| 61821 | Tgfbr3 | transforming growth factor beta receptor 3 | ENCODES a protein that exhibits activin binding; fibroblast growth factor binding; heparin binding; INVOLVED IN animal organ regeneration; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transforming growth factor beta receptor signaling path way; PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH connective tissue disease (ortholog); COVID-19 (ortholog); endometrial adenocarcinoma (ortholog); FOUND IN extracellular space; membrane; receptor complex; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 14 | 2634294 | 2810269 | Rat | 295 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62112 | Tgfbr3 | transforming growth factor, beta receptor III | Enables several functions, including PDZ domain binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity. Involved in several processes, including definitive erythrocyte differentiation; heart development; and positive regulation of SM AD protein signal transduction. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and vasculogenesis. Located in cell surface and endoplasmic reticulum. Is expressed in several structures, including central nervous system; early conceptus; gonad; heart; and jaw. Orthologous to human TGFBR3 (transforming growth factor beta receptor 3). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 107254433 | 107437495 | Mouse | 318 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736539 | TGFBR3 | transforming growth factor beta receptor 3 | This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, w hich may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010] | 1 | 91680343 | 91906002 | Human | 296 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8850410 | Tgfbr3 | transforming growth factor beta receptor 3 | ENCODES a protein that exhibits activin binding (ortholog); BMP binding (ortholog); coreceptor activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); blastocyst development (ortholog); blood vessel development (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH connective tissue disease (ortholog); COVID-19 (ortholog); endometrial adenocarcinoma (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog) | NW_004955423 | 2573851 | 2765353 | Chinchilla | 113 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12042931 | TGFBR3 | transforming growth factor beta receptor 3 | ENCODES a protein that exhibits activin binding (ortholog); fibroblast growth factor binding (ortholog); heparin binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); blastocyst development (ortholog); blood vessel development (ortholog); PARTICIPATES IN transforming growth factor-be ta Smad dependent signaling pathway; ASSOCIATED WITH connective tissue disease (ortholog); COVID-19 (ortholog); endometrial adenocarcinoma (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog) | 1 | 94337275 | 94539229 | Bonobo | 112 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12097183 | TGFBR3 | transforming growth factor beta receptor 3 | ENCODES a protein that exhibits activin binding (ortholog); fibroblast growth factor binding (ortholog); heparin binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); blastocyst development (ortholog); blood vessel development (ortholog); PARTICIPATES IN transforming growth factor-be ta Smad dependent signaling pathway; ASSOCIATED WITH connective tissue disease (ortholog); COVID-19 (ortholog); endometrial adenocarcinoma (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH bisphenol A | 6 | 57025096 | 57220240 | Dog | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12621976 | Tgfbr3 | transforming growth factor beta receptor 3 | ENCODES a protein that exhibits activin binding (ortholog); fibroblast growth factor binding (ortholog); heparin binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); blastocyst development (ortholog); blood vessel development (ortholog); PARTICIPATES IN transforming growth factor-be ta Smad dependent signaling pathway; ASSOCIATED WITH connective tissue disease (ortholog); COVID-19 (ortholog); endometrial adenocarcinoma (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog) | NW_004936537 | 7154125 | 7340218 | Squirrel | 114 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14125113 | TGFBR3 | transforming growth factor beta receptor 3 | ENCODES a protein that exhibits activin binding (ortholog); coreceptor activity (ortholog); fibroblast growth factor binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); blastocyst development (ortholog); blood vessel development (ortholog); PARTICIPATES IN transforming growth facto r-beta Smad dependent signaling pathway; ASSOCIATED WITH connective tissue disease (ortholog); COVID-19 (ortholog); endometrial adenocarcinoma (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH graphene oxide | | | | Pig | 124 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18571112 | TGFBR3 | transforming growth factor beta receptor 3 | ENCODES a protein that exhibits activin binding (ortholog); fibroblast growth factor binding (ortholog); heparin binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); blastocyst development (ortholog); blood vessel development (ortholog); PARTICIPATES IN transforming growth factor-be ta Smad dependent signaling pathway; ASSOCIATED WITH connective tissue disease (ortholog); COVID-19 (ortholog); endometrial adenocarcinoma (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog) | | | | Green Monkey | 112 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18899770 | Tgfbr3 | transforming growth factor beta receptor 3 | ENCODES a protein that exhibits activin binding (ortholog); BMP binding (ortholog); coreceptor activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); blastocyst development (ortholog); blood vessel development (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH connective tissue disease (ortholog); COVID-19 (ortholog); endometrial adenocarcinoma (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog) | | | | Naked Mole-Rat | 114 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232217 | tgfbr3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625969842 | Tgfbr3 | transforming growth factor beta receptor 3 | ENCODES a protein that exhibits activin binding (ortholog); BMP binding (ortholog); coreceptor activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); blastocyst development (ortholog); blood vessel development (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH connective tissue disease (ortholog); COVID-19 (ortholog); endometrial adenocarcinoma (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog) | | | | Black Rat | 112 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249710 | tgfbr3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232218 | tgfbr3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1586419 | Tgfbr3l | transforming growth factor beta receptor 3 like | INTERACTS WITH paracetamol; thioacetamide; 4,4'-sulfonyldiphenol (ortholog) | 12 | 7398512 | 7402054 | Rat | 18 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 2304167 | Tgfbr3l | transforming growth factor, beta receptor III-like | Predicted to enable glycosaminoglycan binding activity; transforming growth factor beta receptor activity; and type II transforming growth factor beta receptor binding activity. Predicted to contribute to transforming growth factor beta binding activity. Predicted to be involved in several processes , including epithelial to mesenchymal transition; regulation of transforming growth factor beta receptor signaling pathway; and transforming growth factor beta receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in pituitary gland. Orthologous to human TGFBR3L (transforming growth factor beta receptor 3 like). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 4297994 | 4301528 | Mouse | 25 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 6770737 | TGFBR3L | transforming growth factor beta receptor 3 like | Predicted to enable glycosaminoglycan binding activity; transforming growth factor beta receptor activity; and type II transforming growth factor beta receptor binding activity. Predicted to contribute to transforming growth factor beta binding activity. Predicted to be involved in several processes , including epithelial to mesenchymal transition; regulation of transforming growth factor beta receptor signaling pathway; and transforming growth factor beta receptor signaling pathway. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 7914830 | 7919097 | Human | 18 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 9040448 | Tgfbr3l | transforming growth factor beta receptor 3 like | | NW_004955563 | 1348698 | 1353748 | Chinchilla | | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11811284 | TGFBR3L | transforming growth factor beta receptor 3 like | ENCODES a protein that exhibits glycosaminoglycan binding (inferred); transforming growth factor beta binding (inferred); transforming growth factor beta receptor activity (inferred); INVOLVED IN cell migration (inferred); epithelial to mesenchymal transition (inferred); regulation of transforming g rowth factor beta receptor signaling pathway (inferred) | 19 | 7216766 | 7220394 | Bonobo | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12716894 | Tgfbr3l | transforming growth factor beta receptor 3 like | ENCODES a protein that exhibits glycosaminoglycan binding (inferred); transforming growth factor beta binding (inferred); transforming growth factor beta receptor activity (inferred); INVOLVED IN cell migration (inferred); epithelial to mesenchymal transition (inferred); regulation of transforming g rowth factor beta receptor signaling pathway (inferred) | NW_004936588 | 4892081 | 4896112 | Squirrel | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13228026 | TGFBR3L | transforming growth factor beta receptor 3 like | | 20 | 52607145 | 52607794 | Dog | | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14280342 | TGFBR3L | transforming growth factor beta receptor 3 like | | | | | Pig | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18338683 | TGFBR3L | transforming growth factor beta receptor 3 like | ENCODES a protein that exhibits glycosaminoglycan binding (inferred); transforming growth factor beta binding (inferred); transforming growth factor beta receptor activity (inferred); INVOLVED IN cell migration (inferred); epithelial to mesenchymal transition (inferred); regulation of transforming g rowth factor beta receptor signaling pathway (inferred) | | | | Green Monkey | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926073 | Tgfbr3l | transforming growth factor beta receptor 3 like | ENCODES a protein that exhibits glycosaminoglycan binding (inferred); transforming growth factor beta binding (inferred); transforming growth factor beta receptor activity (inferred); INVOLVED IN cell migration (inferred); epithelial to mesenchymal transition (inferred); regulation of transforming g rowth factor beta receptor signaling pathway (inferred) | | | | Naked Mole-Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866440 | TGFBR3L | transforming growth factor beta receptor 3 like | | | | | Green Monkey | | symbol | gene, protein-coding |
| 625964852 | Tgfbr3l | transforming growth factor beta receptor 3 like | | | | | Black Rat | | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626173800 | tgfbr3l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626179539 | tgfbr3l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626187847 | tgfbr3l | | | | | | Tropical Clawed Frog | | symbol | gene, null |