| 3567 | Rgs4 | regulator of G-protein signaling 4 | ENCODES a protein that exhibits G-protein alpha-subunit binding; GTPase activator activity; protein kinase binding; INVOLVED IN dorsal root ganglion development; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of dopamine receptor signaling pathway ; PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH bladder disease; Drug-Induced Dyskinesia; epilepsy; FOUND IN protein-containing complex; cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH (S)-amphetamine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 13 | 84469593 | 84475884 | Rat | 240 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 70082 | RGS4 | regulator of G protein signaling 4 | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G protein s into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] | 1 | 163068871 | 163076802 | Human | 259 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 70083 | Rgs4 | regulator of G-protein signaling 4 | Predicted to enable G-protein alpha-subunit binding activity; GTPase activator activity; and protein kinase binding activity. Predicted to be involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of transmembrane transport; and regulation of signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Is expressed in several structures, including eye; genitourinary system; gut; immune system; and nervous system. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human RGS4 (regulator of G protein signaling 4). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 169569046 | 169575211 | Mouse | 290 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8826588 | Rgs4 | regulator of G protein signaling 4 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN dorsal root ganglion development (ortholog); negative regulation of cell growth involved in cardiac muscle cell development (ortholog); neg ative regulation of dopamine receptor signaling pathway (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH alcohol dependence (ortholog); bladder disease (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-containing complex (ortholog) | NW_004955462 | 13340812 | 13347598 | Chinchilla | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11899310 | RGS4 | regulator of G protein signaling 4 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN dorsal root ganglion development (ortholog); negative regulation of cell growth involved in cardiac muscle cell development (ortholog); neg ative regulation of dopamine receptor signaling pathway (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH alcohol dependence (ortholog); bladder disease (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-containing complex (ortholog) | 1 | 138488317 | 138496497 | Bonobo | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12341747 | RGS4 | regulator of G protein signaling 4 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN dorsal root ganglion development (ortholog); negative regulation of cell growth involved in cardiac muscle cell development (ortholog); neg ative regulation of dopamine receptor signaling pathway (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH alcohol dependence (ortholog); bladder disease (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN protein-containing complex (ortholog) | 38 | 19771454 | 19778917 | Dog | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12480430 | Rgs4 | regulator of G protein signaling 4 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN dorsal root ganglion development (ortholog); negative regulation of cell growth involved in cardiac muscle cell development (ortholog); neg ative regulation of dopamine receptor signaling pathway (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH alcohol dependence (ortholog); bladder disease (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN protein-containing complex (ortholog) | NW_004937238 | 101948 | 109513 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14136174 | RGS4 | regulator of G protein signaling 4 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN dorsal root ganglion development (ortholog); negative regulation of cell growth involved in cardiac muscle cell development (ortholog); neg ative regulation of dopamine receptor signaling pathway (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH alcohol dependence (ortholog); bladder disease (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN protein-containing complex (ortholog); INTERACTS WITH graphene oxide | | | | Pig | 46 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18899968 | Rgs4 | regulator of G protein signaling 4 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN dorsal root ganglion development (ortholog); negative regulation of cell growth involved in cardiac muscle cell development (ortholog); neg ative regulation of dopamine receptor signaling pathway (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH alcohol dependence (ortholog); bladder disease (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-containing complex (ortholog) | | | | Naked Mole-Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626064059 | Rgs4 | regulator of G protein signaling 4 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN dorsal root ganglion development (ortholog); negative regulation of cell growth involved in cardiac muscle cell development (ortholog); neg ative regulation of dopamine receptor signaling pathway (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH alcohol dependence (ortholog); bladder disease (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-containing complex (ortholog) | | | | Black Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18542034 | RGS4 | regulator of G protein signaling 4 | ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); protein kinase binding (ortholog); INVOLVED IN dorsal root ganglion development (ortholog); negative regulation of cell growth involved in cardiac muscle cell development (ortholog); neg ative regulation of dopamine receptor signaling pathway (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH alcohol dependence (ortholog); bladder disease (ortholog); Drug-Induced Dyskinesia (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Green Monkey | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254156 | rgs4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155249414 | rgs4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239079 | rgs4.S | | | | | | African Clawed Frog | | symbol | gene, null |