SRMS (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites) - Rat Genome Database

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Gene: SRMS (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites) Canis lupus familiaris
Analyze
Symbol: SRMS
Name: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
RGD ID: 12246518
Description: ENCODES a protein that exhibits ATP binding (inferred); protein tyrosine kinase activity (inferred); INVOLVED IN positive regulation of TORC1 signaling (ortholog); ASSOCIATED WITH autosomal dominant nocturnal frontal lobe epilepsy (ortholog); autosomal recessive dyskeratosis congenita 5 (ortholog); benign familial infantile seizures 6 (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein kinase Srms
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12447,131,914 - 47,139,616 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2447,133,911 - 47,139,537 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2446,330,614 - 46,338,315 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02448,101,329 - 48,108,493 (-)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.02447,241,060 - 47,248,754 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,979,092 - 47,986,798 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SRMS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12447,131,914 - 47,139,616 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2447,133,911 - 47,139,537 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2446,330,614 - 46,338,315 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02448,101,329 - 48,108,493 (-)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.02447,241,060 - 47,248,754 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,979,092 - 47,986,798 (-)NCBIUU_Cfam_GSD_1.0
SRMS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,538,489 - 63,547,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,538,489 - 63,547,749 (-)EnsemblGRCh38hg38GRCh38
GRCh372062,169,842 - 62,179,102 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,642,607 - 61,649,301 (-)NCBINCBI36Build 36hg18NCBI36
Build 342061,642,606 - 61,649,301NCBI
Celera2058,852,519 - 58,859,217 (-)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,902,368 - 58,909,062 (-)NCBIHuRef
CHM1_12062,073,171 - 62,079,865 (-)NCBICHM1_1
T2T-CHM13v2.02065,351,086 - 65,360,346 (-)NCBIT2T-CHM13v2.0
Srms
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,847,356 - 180,854,964 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,847,355 - 180,854,978 (-)EnsemblGRCm39 Ensembl
GRCm382181,205,563 - 181,213,245 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,205,562 - 181,213,185 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,940,268 - 180,947,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,134,970 - 181,142,578 (-)NCBIMGSCv36mm8
Celera2185,288,382 - 185,295,958 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.62NCBI
Srms
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,696,070 - 188,702,474 (-)NCBIGRCr8
mRatBN7.23168,318,511 - 168,324,915 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,318,512 - 168,324,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,699,340 - 172,705,748 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,658,443 - 181,664,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,319,462 - 178,325,866 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,709,742 - 176,716,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,709,743 - 176,716,146 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,419,924 - 180,426,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,347,942 - 170,354,346 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,253,978 - 170,260,382 (-)NCBI
Celera3164,260,970 - 164,267,374 (+)NCBICelera
Cytogenetic Map3q43NCBI
Srms
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528677,628 - 684,340 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955528677,332 - 685,903 (+)NCBIChiLan1.0ChiLan1.0
SRMS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22169,343,774 - 69,351,250 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12069,334,043 - 69,343,256 (-)NCBINHGRI_mPanPan1
PanPan1.12061,464,318 - 61,473,057 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,465,539 - 61,473,057 (-)Ensemblpanpan1.1panPan2
Srms
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,382,288 - 195,392,095 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,836,156 - 10,843,303 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651410,835,931 - 10,843,303 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRMS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,548,182 - 62,556,975 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,549,025 - 62,555,904 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SRMS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12657,315 - 664,883 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2657,623 - 664,064 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605048,216,450 - 48,225,224 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srms
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,195,599 - 29,202,285 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474129,194,227 - 29,205,752 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SRMS
181 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 3 1 1 6 6 8 5 3
Below cutoff 5 2 20 5 5 5 6 6 5 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000020551   ⟹   ENSCAFP00000019074
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2447,133,911 - 47,139,537 (-)Ensembl
RefSeq Acc Id: XM_022408975   ⟹   XP_022264683
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12447,131,914 - 47,139,616 (-)NCBI
Dog10K_Boxer_Tasha2446,330,614 - 46,338,315 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038434369   ⟹   XP_038290297
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02448,101,329 - 48,108,493 (-)NCBI
RefSeq Acc Id: XM_038572870   ⟹   XP_038428798
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02447,979,092 - 47,986,798 (-)NCBI
RefSeq Acc Id: XM_038637154   ⟹   XP_038493082
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02447,241,060 - 47,248,754 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_022264683   ⟸   XM_022408975
- Peptide Label: isoform X4
- UniProtKB: A0A8C0JM67 (UniProtKB/TrEMBL),   A0A8C0N4V2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000019074   ⟸   ENSCAFT00000020551
RefSeq Acc Id: XP_038493082   ⟸   XM_038637154
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038290297   ⟸   XM_038434369
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JM67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038428798   ⟸   XM_038572870
- Peptide Label: isoform X3
- UniProtKB: A0A8C0JM67 (UniProtKB/TrEMBL),   A0A8C0N4V2 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase   SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012942 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011936 UniProtKB/TrEMBL
  ENSCAFG00040024759 UniProtKB/TrEMBL
  ENSCAFG00845021922 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000020551.4 UniProtKB/TrEMBL
  ENSCAFT00030022086.1 UniProtKB/TrEMBL
  ENSCAFT00040046145.1 UniProtKB/TrEMBL
  ENSCAFT00845038705 ENTREZGENE
  ENSCAFT00845038705.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene SRMS ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE SRMS UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0JM67 ENTREZGENE
  A0A8C0N4V2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TVC7_CANLF UniProtKB/TrEMBL
  A0A8I3P9Q4_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:46806 ENTREZGENE