Rnf43 (ring finger protein 43) - Rat Genome Database

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Gene: Rnf43 (ring finger protein 43) Mus musculus
Analyze
Symbol: Rnf43
Name: ring finger protein 43
RGD ID: 1332400
MGI Page MGI
Description: Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in negative regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; forelimb epidermis; genitourinary system; lung; and submandibular gland primordium. Human ortholog(s) of this gene implicated in endometrial cancer; gastrointestinal system cancer (multiple); irritable bowel syndrome; lung adenocarcinoma; and villous adenoma. Orthologous to human RNF43 (ring finger protein 43).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4732452J19Rik; E3 ubiquitin-protein ligase RNF43; RING-type E3 ubiquitin transferase RNF43; RP23-449P23.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,553,913 - 87,626,365 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,553,548 - 87,626,365 (+)EnsemblGRCm39 Ensembl
GRCm381187,663,087 - 87,735,539 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,662,722 - 87,735,539 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,476,589 - 87,549,041 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,516,092 - 87,551,733 (+)NCBIMGSCv36mm8
Celera1197,258,357 - 97,331,075 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buta-1,3-diene  (EXP)
C60 fullerene  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroprene  (EXP)
chrysene  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethylparaben  (ISO)
genistein  (EXP)
gentamycin  (ISO)
leflunomide  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
oxaliplatin  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis. Bond CE, etal., Oncotarget. 2016 Oct 25;7(43):70589-70600. doi: 10.18632/oncotarget.12130.
2. Impact of loss-of-function mutations at the RNF43 locus on colorectal cancer development and progression. Eto T, etal., J Pathol. 2018 Aug;245(4):445-455. doi: 10.1002/path.5098. Epub 2018 Jun 20.
3. Genomic landscape of colitis-associated cancer indicates the impact of chronic inflammation and its stratification by mutations in the Wnt signaling. Fujita M, etal., Oncotarget. 2017 Dec 12;9(1):969-981. doi: 10.18632/oncotarget.22867. eCollection 2018 Jan 2.
4. Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas. Gala MK, etal., Gastroenterology. 2014 Feb;146(2):520-9.
5. RNF43 is frequently mutated in colorectal and endometrial cancers. Giannakis M, etal., Nat Genet. 2014 Dec;46(12):1264-6. doi: 10.1038/ng.3127. Epub 2014 Oct 26.
6. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
7. DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer. Huang S, etal., Cancer Res. 2017 Dec 1;77(23):6562-6575. doi: 10.1158/0008-5472.CAN-17-1570. Epub 2017 Oct 11.
8. Frequent frameshift mutations in 2 mononucleotide repeats of RNF43 gene and its regional heterogeneity in gastric and colorectal cancers. Jo YS, etal., Hum Pathol. 2015 Nov;46(11):1640-6. doi: 10.1016/j.humpath.2015.07.004. Epub 2015 Jul 15.
9. Cytotoxic T lymphocyte response to peptide vaccination predicts survival in stage III colorectal cancer. Kawamura J, etal., Cancer Sci. 2018 May;109(5):1545-1551. doi: 10.1111/cas.13547. Epub 2018 Mar 31.
10. The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated beta-catenin by sequestering TCF4 to the nuclear membrane. Loregger A, etal., Sci Signal. 2015 Sep 8;8(393):ra90. doi: 10.1126/scisignal.aac6757.
11. RNF43 mutation is associated with aggressive tumor biology along with BRAF V600E mutation in right-sided colorectal cancer. Matsumoto A, etal., Oncol Rep. 2020 Jun;43(6):1853-1862. doi: 10.3892/or.2020.7561. Epub 2020 Mar 23.
12. RT-qPCR analysis of the tumor antigens TOMM34 and RNF43 in samples extracted from paraffin-embedded specimens of colorectal cancer. Matsushita N, etal., Oncol Lett. 2017 Aug;14(2):2281-2287. doi: 10.3892/ol.2017.6412. Epub 2017 Jun 19.
13. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. Dysregulated Wnt signalling and recurrent mutations of the tumour suppressor RNF43 in early gastric carcinogenesis. Min BH, etal., J Pathol. 2016 Nov;240(3):304-314. doi: 10.1002/path.4777.
16. Mutated Rnf43 Aggravates Helicobacter Pylori-Induced Gastric Pathology. Neumeyer V, etal., Cancers (Basel). 2019 Mar 16;11(3). pii: cancers11030372. doi: 10.3390/cancers11030372.
17. Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells. Neumeyer V, etal., Carcinogenesis. 2019 Jun 10;40(4):551-559. doi: 10.1093/carcin/bgy152.
18. The complex world of WNT receptor signalling. Niehrs C Nat Rev Mol Cell Biol. 2012 Dec;13(12):767-79. doi: 10.1038/nrm3470. Epub 2012 Nov 15.
19. RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma. Niu L, etal., Cell Physiol Biochem. 2015;36(5):1835-46.
20. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
21. Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer. Okuno K, etal., Exp Ther Med. 2011 Jan;2(1):73-79. doi: 10.3892/etm.2010.182. Epub 2010 Dec 2.
22. [Preliminary study of Peptide vaccine with UFT/LV as adjuvant setting for stage III colorectal cancer]. Okuno K, etal., Gan To Kagaku Ryoho. 2011 Nov;38(12):1906-8.
23. Exome sequencing of liver fluke-associated cholangiocarcinoma. Ong CK, etal., Nat Genet. 2012 May 6;44(6):690-3. doi: 10.1038/ng.2273.
24. Mouse MP Annotation Import Pipeline RGD automated import pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. [Clinical study of Peptide-cocktail vaccination with tegafur-uracil/leucovorin for advanced colorectal cancer]. Sugiura F, etal., Gan To Kagaku Ryoho. 2012 Nov;39(12):1760-2.
28. Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development. Takeda H, etal., Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2057-65. doi: 10.1073/pnas.1603223113. Epub 2016 Mar 22.
29. Ring finger protein 43 expression is associated with genetic alteration status and poor prognosis among patients with intrahepatic cholangiocarcinoma. Talabnin C, etal., Hum Pathol. 2016 Jun;52:47-54. doi: 10.1016/j.humpath.2015.12.027. Epub 2016 Feb 1.
30. Wild-type APC Is Associated with Poor Survival in Metastatic Microsatellite Stable Colorectal Cancer. Wang C, etal., Oncologist. 2021 Mar;26(3):208-214. doi: 10.1002/onco.13607. Epub 2020 Dec 7.
31. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Wang K, etal., Nat Genet. 2014 Jun;46(6):573-82. doi: 10.1038/ng.2983. Epub 2014 May 11.
32. Reduced Frequency and Prognostic Significance of Ring Finger Protein 43 Nucleotide Polymorphisms in a Chinese Colorectal Cancer Cohort. Wen D, etal., DNA Cell Biol. 2019 Jun;38(6):541-548. doi: 10.1089/dna.2019.4645. Epub 2019 May 28.
33. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
34. Downregulation of ring-finger protein 43 in glioma associates with poor prognosis. Xi S, etal., Int J Clin Exp Pathol. 2015 Jan 1;8(1):490-6. eCollection 2015.
35. Reversing effect of ring finger protein 43 inhibition on malignant phenotypes of human hepatocellular carcinoma. Xing C, etal., Mol Cancer Ther. 2013 Jan;12(1):94-103. doi: 10.1158/1535-7163.MCT-12-0672. Epub 2012 Nov 6.
36. Germline Profiling and Molecular Characterization of Early Onset Metastatic Colorectal Cancer. Xu T, etal., Front Oncol. 2020 Oct 19;10:568911. doi: 10.3389/fonc.2020.568911. eCollection 2020.
37. RNF43 ubiquitinates and degrades phosphorylated E-cadherin by c-Src to facilitate epithelial-mesenchymal transition in lung adenocarcinoma. Zhang Y, etal., BMC Cancer. 2019 Jul 8;19(1):670. doi: 10.1186/s12885-019-5880-1.
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17609113   PMID:18287559   PMID:18554416  
PMID:21267068   PMID:21873635   PMID:22895187   PMID:22988430   PMID:26023187   PMID:27088858   PMID:27510977   PMID:28813421   PMID:29735715   PMID:29769720   PMID:30692207   PMID:31073040  
PMID:32008206   PMID:32324134   PMID:32934222   PMID:32939879   PMID:33188943   PMID:34079124   PMID:34129813   PMID:34973294   PMID:34995498   PMID:35229994   PMID:35456965   PMID:36468684  
PMID:38355793   PMID:38622664  


Genomics

Comparative Map Data
Rnf43
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,553,913 - 87,626,365 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,553,548 - 87,626,365 (+)EnsemblGRCm39 Ensembl
GRCm381187,663,087 - 87,735,539 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,662,722 - 87,735,539 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,476,589 - 87,549,041 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,516,092 - 87,551,733 (+)NCBIMGSCv36mm8
Celera1197,258,357 - 97,331,075 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.17NCBI
RNF43
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381758,352,500 - 58,417,534 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1758,353,676 - 58,417,595 (-)EnsemblGRCh38hg38GRCh38
GRCh371756,429,861 - 56,494,895 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,786,036 - 53,849,893 (-)NCBINCBI36Build 36hg18NCBI36
Celera1752,892,826 - 52,956,720 (-)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1751,791,664 - 51,855,538 (-)NCBIHuRef
CHM1_11756,496,051 - 56,559,939 (-)NCBICHM1_1
T2T-CHM13v2.01759,220,375 - 59,286,465 (-)NCBIT2T-CHM13v2.0
Rnf43
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81072,958,744 - 73,034,540 (+)NCBIGRCr8
mRatBN7.21072,461,508 - 72,537,301 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,464,348 - 72,536,977 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1077,076,871 - 77,146,437 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,581,783 - 76,651,384 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01072,046,299 - 72,115,890 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01074,956,411 - 75,028,951 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1074,959,285 - 75,028,951 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,073,437 - 75,145,501 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41075,957,792 - 76,027,392 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11075,970,268 - 76,041,762 (+)NCBI
Celera1071,380,030 - 71,449,285 (+)NCBICelera
Cytogenetic Map10q26NCBI
Rnf43
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554514,604,985 - 4,680,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554514,604,985 - 4,680,762 (+)NCBIChiLan1.0ChiLan1.0
RNF43
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21974,524,931 - 74,588,376 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11779,336,108 - 79,399,545 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01752,420,516 - 52,492,813 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11757,276,761 - 57,347,748 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1757,276,761 - 57,347,748 (-)Ensemblpanpan1.1panPan2
RNF43
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1932,996,668 - 33,061,781 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl932,997,937 - 33,060,313 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha932,233,662 - 32,298,953 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0933,804,112 - 33,869,488 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl933,805,560 - 33,867,835 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1932,590,253 - 32,654,698 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0932,872,945 - 32,938,201 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0932,966,428 - 33,031,867 (-)NCBIUU_Cfam_GSD_1.0
Rnf43
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560232,332,381 - 32,394,172 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364904,683,725 - 4,741,828 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364904,660,904 - 4,742,669 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNF43
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1234,635,228 - 34,694,378 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11234,631,574 - 34,695,021 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21236,120,577 - 36,181,757 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNF43
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11634,981,126 - 35,046,478 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1634,980,922 - 35,045,107 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660775,794,244 - 5,861,143 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnf43
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624871191,546 - 259,120 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624871191,534 - 259,134 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnf43
350 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2796
Count of miRNA genes:645
Interacting mature miRNAs:796
Transcripts:ENSMUST00000040089, ENSMUST00000092800, ENSMUST00000121782, ENSMUST00000123658, ENSMUST00000124625, ENSMUST00000134684, ENSMUST00000150866, ENSMUST00000162740, ENSMUST00000165679
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
15092049Wsigrme3_mweek six growth rate, maternal effect 3 (mouse)118487732496629512Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
15092057Lgrme3_mlate growth rate, maternal effect 3 (mouse)118487732496629512Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse

Markers in Region
D10Chm6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381187,705,981 - 87,706,275UniSTSGRCm38
MGSCv371187,519,483 - 87,519,777UniSTSGRCm37
Celera1197,301,400 - 97,301,694UniSTS
Cytogenetic Map11CUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000040089   ⟹   ENSMUSP00000044241
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,590,723 - 87,626,365 (+)Ensembl
GRCm38.p6 Ensembl1187,699,897 - 87,735,539 (+)Ensembl
Ensembl Acc Id: ENSMUST00000092800   ⟹   ENSMUSP00000090476
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,555,100 - 87,626,365 (+)Ensembl
GRCm38.p6 Ensembl1187,664,274 - 87,735,539 (+)Ensembl
Ensembl Acc Id: ENSMUST00000121782   ⟹   ENSMUSP00000112748
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,555,375 - 87,625,366 (+)Ensembl
GRCm38.p6 Ensembl1187,664,549 - 87,734,540 (+)Ensembl
Ensembl Acc Id: ENSMUST00000123658
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,553,913 - 87,609,285 (+)Ensembl
GRCm38.p6 Ensembl1187,663,087 - 87,718,459 (+)Ensembl
Ensembl Acc Id: ENSMUST00000124625
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,620,200 - 87,621,939 (+)Ensembl
GRCm38.p6 Ensembl1187,729,374 - 87,731,113 (+)Ensembl
Ensembl Acc Id: ENSMUST00000134684
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,553,548 - 87,620,760 (+)Ensembl
GRCm38.p6 Ensembl1187,662,722 - 87,729,934 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150866
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,624,746 - 87,625,294 (+)Ensembl
GRCm38.p6 Ensembl1187,733,920 - 87,734,468 (+)Ensembl
Ensembl Acc Id: ENSMUST00000162740
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,618,252 - 87,621,352 (+)Ensembl
GRCm38.p6 Ensembl1187,727,426 - 87,730,526 (+)Ensembl
Ensembl Acc Id: ENSMUST00000165679   ⟹   ENSMUSP00000130685
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1187,553,913 - 87,626,364 (+)Ensembl
GRCm38.p6 Ensembl1187,663,087 - 87,735,538 (+)Ensembl
RefSeq Acc Id: NM_001363437   ⟹   NP_001350366
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391187,590,723 - 87,626,365 (+)NCBI
GRCm381187,699,897 - 87,735,539 (+)NCBI
Sequence:
RefSeq Acc Id: NM_172448   ⟹   NP_766036
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391187,553,913 - 87,626,365 (+)NCBI
GRCm381187,663,087 - 87,735,539 (+)NCBI
MGSCv371187,476,589 - 87,549,041 (+)RGD
Celera1197,258,357 - 97,331,075 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_766036   ⟸   NM_172448
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8C191 (UniProtKB/Swiss-Prot),   Q8BME0 (UniProtKB/Swiss-Prot),   Q6DI76 (UniProtKB/Swiss-Prot),   B2KGH3 (UniProtKB/Swiss-Prot),   Q8K0X4 (UniProtKB/Swiss-Prot),   Q5NCP0 (UniProtKB/Swiss-Prot),   E9PWJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001350366   ⟸   NM_001363437
- Peptide Label: isoform 2
- UniProtKB: A3KMI3 (UniProtKB/TrEMBL),   E9PWJ5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000044241   ⟸   ENSMUST00000040089
Ensembl Acc Id: ENSMUSP00000090476   ⟸   ENSMUST00000092800
Ensembl Acc Id: ENSMUSP00000130685   ⟸   ENSMUST00000165679
Ensembl Acc Id: ENSMUSP00000112748   ⟸   ENSMUST00000121782
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5NCP0-F1-model_v2 AlphaFold Q5NCP0 1-784 view protein structure

Promoters
RGD ID:6821751
Promoter ID:MM_KWN:9084
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000002602
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361187,546,501 - 87,547,001 (+)MPROMDB
RGD ID:8676068
Promoter ID:EPDNEW_M16065
Type:initiation region
Name:Rnf43_1
Description:Mus musculus ring finger protein 43 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381187,662,673 - 87,662,733EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442609 AgrOrtholog
Ensembl Genes ENSMUSG00000034177 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000040089 ENTREZGENE
  ENSMUST00000040089.5 UniProtKB/Swiss-Prot
  ENSMUST00000092800.12 UniProtKB/Swiss-Prot
  ENSMUST00000121782.9 UniProtKB/TrEMBL
  ENSMUST00000165679 ENTREZGENE
  ENSMUST00000165679.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.30.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RNF43_Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZNRF-3_ecto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZNRF3_Arkadia_E3_ligases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:207742 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2442609 ENTREZGENE
NCBI Gene 207742 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE RNF43 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING ZINC FINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZNRF_3_ecto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rnf43 PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A3KMI3 ENTREZGENE, UniProtKB/TrEMBL
  B2KGH3 ENTREZGENE
  E9PWJ5 ENTREZGENE, UniProtKB/TrEMBL
  Q5NCP0 ENTREZGENE
  Q6DI76 ENTREZGENE
  Q8BME0 ENTREZGENE
  Q8C191 ENTREZGENE
  Q8K0X4 ENTREZGENE
  Q99KA9_MOUSE UniProtKB/TrEMBL
  RNF43_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary B2KGH3 UniProtKB/Swiss-Prot
  Q6DI76 UniProtKB/Swiss-Prot
  Q8BME0 UniProtKB/Swiss-Prot
  Q8C191 UniProtKB/Swiss-Prot
  Q8K0X4 UniProtKB/Swiss-Prot