| 621324 | Pdxk | pyridoxal kinase | ENCODES a protein that exhibits pyridoxal binding; pyridoxal kinase activity; phosphotransferase activity, alcohol group as acceptor (ortholog); INVOLVED IN negative regulation of apoptotic process; pyridoxal phosphate biosynthetic process; response to amine; PARTICIPATES IN hypophosphatasia pathway ; vitamin B6 metabolic pathway; ASSOCIATED WITH Experimental Liver Cirrhosis; FOUND IN cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 1,2-dimethylhydrazine (ortholog); 17alpha-ethynylestradiol (ortholog) | 20 | 10209975 | 10232012 | Rat | 87 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1352351 | PDXK | pyridoxal kinase | ENCODES an ncrna that exhibits phosphotransferase activity, alcohol group as acceptor (ortholog); pyridoxal binding (ortholog); pyridoxal kinase activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); pyridoxal phosphate biosynthetic process (ortholog); response to amin e (ortholog); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN nucleoplasm; cytosol (ortholog); INTERACTS WITH 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 1,2-dimethylhydrazine (ortholog); 17alpha-ethynylestradiol (ortholog) | 21 | 43737000 | 43738097 | Human | 76 | symbol , COSMIC , Human Proteome Map | gene, ncrna, MODEL [RefSeq] |
| 1553638 | Pdxk | pyridoxal (pyridoxine, vitamin B6) kinase | Enables pyridoxal kinase activity. Involved in pyridoxal metabolic process; pyridoxal phosphate metabolic process; and pyridoxamine metabolic process. Is active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensor y organ. Orthologous to human PDXK (pyridoxal kinase). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 78272581 | 78300782 | Mouse | 114 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8918779 | Pdxk | pyridoxal kinase | ENCODES a protein that exhibits phosphotransferase activity, alcohol group as acceptor (ortholog); pyridoxal binding (ortholog); pyridoxal kinase activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); pyridoxal phosphate biosynthetic process (ortholog); response to ami ne (ortholog); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | NW_004955407 | 41482216 | 41494174 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11807824 | PDXK | pyridoxal kinase | ENCODES a protein that exhibits phosphotransferase activity, alcohol group as acceptor (ortholog); pyridoxal binding (ortholog); pyridoxal kinase activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); pyridoxal phosphate biosynthetic process (ortholog); response to ami ne (ortholog); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytosol (ortholog) | 21 | 29977286 | 30021266 | Bonobo | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12192240 | PDXK | pyridoxal kinase | ENCODES a protein that exhibits lithium ion binding (ortholog); magnesium ion binding (ortholog); potassium ion binding (ortholog); INVOLVED IN pyridoxal 5'-phosphate salvage (inferred); pyridoxal phosphate metabolic process (inferred); vitamin B6 metabolic process (inferred); ASSOCIATED WITH Charco t-Marie-Tooth Disease Type 6C (ortholog); status epilepticus (ortholog); FOUND IN nucleoplasm (ortholog) | 31 | 37686002 | 37710059 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12489156 | Pdxk | pyridoxal kinase | ENCODES a protein that exhibits pyridoxal binding (ortholog); pyridoxal kinase activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); pyridoxal phosphate biosynthetic process (ortholog); response to amine (ortholog); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred) | NW_004936500 | 510977 | 539166 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 30302202 | PDXK | pyridoxal kinase | The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] | 21 | 43719129 | 43762299 | Human | 135 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 14163926 | PDXK | pyridoxal kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); lithium ion binding (inferred); INVOLVED IN pyridoxal 5'-phosphate salvage (inferred); pyridoxal phosphate metabolic process (inferred); ASSOCIATED WITH Charcot-Marie-Tooth Disease Type 6C (ortholog); status epilepti cus (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred) | | | | Pig | 29 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18638960 | PDXK | pyridoxal kinase | ENCODES a protein that exhibits phosphotransferase activity, alcohol group as acceptor (ortholog); pyridoxal binding (ortholog); pyridoxal kinase activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); pyridoxal phosphate biosynthetic process (ortholog); response to ami ne (ortholog); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytosol (ortholog) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14375504 | Pdxk | | | | | | Fly | | symbol | gene, null |
| 155244824 | pdxk | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626100339 | Pdxk | pyridoxal kinase | ENCODES a protein that exhibits ATP binding (ortholog); lithium ion binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN pyridoxal 5'-phosphate salvage (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth Disease Type 6C (ortholog); status epilepticus (ortholog); FOUND IN nucleoplasm (orthol og) | | | | Black Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18925605 | Pdxk | pyridoxal kinase | ENCODES a protein that exhibits phosphotransferase activity, alcohol group as acceptor (ortholog); pyridoxal binding (ortholog); pyridoxal kinase activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); pyridoxal phosphate biosynthetic process (ortholog); response to ami ne (ortholog); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14375505 | pdxk-1 | | | | | | Roundworm | | symbol | gene, null |
| 155245632 | pdxk.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155244825 | pdxk.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1624806 | Pdxk-ps | pyridoxal (pyridoxine, vitamin B6) kinase, pseudogene | INTERACTS WITH triptonide | 17 | 32295057 | 32310397 | Mouse | 1 | symbol , PhenoGen | gene, pseudo, VALIDATED [RefSeq] |
| 16552382 | AL451046.1 | pyridoxal (pyridoxine, vitamin B6) kinase (PDXK) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1566085 | Pdxkl1 | pyridoxal kinase like 1 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); metal ion binding (inferred); INVOLVED IN pyridoxal 5'-phosphate salvage (inferred); pyridoxal phosphate metabolic process (inferred); vitamin B6 metabolic process (inferred); PARTICIPATES IN vitamin B6 metabolic pat hway; FOUND IN cytosol (inferred); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 20 | 10162634 | 10192271 | Rat | 33 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 16572591 | AP001053.1 | novel transcript, sense intronic to C21orf33and PDXKand MX2 | | | | | Human | | name | gene, lncrna |