RASSF1 (Ras association domain family member 1) - Rat Genome Database

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Gene: RASSF1 (Ras association domain family member 1) Homo sapiens
Analyze
Symbol: RASSF1
Name: Ras association domain family member 1
RGD ID: 1343966
HGNC Page HGNC:9882
Description: Enables identical protein binding activity. Involved in several processes, including Ras protein signal transduction; positive regulation of protein ubiquitination; and protein stabilization. Acts upstream of with a negative effect on regulation of cell cycle G1/S phase transition. Located in microtubule cytoskeleton and nucleus. Implicated in breast cancer; carcinoma (multiple); reproductive organ cancer (multiple); and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 123F2; cardiac-specific ras association domain family 1 protein; NORE2A; pancreas-specific ras association domain family 1 protein; Ras association (RalGDS/AF-6) domain family 1; Ras association (RalGDS/AF-6) domain family member 1; Ras association domain family protein 1; ras association domain-containing protein 1; RASSF1A; RDA32; REH3P21; tumor suppressor protein RDA32; WUGSC:H_LUCA12.5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,329,788 - 50,340,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,329,782 - 50,340,980 (-)EnsemblGRCh38hg38GRCh38
GRCh37350,367,219 - 50,378,267 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,342,221 - 50,353,371 (-)NCBINCBI36Build 36hg18NCBI36
Build 34350,342,220 - 50,353,371NCBI
Celera350,340,051 - 50,351,201 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,422,848 - 50,433,998 (-)NCBIHuRef
CHM1_1350,319,475 - 50,330,627 (-)NCBICHM1_1
T2T-CHM13v2.0350,359,511 - 50,370,560 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-methylcholine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
ABT-737  (EXP)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
amphetamine  (ISO)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
asbestos  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzophenanthridine  (EXP)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (EXP)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP)
elemental selenium  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
etoposide  (EXP)
fluoranthene  (ISO)
folic acid  (EXP,ISO)
furan  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
hydrogen chloride  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP)
isoprenaline  (ISO)
menadione  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
mitomycin C  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
orphenadrine  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
picoxystrobin  (EXP)
potassium chloride  (EXP)
procainamide  (EXP)
propiconazole  (ISO)
quercetin  (EXP)
resveratrol  (EXP)
selenium atom  (EXP)
senecionine  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
Soman  (ISO)
succimer  (ISO)
sunitinib  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (EXP)
valproic acid  (EXP)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vinyl carbamate  (ISO)
vitamin E  (EXP)
zearalenone  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA)
cytoplasm  (IEA)
cytoskeleton  (IEA)
microtubule  (IEA)
microtubule cytoskeleton  (IBA,IDA,IEA)
nucleus  (IBA,IDA,IEA)
spindle  (IEA)
spindle pole  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors. Costa VL, etal., BMC Cancer. 2007 Jul 23;7:133.
2. DNA methylation in benign breast epithelium in relation to age and breast cancer risk. Euhus DM, etal., Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1051-9.
3. The role of RASSF1A methylation in cancer. Hesson LB, etal., Dis Markers. 2007;23(1-2):73-87.
4. Relationship between the expression of RASSF1A protein and promoter hypermethylation of RASSF1A gene in bladder tumor. Hu J, etal., J Huazhong Univ Sci Technolog Med Sci. 2008 Apr;28(2):182-4. Epub 2008 May 15.
5. Expression and promoter methylation of the RASSF1A gene in sporadic breast cancers in Chinese women. Li Y, etal., Oncol Rep. 2008 May;19(5):1149-53.
6. [Detection of circulating hypermethylated tumor-specific RASSF1A DNA in ovarian cancer patients] Ma L, etal., Zhonghua Bing Li Xue Za Zhi. 2005 Dec;34(12):785-7.
7. DNA methylation patterns in bladder cancer and washing cell sediments: a perspective for tumor recurrence detection. Negraes PD, etal., BMC Cancer. 2008 Aug 14;8(1):238.
8. Effect of aberrant promoter methylation of FHIT and RASSF1A genes on susceptibility to cervical cancer in a North Indian population. Neyaz MK, etal., Biomarkers. 2008 Apr 23:1-10.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Promoter hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma. Pallares J, etal., Mod Pathol. 2008 Jun;21(6):691-9. Epub 2008 May 9.
11. Methylation of the RASSF1A gene in human cancers. Pfeifer GP, etal., Biol Chem. 2002 Jun;383(6):907-14.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
17. Promoter hypermethylation in circulating blood cells identifies prostate cancer progression. Roupret M, etal., Int J Cancer. 2008 Feb 15;122(4):952-6.
18. Integrating DNA methylation and microRNA biomarkers in sputum for lung cancer detection. Su Y, etal., Clin Epigenetics. 2016 Oct 19;8:109. doi: 10.1186/s13148-016-0275-5. eCollection 2016.
Additional References at PubMed
PMID:10608806   PMID:10888881   PMID:10998413   PMID:11085536   PMID:11306494   PMID:11333291   PMID:11390984   PMID:11857081   PMID:12024041   PMID:12032847   PMID:12067994   PMID:12082610  
PMID:12082623   PMID:12082624   PMID:12114441   PMID:12142046   PMID:12399230   PMID:12477932   PMID:12527916   PMID:12545168   PMID:12594816   PMID:12647816   PMID:12670917   PMID:12673680  
PMID:12684417   PMID:12762840   PMID:12792742   PMID:12794755   PMID:12795841   PMID:12839965   PMID:12839968   PMID:12912945   PMID:14506151   PMID:14511407   PMID:14601057   PMID:14603253  
PMID:14688019   PMID:14729613   PMID:14743218   PMID:14871978   PMID:14961078   PMID:14961576   PMID:15027117   PMID:15075335   PMID:15109305   PMID:15145946   PMID:15205320   PMID:15231747  
PMID:15251938   PMID:15375503   PMID:15378022   PMID:15447998   PMID:15469871   PMID:15480433   PMID:15540210   PMID:15546880   PMID:15700308   PMID:15711568   PMID:15736067   PMID:15753381  
PMID:15761971   PMID:15780049   PMID:15799820   PMID:15867337   PMID:15867363   PMID:15870267   PMID:15942659   PMID:15948711   PMID:15949439   PMID:15980887   PMID:15987713   PMID:16007340  
PMID:16028839   PMID:16096369   PMID:16125301   PMID:16140931   PMID:16169070   PMID:16186793   PMID:16229803   PMID:16315018   PMID:16316825   PMID:16329043   PMID:16344548   PMID:16510573  
PMID:16596198   PMID:16606445   PMID:16619251   PMID:16641997   PMID:16810318   PMID:16891396   PMID:16912161   PMID:16918136   PMID:16937357   PMID:16951144   PMID:17064406   PMID:17099724  
PMID:17170014   PMID:17251440   PMID:17320110   PMID:17342751   PMID:17360030   PMID:17379520   PMID:17444856   PMID:17473182   PMID:17477876   PMID:17523078   PMID:17526942   PMID:17538946  
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PMID:17920725   PMID:17967182   PMID:17994635   PMID:18029348   PMID:18058812   PMID:18071316   PMID:18086755   PMID:18172292   PMID:18182852   PMID:18286482   PMID:18313166   PMID:18322962  
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PMID:18566590   PMID:18592002   PMID:18616639   PMID:18641684   PMID:18679651   PMID:18691570   PMID:18783461   PMID:18788633   PMID:18799029   PMID:18822131   PMID:18824877   PMID:19024105  
PMID:19062280   PMID:19098985   PMID:19118008   PMID:19140316   PMID:19145506   PMID:19148529   PMID:19160099   PMID:19165202   PMID:19172108   PMID:19181545   PMID:19193434   PMID:19221469  
PMID:19223555   PMID:19276349   PMID:19326371   PMID:19366060   PMID:19374895   PMID:19450668   PMID:19454503   PMID:19470737   PMID:19473831   PMID:19478941   PMID:19506903   PMID:19509163  
PMID:19548529   PMID:19578875   PMID:19637319   PMID:19652091   PMID:19657672   PMID:19686743   PMID:19727727   PMID:19761124   PMID:19795445   PMID:19799084   PMID:19821102   PMID:19854132  
PMID:19887622   PMID:19940364   PMID:19957692   PMID:19962312   PMID:20038516   PMID:20042089   PMID:20056647   PMID:20069457   PMID:20075396   PMID:20079060   PMID:20086174   PMID:20140873  
PMID:20146887   PMID:20184324   PMID:20193080   PMID:20208994   PMID:20237496   PMID:20360068   PMID:20360646   PMID:20361264   PMID:20453000   PMID:20471512   PMID:20496080   PMID:20497257  
PMID:20505321   PMID:20535589   PMID:20562859   PMID:20668305   PMID:20677556   PMID:20697344   PMID:20800513   PMID:20800603   PMID:20842524   PMID:20864173   PMID:20877461   PMID:20920251  
PMID:20955597   PMID:21036752   PMID:21115918   PMID:21134643   PMID:21156971   PMID:21199877   PMID:21205828   PMID:21221769   PMID:21274674   PMID:21338215   PMID:21364923   PMID:21450690  
PMID:21468893   PMID:21473137   PMID:21473856   PMID:21489991   PMID:21624251   PMID:21643015   PMID:21660959   PMID:21722812   PMID:21788308   PMID:21809394   PMID:21822036   PMID:21838870  
PMID:21868547   PMID:21873635   PMID:21873787   PMID:21874044   PMID:21884695   PMID:21900206   PMID:21910689   PMID:21955482   PMID:22139571   PMID:22142825   PMID:22172412   PMID:22195963  
PMID:22232300   PMID:22246327   PMID:22266866   PMID:22297548   PMID:22315090   PMID:22332908   PMID:22382007   PMID:22389451   PMID:22394463   PMID:22446336   PMID:22447862   PMID:22520501  
PMID:22581300   PMID:22591718   PMID:22615811   PMID:22670522   PMID:22694820   PMID:22695491   PMID:22716213   PMID:22733432   PMID:22766745   PMID:23009572   PMID:23038753   PMID:23055343  
PMID:23128528   PMID:23139773   PMID:23147544   PMID:23187089   PMID:23192464   PMID:23319821   PMID:23320751   PMID:23455922   PMID:23455924   PMID:23526657   PMID:23579583   PMID:23594797  
PMID:23705663   PMID:23865079   PMID:23886171   PMID:23887284   PMID:23888343   PMID:23891693   PMID:23891964   PMID:23902976   PMID:23915220   PMID:23979608   PMID:23982879   PMID:23989600  
PMID:23990798   PMID:24001151   PMID:24068440   PMID:24073258   PMID:24116157   PMID:24197116   PMID:24247422   PMID:24248815   PMID:24253900   PMID:24255178   PMID:24353088   PMID:24366813  
PMID:24383114   PMID:24460357   PMID:24464006   PMID:24478455   PMID:24505629   PMID:24510557   PMID:24573512   PMID:24598366   PMID:24665911   PMID:24680815   PMID:24732797   PMID:24747657  
PMID:24756244   PMID:24870779   PMID:24935575   PMID:24980613   PMID:24981860   PMID:24998565   PMID:25007054   PMID:25038505   PMID:25040980   PMID:25053593   PMID:25152984   PMID:25218637  
PMID:25225292   PMID:25229773   PMID:25302792   PMID:25332235   PMID:25339045   PMID:25368379   PMID:25483734   PMID:25514805   PMID:25556469   PMID:25703593   PMID:25805039   PMID:25814554  
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PMID:26182870   PMID:26186194   PMID:26201719   PMID:26269600   PMID:26320446   PMID:26370119   PMID:26392358   PMID:26457492   PMID:26482848   PMID:26549256   PMID:26578655   PMID:26598620  
PMID:26648328   PMID:26671036   PMID:26673895   PMID:26735582   PMID:26750098   PMID:26754001   PMID:26759237   PMID:26825171   PMID:26857374   PMID:26921475   PMID:26935905   PMID:26980762  
PMID:27034171   PMID:27072261   PMID:27078152   PMID:27165812   PMID:27173228   PMID:27230238   PMID:27286455   PMID:27292796   PMID:27506957   PMID:27698403   PMID:27716889   PMID:27880743  
PMID:28026816   PMID:28069272   PMID:28160561   PMID:28205554   PMID:28206954   PMID:28207831   PMID:28325362   PMID:28514442   PMID:28592132   PMID:28600574   PMID:28628118   PMID:28669560  
PMID:28838380   PMID:28871003   PMID:28875283   PMID:29098560   PMID:29122566   PMID:29128865   PMID:29130987   PMID:29368096   PMID:29382819   PMID:29470995   PMID:29480000   PMID:29538221  
PMID:29562656   PMID:29670073   PMID:29778234   PMID:29851970   PMID:30003738   PMID:30049201   PMID:30074127   PMID:30082160   PMID:30106448   PMID:30226276   PMID:30305100   PMID:30315205  
PMID:30418048   PMID:30507050   PMID:30689554   PMID:30764677   PMID:30944388   PMID:30979377   PMID:31062660   PMID:31086178   PMID:31196964   PMID:31202904   PMID:31242460   PMID:31268606  
PMID:31414556   PMID:31435022   PMID:31436249   PMID:31500788   PMID:31547587   PMID:31578881   PMID:31653147   PMID:31653608   PMID:31735284   PMID:31754973   PMID:31773698   PMID:31790342  
PMID:31804463   PMID:31839603   PMID:32017063   PMID:32266538   PMID:32296183   PMID:32530576   PMID:32690868   PMID:32703486   PMID:32707033   PMID:32853942   PMID:32870805   PMID:33051258  
PMID:33057010   PMID:33175673   PMID:33381579   PMID:33442234   PMID:33621744   PMID:33796885   PMID:33928818   PMID:33960627   PMID:33961781   PMID:34183450   PMID:34315543   PMID:34532864  
PMID:34831091   PMID:34897944   PMID:35032689   PMID:35081499   PMID:35271311   PMID:35941108   PMID:36215168   PMID:36404583   PMID:36584330   PMID:36736316   PMID:36905106   PMID:38093706  
PMID:38115290   PMID:38203733  


Genomics

Comparative Map Data
RASSF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,329,788 - 50,340,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,329,782 - 50,340,980 (-)EnsemblGRCh38hg38GRCh38
GRCh37350,367,219 - 50,378,267 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,342,221 - 50,353,371 (-)NCBINCBI36Build 36hg18NCBI36
Build 34350,342,220 - 50,353,371NCBI
Celera350,340,051 - 50,351,201 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,422,848 - 50,433,998 (-)NCBIHuRef
CHM1_1350,319,475 - 50,330,627 (-)NCBICHM1_1
T2T-CHM13v2.0350,359,511 - 50,370,560 (-)NCBIT2T-CHM13v2.0
Rassf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,428,752 - 107,439,460 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,428,754 - 107,439,466 (+)EnsemblGRCm39 Ensembl
GRCm389107,551,434 - 107,562,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,551,555 - 107,562,267 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,456,987 - 107,464,591 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,412,757 - 107,420,361 (+)NCBIMGSCv36mm8
Celera9107,163,421 - 107,171,009 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.12NCBI
Rassf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,103,665 - 117,114,805 (+)NCBIGRCr8
mRatBN7.28108,225,023 - 108,236,164 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,225,023 - 108,236,164 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,852,061 - 113,863,191 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,051,217 - 112,062,347 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,893,998 - 109,905,128 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,307,149 - 116,318,289 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,307,141 - 116,318,289 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,663,409 - 115,674,549 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,798,863 - 112,810,004 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,822,246 - 112,829,459 (+)NCBI
Celera8107,531,445 - 107,542,731 (+)NCBICelera
Cytogenetic Map8q32NCBI
Rassf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,132,822 - 2,142,106 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,132,892 - 2,142,106 (-)NCBIChiLan1.0ChiLan1.0
RASSF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,310,363 - 50,321,411 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,315,138 - 50,326,157 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,255,897 - 50,267,042 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,491,548 - 51,502,386 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,491,548 - 51,502,392 (-)Ensemblpanpan1.1panPan2
RASSF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,014,639 - 39,023,393 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,014,666 - 39,022,585 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,935,865 - 38,944,610 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,370,859 - 39,379,601 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,370,874 - 39,379,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,738,691 - 38,747,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,142,254 - 39,150,992 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,422,263 - 39,431,009 (+)NCBIUU_Cfam_GSD_1.0
Rassf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,096,680 - 65,105,871 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,857,145 - 1,867,260 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,857,177 - 1,866,198 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASSF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,816,156 - 32,825,226 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,816,156 - 32,825,486 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,994,689 - 36,003,831 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RASSF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,716,969 - 11,728,646 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,716,918 - 11,725,027 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041155,258,161 - 155,269,986 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rassf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,181,462 - 4,190,431 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247304,181,207 - 4,190,603 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RASSF1
23 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p21.31-14.3(chr3:49461000-55314500)x1 copy number loss See cases [RCV000051511] Chr3:49461000..55314500 [GRCh38]
Chr3:49498433..55348528 [GRCh37]
Chr3:49473437..55323568 [NCBI36]
Chr3:3p21.31-14.3
pathogenic
NM_170714.1(RASSF1):c.969C>T (p.Ile323=) single nucleotide variant Malignant melanoma [RCV000060843] Chr3:50330647 [GRCh38]
Chr3:50368078 [GRCh37]
Chr3:50343082 [NCBI36]
Chr3:3p21.31
not provided
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
Chr3:3p21.31-21.2
pathogenic
GRCh37/hg19 3p21.31(chr3:50273827-50403519)x3 copy number gain Breast ductal adenocarcinoma [RCV000207033] Chr3:50273827..50403519 [GRCh37]
Chr3:3p21.31
uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_007182.5(RASSF1):c.74G>A (p.Arg25Gln) single nucleotide variant Inborn genetic diseases [RCV003262038] Chr3:50340732 [GRCh38]
Chr3:50378163 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.566G>A (p.Arg189Gln) single nucleotide variant Inborn genetic diseases [RCV003247591] Chr3:50331753 [GRCh38]
Chr3:50369184 [GRCh37]
Chr3:3p21.31
uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_007182.5(RASSF1):c.753C>T (p.His251=) single nucleotide variant not provided [RCV000968003] Chr3:50331566 [GRCh38]
Chr3:50368997 [GRCh37]
Chr3:3p21.31
benign
GRCh37/hg19 3p21.31-21.1(chr3:45153770-53878616) copy number gain not provided [RCV000767704] Chr3:45153770..53878616 [GRCh37]
Chr3:3p21.31-21.1
pathogenic
NM_007182.5(RASSF1):c.483A>G (p.Thr161=) single nucleotide variant not provided [RCV000902662] Chr3:50331836 [GRCh38]
Chr3:50369267 [GRCh37]
Chr3:3p21.31
benign
GRCh37/hg19 3p21.31-21.2(chr3:48807193-51363558)x1 copy number loss not provided [RCV001259686] Chr3:48807193..51363558 [GRCh37]
Chr3:3p21.31-21.2
pathogenic
NC_000003.11:g.(?_49547968)_(50685477_?)del deletion Early infantile epileptic encephalopathy with suppression bursts [RCV001970206] Chr3:49547968..50685477 [GRCh37]
Chr3:3p21.31-21.2
pathogenic
NC_000003.11:g.(?_49866536)_(50540854_?)dup duplication Primary ciliary dyskinesia [RCV003119656] Chr3:49866536..50540854 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.799C>T (p.Arg267Trp) single nucleotide variant Inborn genetic diseases [RCV002990603] Chr3:50331411 [GRCh38]
Chr3:50368842 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.572G>A (p.Gly191Asp) single nucleotide variant Inborn genetic diseases [RCV003307119] Chr3:50331747 [GRCh38]
Chr3:50369178 [GRCh37]
Chr3:3p21.31
uncertain significance
GRCh37/hg19 3p21.31(chr3:50364292-50492932)x1 copy number loss not provided [RCV002473664] Chr3:50364292..50492932 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.784G>C (p.Asp262His) single nucleotide variant Inborn genetic diseases [RCV002687098] Chr3:50331426 [GRCh38]
Chr3:50368857 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.699C>G (p.Phe233Leu) single nucleotide variant Inborn genetic diseases [RCV002794250] Chr3:50331620 [GRCh38]
Chr3:50369051 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.883G>A (p.Ala295Thr) single nucleotide variant Inborn genetic diseases [RCV002758870] Chr3:50330721 [GRCh38]
Chr3:50368152 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.1001T>C (p.Leu334Pro) single nucleotide variant Inborn genetic diseases [RCV002802360] Chr3:50330603 [GRCh38]
Chr3:50368034 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.740G>A (p.Arg247His) single nucleotide variant Inborn genetic diseases [RCV002664839] Chr3:50331579 [GRCh38]
Chr3:50369010 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.182C>G (p.Thr61Arg) single nucleotide variant Inborn genetic diseases [RCV002835827] Chr3:50340624 [GRCh38]
Chr3:50378055 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.692G>A (p.Arg231Gln) single nucleotide variant Inborn genetic diseases [RCV002718291] Chr3:50331627 [GRCh38]
Chr3:50369058 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.677T>C (p.Ile226Thr) single nucleotide variant Inborn genetic diseases [RCV003203137] Chr3:50331642 [GRCh38]
Chr3:50369073 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.980G>A (p.Arg327His) single nucleotide variant Inborn genetic diseases [RCV003359672] Chr3:50330624 [GRCh38]
Chr3:50368055 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_007182.5(RASSF1):c.357+630C>T single nucleotide variant not provided [RCV003437859] Chr3:50337275 [GRCh38]
Chr3:50374706 [GRCh37]
Chr3:3p21.31
likely benign
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR181Dhsa-miR-181d-5pOncomiRDBexternal_infoNANA21352471
MIR181A2hsa-miR-181a-5pOncomiRDBexternal_infoNANA21352471
MIR181Chsa-miR-181c-5pOncomiRDBexternal_infoNANA21352471
MIR181B2hsa-miR-181b-5pOncomiRDBexternal_infoNANA21352471
MIR181B1hsa-miR-181b-5pOncomiRDBexternal_infoNANA21352471
MIR181A1hsa-miR-181a-5pOncomiRDBexternal_infoNANA21352471

Predicted Target Of
Summary Value
Count of predictions:3851
Count of miRNA genes:795
Interacting mature miRNAs:949
Transcripts:ENST00000327761, ENST00000357043, ENST00000359365, ENST00000395117, ENST00000395126, ENST00000478619, ENST00000482447, ENST00000488024, ENST00000494145
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH91127  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37350,367,244 - 50,367,431UniSTSGRCh37
Build 36350,342,248 - 50,342,435RGDNCBI36
Celera350,340,078 - 50,340,265RGD
Cytogenetic Map3p21.3UniSTS
HuRef350,422,875 - 50,423,062UniSTS
GeneMap99-GB4 RH Map3158.9UniSTS
D3S2832E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37350,367,294 - 50,367,436UniSTSGRCh37
Build 36350,342,298 - 50,342,440RGDNCBI36
Celera350,340,128 - 50,340,270RGD
Cytogenetic Map3p21.3UniSTS
HuRef350,422,925 - 50,423,067UniSTS
SHGC-56838  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37350,378,617 - 50,378,710UniSTSGRCh37
Build 36350,353,621 - 50,353,714RGDNCBI36
Celera350,351,451 - 50,351,544RGD
Cytogenetic Map3p21.3UniSTS
HuRef350,434,248 - 50,434,341UniSTS
TNG Radiation Hybrid Map331355.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2413 2786 1463 401 1909 242 4092 1887 2666 310 1412 1559 170 1204 2635 3
Low 25 201 261 223 42 223 264 309 1043 106 41 51 1 153 1 2
Below cutoff 1 2 1 1 18 1 7 2 3 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_023270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001206957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_170712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_170713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_170714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011533316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024453328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047447372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054345090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC002455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC002481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF040703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF102770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF102771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF102772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF132675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF132676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF132677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF286217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF291719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX505275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE247372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI915594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI966696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM152368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM562405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ072763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT020047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT020048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ444319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000327761   ⟹   ENSP00000333327
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,329,782 - 50,337,464 (-)Ensembl
RefSeq Acc Id: ENST00000357043   ⟹   ENSP00000349547
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,329,788 - 50,340,841 (-)Ensembl
RefSeq Acc Id: ENST00000359365   ⟹   ENSP00000352323
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,329,788 - 50,340,836 (-)Ensembl
RefSeq Acc Id: ENST00000395117   ⟹   ENSP00000378549
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,329,788 - 50,340,841 (-)Ensembl
RefSeq Acc Id: ENST00000395126   ⟹   ENSP00000378558
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,329,788 - 50,338,233 (-)Ensembl
RefSeq Acc Id: ENST00000478619
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,336,377 - 50,340,980 (-)Ensembl
RefSeq Acc Id: ENST00000482447   ⟹   ENSP00000433000
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,329,788 - 50,340,912 (-)Ensembl
RefSeq Acc Id: ENST00000488024
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,336,570 - 50,340,830 (-)Ensembl
RefSeq Acc Id: ENST00000494145
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,336,800 - 50,338,288 (-)Ensembl
RefSeq Acc Id: ENST00000616212   ⟹   ENSP00000482696
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl350,329,786 - 50,340,936 (-)Ensembl
RefSeq Acc Id: NM_001206957   ⟹   NP_001193886
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,329,788 - 50,340,836 (-)NCBI
GRCh37350,367,217 - 50,378,367 (-)ENTREZGENE
HuRef350,422,848 - 50,433,998 (-)ENTREZGENE
CHM1_1350,319,475 - 50,330,627 (-)NCBI
T2T-CHM13v2.0350,359,511 - 50,370,560 (-)NCBI
Sequence:
RefSeq Acc Id: NM_007182   ⟹   NP_009113
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,329,788 - 50,340,836 (-)NCBI
GRCh37350,367,217 - 50,378,367 (-)ENTREZGENE
Build 36350,342,221 - 50,353,371 (-)NCBI Archive
HuRef350,422,848 - 50,433,998 (-)ENTREZGENE
CHM1_1350,319,475 - 50,330,627 (-)NCBI
T2T-CHM13v2.0350,359,511 - 50,370,560 (-)NCBI
Sequence:
RefSeq Acc Id: NM_170712   ⟹   NP_733830
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,329,788 - 50,338,252 (-)NCBI
GRCh37350,367,217 - 50,378,367 (-)ENTREZGENE
Build 36350,342,221 - 50,350,666 (-)NCBI Archive
HuRef350,422,848 - 50,433,998 (-)ENTREZGENE
CHM1_1350,319,475 - 50,327,921 (-)NCBI
T2T-CHM13v2.0350,359,511 - 50,367,976 (-)NCBI
Sequence:
RefSeq Acc Id: NM_170713   ⟹   NP_733831
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,329,788 - 50,337,450 (-)NCBI
GRCh37350,367,217 - 50,378,367 (-)ENTREZGENE
Build 36350,342,221 - 50,349,899 (-)NCBI Archive
HuRef350,422,848 - 50,433,998 (-)ENTREZGENE
CHM1_1350,319,475 - 50,327,152 (-)NCBI
T2T-CHM13v2.0350,359,511 - 50,367,173 (-)NCBI
Sequence:
RefSeq Acc Id: NM_170714   ⟹   NP_733832
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,329,788 - 50,340,836 (-)NCBI
GRCh37350,367,217 - 50,378,367 (-)ENTREZGENE
Build 36350,342,221 - 50,353,371 (-)NCBI Archive
HuRef350,422,848 - 50,433,998 (-)ENTREZGENE
CHM1_1350,319,475 - 50,330,627 (-)NCBI
T2T-CHM13v2.0350,359,511 - 50,370,560 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011533316   ⟹   XP_011531618
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,329,788 - 50,337,131 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047447372   ⟹   XP_047303328
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,329,788 - 50,339,206 (-)NCBI
RefSeq Acc Id: XM_054345089   ⟹   XP_054201064
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0350,359,511 - 50,369,078 (-)NCBI
RefSeq Acc Id: XM_054345090   ⟹   XP_054201065
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0350,359,511 - 50,366,855 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001193886 (Get FASTA)   NCBI Sequence Viewer  
  NP_009113 (Get FASTA)   NCBI Sequence Viewer  
  NP_733830 (Get FASTA)   NCBI Sequence Viewer  
  NP_733831 (Get FASTA)   NCBI Sequence Viewer  
  NP_733832 (Get FASTA)   NCBI Sequence Viewer  
  XP_011531618 (Get FASTA)   NCBI Sequence Viewer  
  XP_047303328 (Get FASTA)   NCBI Sequence Viewer  
  XP_054201064 (Get FASTA)   NCBI Sequence Viewer  
  XP_054201065 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB67312 (Get FASTA)   NCBI Sequence Viewer  
  AAC16001 (Get FASTA)   NCBI Sequence Viewer  
  AAC70910 (Get FASTA)   NCBI Sequence Viewer  
  AAD44174 (Get FASTA)   NCBI Sequence Viewer  
  AAD44175 (Get FASTA)   NCBI Sequence Viewer  
  AAD44176 (Get FASTA)   NCBI Sequence Viewer  
  AAF35127 (Get FASTA)   NCBI Sequence Viewer  
  AAF35128 (Get FASTA)   NCBI Sequence Viewer  
  AAF35129 (Get FASTA)   NCBI Sequence Viewer  
  AAG10038 (Get FASTA)   NCBI Sequence Viewer  
  AAG10064 (Get FASTA)   NCBI Sequence Viewer  
  AAI10413 (Get FASTA)   NCBI Sequence Viewer  
  AAI17154 (Get FASTA)   NCBI Sequence Viewer  
  AAI43880 (Get FASTA)   NCBI Sequence Viewer  
  AAV38850 (Get FASTA)   NCBI Sequence Viewer  
  AAV38851 (Get FASTA)   NCBI Sequence Viewer  
  ABD97859 (Get FASTA)   NCBI Sequence Viewer  
  BAF85327 (Get FASTA)   NCBI Sequence Viewer  
  BAG62613 (Get FASTA)   NCBI Sequence Viewer  
  CAD48844 (Get FASTA)   NCBI Sequence Viewer  
  EAW65098 (Get FASTA)   NCBI Sequence Viewer  
  EAW65099 (Get FASTA)   NCBI Sequence Viewer  
  EAW65100 (Get FASTA)   NCBI Sequence Viewer  
  EAW65101 (Get FASTA)   NCBI Sequence Viewer  
  EAW65102 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000333327
  ENSP00000333327.3
  ENSP00000349547
  ENSP00000349547.2
  ENSP00000352323
  ENSP00000352323.4
  ENSP00000378549.2
  ENSP00000378558
  ENSP00000378558.3
  ENSP00000433000.1
  ENSP00000482696
  ENSP00000482696.1
GenBank Protein Q9NS23 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001193886   ⟸   NM_001206957
- Peptide Label: isoform B
- UniProtKB: Q9NS23 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_009113   ⟸   NM_007182
- Peptide Label: isoform A
- UniProtKB: Q17RX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_733832   ⟸   NM_170714
- Peptide Label: isoform D
- UniProtKB: Q9UND4 (UniProtKB/Swiss-Prot),   Q9NS22 (UniProtKB/Swiss-Prot),   Q9HB18 (UniProtKB/Swiss-Prot),   Q9HB04 (UniProtKB/Swiss-Prot),   Q5TZT2 (UniProtKB/Swiss-Prot),   Q0VGC6 (UniProtKB/Swiss-Prot),   O60710 (UniProtKB/Swiss-Prot),   O60539 (UniProtKB/Swiss-Prot),   O14571 (UniProtKB/Swiss-Prot),   B7ZLL1 (UniProtKB/Swiss-Prot),   Q9UND5 (UniProtKB/Swiss-Prot),   Q9NS23 (UniProtKB/Swiss-Prot),   Q17RX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_733830   ⟸   NM_170712
- Peptide Label: isoform B
- UniProtKB: Q9NS23 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_733831   ⟸   NM_170713
- Peptide Label: isoform C
- UniProtKB: A8K9C3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011531618   ⟸   XM_011533316
- Peptide Label: isoform X1
- UniProtKB: Q9NS23 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000352323   ⟸   ENST00000359365
RefSeq Acc Id: ENSP00000433000   ⟸   ENST00000482447
RefSeq Acc Id: ENSP00000482696   ⟸   ENST00000616212
RefSeq Acc Id: ENSP00000333327   ⟸   ENST00000327761
RefSeq Acc Id: ENSP00000378549   ⟸   ENST00000395117
RefSeq Acc Id: ENSP00000378558   ⟸   ENST00000395126
RefSeq Acc Id: ENSP00000349547   ⟸   ENST00000357043
RefSeq Acc Id: XP_047303328   ⟸   XM_047447372
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054201064   ⟸   XM_054345089
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054201065   ⟸   XM_054345090
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9NS23-F1-model_v2 AlphaFold Q9NS23 1-344 view protein structure

Promoters
RGD ID:6864514
Promoter ID:EPDNEW_H5421
Type:initiation region
Name:RASSF1_1
Description:Ras association domain family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5422  EPDNEW_H5424  EPDNEW_H5423  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,337,450 - 50,337,510EPDNEW
RGD ID:6864516
Promoter ID:EPDNEW_H5422
Type:initiation region
Name:RASSF1_4
Description:Ras association domain family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5421  EPDNEW_H5424  EPDNEW_H5423  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,338,252 - 50,338,312EPDNEW
RGD ID:6864546
Promoter ID:EPDNEW_H5423
Type:initiation region
Name:RASSF1_2
Description:Ras association domain family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5421  EPDNEW_H5422  EPDNEW_H5424  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,340,822 - 50,340,882EPDNEW
RGD ID:6864518
Promoter ID:EPDNEW_H5424
Type:initiation region
Name:RASSF1_3
Description:Ras association domain family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5421  EPDNEW_H5422  EPDNEW_H5423  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,340,969 - 50,341,029EPDNEW
RGD ID:6801509
Promoter ID:HG_KWN:45134
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid,   NB4
Transcripts:UC003DAA.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36350,344,346 - 50,344,846 (-)MPROMDB
RGD ID:6801508
Promoter ID:HG_KWN:45135
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_170713
Position:
Human AssemblyChrPosition (strand)Source
Build 36350,349,641 - 50,350,141 (-)MPROMDB
RGD ID:6801505
Promoter ID:HG_KWN:45136
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_170712,   OTTHUMT00000314311
Position:
Human AssemblyChrPosition (strand)Source
Build 36350,350,591 - 50,351,562 (-)MPROMDB
RGD ID:6800525
Promoter ID:HG_KWN:45137
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000266020,   ENST00000395117,   ENST00000395129,   NM_007182,   NM_170714,   OTTHUMT00000346386,   OTTHUMT00000346387,   OTTHUMT00000346388
Position:
Human AssemblyChrPosition (strand)Source
Build 36350,352,101 - 50,353,597 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9882 AgrOrtholog
COSMIC RASSF1 COSMIC
Ensembl Genes ENSG00000068028 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000327761 ENTREZGENE
  ENST00000327761.7 UniProtKB/Swiss-Prot
  ENST00000357043 ENTREZGENE
  ENST00000357043.6 UniProtKB/Swiss-Prot
  ENST00000359365 ENTREZGENE
  ENST00000359365.9 UniProtKB/Swiss-Prot
  ENST00000395117.6 UniProtKB/Swiss-Prot
  ENST00000395126 ENTREZGENE
  ENST00000395126.7 UniProtKB/Swiss-Prot
  ENST00000482447.1 UniProtKB/Swiss-Prot
  ENST00000616212 ENTREZGENE
  ENST00000616212.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000068028 GTEx
HGNC ID HGNC:9882 ENTREZGENE
Human Proteome Map RASSF1 Human Proteome Map
InterPro C-RASSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASSF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARAH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:11186 UniProtKB/Swiss-Prot
NCBI Gene 11186 ENTREZGENE
OMIM 605082 OMIM
PANTHER PTHR22738 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22738:SF12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nore1-SARAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34245 PharmGKB
PROSITE PS50200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00314 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K9C3 ENTREZGENE, UniProtKB/TrEMBL
  B7ZLL1 ENTREZGENE
  O14571 ENTREZGENE
  O60539 ENTREZGENE
  O60710 ENTREZGENE
  Q0VGC6 ENTREZGENE
  Q17RX7 ENTREZGENE, UniProtKB/TrEMBL
  Q1W2K8_HUMAN UniProtKB/TrEMBL
  Q5TZT2 ENTREZGENE
  Q9HB04 ENTREZGENE
  Q9HB18 ENTREZGENE
  Q9NS22 ENTREZGENE
  Q9NS23 ENTREZGENE
  Q9UND4 ENTREZGENE
  Q9UND5 ENTREZGENE
  RASF1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B7ZLL1 UniProtKB/Swiss-Prot
  O14571 UniProtKB/Swiss-Prot
  O60539 UniProtKB/Swiss-Prot
  O60710 UniProtKB/Swiss-Prot
  Q0VGC6 UniProtKB/Swiss-Prot
  Q5TZT2 UniProtKB/Swiss-Prot
  Q9HB04 UniProtKB/Swiss-Prot
  Q9HB18 UniProtKB/Swiss-Prot
  Q9NS22 UniProtKB/Swiss-Prot
  Q9UND4 UniProtKB/Swiss-Prot
  Q9UND5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 RASSF1  Ras association domain family member 1    Ras association (RalGDS/AF-6) domain family member 1  Symbol and/or name change 5135510 APPROVED