| 3762 | Sstr1 | somatostatin receptor 1 | ENCODES a protein that exhibits somatostatin receptor activity; protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cellular response to estradiol stimulus; cerebellum development; forebrain development; PARTICIPATES IN somatostatin signaling pat hway; ASSOCIATED WITH Experimental Diabetes Mellitus; neuroendocrine tumor (ortholog); pancreatic cancer (ortholog); FOUND IN cytoplasm (ortholog); G protein-coupled receptor heterodimeric complex (ortholog); G protein-coupled receptor homodimeric complex (ortholog); INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 6 | 81567237 | 81571759 | Rat | 114 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 737191 | SSTR1 | somatostatin receptor 1 | Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biologic al effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012] | 14 | 38207904 | 38213067 | Human | 116 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737192 | Sstr1 | somatostatin receptor 1 | Enables somatostatin receptor activity. Acts upstream of or within cellular response to leukemia inhibitory factor; glutamate receptor signaling pathway; and neuropeptide signaling pathway. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; re spiratory system; and sensory organ. Orthologous to human SSTR1 (somatostatin receptor 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 58258524 | 58262822 | Mouse | 123 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9046163 | Sstr1 | somatostatin receptor 1 | ENCODES a protein that exhibits protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); somatostatin receptor activity (ortholog); INVOLVED IN cellular response to estradiol stimulus (ortholog); cellular response to leukemia inhibitory factor (ortholog); cerebel lum development (ortholog); PARTICIPATES IN somatostatin signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); neuroendocrine tumor (ortholog); pancreatic cancer (ortholog); FOUND IN cytoplasm (ortholog); G protein-coupled receptor heterodimeric complex (ortholog); G protein-coupled receptor homodimeric complex (ortholog) | NW_004955409 | 22889800 | 22894480 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11809500 | SSTR1 | somatostatin receptor 1 | ENCODES a protein that exhibits protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); somatostatin receptor activity (ortholog); INVOLVED IN cellular response to estradiol stimulus (ortholog); cellular response to leukemia inhibitory factor (ortholog); cerebel lum development (ortholog); PARTICIPATES IN somatostatin signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); neuroendocrine tumor (ortholog); pancreatic cancer (ortholog); FOUND IN cytoplasm (ortholog); G protein-coupled receptor heterodimeric complex (ortholog); G protein-coupled receptor homodimeric complex (ortholog) | 14 | 18968969 | 18973560 | Bonobo | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12135678 | SSTR1 | somatostatin receptor 1 | ENCODES a protein that exhibits protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); somatostatin receptor activity (ortholog); INVOLVED IN cellular response to estradiol stimulus (ortholog); cellular response to leukemia inhibitory factor (ortholog); cerebel lum development (ortholog); PARTICIPATES IN somatostatin signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); neuroendocrine tumor (ortholog); pancreatic cancer (ortholog); FOUND IN cytoplasm (ortholog); G protein-coupled receptor heterodimeric complex (ortholog); G protein-coupled receptor homodimeric complex (ortholog) | 8 | 16571069 | 16575730 | Dog | 42 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12544641 | Sstr1 | somatostatin receptor 1 | ENCODES a protein that exhibits protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); somatostatin receptor activity (ortholog); INVOLVED IN cellular response to estradiol stimulus (ortholog); cellular response to leukemia inhibitory factor (ortholog); cerebel lum development (ortholog); PARTICIPATES IN somatostatin signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); neuroendocrine tumor (ortholog); pancreatic cancer (ortholog); FOUND IN cytoplasm (ortholog); G protein-coupled receptor heterodimeric complex (ortholog); G protein-coupled receptor homodimeric complex (ortholog) | NW_004936494 | 12065388 | 12067759 | Squirrel | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18375432 | SSTR1 | somatostatin receptor 1 | ENCODES a protein that exhibits protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); somatostatin receptor activity (ortholog); INVOLVED IN cellular response to estradiol stimulus (ortholog); cellular response to leukemia inhibitory factor (ortholog); cerebel lum development (ortholog); PARTICIPATES IN somatostatin signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); neuroendocrine tumor (ortholog); pancreatic cancer (ortholog); FOUND IN cytoplasm (ortholog); G protein-coupled receptor heterodimeric complex (ortholog); G protein-coupled receptor homodimeric complex (ortholog) | | | | Green Monkey | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625954546 | Sstr1 | somatostatin receptor 1 | ENCODES a protein that exhibits protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); somatostatin receptor activity (ortholog); INVOLVED IN cellular response to estradiol stimulus (ortholog); cellular response to leukemia inhibitory factor (ortholog); cerebel lum development (ortholog); PARTICIPATES IN somatostatin signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); neuroendocrine tumor (ortholog); pancreatic cancer (ortholog); FOUND IN cytoplasm (ortholog); G protein-coupled receptor heterodimeric complex (ortholog); G protein-coupled receptor homodimeric complex (ortholog) | | | | Black Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 19259617 | SSTR1 | somatostatin receptor 1 | | | | | Dog | | symbol | gene, protein-coding |
| 14201621 | SSTR1 | somatostatin receptor 1 | ENCODES a protein that exhibits protein heterodimerization activity; protein homodimerization activity; somatostatin receptor activity (ortholog); INVOLVED IN negative regulation of growth hormone secretion; cellular response to estradiol stimulus (ortholog); cellular response to leukemia inhibitory factor (ortholog); PARTICIPATES IN somatostatin signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); neuroendocrine tumor (ortholog); pancreatic cancer (ortholog); FOUND IN cytoplasm; G protein-coupled receptor heterodimeric complex; G protein-coupled receptor homodimeric complex | | | | Pig | 44 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 284354508 | sstr1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18899958 | Sstr1 | somatostatin receptor 1 | ENCODES a protein that exhibits protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); somatostatin receptor activity (ortholog); INVOLVED IN cellular response to estradiol stimulus (ortholog); cellular response to leukemia inhibitory factor (ortholog); cerebel lum development (ortholog); PARTICIPATES IN somatostatin signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); neuroendocrine tumor (ortholog); pancreatic cancer (ortholog); FOUND IN cytoplasm (ortholog); G protein-coupled receptor heterodimeric complex (ortholog); G protein-coupled receptor homodimeric complex (ortholog) | | | | Naked Mole-Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 329332815 | sstr1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284296692 | sstr1.S | | | | | | African Clawed Frog | | symbol | gene, null |