Tgfbr3l (transforming growth factor beta receptor 3 like) - Rat Genome Database

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Gene: Tgfbr3l (transforming growth factor beta receptor 3 like) Rattus norvegicus
Analyze
Symbol: Tgfbr3l
Name: transforming growth factor beta receptor 3 like
RGD ID: 1586419
Description: Predicted to be located in membrane. Orthologous to human TGFBR3L (transforming growth factor beta receptor 3 like); INTERACTS WITH paracetamol; thioacetamide; 4,4'-sulfonyldiphenol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC688681; similar to transforming growth factor, beta receptor III (betaglycan, 300kDa); transforming growth factor, beta receptor III-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,398,512 - 7,402,054 (+)NCBIGRCr8
mRatBN7.2122,600,874 - 2,604,211 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,600,934 - 2,604,222 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx123,248,837 - 3,252,293 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,872,428 - 3,875,884 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,635,548 - 2,638,897 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,540,494 - 2,545,315 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,542,612 - 2,545,740 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,695,235 - 4,698,824 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,541,111 - 1,542,111 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera124,417,335 - 4,419,744 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Comparative Map Data
Tgfbr3l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,398,512 - 7,402,054 (+)NCBIGRCr8
mRatBN7.2122,600,874 - 2,604,211 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,600,934 - 2,604,222 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx123,248,837 - 3,252,293 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,872,428 - 3,875,884 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,635,548 - 2,638,897 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,540,494 - 2,545,315 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,542,612 - 2,545,740 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,695,235 - 4,698,824 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,541,111 - 1,542,111 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera124,417,335 - 4,419,744 (+)NCBICelera
Cytogenetic Map12p12NCBI
TGFBR3L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,914,830 - 7,919,097 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,914,830 - 7,919,097 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,979,715 - 7,983,982 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map19p13.2NCBI
HuRef197,651,331 - 7,654,279 (+)NCBIHuRef
CHM1_1197,980,505 - 7,983,449 (+)NCBICHM1_1
T2T-CHM13v2.0197,915,785 - 7,920,052 (+)NCBIT2T-CHM13v2.0
Tgfbr3l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,297,994 - 4,301,528 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl84,298,214 - 4,301,423 (+)EnsemblGRCm39 Ensembl
GRCm3884,248,214 - 4,251,423 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,248,214 - 4,251,423 (+)EnsemblGRCm38mm10GRCm38
MGSCv3784,248,214 - 4,251,421 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3684,248,214 - 4,251,421 (+)NCBIMGSCv36mm8
Celera84,448,809 - 4,452,010 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.99NCBI
Tgfbr3l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555631,348,698 - 1,353,748 (-)NCBIChiLan1.0ChiLan1.0
TGFBR3L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,597,449 - 12,603,265 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,714,657 - 11,720,462 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,216,766 - 7,220,394 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,069,851 - 8,073,290 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,070,344 - 8,072,052 (+)Ensemblpanpan1.1panPan2
TGFBR3L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,607,145 - 52,607,794 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,406,908 - 52,410,843 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02053,132,579 - 53,136,516 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12052,335,850 - 52,339,784 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,780,454 - 52,784,390 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,011,833 - 53,015,767 (+)NCBIUU_Cfam_GSD_1.0
Tgfbr3l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118212,938,455 - 212,942,948 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,892,208 - 4,895,333 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,892,081 - 4,896,112 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBR3L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,294,968 - 71,297,927 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,294,960 - 71,298,172 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,695,348 - 71,698,601 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBR3L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,366,040 - 7,370,498 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666081443,813 - 447,493 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfbr3l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828878,741 - 881,510 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828878,551 - 882,179 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgfbr3l
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:111
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000075527
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat

Markers in Region
RH134914  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2122,600,117 - 2,600,306 (-)MAPPERmRatBN7.2
Rnor_6.0122,546,368 - 2,546,556NCBIRnor6.0
Rnor_5.0124,699,140 - 4,699,328UniSTSRnor5.0
RGSC_v3.4121,543,557 - 1,543,745UniSTSRGSC3.4
Celera124,415,652 - 4,415,840UniSTS
Cytogenetic Map12p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000075527   ⟹   ENSRNOP00000064036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,600,934 - 2,604,222 (+)Ensembl
Rnor_6.0 Ensembl122,542,612 - 2,545,740 (-)Ensembl
RefSeq Acc Id: NM_001401205   ⟹   NP_001388134
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,398,717 - 7,402,054 (+)NCBI
mRatBN7.2122,600,874 - 2,604,211 (+)NCBI
RefSeq Acc Id: XM_063271661   ⟹   XP_063127731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,398,512 - 7,402,050 (+)NCBI
RefSeq Acc Id: XM_063271662   ⟹   XP_063127732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,398,512 - 7,402,050 (+)NCBI
RefSeq Acc Id: XM_063271663   ⟹   XP_063127733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,398,512 - 7,402,050 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388134 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127731 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127732 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127733 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064036.3
Ensembl Acc Id: ENSRNOP00000064036   ⟸   ENSRNOT00000075527
RefSeq Acc Id: NP_001388134   ⟸   NM_001401205
- Peptide Label: precursor
RefSeq Acc Id: XP_063127731   ⟸   XM_063271661
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063127732   ⟸   XM_063271662
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063127733   ⟸   XM_063271663
- Peptide Label: isoform X3
Protein Domains
ZP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R3W3-F1-model_v2 AlphaFold M0R3W3 1-297 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586419 AgrOrtholog
Ensembl Genes ENSRNOG00000050573 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075527.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.4100 UniProtKB/TrEMBL
InterPro ZP-C UniProtKB/TrEMBL
  ZP_dom UniProtKB/TrEMBL
NCBI Gene 688681 ENTREZGENE
PANTHER ENDOGLIN/TGF-BETA RECEPTOR TYPE III UniProtKB/TrEMBL
  TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE 3-LIKE PROTEIN UniProtKB/TrEMBL
Pfam Zona_pellucida UniProtKB/TrEMBL
PhenoGen Tgfbr3l PhenoGen
PROSITE ZP_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050573 RatGTEx
UniProt M0R3W3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 Tgfbr3l  transforming growth factor beta receptor 3 like  Tgfbr3l  transforming growth factor, beta receptor III-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-10-17 Tgfbr3l  transforming growth factor, beta receptor III-like  LOC688681  similar to transforming growth factor, beta receptor III (betaglycan, 300kDa)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC688681  similar to transforming growth factor, beta receptor III (betaglycan, 300kDa)      Symbol and Name status set to provisional 70820 PROVISIONAL