| 1343966 | RASSF1 | Ras association domain family member 1 | This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hy permethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011] | 3 | 50329788 | 50340836 | Human | 238 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1359383 | Rassf1 | Ras association domain family member 1 | ENCODES a protein that exhibits identical protein binding (ortholog); small GTPase binding (ortholog); INVOLVED IN DNA damage response (ortholog); positive regulation of protein ubiquitination (ortholog); protein stabilization (ortholog); PARTICIPATES IN p53 signaling pathway; lung non-small cell ca rcinoma pathway; urinary bladder cancer pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); bladder disease (ortholog); FOUND IN microtubule cytoskeleton (ortholog); nucleus (ortholog); INTERACTS WITH (S)-colchicine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17beta-estradiol | 8 | 117103665 | 117114805 | Rat | 232 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1621553 | Rassf1 | Ras association (RalGDS/AF-6) domain family member 1 | Enables small GTPase binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; positive regulation of protein ubiquitination; and protein stabilization. Predicted to act upstream of with a negative effect on regulation of cell cycle G1/S phase transi tion. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be active in microtubule cytoskeleton and nucleus. Is expressed in liver; metanephros; and neural retina. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human RASSF1 (Ras association domain family member 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 107428752 | 107439460 | Mouse | 257 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8807181 | Rassf1 | Ras association domain family member 1 | ENCODES a protein that exhibits identical protein binding (ortholog); small GTPase binding (ortholog); INVOLVED IN DNA damage response (ortholog); positive regulation of protein ubiquitination (ortholog); protein stabilization (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adenoc arcinoma (ortholog); Animal Mammary Neoplasms (ortholog); bladder disease (ortholog); FOUND IN microtubule cytoskeleton (ortholog); nucleus (ortholog) | NW_004955532 | 2132892 | 2142106 | Chinchilla | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11778671 | RASSF1 | Ras association domain family member 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN DNA damage response (ortholog); positive regulation of protein ubiquitination (ortholog); protein stabilization (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Animal Mamma ry Neoplasms (ortholog); bladder disease (ortholog); FOUND IN centrosome (inferred); cytoskeleton (inferred); microtubule (inferred) | 3 | 50255897 | 50267042 | Bonobo | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12157009 | RASSF1 | Ras association domain family member 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN DNA damage response (ortholog); positive regulation of protein ubiquitination (ortholog); protein stabilization (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Animal Mamma ry Neoplasms (ortholog); bladder disease (ortholog); FOUND IN centrosome (inferred); cytoskeleton (inferred); microtubule (inferred) | 20 | 39014639 | 39023393 | Dog | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12618826 | Rassf1 | Ras association domain family member 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN DNA damage response (ortholog); positive regulation of protein ubiquitination (ortholog); protein stabilization (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Animal Mamma ry Neoplasms (ortholog); bladder disease (ortholog); FOUND IN centrosome (inferred); cytoskeleton (inferred); microtubule (inferred) | NW_004936529 | 1857177 | 1866198 | Squirrel | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13946768 | RASSF1 | Ras association domain family member 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN DNA damage response (ortholog); positive regulation of protein ubiquitination (ortholog); protein stabilization (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Animal Mamma ry Neoplasms (ortholog); bladder disease (ortholog); FOUND IN centrosome (inferred); cytoskeleton (inferred); microtubule (inferred) | | | | Pig | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18524809 | RASSF1 | Ras association domain family member 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN DNA damage response (ortholog); positive regulation of protein ubiquitination (ortholog); protein stabilization (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Animal Mamma ry Neoplasms (ortholog); bladder disease (ortholog); FOUND IN cytoskeleton (inferred); microtubule (inferred); microtubule cytoskeleton (inferred) | | | | Green Monkey | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915061 | Rassf1 | Ras association domain family member 1 | ENCODES a protein that exhibits identical protein binding (ortholog); small GTPase binding (ortholog); INVOLVED IN DNA damage response (ortholog); positive regulation of protein ubiquitination (ortholog); protein stabilization (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adenoc arcinoma (ortholog); Animal Mammary Neoplasms (ortholog); bladder disease (ortholog); FOUND IN cytoskeleton (inferred); microtubule (inferred); microtubule cytoskeleton (inferred) | | | | Naked Mole-Rat | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244672 | rassf1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625958406 | Rassf1 | Ras association domain family member 1 | ENCODES a protein that exhibits identical protein binding (ortholog); small GTPase binding (ortholog); INVOLVED IN DNA damage response (ortholog); positive regulation of protein ubiquitination (ortholog); protein stabilization (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adenoc arcinoma (ortholog); Animal Mammary Neoplasms (ortholog); bladder disease (ortholog); FOUND IN microtubule cytoskeleton (ortholog); nucleus (ortholog) | | | | Black Rat | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244673 | rassf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242674 | rassf1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 7316575 | RASSF1-AS1 | RASSF1 antisense RNA 1 | INTERACTS WITH beta-lapachone | 3 | 50337511 | 50338300 | Human | 1 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1309847 | Rassf10 | Ras association domain family member 10 | INVOLVED IN positive regulation of neural precursor cell proliferation (ortholog); positive regulation of neurogenesis (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH alpha-Zearalanol; cisplatin; Cuprizon | 1 | 176492814 | 176498127 | Rat | 47 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1320411 | Rassf10 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 | Involved in positive regulation of neural precursor cell proliferation and positive regulation of neurogenesis. Predicted to be located in centrosome; cytosol; and spindle pole. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and respiratory system. Orthologous to human RASSF10 (Ras association domain family member 10). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 112553169 | 112556665 | Mouse | 53 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 2290196 | RASSF10 | Ras association domain family member 10 | Predicted to be involved in positive regulation of neural precursor cell proliferation and positive regulation of neurogenesis. Predicted to be located in centrosome; cytosol; and spindle pole. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 13009316 | 13012119 | Human | 53 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8919008 | Rassf10 | Ras association domain family member 10 | INVOLVED IN positive regulation of neural precursor cell proliferation (ortholog); positive regulation of neurogenesis (ortholog); FOUND IN cytosol (ortholog) | NW_004955414 | 28405024 | 28407734 | Chinchilla | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12005289 | RASSF10 | Ras association domain family member 10 | INVOLVED IN positive regulation of neural precursor cell proliferation (inferred); positive regulation of neurogenesis (inferred); signal transduction (inferred); FOUND IN cytosol (inferred) | 11 | 13176035 | 13179744 | Bonobo | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12124813 | RASSF10 | Ras association domain family member 10 | INVOLVED IN positive regulation of neural precursor cell proliferation (inferred); positive regulation of neurogenesis (inferred); signal transduction (inferred); FOUND IN cytosol (inferred) | 21 | 35984334 | 35986358 | Dog | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12625876 | Rassf10 | Ras association domain family member 10 | INVOLVED IN positive regulation of neural precursor cell proliferation (inferred); positive regulation of neurogenesis (inferred); signal transduction (inferred); FOUND IN cytosol (inferred) | NW_004936528 | 5536775 | 5541485 | Squirrel | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14089801 | RASSF10 | Ras association domain family member 10 | INVOLVED IN positive regulation of neural precursor cell proliferation (inferred); positive regulation of neurogenesis (inferred); signal transduction (inferred); FOUND IN cytosol (inferred); INTERACTS WITH graphene oxide | | | | Pig | 6 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18512618 | RASSF10 | Ras association domain family member 10 | INVOLVED IN positive regulation of neural precursor cell proliferation (inferred); positive regulation of neurogenesis (inferred); signal transduction (inferred); FOUND IN cytosol (inferred) | | | | Green Monkey | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18906882 | Rassf10 | Ras association domain family member 10 | INVOLVED IN positive regulation of neural precursor cell proliferation (ortholog); positive regulation of neurogenesis (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 5 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245162 | rassf10 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626107337 | Rassf10 | Ras association domain family member 10 | INVOLVED IN positive regulation of neural precursor cell proliferation (ortholog); positive regulation of neurogenesis (ortholog); FOUND IN cytosol (ortholog) | | | | Black Rat | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238059 | rassf10.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234813 | rassf10.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14401949 | RASSF10-DT | RASSF10 divergent transcript | | 11 | 12991501 | 13009116 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
