| 3583 | Rnf4 | ring finger protein 4 | ENCODES a protein that exhibits DNA binding; identical protein binding; nuclear androgen receptor binding; INVOLVED IN cellular response to arsenic-containing substance; cellular response to cytokine stimulus; cellular response to gamma radiation; PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH Angelman syndrome (ortholog); Testicular Neoplasms (ortholog); FOUND IN nucleoplasm; nucleus; PML body; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 14 | 80625864 | 80647138 | Rat | 198 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 737478 | RNF4 | ring finger protein 4 | The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact w ith this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010] | 4 | 2469106 | 2515857 | Human | 166 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737479 | Rnf4 | ring finger protein 4 | This gene encodes a small nuclear RING finger protein that mediates ubiquitylation of polysumoylated proteins. Deficiency of the encoded protein in mice leads to embryonic lethality and global DNA hypermethylation. A similar protein in humans is required for arsenic-induced degradation of promyelocy tic leukemia protein in acute promyelocytic leukemia. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 10. [provided by RefSeq, Jan 2015] | 5 | 34493594 | 34510789 | Mouse | 225 | symbol , old_gene_name , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8841763 | Rnf4 | ring finger protein 4 | ENCODES a protein that exhibits DNA binding (ortholog); identical protein binding (ortholog); nuclear androgen receptor binding (ortholog); INVOLVED IN cellular response to arsenic-containing substance (ortholog); cellular response to cytokine stimulus (ortholog); cellular response to gamma radiatio n (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH Angelman syndrome (ortholog); Testicular Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | NW_004955514 | 1501943 | 1525689 | Chinchilla | 69 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11803532 | RNF4 | ring finger protein 4 | ENCODES a protein that exhibits identical protein binding (ortholog); nuclear androgen receptor binding (ortholog); nuclear estrogen receptor binding (ortholog); INVOLVED IN cellular response to arsenic-containing substance (ortholog); cellular response to cytokine stimulus (ortholog); cellular resp onse to gamma radiation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH Angelman syndrome (ortholog); Testicular Neoplasms (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | 4 | 2614918 | 2661785 | Bonobo | 72 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12248962 | RNF4 | ring finger protein 4 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred) | 30 | 11352475 | 11356610 | Dog | 2 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12388698 | RNF4 | ring finger protein 4 | ENCODES a protein that exhibits identical protein binding (ortholog); nuclear androgen receptor binding (ortholog); nuclear estrogen receptor binding (ortholog); INVOLVED IN cellular response to arsenic-containing substance (ortholog); cellular response to cytokine stimulus (ortholog); cellular resp onse to gamma radiation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH Angelman syndrome (ortholog); Testicular Neoplasms (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | 3 | 61721752 | 61759797 | Dog | 70 | symbol , old_gene_name | gene, protein-coding |
| 12737282 | Rnf4 | ring finger protein 4 | ENCODES a protein that exhibits identical protein binding (ortholog); nuclear androgen receptor binding (ortholog); nuclear estrogen receptor binding (ortholog); INVOLVED IN cellular response to arsenic-containing substance (ortholog); cellular response to cytokine stimulus (ortholog); cellular resp onse to gamma radiation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH Angelman syndrome (ortholog); Testicular Neoplasms (ortholog); FOUND IN nuclear body (ortholog); nucleoplasm (ortholog) | NW_004936477 | 21025040 | 21055821 | Squirrel | 73 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14297251 | RNF4 | ring finger protein 4 | ENCODES a protein that exhibits identical protein binding (ortholog); nuclear androgen receptor binding (ortholog); nuclear estrogen receptor binding (ortholog); INVOLVED IN cellular response to arsenic-containing substance (ortholog); cellular response to cytokine stimulus (ortholog); cellular resp onse to gamma radiation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH Angelman syndrome (ortholog); Testicular Neoplasms (ortholog); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | | | | Pig | 74 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18483391 | RNF4 | ring finger protein 4 | ENCODES a protein that exhibits identical protein binding (ortholog); nuclear androgen receptor binding (ortholog); nuclear estrogen receptor binding (ortholog); INVOLVED IN cellular response to arsenic-containing substance (ortholog); cellular response to cytokine stimulus (ortholog); cellular resp onse to gamma radiation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH Angelman syndrome (ortholog); Testicular Neoplasms (ortholog); FOUND IN nuclear body (ortholog); nucleoplasm (ortholog) | | | | Green Monkey | 73 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18911040 | Rnf4 | ring finger protein 4 | ENCODES a protein that exhibits identical protein binding (ortholog); nuclear androgen receptor binding (ortholog); nuclear estrogen receptor binding (ortholog); INVOLVED IN cellular response to arsenic-containing substance (ortholog); cellular response to cytokine stimulus (ortholog); cellular resp onse to gamma radiation (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH Angelman syndrome (ortholog); Testicular Neoplasms (ortholog); FOUND IN nuclear body (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 73 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 150657687 | RNF4 | ring finger protein 4 | ENCODES a protein that exhibits DNA binding (inferred); identical protein binding (inferred); metal ion binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of protein localization to chromatin (inferred); positive regulation of transcription by RNA polymerase II (inferred); FOUND IN cytoplasm (inferred); nuclear body (inferred); nucleoplasm (inferred) | | | | Dog | 29 | symbol | gene, protein-coding |
| 155238647 | rnf4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626073970 | Rnf4 | ring finger protein 4 | ENCODES a protein that exhibits DNA binding (ortholog); identical protein binding (ortholog); nuclear androgen receptor binding (ortholog); INVOLVED IN cellular response to arsenic-containing substance (ortholog); cellular response to cytokine stimulus (ortholog); cellular response to gamma radiatio n (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH Angelman syndrome (ortholog); Testicular Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); nuclear body (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 69 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155256318 | rnf4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155238646 | rnf4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38669413 | RNF4-DT | RNF4 divergent transcript | | 4 | 2464522 | 2468951 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1622861 | A830049F12Rik | RIKEN cDNA A830049F12 gene | Is expressed in adrenal gland; amygdala; and telencephalon mantle layer. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 34492474 | 34494549 | Mouse | | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11827640 | LOC100993046 | E3 ubiquitin-protein ligase RNF4-like | ENCODES a protein that exhibits DNA binding (inferred); metal ion binding (inferred); transferase activity (inferred); INVOLVED IN DNA-templated transcription (inferred); positive regulation of transcription by RNA polymerase II (inferred); FOUND IN cytoplasm (inferred); nucleus (inferred); PML body (inferred) | 1 | 206570482 | 206574574 | Bonobo | 13 | name | gene, protein-coding, MODEL [RefSeq] |
| 12522400 | LOC101958406 | E3 ubiquitin-protein ligase RNF4-like | | NW_004936566 | 5964801 | 5966526 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 12676605 | LOC101963379 | E3 ubiquitin-protein ligase RNF4-like | | NW_004936765 | 302612 | 312421 | Squirrel | | name | gene, protein-coding, MODEL [RefSeq] |
| 8966923 | LOC102019957 | E3 ubiquitin-protein ligase RNF4-like | | NW_004955437 | 9151213 | 9163753 | Chinchilla | | name | gene, protein-coding, MODEL [RefSeq] |
| 625916773 | LOC116912747 | E3 ubiquitin-protein ligase RNF4-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 16553936 | AL732414.1 | ring finger protein 4 (RNF4) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 40895785 | LOC119620934 | E3 ubiquitin-protein ligase RNF4 pseudogene | | | | | Green Monkey | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 628638 | Rnf40 | ring finger protein 40 | ENCODES a protein that exhibits syntaxin-1 binding; ubiquitin conjugating enzyme binding; ubiquitin-protein transferase activity; INVOLVED IN positive regulation of proteasomal protein catabolic process; positive regulation of protein polyubiquitination; response to peptide hormone; PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH nephrogenic diabetes insipidus; FOUND IN protein-containing complex; HULC complex (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol | 1 | 191632988 | 191649231 | Rat | 114 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732458 | RNF40 | ring finger protein 40 | The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquit in-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] | 16 | 30761612 | 30776307 | Human | 116 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737000 | Rnf40 | ring finger protein 40 | Predicted to enable several functions, including enzyme binding activity; protein homodimerization activity; and syntaxin-1 binding activity. Predicted to be involved in positive regulation of macromolecule metabolic process and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of HULC complex. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and islets of Langerhans. Orthologous to human RNF40 (ring finger protein 40). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 127187936 | 127202777 | Mouse | 120 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8938375 | Rnf40 | ring finger protein 40 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); protein homodimerization activity (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN positive regulation of proteasomal protein catabolic process (ortholog); positive regulation of protein polyubiquitination (ortholog); positive reg ulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH nephrogenic diabetes insipidus (ortholog); FOUND IN BRE1 E3 ubiquitin ligase complex (ortholog); HULC complex (ortholog); nucleoplasm (ortholog) | NW_004955493 | 7627189 | 7640711 | Chinchilla | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11912705 | RNF40 | ring finger protein 40 | ENCODES a protein that exhibits syntaxin-1 binding (ortholog); ubiquitin conjugating enzyme binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN positive regulation of proteasomal protein catabolic process (ortholog); positive regulation of protein polyubiquitination (o rtholog); regulation of mitotic cell cycle (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH nephrogenic diabetes insipidus (ortholog); FOUND IN protein-containing complex (ortholog) | 16 | 24194293 | 24207460 | Bonobo | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12141849 | RNF40 | ring finger protein 40 | ENCODES a protein that exhibits syntaxin-1 binding (ortholog); ubiquitin conjugating enzyme binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN positive regulation of proteasomal protein catabolic process (ortholog); positive regulation of protein polyubiquitination (o rtholog); regulation of mitotic cell cycle (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH nephrogenic diabetes insipidus (ortholog); FOUND IN protein-containing complex (ortholog) | 6 | 17402022 | 17414494 | Dog | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12593263 | Rnf40 | ring finger protein 40 | ENCODES a protein that exhibits syntaxin-1 binding (ortholog); ubiquitin conjugating enzyme binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN positive regulation of proteasomal protein catabolic process (ortholog); positive regulation of protein polyubiquitination (o rtholog); regulation of mitotic cell cycle (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH nephrogenic diabetes insipidus (ortholog); FOUND IN protein-containing complex (ortholog) | NW_004936501 | 13154963 | 13167211 | Squirrel | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14237391 | RNF40 | ring finger protein 40 | ENCODES a protein that exhibits syntaxin-1 binding (ortholog); ubiquitin conjugating enzyme binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN positive regulation of proteasomal protein catabolic process (ortholog); positive regulation of protein polyubiquitination (o rtholog); regulation of mitotic cell cycle (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH nephrogenic diabetes insipidus (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Pig | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18537012 | RNF40 | ring finger protein 40 | ENCODES a protein that exhibits syntaxin-1 binding (ortholog); ubiquitin conjugating enzyme binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN positive regulation of proteasomal protein catabolic process (ortholog); positive regulation of protein polyubiquitination (o rtholog); regulation of mitotic cell cycle (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH nephrogenic diabetes insipidus (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Green Monkey | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931315 | Rnf40 | ring finger protein 40 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); protein homodimerization activity (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN positive regulation of proteasomal protein catabolic process (ortholog); positive regulation of protein polyubiquitination (ortholog); positive reg ulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH nephrogenic diabetes insipidus (ortholog); FOUND IN BRE1 E3 ubiquitin ligase complex (ortholog); nucleoplasm (ortholog); protein-containing complex (ortholog) | | | | Naked Mole-Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250400 | rnf40 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625858295 | Rnf40 | ring finger protein 40 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); protein homodimerization activity (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN positive regulation of proteasomal protein catabolic process (ortholog); positive regulation of protein polyubiquitination (ortholog); positive reg ulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH nephrogenic diabetes insipidus (ortholog); FOUND IN BRE1 E3 ubiquitin ligase complex (ortholog); HULC complex (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1309557 | Rnf41 | ring finger protein 41 | ENCODES a protein that exhibits erythropoietin receptor binding (ortholog); identical protein binding (ortholog); interleukin-3 receptor binding (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway (ortholog); negative regulation of cell migration (ortholog); negative regulation of cell pop ulation proliferation (ortholog); PARTICIPATES IN endocytosis pathway; ASSOCIATED WITH congenital heart disease (ortholog); Myocardial Reperfusion Injury (ortholog); FOUND IN endoplasmic reticulum tubular network (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; bisphenol A | 7 | 1422651 | 1461700 | Rat | 97 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1319962 | RNF41 | ring finger protein 41 | This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Jun 2011] | 12 | 56202179 | 56221969 | Human | 99 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551303 | Rnf41 | ring finger protein 41 | Enables erythropoietin receptor binding activity and interleukin-3 receptor binding activity. Acts upstream of or within negative regulation of mitophagy; protein polyubiquitination; and regulation of hemopoiesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum tubular network. Is expressed in several structures, including central nervous system; dorsal root ganglion; male reproductive system; and urinary system. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RNF41 (ring finger protein 41). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 128247485 | 128277310 | Mouse | 109 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8926018 | Rnf41 | ring finger protein 41 | ENCODES a protein that exhibits erythropoietin receptor binding (ortholog); identical protein binding (ortholog); interleukin-3 receptor binding (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway (ortholog); negative regulation of cell migration (ortholog); negative regulation of cell pop ulation proliferation (ortholog); ASSOCIATED WITH congenital heart disease (ortholog); Myocardial Reperfusion Injury (ortholog); FOUND IN endoplasmic reticulum tubular network (ortholog); perinuclear region of cytoplasm (ortholog) | NW_004955458 | 3799450 | 3833269 | Chinchilla | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11684756 | RNF41 | ring finger protein 41 | ENCODES a protein that exhibits enzyme binding (inferred); erythropoietin receptor binding (inferred); identical protein binding (inferred); INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of mitophagy (ortholog); ASSOCIATED WITH congenital heart disease (ortholog); Myocardial Reperfusion Injury (ortholog); FOUND IN endoplasmic reticulum tubular network (inferred); perinuclear region of cytoplasm (inferred) | 12 | 32693349 | 32710866 | Bonobo | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12212398 | RNF41 | ring finger protein 41 | ENCODES a protein that exhibits erythropoietin receptor binding (inferred); identical protein binding (inferred); interleukin-3 receptor binding (inferred); INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of cell population proliferation (ortholog); negative regulat ion of mitophagy (ortholog); ASSOCIATED WITH congenital heart disease (ortholog); Myocardial Reperfusion Injury (ortholog); FOUND IN endoplasmic reticulum tubular network (inferred); perinuclear region of cytoplasm (inferred) | 10 | 512650 | 521293 | Dog | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12467341 | Rnf41 | ring finger protein 41 | ENCODES a protein that exhibits erythropoietin receptor binding (inferred); identical protein binding (inferred); interleukin-3 receptor binding (inferred); INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of cell population proliferation (ortholog); negative regulat ion of mitophagy (ortholog); ASSOCIATED WITH congenital heart disease (ortholog); Myocardial Reperfusion Injury (ortholog); FOUND IN endoplasmic reticulum tubular network (inferred); perinuclear region of cytoplasm (inferred) | NW_004936646 | 605302 | 630645 | Squirrel | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13891596 | RNF41 | ring finger protein 41 | ENCODES a protein that exhibits erythropoietin receptor binding (inferred); identical protein binding (inferred); interleukin-3 receptor binding (inferred); INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of cell population proliferation (ortholog); negative regulat ion of mitophagy (ortholog); ASSOCIATED WITH congenital heart disease (ortholog); Myocardial Reperfusion Injury (ortholog); FOUND IN endoplasmic reticulum tubular network (inferred); perinuclear region of cytoplasm (inferred) | | | | Pig | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18591976 | RNF41 | ring finger protein 41 | ENCODES a protein that exhibits enzyme binding (inferred); erythropoietin receptor binding (inferred); identical protein binding (inferred); INVOLVED IN negative regulation of cell migration (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of mitophagy (ortholog); ASSOCIATED WITH congenital heart disease (ortholog); Myocardial Reperfusion Injury (ortholog); FOUND IN endoplasmic reticulum tubular network (inferred); perinuclear region of cytoplasm (inferred) | | | | Green Monkey | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18933359 | Rnf41 | ring finger protein 41 | ENCODES a protein that exhibits erythropoietin receptor binding (ortholog); identical protein binding (ortholog); interleukin-3 receptor binding (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway (ortholog); negative regulation of cell migration (ortholog); negative regulation of cell pop ulation proliferation (ortholog); ASSOCIATED WITH congenital heart disease (ortholog); Myocardial Reperfusion Injury (ortholog); FOUND IN endoplasmic reticulum tubular network (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Naked Mole-Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866110 | RNF41 | ring finger protein 41 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 155245453 | rnf41 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625992924 | Rnf41 | ring finger protein 41 | ENCODES a protein that exhibits erythropoietin receptor binding (ortholog); identical protein binding (ortholog); interleukin-3 receptor binding (ortholog); INVOLVED IN extrinsic apoptotic signaling pathway (ortholog); negative regulation of cell migration (ortholog); negative regulation of cell pop ulation proliferation (ortholog); ASSOCIATED WITH congenital heart disease (ortholog); Myocardial Reperfusion Injury (ortholog); FOUND IN endoplasmic reticulum tubular network (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Black Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1305204 | Rnf43 | ring finger protein 43 | ENCODES a protein that exhibits frizzled binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN negative regulation of Wnt signaling pathway (ortholog); protein ubiquitination (ortholog); stem cell proliferation (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway ; ASSOCIATED WITH ascending colon cancer (ortholog); cholangiocarcinoma (ortholog); colon cancer (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 72958744 | 73034540 | Rat | 189 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1332400 | Rnf43 | ring finger protein 43 | Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in negative regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in plasma membrane. Is exp ressed in several structures, including alimentary system; forelimb epidermis; genitourinary system; lung; and submandibular gland primordium. Human ortholog(s) of this gene implicated in endometrial cancer; gastrointestinal system cancer (multiple); irritable bowel syndrome; lung adenocarcinoma; and villous adenoma. Orthologous to human RNF43 (ring finger protein 43). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 87553913 | 87626365 | Mouse | 214 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1342772 | RNF43 | ring finger protein 43 | The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015] | 17 | 58352500 | 58417534 | Human | 227 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8921092 | Rnf43 | ring finger protein 43 | ENCODES a protein that exhibits frizzled binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN negative regulation of Wnt signaling pathway (ortholog); protein ubiquitination (ortholog); stem cell proliferation (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway ; ASSOCIATED WITH ascending colon cancer (ortholog); cholangiocarcinoma (ortholog); colon cancer (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955451 | 4604985 | 4680762 | Chinchilla | 55 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12011254 | RNF43 | ring finger protein 43 | ENCODES a protein that exhibits frizzled binding (inferred); metal ion binding (inferred); transferase activity (inferred); INVOLVED IN negative regulation of Wnt signaling pathway (inferred); protein ubiquitination (inferred); stem cell proliferation (inferred); PARTICIPATES IN Wnt signaling, canon ical pathway; ASSOCIATED WITH ascending colon cancer (ortholog); cholangiocarcinoma (ortholog); colon cancer (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); nuclear envelope (inferred); plasma membrane (inferred) | 17 | 52420516 | 52492813 | Bonobo | 65 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12419912 | RNF43 | ring finger protein 43 | ENCODES a protein that exhibits frizzled binding (inferred); metal ion binding (inferred); transferase activity (inferred); INVOLVED IN negative regulation of Wnt signaling pathway (inferred); protein ubiquitination (inferred); stem cell proliferation (inferred); PARTICIPATES IN Wnt signaling, canon ical pathway; ASSOCIATED WITH ascending colon cancer (ortholog); cholangiocarcinoma (ortholog); colon cancer (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); nuclear envelope (inferred); plasma membrane (inferred) | 9 | 32996668 | 33061781 | Dog | 69 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12464284 | Rnf43 | ring finger protein 43 | ENCODES a protein that exhibits frizzled binding (inferred); metal ion binding (inferred); transferase activity (inferred); INVOLVED IN negative regulation of Wnt signaling pathway (inferred); protein ubiquitination (inferred); stem cell proliferation (inferred); PARTICIPATES IN Wnt signaling, canon ical pathway; ASSOCIATED WITH ascending colon cancer (ortholog); cholangiocarcinoma (ortholog); colon cancer (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); nuclear envelope (inferred); plasma membrane (inferred) | NW_004936490 | 4660904 | 4742669 | Squirrel | 65 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14227772 | RNF43 | ring finger protein 43 | ENCODES a protein that exhibits frizzled binding (inferred); metal ion binding (inferred); transferase activity (inferred); INVOLVED IN negative regulation of Wnt signaling pathway (inferred); protein ubiquitination (inferred); stem cell proliferation (inferred); PARTICIPATES IN Wnt signaling, canon ical pathway; ASSOCIATED WITH ascending colon cancer (ortholog); cholangiocarcinoma (ortholog); colon cancer (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); nuclear envelope (inferred); plasma membrane (inferred) | | | | Pig | 69 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18511576 | RNF43 | ring finger protein 43 | ENCODES a protein that exhibits frizzled binding (inferred); metal ion binding (inferred); transferase activity (inferred); INVOLVED IN negative regulation of Wnt signaling pathway (inferred); protein ubiquitination (inferred); stem cell proliferation (inferred); PARTICIPATES IN Wnt signaling, canon ical pathway; ASSOCIATED WITH ascending colon cancer (ortholog); cholangiocarcinoma (ortholog); colon cancer (ortholog); FOUND IN plasma membrane (inferred) | | | | Green Monkey | 63 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18917510 | Rnf43 | ring finger protein 43 | ENCODES a protein that exhibits frizzled binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN ubiquitin-dependent protein catabolic process (ortholog); Wnt receptor catabolic process (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH ascending colon cancer (ortholog); cholangiocarcinoma (ortholog); colon cancer (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); nuclear envelope (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 61 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 286228274 | rnf43 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626160756 | Rnf43 | ring finger protein 43 | ENCODES a protein that exhibits frizzled binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN negative regulation of Wnt signaling pathway (ortholog); protein ubiquitination (ortholog); stem cell proliferation (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway ; ASSOCIATED WITH ascending colon cancer (ortholog); cholangiocarcinoma (ortholog); colon cancer (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 54 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1307212 | Rnf44 | ring finger protein 44 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide | 17 | 9925100 | 9939496 | Rat | 69 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1316271 | RNF44 | ring finger protein 44 | The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008] | 5 | 176526712 | 176543513 | Human | 69 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1316272 | Rnf44 | ring finger protein 44 | Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Is expressed in several structures, including central nervous system; dorsal root ganglion; ear; male reproductive system; and urinary system. Orthologous to human RNF4 '>RNF44 (ring finger protein 44). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 54827212 | 54841889 | Mouse | 73 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8843091 | Rnf44 | ring finger protein 44 | | NW_004955408 | 28809383 | 28826587 | Chinchilla | 1 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11840357 | RNF44 | ring finger protein 44 | | 5 | 171824102 | 171840582 | Bonobo | 1 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12429619 | RNF44 | ring finger protein 44 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred) | 4 | 36785556 | 36818688 | Dog | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12509689 | Rnf44 | ring finger protein 44 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin protein ligase activity (inferred); zinc ion binding (inferred); INVOLVED IN protein ubiquitination (inferred) | NW_004936597 | 786256 | 802469 | Squirrel | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14171366 | RNF44 | ring finger protein 44 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred) | | | | Pig | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18624138 | RNF44 | ring finger protein 44 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin protein ligase activity (inferred); zinc ion binding (inferred); INVOLVED IN protein ubiquitination (inferred) | | | | Green Monkey | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917503 | Rnf44 | ring finger protein 44 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin protein ligase activity (inferred); zinc ion binding (inferred); INVOLVED IN protein ubiquitination (inferred) | | | | Naked Mole-Rat | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248973 | rnf44 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626141100 | Rnf44 | ring finger protein 44 | | | | | Black Rat | 1 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 38661900 | RNF4BP | ring finger protein 4B, pseudogene | | 15 | 44728988 | 44732851 | Human | | symbol , GTEx , COSMIC , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 155256526 | rnf40.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256534 | rnf40.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234255 | rnf41.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155235487 | rnf41.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 286229052 | rnf43.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288074829 | rnf43.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259365 | rnf44.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248972 | rnf44.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1588217 | Rnf41-ps1 | ring finger protein 41, pseudogene 1 | | X | 46567385 | 46568678 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1323068 | AMFR | autocrine motility factor receptor | This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum -associated degradation of specific proteins. [provided by RefSeq, Feb 2012] | 16 | 56361452 | 56425545 | Human | 169 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312438 | BFAR | bifunctional apoptosis regulator | Enables caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Acts upstream of or within negative regulation of apoptotic process. Located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 14632951 | 14669236 | Human | 87 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1312439 | Bfar | bifunctional apoptosis regulator | Predicted to enable caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiq uitination. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in central nervous system; heart valve; reproductive system; and urinary system. Orthologous to human BFAR (bifunctional apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 13489722 | 13521476 | Mouse | 87 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732625 | Birc2 | baculoviral IAP repeat-containing 2 | Enables ubiquitin-protein transferase activity. Involved in necroptotic process and positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including negative regulation of necroptotic process; negative regulation of ripoptosome assembly involved in necroptotic process; and regulation of intracellular signal transduction. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including central nervous system; genitourinary system; and thymus primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 7818227 | 7837123 | Mouse | 417 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1347209 | BIRC2 | baculoviral IAP repeat containing 2 | The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum depriv ation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] | 11 | 102347214 | 102378670 | Human | 420 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 732624 | BIRC3 | baculoviral IAP repeat containing 3 | This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011] | 11 | 102317484 | 102339403 | Human | 542 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733266 | Birc3 | baculoviral IAP repeat-containing 3 | Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Involved in necroptotic process; negative regulation of metabolic process; and negative regulation of necroptotic process. Acts upstream of or within cellular respo nse to tumor necrosis factor; positive regulation of protein polyubiquitination; and regulation of non-canonical NF-kappaB signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus adenocarcinoma; extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 7848698 | 7873199 | Mouse | 533 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1606340 | TRIM23 | tripartite motif containing 23 | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-bindi ng family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008] | 5 | 65589690 | 65624333 | Human | 115 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1315378 | Znrf1 | zinc and ring finger 1 | Enables ubiquitin protein ligase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Predicted to be located in cytosol and endosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane . Is expressed in several structures, including central nervous system; genitourinary system; and retina nuclear layer. Orthologous to human ZNRF1 (zinc and ring finger 1). [provided by Alliance of Genome Resources, Apr 2025] | 8 | 112262652 | 112352352 | Mouse | 123 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16569701 | AC106886.4 | novel transcript, antisense to RNF40 | | | | | Human | | name | gene, tec |
| 6770613 | TSPOAP1-AS1 | TSPOAP1, SUPT4H1 and RNF43 antisense RNA 1 | INTERACTS WITH 17beta-estradiol; aristolochic acid A; beta-lapachone | 17 | 58325450 | 58353727 | Human | 20 | name | gene, ncrna, VALIDATED [RefSeq] |