31937609..91227546 [GRCh37]
Chr13:30835609..90025547 [NCBI36]
Chr13:13q12.3-31.3
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000148126] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34
pathogenic
NM_001286272.1(TPT1):c.*1472_*277473dup duplication Gestational diabetes mellitus uncontrolled [RCV000161697] Chr13:45060003..45336004 [GRCh38]
Chr13:45634138..45910139 [GRCh37]
Chr13:13q14.12-14.13
not provided
GRCh37/hg19 13q12.11-34(chr13:19571503-115092569)x3 copy number gain See cases [RCV000240150] Chr13:19571503..115092569 [GRCh37]
Chr13:13q12.11-34
pathogenic
GRCh37/hg19 13q12.11-34(chr13:19571503-115092510) copy number gain See cases [RCV000449142] Chr13:19571503..115092510 [GRCh37]
Chr13:13q12.11-34
pathogenic
GRCh37/hg19 13q14.11-31.3(chr13:42457841-91796698)x1 copy number loss See cases [RCV000446747] Chr13:42457841..91796698 [GRCh37]
Chr13:13q14.11-31.3
pathogenic
GRCh37/hg19 13q13.1-21.31(chr13:32946120-62698217)x1 copy number loss See cases [RCV000446067] Chr13:32946120..62698217 [GRCh37]
Chr13:13q13.1-21.31
pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain See cases [RCV000445886] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733) copy number gain See cases [RCV000510405] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733)x3 copy number gain See cases [RCV000511880] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-22.1(chr13:19436286-74045459)x3 copy number gain not provided [RCV000683572] Chr13:19436286..74045459 [GRCh37]
Chr13:13q11-22.1
pathogenic
GRCh37/hg19 13q11-34(chr13:19058717-115103529)x3 copy number gain not provided [RCV000738115] Chr13:19058717..115103529 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-34(chr13:19031237-115107157)x3 copy number gain not provided [RCV000750643] Chr13:19031237..115107157 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain not provided [RCV000849129] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
NM_003295.4(TPT1):c.492G>A (p.Lys164=) single nucleotide variant not provided [RCV000909730] Chr13:45338684 [GRCh38]
Chr13:45912819 [GRCh37]
Chr13:13q14.13
benign
GRCh37/hg19 13q14.12-14.3(chr13:45487628-52639336)x3 copy number gain not provided [RCV001258545] Chr13:45487628..52639336 [GRCh37]
Chr13:13q14.12-14.3
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12022 AgrOrtholog
COSMIC TPT1 COSMIC
Ensembl Genes ENSG00000133112 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000339051 UniProtKB/TrEMBL
  ENSP00000368344 UniProtKB/Swiss-Prot
  ENSP00000368345 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000368350 UniProtKB/TrEMBL
  ENSP00000431872 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000432457 UniProtKB/TrEMBL
  ENSP00000433091 UniProtKB/TrEMBL
  ENSP00000433738 UniProtKB/TrEMBL
  ENSP00000477781 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000309246 UniProtKB/TrEMBL
  ENST00000379055 UniProtKB/Swiss-Prot
  ENST00000379056 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000379060 UniProtKB/TrEMBL
  ENST00000527226 UniProtKB/TrEMBL
  ENST00000528619 UniProtKB/TrEMBL
  ENST00000530245 UniProtKB/TrEMBL
  ENST00000530705 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000616577 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.170.150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000133112 GTEx
HGNC ID HGNC:12022 ENTREZGENE
Human Proteome Map TPT1 Human Proteome Map
InterPro Mss4-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mss4/transl-control_tumour UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Translation_control_tumour_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Translational_control_tumour_p UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7178 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 7178 ENTREZGENE
OMIM 600763 OMIM
PANTHER PTHR11991 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TCTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36701 PharmGKB
PRINTS TCTPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TCTP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCTP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCTP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51316 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RDY2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0B4J2C3 ENTREZGENE, UniProtKB/TrEMBL
  A0A0P1J1R0 ENTREZGENE, UniProtKB/TrEMBL
  E9PJF7_HUMAN UniProtKB/TrEMBL
  H0YCX0_HUMAN UniProtKB/TrEMBL
  J3KPG2_HUMAN UniProtKB/TrEMBL
  P13693 ENTREZGENE
  Q5W0H4_HUMAN UniProtKB/TrEMBL
  TCTP_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B2R7E5 UniProtKB/Swiss-Prot
  Q6YLS2 UniProtKB/Swiss-Prot
  Q7Z4J4 UniProtKB/Swiss-Prot
  Q8TBK7 UniProtKB/Swiss-Prot
  Q96EE2 UniProtKB/Swiss-Prot
  Q9UC70 UniProtKB/Swiss-Prot