| 3452 | Ptprs | protein tyrosine phosphatase, receptor type, S | ENCODES a protein that exhibits protein tyrosine phosphatase activity; chondroitin sulfate binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN presynapse assembly; regulation of postsynaptic density assembly; synaptic membrane adhesion; ASSOCIATED WITH COVID-19 (ortholog ); Hearing Loss (ortholog); NATURAL KILLER CELL ENTEROPATHY (ortholog); FOUND IN glutamatergic synapse; postsynaptic density membrane; presynaptic membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil | 9 | 1332558 | 1394161 | Rat | 214 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 734357 | PTPRS | protein tyrosine phosphatase receptor type S | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellula r region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] | 19 | 5205508 | 5340812 | Human | 206 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 734358 | Ptprs | protein tyrosine phosphatase receptor type S | Enables chondroitin sulfate binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; and regulation of postsynaptic density assembly. Acts upstream of or within central nervous system development and establishment of endothelial intestinal barrier. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic membrane. Is expressed in several structures, including adipose tissue; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human PTPRS (protein tyrosine phosphatase receptor type S). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 56719426 | 56783480 | Mouse | 292 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8858332 | Ptprs | protein tyrosine phosphatase receptor type S | ENCODES a protein that exhibits chondroitin sulfate binding (ortholog); heparin binding (ortholog); phosphoprotein phosphatase activity (ortholog); INVOLVED IN cerebellum development (ortholog); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Hearing Loss (ortholog); NATURAL KILLER CELL ENTEROPATHY (ortholog); FOUND IN glutamatergic synapse (ortholog); plasma membrane (ortholog); postsynaptic density membrane (ortholog) | NW_004955495 | 3943075 | 3991361 | Chinchilla | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11893159 | PTPRS | protein tyrosine phosphatase receptor type S | ENCODES a protein that exhibits protein tyrosine phosphatase activity (ortholog); INVOLVED IN cerebellum development (ortholog); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Hearing Loss (ortholog); NATURAL KILLER CELL ENTEROPAT HY (ortholog); FOUND IN postsynaptic density membrane (ortholog) | 19 | 4227038 | 4361958 | Bonobo | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12178412 | PTPRS | protein tyrosine phosphatase receptor type S | ENCODES a protein that exhibits protein tyrosine phosphatase activity (ortholog); INVOLVED IN cerebellum development (ortholog); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Hearing Loss (ortholog); NATURAL KILLER CELL ENTEROPAT HY (ortholog); FOUND IN postsynaptic density membrane (ortholog) | 20 | 54575853 | 54672141 | Dog | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12479697 | Ptprs | protein tyrosine phosphatase receptor type S | ENCODES a protein that exhibits protein tyrosine phosphatase activity (ortholog); INVOLVED IN cerebellum development (ortholog); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Hearing Loss (ortholog); NATURAL KILLER CELL ENTEROPAT HY (ortholog); FOUND IN postsynaptic density membrane (ortholog); synaptic vesicle membrane (ortholog) | NW_004936588 | 3021418 | 3073080 | Squirrel | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237179 | ptprs | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18403744 | PTPRS | protein tyrosine phosphatase receptor type S | ENCODES a protein that exhibits protein tyrosine phosphatase activity (ortholog); INVOLVED IN cerebellum development (ortholog); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Hearing Loss (ortholog); NATURAL KILLER CELL ENTEROPAT HY (ortholog); FOUND IN postsynaptic density membrane (ortholog) | | | | Green Monkey | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18911100 | Ptprs | protein tyrosine phosphatase receptor type S | ENCODES a protein that exhibits chondroitin sulfate binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN cerebellum development (ortholog); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Hearing Loss ( ortholog); NATURAL KILLER CELL ENTEROPATHY (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog); presynaptic membrane (ortholog) | | | | Naked Mole-Rat | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14157742 | PTPRS | protein tyrosine phosphatase receptor type S | ENCODES a protein that exhibits protein tyrosine phosphatase activity (ortholog); INVOLVED IN cerebellum development (ortholog); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Hearing Loss (ortholog); NATURAL KILLER CELL ENTEROPAT HY (ortholog); FOUND IN postsynaptic density membrane (ortholog) | | | | Pig | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625886233 | Ptprs | protein tyrosine phosphatase receptor type S | ENCODES a protein that exhibits chondroitin sulfate binding (ortholog); heparin binding (ortholog); phosphoprotein phosphatase activity (ortholog); INVOLVED IN cerebellum development (ortholog); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Hearing Loss (ortholog); NATURAL KILLER CELL ENTEROPATHY (ortholog); FOUND IN glutamatergic synapse (ortholog); plasma membrane (ortholog); postsynaptic density membrane (ortholog) | | | | Black Rat | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 628359524 | ptprs.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246871 | ptprs.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 152025304 | PTPRS-AS1 | PTPRS antisense RNA 1 | | 19 | 5177746 | 5178464 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16564699 | PTPRS-AS1 | PTPRS antisense RNA 1 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, lncrna |
| 16567215 | AC005790.1 | novel transcript, antisense to PTPRS | | | | | Human | | name | gene, lncrna |