| 3185 | Nos2 | nitric oxide synthase 2 | ENCODES a protein that exhibits actin binding; beta-catenin binding; cadherin binding; INVOLVED IN blood vessel remodeling; cellular response to cytokine stimulus; cellular response to interleukin-1; PARTICIPATES IN endothelin signaling pathway; hypoxia inducible factor pathway; interleukin-12 signa ling pathway; ASSOCIATED WITH abdominal aortic aneurysm; Acute Hepatitis; Acute Liver Failure; FOUND IN cytoplasm; cytosol; extracellular space; INTERACTS WITH (+)-pilocarpine; (+)-sesamin; (+)-Tetrandrine | 10 | 64313335 | 64349221 | Rat | 2445 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10996 | Nos2 | nitric oxide synthase 2, inducible | Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three tr anscript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] | 11 | 78811613 | 78851052 | Mouse | 2708 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 730951 | NOS2 | nitric oxide synthase 2 | Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] | 17 | 27756766 | 27800529 | Human | 2448 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8843029 | Nos2 | nitric oxide synthase 2 | ENCODES a protein that exhibits actin binding (ortholog); arginine binding (ortholog); beta-catenin binding (ortholog); INVOLVED IN blood vessel remodeling (ortholog); cellular response to cytokine stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN endothelin signali ng pathway; hypoxia inducible factor pathway; interleukin-12 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN cortical cytoskeleton (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955481 | 5197957 | 5232406 | Chinchilla | 362 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12013113 | NOS2 | nitric oxide synthase 2 | ENCODES a protein that exhibits actin binding (ortholog); beta-catenin binding (ortholog); cadherin binding (ortholog); INVOLVED IN blood vessel remodeling (ortholog); cellular response to cytokine stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN endothelin signali ng pathway; hypoxia inducible factor pathway; interleukin-12 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN extracellular space (ortholog); nucleus (ortholog); perinuclear region of cytoplasm (ortholog) | 17 | 28984295 | 29021516 | Bonobo | 372 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12162018 | NOS2 | nitric oxide synthase 2 | ENCODES a protein that exhibits actin binding (ortholog); beta-catenin binding (ortholog); cadherin binding (ortholog); INVOLVED IN blood vessel remodeling (ortholog); cellular response to cytokine stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN endothelin signali ng pathway; hypoxia inducible factor pathway; interleukin-12 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN extracellular space (ortholog); nucleus (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH hydrogen chloride | 9 | 42171821 | 42210217 | Dog | 393 | symbol , old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12678826 | Nos2 | nitric oxide synthase 2 | ENCODES a protein that exhibits actin binding (ortholog); beta-catenin binding (ortholog); cadherin binding (ortholog); INVOLVED IN blood vessel remodeling (ortholog); cellular response to cytokine stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN endothelin signali ng pathway; hypoxia inducible factor pathway; interleukin-12 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN extracellular space (ortholog); nucleus (ortholog); perinuclear region of cytoplasm (ortholog) | NW_004936538 | 4052277 | 4097051 | Squirrel | 372 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14038749 | NOS2 | nitric oxide synthase 2 | ENCODES a protein that exhibits actin binding (ortholog); beta-catenin binding (ortholog); cadherin binding (ortholog); INVOLVED IN blood vessel remodeling (ortholog); cellular response to cytokine stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN endothelin signali ng pathway; hypoxia inducible factor pathway; interleukin-12 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN extracellular space (ortholog); nucleus (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH aldehydo-D-glucose; cadmium atom; cadmium dichloride | | | | Pig | 414 | symbol , old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18697346 | NOS2 | nitric oxide synthase 2 | ENCODES a protein that exhibits actin binding (ortholog); beta-catenin binding (ortholog); cadherin binding (ortholog); INVOLVED IN blood vessel remodeling (ortholog); cellular response to cytokine stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN endothelin signali ng pathway; hypoxia inducible factor pathway; interleukin-12 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN extracellular space (ortholog); nucleus (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Green Monkey | 372 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918639 | Nos2 | nitric oxide synthase 2 | ENCODES a protein that exhibits actin binding (ortholog); arginine binding (ortholog); beta-catenin binding (ortholog); INVOLVED IN blood vessel remodeling (ortholog); cellular response to cytokine stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN endothelin signali ng pathway; hypoxia inducible factor pathway; interleukin-12 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN cortical cytoskeleton (ortholog); cytoplasm (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 371 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246741 | nos2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626125594 | Nos2 | nitric oxide synthase 2 | ENCODES a protein that exhibits actin binding (ortholog); arginine binding (ortholog); beta-catenin binding (ortholog); INVOLVED IN blood vessel remodeling (ortholog); cellular response to cytokine stimulus (ortholog); cellular response to interleukin-1 (ortholog); PARTICIPATES IN endothelin signali ng pathway; hypoxia inducible factor pathway; interleukin-12 signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN cortical cytoskeleton (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 362 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258125 | nos2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241358 | nos2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2323679 | Nos2-ps1 | nitric oxide synthase 2, pseudogene 1 | | 10 | 64358012 | 64405334 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1354099 | NANOS2 | nanos C2HC-type zinc finger 2 | Enables enzyme activator activity. Involved in mRNA destabilization and negative regulation of translation. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 45913214 | 45914778 | Human | 66 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1622821 | Nanos2 | nanos C2HC-type zinc finger 2 | Enables mRNA binding activity. Involved in several processes, including germ-line stem cell population maintenance; mRNA catabolic process; and negative regulation of meiotic nuclear division. Located in P-body and perinuclear region of cytoplasm. Is expressed in early conceptus; gonad; mesonephros; and telencephalon. Orthologous to human NANOS2 (nanos C2HC-type zinc finger 2). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 18721449 | 18722887 | Mouse | 78 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 16553195 | AC009477.1 | nitric oxide synthase 2A (NOS2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16563763 | AC015688.1 | nitric oxide synthase 2, inducible (NOS2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16564278 | AC053481.4 | nitric oxide synthase 2, inducible (NOS2) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 16570044 | AC243829.7 | nitric oxide synthase 2, inducible (NOS2) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 16561233 | CR383656.2 | nitric oxide synthase 2, inducible (NOS2) pseudogene | | | | | Human | | name | gene, transcribed_processed_pseudogene |
| 1350414 | NOS2P1 | nitric oxide synthase 2 pseudogene 1 | | 17 | 27651443 | 27664655 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1343413 | NOS2P2 | nitric oxide synthase 2 pseudogene 2 | INTERACTS WITH aristolochic acid A | 17 | 18497090 | 18503285 | Human | 1 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 2301119 | NOS2P3 | nitric oxide synthase 2 pseudogene 3 | INTERACTS WITH aristolochic acid A | 17 | 20436824 | 20447244 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 8661810 | NOS2P4 | nitric oxide synthase 2 pseudogene 4 | | 17 | 16812441 | 16812651 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1553657 | Cd74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | Enables MHC class II protein binding activity; cytokine receptor activity; and nitric-oxide synthase binding activity. Contributes to cytokine binding activity. Involved in several processes, including macrophage migration inhibitory factor signaling pathway; positive regulation of cytokine producti on; and regulation of signal transduction. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; regulation of T cell differentiation; and thymic T cell selection. Located in several cellular components, including external side of plasma membrane; lysosome; and multivesicular body. Part of MHC class II protein complex; NOS2-CD74 complex; and macrophage migration inhibitory factor receptor complex. Is expressed in lower jaw; lower jaw incisor; lower jaw molar; and thymus primordium. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 60936921 | 60945724 | Mouse | 481 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1351047 | IL12A | interleukin 12A | This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008] | 3 | 159988835 | 159996019 | Human | 479 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 16553488 | AP000532.1 | nitric oxide synthase 2A (inducible, hepatocytes) (NOS2A) pseudogene. | | | | | Human | | name | gene, unprocessed_pseudogene |