| 620020 | Ptger2 | prostaglandin E receptor 2 | ENCODES a protein that exhibits prostaglandin E receptor activity; INVOLVED IN negative regulation of mucus secretion; positive regulation of gastric mucosal blood circulation; adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH heart disease; allerg ic asthma (ortholog); asthma (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol | 15 | 20694765 | 20708475 | Rat | 225 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734162 | Ptger2 | prostaglandin E receptor 2 (subtype EP2) | Predicted to enable prostaglandin E receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to prostaglandin E stimulus; and response to progesterone. Acts upstream of or within regulation of cell population proliferation; response to lipopolysaccharide; and response to nematode. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human PTGER2 (prostaglandin E receptor 2). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 45225568 | 45241277 | Mouse | 274 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1342884 | PTGER2 | prostaglandin E receptor 2 | This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009] | 14 | 52314312 | 52328598 | Human | 230 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9049626 | Ptger2 | prostaglandin E receptor 2 | ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to prostaglandin E stimulus (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WI TH allergic asthma (ortholog); asthma (ortholog); asthma, nasal polyps, and aspirin intolerance (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955409 | 10760801 | 10775197 | Chinchilla | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12038347 | PTGER2 | prostaglandin E receptor 2 | ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress (ortholog); negative regulation of mucus secretion (ortholog); ASS OCIATED WITH allergic asthma (ortholog); aspirin-induced respiratory disease (ortholog); asthma (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 14 | 32910755 | 32926138 | Bonobo | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12343678 | PTGER2 | prostaglandin E receptor 2 | ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; cellular response to prostaglandin E stimulus (ortholog); ASSOCIATED WITH al lergic asthma (ortholog); asthma (ortholog); asthma, nasal polyps, and aspirin intolerance (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 8 | 28523318 | 28536936 | Dog | 42 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12538215 | Ptger2 | prostaglandin E receptor 2 | ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress (ortholog); negative regulation of mucus secretion (ortholog); ASS OCIATED WITH allergic asthma (ortholog); asthma (ortholog); asthma, nasal polyps, and aspirin intolerance (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936697 | 2440943 | 2453897 | Squirrel | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13877206 | PTGER2 | prostaglandin E receptor 2 | ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress (ortholog); negative regulation of mucus secretion (ortholog); ASS OCIATED WITH allergic asthma (ortholog); aspirin-induced respiratory disease (ortholog); asthma (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Pig | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240626 | ptger2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626119797 | Ptger2 | prostaglandin E receptor 2 | ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to prostaglandin E stimulus (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WI TH allergic asthma (ortholog); asthma (ortholog); asthma, nasal polyps, and aspirin intolerance (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922321 | Ptger2 | prostaglandin E receptor 2 | ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress (ortholog); negative regulation of mucus secretion (ortholog); ASS OCIATED WITH allergic asthma (ortholog); aspirin-induced respiratory disease (ortholog); asthma (ortholog); FOUND IN plasma membrane (ortholog) | | | | Naked Mole-Rat | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18578872 | PTGER2 | prostaglandin E receptor 2 | ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress (ortholog); negative regulation of mucus secretion (ortholog); ASS OCIATED WITH allergic asthma (ortholog); asthma (ortholog); asthma, nasal polyps, and aspirin intolerance (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248236 | ptger2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246212 | ptger2.S | | | | | | African Clawed Frog | | symbol | gene, null |