Pik3ca Gene Search Result

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18 records found for search term Pik3ca

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
620916	Pik3ca	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (ortholog); insulin receptor substrate binding (ortholog); INVOLVED IN negative regulation of gene expression; phosphatidylinositol phosphate biosynthetic process; posi ... (more) tive regulation of smooth muscle cell proliferation; PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH autosomal recessive polycystic kidney disease; hepatocellular carcinoma; adenocarcinoma (ortholog); FOUND IN phosphatidylinositol 3-kinase complex; intercalated disc (ortholog); lamellipodium (ortholog); INTERACTS WITH (+)-taxifolin; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,2',4,4'-Tetrabromodiphenyl ether	2	117103643	117177411	Rat	611	symbol , old_gene_name , PhenoGen	gene, protein-coding, VALIDATED [RefSeq]
1352691	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been impl ... (more) icated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]	3	179148126	179240093	Human	1575	symbol , old_gene_name , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1551142	Pik3ca	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Enables 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding activity; and protein kinase activator activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to hydrostatic pressure; and phosphatidyli ... (more) nositol 3-kinase/protein kinase B signal transduction. Acts upstream of with a negative effect on autosome genomic imprinting. Acts upstream of or within several processes, including cellular response to glucose stimulus; negative regulation of apoptotic process; and regulation of macromolecule metabolic process. Located in intercalated disc and lamellipodium. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including early embryo; eye; and nervous system. Used to study CLOVES syndrome and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]	3	32451203	32520256	Mouse	719	symbol , old_gene_name , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
8979187	Pik3ca	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (ortholog); insulin receptor substrate binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); adipose tissue development (ortholog); aut ... (more) osome genomic imprinting (ortholog); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); adenoid cystic carcinoma (ortholog); Agenesis of Corpus Callosum (ortholog); FOUND IN intercalated disc (ortholog); lamellipodium (ortholog); phosphatidylinositol 3-kinase complex (ortholog)	NW_004955420	8355415	8427024	Chinchilla	291	symbol	gene, protein-coding, MODEL [RefSeq]
11714942	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); autosome genomic imprinting (ortholog); cellular response to glucose stimulus (ortholog); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol ... (more) 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); adenoid cystic carcinoma (ortholog); Agenesis of Corpus Callosum (ortholog); FOUND IN phosphatidylinositol 3-kinase complex (ortholog)	3	176182765	176272024	Bonobo	320	symbol	gene, protein-coding, MODEL [RefSeq]
12218420	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); insulin receptor substrate binding (ortholog); protein kinase activator activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); adipose tissue development (ortholog); autosome genomic imprinting ... (more) (ortholog); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); adenoid cystic carcinoma (ortholog); Agenesis of Corpus Callosum (ortholog); FOUND IN intercalated disc (ortholog); lamellipodium (ortholog); phosphatidylinositol 3-kinase complex (ortholog)	34	12600140	12681905	Dog	310	symbol	gene, protein-coding, MODEL [RefSeq]
12588732	Pik3ca	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); autosome genomic imprinting (ortholog); cellular response to glucose stimulus (ortholog); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol ... (more) 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); adenoid cystic carcinoma (ortholog); Agenesis of Corpus Callosum (ortholog); FOUND IN phosphatidylinositol 3-kinase complex (ortholog)	NW_004936566	3924013	3951052	Squirrel	319	symbol	gene, protein-coding, MODEL [RefSeq]
13937373	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); autosome genomic imprinting (ortholog); cellular response to glucose stimulus (ortholog); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol ... (more) 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); adenoid cystic carcinoma (ortholog); Agenesis of Corpus Callosum (ortholog); FOUND IN phosphatidylinositol 3-kinase complex (ortholog)				Pig	314	symbol	gene, protein-coding, MODEL [RefSeq]
18935734	Pik3ca	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); insulin receptor substrate binding (ortholog); protein kinase activator activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); adipose tissue development (ortholog); autosome genomic imprinting ... (more) (ortholog); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); adenoid cystic carcinoma (ortholog); Agenesis of Corpus Callosum (ortholog); FOUND IN intercalated disc (ortholog); lamellipodium (ortholog); phosphatidylinositol 3-kinase complex (ortholog)				Naked Mole-Rat	315	symbol	gene, protein-coding, MODEL [RefSeq]
155260152	pik3ca						Tropical Clawed Frog		symbol	gene, null
18689729	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); autosome genomic imprinting (ortholog); cellular response to glucose stimulus (ortholog); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol ... (more) 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); adenoid cystic carcinoma (ortholog); Agenesis of Corpus Callosum (ortholog); FOUND IN phosphatidylinositol 3-kinase complex (ortholog)				Green Monkey	320	symbol	gene, protein-coding, MODEL [RefSeq]
625938335	Pik3ca	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (ortholog); insulin receptor substrate binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); adipose tissue development (ortholog); aut ... (more) osome genomic imprinting (ortholog); PARTICIPATES IN adenosine signaling pathway; altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); adenoid cystic carcinoma (ortholog); Agenesis of Corpus Callosum (ortholog); FOUND IN intercalated disc (ortholog); lamellipodium (ortholog); phosphatidylinositol 3-kinase complex (ortholog)				Black Rat	258	symbol	gene, protein-coding, MODEL [RefSeq]
155257679	pik3ca.L						African Clawed Frog		symbol	gene, null
155254640	pik3ca.S						African Clawed Frog		symbol	gene, null
16554317	PIK3CA-DT	PIK3CA divergent transcript		3	179101371	179147973	Human		symbol , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]
16555796	AP000547.1	phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA) pseudogene					Human		name	gene, unprocessed_pseudogene
1607055	APPL1	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA ... (more) IK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]	3	57227729	57273471	Human	245	description	gene, protein-coding, REVIEWED [RefSeq]
1604816	MTFP1	mitochondrial fission process 1	MTP18 is a mitochondrial protein and downstream target of the phosphatidylinositol 3-kinase (see PIK3CA, MIM 171834) signaling pathway that plays a role in cell viability and mitochondrial dynamics (Tondera et al., 2004 [PubMed 15155745]).[supplied by OMIM, Mar ... (more) 2008]	22	30425768	30429054	Human	94	description	gene, protein-coding, VALIDATED [RefSeq]