| 620796 | Srm | spermidine synthase | ENCODES a protein that exhibits spermidine synthase activity; identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN response to testosterone; spermidine biosynthetic process; cellular response to leukemia inhibitory factor (ortholog); PARTICIPATES IN spermid ine metabolic pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 164309002 | 164312203 | Rat | 226 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732806 | SRM | spermidine synthase | The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversi on of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008] | 1 | 11054589 | 11060018 | Human | 228 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732807 | Srm | spermidine synthase | Predicted to enable protein homodimerization activity and spermidine synthase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; ear; genitourinary system; an d integumental system. Orthologous to human SRM (spermidine synthase). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 148675970 | 148679076 | Mouse | 229 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8798793 | Srm | spermidine synthase | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); spermidine synthase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to testosterone (ortholog); spermidine biosynthetic process (o rtholog); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystinuria pathway; hypermethioninemia pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN cytosol (ortholog) | NW_004955486 | 2631579 | 2634779 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11937509 | SRM | spermidine synthase | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); spermidine synthase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to testosterone (ortholog); spermidine biosynthetic process (o rtholog); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystinuria pathway; hypermethioninemia pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN cytosol (ortholog) | 1 | 9817765 | 9823244 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12158155 | SRM | spermidine synthase | ENCODES a protein that exhibits spermidine synthase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to testosterone (ortholog); spermidine biosynthetic process (ortholog); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystin uria pathway; hypermethioninemia pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN cytosol (inferred) | 2 | 84968833 | 84973111 | Dog | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12720791 | Srm | spermidine synthase | ENCODES a protein that exhibits spermidine synthase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to testosterone (ortholog); spermidine biosynthetic process (ortholog); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystin uria pathway; hypermethioninemia pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN cytosol (inferred) | NW_004936474 | 121135 | 124894 | Squirrel | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13957717 | SRM | spermidine synthase | ENCODES a protein that exhibits spermidine synthase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to testosterone (ortholog); spermidine biosynthetic process (ortholog); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystin uria pathway; hypermethioninemia pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN cytosol (inferred) | | | | Pig | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18620607 | SRM | spermidine synthase | ENCODES a protein that exhibits spermidine synthase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to testosterone (ortholog); spermidine biosynthetic process (ortholog); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystin uria pathway; hypermethioninemia pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN cytosol (inferred) | | | | Green Monkey | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929840 | Srm | spermidine synthase | ENCODES a protein that exhibits spermidine synthase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to testosterone (ortholog); spermidine biosynthetic process (ortholog); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystin uria pathway; hypermethioninemia pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN cytosol (inferred) | | | | Naked Mole-Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248946 | srm | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625920203 | Srm | spermidine synthase | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); spermidine synthase activity (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); response to testosterone (ortholog); spermidine biosynthetic process (o rtholog); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystinuria pathway; hypermethioninemia pathway; ASSOCIATED WITH Animal Disease Models (ortholog); lung adenocarcinoma (ortholog); FOUND IN cytosol (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250167 | srm.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1315310 | SRMS | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | Enables protein tyrosine kinase activity. Involved in peptidyl-tyrosine autophosphorylation and positive regulation of TORC1 signaling. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 20 | 63538489 | 63547749 | Human | 73 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1624077 | Srms | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; peptidyl-tyrosine autophosphorylation; and positive regulation of TORC1 signaling. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; gut; integumental system; liver and biliary system; and reproductive system. Orthologous to human SRMS (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 180847356 | 180854964 | Mouse | 83 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1345441 | SRMP1 | SRM pseudogene 1 | | 20 | 47859717 | 47860959 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1353214 | SRMP2 | SRM pseudogene 2 | | 14 | 60918982 | 60920163 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 15043211 | SRMP3 | SRM pseudogene 3 | | 2 | 128139442 | 128140647 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16554335 | AC108059.2 | spermidine synthase (SRM) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 14386555 | SRM1 | | | | | | Yeast | | symbol | gene, null |
| 1306602 | Srms | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN peptidyl-tyrosine autophosphorylation (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positive regulation of TORC1 signaling (ortholog); ASSOCIATED WITH Liver Neoplasms (ortholog); neuronal ceroid lipo fuscinosis (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate | 3 | 188696070 | 188702474 | Rat | 74 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9044335 | Srms | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN peptidyl-tyrosine autophosphorylation (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positive regulation of TORC1 signaling (ortholog); ASSOCIATED WITH Liver Neoplasms (ortholog); neuronal ceroid lipo fuscinosis (ortholog); FOUND IN cytoplasm (ortholog) | NW_004955528 | 677332 | 685903 | Chinchilla | 10 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11826963 | SRMS | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); non-membrane spanning protein tyrosine kinase activity (inferred); INVOLVED IN peptidyl-tyrosine autophosphorylation (ortholog); peptidyl-tyrosine phosphorylation (ortholog); ASSOCIATED WITH Liver Neoplasms (ortholog ); neuronal ceroid lipofuscinosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Bonobo | 23 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12246518 | SRMS | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); non-membrane spanning protein tyrosine kinase activity (inferred); INVOLVED IN peptidyl-tyrosine autophosphorylation (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positive regulation of TORC1 signaling (o rtholog); ASSOCIATED WITH Liver Neoplasms (ortholog); neuronal ceroid lipofuscinosis (ortholog); FOUND IN cytoplasm (ortholog) | 24 | 47131914 | 47139616 | Dog | 24 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12712241 | Srms | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); non-membrane spanning protein tyrosine kinase activity (inferred); INVOLVED IN peptidyl-tyrosine autophosphorylation (ortholog); peptidyl-tyrosine phosphorylation (ortholog); ASSOCIATED WITH Liver Neoplasms (ortholog ); neuronal ceroid lipofuscinosis (ortholog); FOUND IN cytoplasm (inferred) | NW_004936514 | 10835931 | 10843303 | Squirrel | 22 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13905717 | SRMS | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); non-membrane spanning protein tyrosine kinase activity (inferred); INVOLVED IN peptidyl-tyrosine autophosphorylation (ortholog); peptidyl-tyrosine phosphorylation (ortholog); ASSOCIATED WITH Liver Neoplasms (ortholog ); neuronal ceroid lipofuscinosis (ortholog); FOUND IN cytoplasm (inferred) | | | | Pig | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18594520 | SRMS | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); non-membrane spanning protein tyrosine kinase activity (inferred); INVOLVED IN peptidyl-tyrosine autophosphorylation (ortholog); peptidyl-tyrosine phosphorylation (ortholog); ASSOCIATED WITH Liver Neoplasms (ortholog ); neuronal ceroid lipofuscinosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 23 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18922821 | Srms | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); non-membrane spanning protein tyrosine kinase activity (inferred); INVOLVED IN peptidyl-tyrosine autophosphorylation (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positive regulation of TORC1 signaling (o rtholog); ASSOCIATED WITH Liver Neoplasms (ortholog); neuronal ceroid lipofuscinosis (ortholog); FOUND IN cytoplasm (inferred); endomembrane system (inferred) | | | | Naked Mole-Rat | 22 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 329332796 | srms | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934779 | srms | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935429 | srms | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626152735 | Srms | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN peptidyl-tyrosine autophosphorylation (ortholog); peptidyl-tyrosine phosphorylation (ortholog); positive regulation of TORC1 signaling (ortholog); ASSOCIATED WITH Liver Neoplasms (ortholog); FOUND IN cytoplasm ( ortholog) | | | | Black Rat | 9 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14387130 | SRm160 | | | | | | Fly | | symbol | gene, null |
| 284359523 | srms.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1322620 | Srrm1 | serine/arginine repetitive matrix 1 | Predicted to enable RNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA splicing, via spliceosome. Part of spliceosomal complex. Is expressed in central nervous system; genitourinary system; pancreas epithelium; and sensory organ. Orthologous to human SRRM1 (serine and arginine repetitive matrix 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 135047795 | 135080787 | Mouse | 126 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1320905 | Srrm2 | serine/arginine repetitive matrix 2 | Predicted to enable C2H2 zinc finger domain binding activity and mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in Cajal body and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceoso me. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 72. Orthologous to human SRRM2 (serine/arginine repetitive matrix 2). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 24009501 | 24043715 | Mouse | 192 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1344658 | ARCN1 | archain 1 coat protein complex I subunit delta | This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fun damental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008] | 11 | 118572409 | 118603033 | Human | 236 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1322619 | SRRM1 | serine and arginine repetitive matrix 1 | Enables RNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome. Located in nuclear speck. Part of catalytic step 2 spliceosome. Biomarker of gestational diabetes. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 24643302 | 24673281 | Human | 124 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1320904 | SRRM2 | serine/arginine repetitive matrix 2 | Enables C2H2 zinc finger domain binding activity. Involved in mRNA splicing, via spliceosome. Located in Cajal body and nuclear speck. Part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Implicated in autosomal dominant intellectual developmental disorder 72. Biomarker of Parkinson's disease. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 2752638 | 2771412 | Human | 229 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1615916 | Srrm3 | serine/arginine repetitive matrix 3 | Predicted to enable mRNA binding activity. Predicted to be located in nucleus. Is expressed in brain; macula of utricle; and spinal cord. Orthologous to human SRRM3 (serine/arginine repetitive matrix 3). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 135835693 | 135903627 | Mouse | 76 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 40923433 | LOC119865729 | tyrosine-protein kinase Srms-like | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); non-membrane spanning protein tyrosine kinase activity (inferred) | | | | Dog | 16 | name | gene, protein-coding, MODEL [RefSeq] |
| 16567679 | AL121829.2 | novel transcript, antisense to SRMS | | | | | Human | | name | gene, lncrna |
| 1587868 | Srrm3 | serine/arginine repetitive matrix 3 | INVOLVED IN negative regulation of insulin secretion; RNA splicing; negative regulation of glucagon secretion (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; atrazine | 12 | 26445718 | 26515185 | Rat | 65 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |