| 3439 | Ptgs1 | prostaglandin-endoperoxide synthase 1 | ENCODES a protein that exhibits oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (ortholog); peroxidase activity (ortholog); prostaglandin-endoperoxide synthase activity (ortholog); INVOLVED IN learning; maintenance of blood-brain barrier; memory; PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Alzheimer's disease; Anaphylaxis; Brain Injuries; FOUND IN nuclear envelope; cytoplasm (ortholog); endoplasmic reticulum lumen (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol | 3 | 39981419 | 40002993 | Rat | 643 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 11184 | Ptgs1 | prostaglandin-endoperoxide synthase 1 | This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclo oxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014] | 2 | 36106758 | 36142287 | Mouse | 728 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 736739 | PTGS1 | prostaglandin-endoperoxide synthase 1 | This is one of two genes encoding similar enzymes that catalyze the conversion of arachidonate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclo oxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2021] | 9 | 122370533 | 122395703 | Human | 632 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8976803 | Ptgs1 | prostaglandin-endoperoxide synthase 1 | ENCODES a protein that exhibits oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (ortholog); peroxidase activity (ortholog); prostaglandin-endoperoxide synthase activity (ortholog); INVOLVED IN cyclooxygenase pathway (ortholog); learning (ortholog ); maintenance of blood-brain barrier (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anaphylaxis (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum lumen (ortholog); nuclear envelope (ortholog) | NW_004955419 | 5678750 | 5699305 | Chinchilla | 130 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11747810 | PTGS1 | prostaglandin-endoperoxide synthase 1 | ENCODES a protein that exhibits dioxygenase activity (inferred); heme binding (inferred); metal ion binding (inferred); INVOLVED IN learning (ortholog); maintenance of blood-brain barrier (ortholog); memory (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pa thway; arachidonic acid metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anaphylaxis (ortholog); autism spectrum disorder (ortholog); FOUND IN nuclear envelope (ortholog) | 9 | 93495365 | 93517557 | Bonobo | 148 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12328669 | PTGS1 | prostaglandin-endoperoxide synthase 1 | ENCODES a protein that exhibits dioxygenase activity (inferred); heme binding (inferred); metal ion binding (inferred); INVOLVED IN learning (ortholog); maintenance of blood-brain barrier (ortholog); memory (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pa thway; arachidonic acid metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anaphylaxis (ortholog); autism spectrum disorder (ortholog); FOUND IN nuclear envelope (ortholog); INTERACTS WITH acetylsalicylic acid; antipyrine; diclofenac | 9 | 60195118 | 60216847 | Dog | 158 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12469762 | Ptgs1 | prostaglandin-endoperoxide synthase 1 | ENCODES a protein that exhibits dioxygenase activity (inferred); heme binding (inferred); metal ion binding (inferred); INVOLVED IN learning (ortholog); maintenance of blood-brain barrier (ortholog); memory (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pa thway; arachidonic acid metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anaphylaxis (ortholog); autism spectrum disorder (ortholog); FOUND IN nuclear envelope (ortholog) | NW_004936487 | 10745465 | 10758812 | Squirrel | 147 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625904031 | Ptgs1 | prostaglandin-endoperoxide synthase 1 | ENCODES a protein that exhibits oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (ortholog); peroxidase activity (ortholog); prostaglandin-endoperoxide synthase activity (ortholog); INVOLVED IN cyclooxygenase pathway (ortholog); learning (ortholog ); maintenance of blood-brain barrier (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anaphylaxis (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum lumen (ortholog); nuclear envelope (ortholog) | | | | Black Rat | 130 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244401 | ptgs1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18491962 | PTGS1 | prostaglandin-endoperoxide synthase 1 | ENCODES a protein that exhibits dioxygenase activity (inferred); heme binding (inferred); metal ion binding (inferred); INVOLVED IN learning (ortholog); maintenance of blood-brain barrier (ortholog); memory (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pa thway; arachidonic acid metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anaphylaxis (ortholog); autism spectrum disorder (ortholog); FOUND IN nuclear envelope (ortholog) | | | | Green Monkey | 147 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935264 | Ptgs1 | prostaglandin-endoperoxide synthase 1 | ENCODES a protein that exhibits oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (ortholog); INVOLVED IN learning (ortholog); maintenance of blood-brain barrier (ortholog); memory (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics p athway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anaphylaxis (ortholog); autism spectrum disorder (ortholog); FOUND IN endoplasmic reticulum lumen (ortholog); nuclear envelope (ortholog); photoreceptor outer segment (ortholog) | | | | Naked Mole-Rat | 144 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13857165 | PTGS1 | prostaglandin-endoperoxide synthase 1 | ENCODES a protein that exhibits dioxygenase activity (inferred); heme binding (inferred); metal ion binding (inferred); INVOLVED IN learning (ortholog); maintenance of blood-brain barrier (ortholog); memory (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pa thway; arachidonic acid metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anaphylaxis (ortholog); autism spectrum disorder (ortholog); FOUND IN nuclear envelope (ortholog); INTERACTS WITH bisphenol A; cadmium atom; deoxynivalenol | | | | Pig | 154 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259332 | ptgs1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16565321 | AL162424.1 | novel transcript, sense intronic to PTGS1 | | | | | Human | | name | gene, lncrna |
| 731006 | PTGS2 | prostaglandin-endoperoxide synthase 2 | Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which diff er in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009] | 1 | 186671791 | 186680423 | Human | 2974 | description | gene, protein-coding, REVIEWED [RefSeq] |