RASSF1 (Ras association domain family member 1) - Rat Genome Database

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Gene: RASSF1 (Ras association domain family member 1) Canis lupus familiaris
Analyze
Symbol: RASSF1
Name: Ras association domain family member 1
RGD ID: 12157009
Description: ENCODES a protein that exhibits identical protein binding (ortholog); small GTPase binding (ortholog); INVOLVED IN DNA damage response (ortholog); positive regulation of protein ubiquitination (ortholog); protein stabilization (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); bladder disease (ortholog); FOUND IN cytoskeleton (inferred); microtubule (inferred); microtubule cytoskeleton (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ras association (RalGDS/AF-6) domain family 1; ras association domain-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,014,639 - 39,023,393 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,014,666 - 39,022,585 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,935,865 - 38,944,610 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,370,859 - 39,379,601 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,370,874 - 39,379,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,738,691 - 38,747,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,142,254 - 39,150,992 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,422,263 - 39,431,009 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
RASSF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,014,639 - 39,023,393 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,014,666 - 39,022,585 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,935,865 - 38,944,610 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,370,859 - 39,379,601 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,370,874 - 39,379,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,738,691 - 38,747,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,142,254 - 39,150,992 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,422,263 - 39,431,009 (+)NCBIUU_Cfam_GSD_1.0
RASSF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,329,788 - 50,340,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,329,782 - 50,340,980 (-)EnsemblGRCh38hg38GRCh38
GRCh37350,367,219 - 50,378,267 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,342,221 - 50,353,371 (-)NCBINCBI36Build 36hg18NCBI36
Build 34350,342,220 - 50,353,371NCBI
Celera350,340,051 - 50,351,201 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,422,848 - 50,433,998 (-)NCBIHuRef
CHM1_1350,319,475 - 50,330,627 (-)NCBICHM1_1
T2T-CHM13v2.0350,359,511 - 50,370,560 (-)NCBIT2T-CHM13v2.0
Rassf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,428,752 - 107,439,460 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,428,754 - 107,439,466 (+)EnsemblGRCm39 Ensembl
GRCm389107,551,434 - 107,562,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,551,555 - 107,562,267 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,456,987 - 107,464,591 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,412,757 - 107,420,361 (+)NCBIMGSCv36mm8
Celera9107,163,421 - 107,171,009 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.12NCBI
Rassf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,103,665 - 117,114,805 (+)NCBIGRCr8
mRatBN7.28108,225,023 - 108,236,164 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,225,023 - 108,236,164 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,852,061 - 113,863,191 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,051,217 - 112,062,347 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,893,998 - 109,905,128 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,307,149 - 116,318,289 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,307,141 - 116,318,289 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,663,409 - 115,674,549 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,798,863 - 112,810,004 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,822,246 - 112,829,459 (+)NCBI
Celera8107,531,445 - 107,542,731 (+)NCBICelera
Cytogenetic Map8q32NCBI
Rassf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,132,822 - 2,142,106 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,132,892 - 2,142,106 (-)NCBIChiLan1.0ChiLan1.0
RASSF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,310,363 - 50,321,411 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,315,138 - 50,326,157 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,255,897 - 50,267,042 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,491,548 - 51,502,386 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,491,548 - 51,502,392 (-)Ensemblpanpan1.1panPan2
Rassf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,096,680 - 65,105,871 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,857,145 - 1,867,260 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,857,177 - 1,866,198 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASSF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,816,156 - 32,825,226 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,816,156 - 32,825,486 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,994,689 - 36,003,831 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RASSF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,716,969 - 11,728,646 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,716,918 - 11,725,027 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041155,258,161 - 155,269,986 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rassf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,181,462 - 4,190,431 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247304,181,207 - 4,190,603 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RASSF1
53 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000016913   ⟹   ENSCAFP00000015650
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2039,014,666 - 39,022,585 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000089232   ⟹   ENSCAFP00000051713
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2039,017,363 - 39,022,585 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845038359   ⟹   ENSCAFP00845030031
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2039,370,874 - 39,379,600 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845038415   ⟹   ENSCAFP00845030077
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2039,373,549 - 39,379,598 (+)Ensembl
RefSeq Acc Id: XM_005632505   ⟹   XP_005632562
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,014,639 - 39,023,393 (+)NCBI
Dog10K_Boxer_Tasha2038,935,865 - 38,944,610 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038427684   ⟹   XP_038283612
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02039,370,859 - 39,379,601 (+)NCBI
RefSeq Acc Id: XM_038427685   ⟹   XP_038283613
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02039,373,467 - 39,379,601 (+)NCBI
RefSeq Acc Id: XM_038503371   ⟹   XP_038359299
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12038,738,691 - 38,747,434 (+)NCBI
RefSeq Acc Id: XM_038503372   ⟹   XP_038359300
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12038,741,300 - 38,747,434 (+)NCBI
RefSeq Acc Id: XM_038566372   ⟹   XP_038422300
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02039,422,263 - 39,431,009 (+)NCBI
RefSeq Acc Id: XM_038566373   ⟹   XP_038422301
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02039,424,875 - 39,431,009 (+)NCBI
RefSeq Acc Id: XM_038630522   ⟹   XP_038486450
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02039,142,254 - 39,150,992 (+)NCBI
RefSeq Acc Id: XM_038630523   ⟹   XP_038486451
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02039,144,858 - 39,150,992 (+)NCBI
RefSeq Acc Id: XM_855985   ⟹   XP_861078
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,016,923 - 39,023,393 (+)NCBI
Dog10K_Boxer_Tasha2038,938,476 - 38,944,610 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005632562   ⟸   XM_005632505
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N6X5 (UniProtKB/TrEMBL),   A0A8I3PD61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_861078   ⟸   XM_855985
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MXK9 (UniProtKB/TrEMBL),   A0A8C0R5S8 (UniProtKB/TrEMBL),   A0A8I3P965 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000051713   ⟸   ENSCAFT00000089232
Ensembl Acc Id: ENSCAFP00000015650   ⟸   ENSCAFT00000016913
RefSeq Acc Id: XP_038359299   ⟸   XM_038503371
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038359300   ⟸   XM_038503372
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038486450   ⟸   XM_038630522
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038486451   ⟸   XM_038630523
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038283612   ⟸   XM_038427684
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N6X5 (UniProtKB/TrEMBL),   A0A8I3PD61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038283613   ⟸   XM_038427685
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MXK9 (UniProtKB/TrEMBL),   A0A8C0R5S8 (UniProtKB/TrEMBL),   A0A8I3P965 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038422300   ⟸   XM_038566372
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N6X5 (UniProtKB/TrEMBL),   A0A8I3PD61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038422301   ⟸   XM_038566373
- Peptide Label: isoform X2
- UniProtKB: A0A8C0MXK9 (UniProtKB/TrEMBL),   A0A8C0R5S8 (UniProtKB/TrEMBL),   A0A8I3P965 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845030077   ⟸   ENSCAFT00845038415
Ensembl Acc Id: ENSCAFP00845030031   ⟸   ENSCAFT00845038359
Protein Domains
Phorbol-ester/DAG-type   Ras-associating   SARAH

Promoters
RGD ID:13686864
Promoter ID:EPDNEW_C4932
Type:single initiation site
Name:RASSF1_1
Description:Ras association domain family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12039,014,546 - 39,014,606EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010627 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011335 UniProtKB/TrEMBL
  ENSCAFG00040015500 UniProtKB/TrEMBL
  ENSCAFG00845021608 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016913.5 UniProtKB/TrEMBL
  ENSCAFT00000089232.2 UniProtKB/TrEMBL
  ENSCAFT00030021056.1 UniProtKB/TrEMBL
  ENSCAFT00030021083.1 UniProtKB/TrEMBL
  ENSCAFT00040028629.1 UniProtKB/TrEMBL
  ENSCAFT00040028666.1 UniProtKB/TrEMBL
  ENSCAFT00845038359 ENTREZGENE
  ENSCAFT00845038359.1 UniProtKB/TrEMBL
  ENSCAFT00845038415 ENTREZGENE
  ENSCAFT00845038415.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro C-RASSF UniProtKB/TrEMBL
  C1-like_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  RA_dom UniProtKB/TrEMBL
  RASSF1 UniProtKB/TrEMBL
  SARAH_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene RASSF1 ENTREZGENE
PANTHER PTHR22738 UniProtKB/TrEMBL
  PTHR22738:SF12 UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  Nore1-SARAH UniProtKB/TrEMBL
  PF00788 UniProtKB/TrEMBL
PROSITE PS50200 UniProtKB/TrEMBL
  SARAH UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART SM00109 UniProtKB/TrEMBL
  SM00314 UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A8C0MXK9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0N6X5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R5S8 ENTREZGENE
  A0A8I3P965 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PD61 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45378 ENTREZGENE