Nanos2 (nanos C2HC-type zinc finger 2) - Rat Genome Database

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Gene: Nanos2 (nanos C2HC-type zinc finger 2) Mus musculus
Analyze
Symbol: Nanos2
Name: nanos C2HC-type zinc finger 2
RGD ID: 1622821
MGI Page MGI
Description: Enables mRNA binding activity. Involved in several processes, including germ-line stem cell population maintenance; mRNA catabolic process; and negative regulation of meiotic nuclear division. Located in P-body and perinuclear region of cytoplasm. Is expressed in early conceptus; gonad; mesonephros; and telencephalon. Orthologous to human NANOS2 (nanos C2HC-type zinc finger 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: n; nanos homolog 2; nanos homolog 2 (Drosophila); NOS-2; nos2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39718,721,449 - 18,722,887 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl718,721,325 - 18,722,887 (+)EnsemblGRCm39 Ensembl
GRCm38718,987,524 - 18,988,962 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl718,987,400 - 18,988,962 (+)EnsemblGRCm38mm10GRCm38
MGSCv37719,572,873 - 19,574,311 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,146,046 - 18,147,484 (+)NCBIMGSCv36mm8
Celera716,399,407 - 16,400,845 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,ISO)
nucleus  (IEA,ISO)
P-body  (IDA)
perinuclear region of cytoplasm  (IBA,IDA,ISO,ISS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12947200   PMID:14656712   PMID:14681479   PMID:16806845   PMID:17138666   PMID:18281459   PMID:19745153   PMID:19818747   PMID:20133598   PMID:20159962   PMID:20652721   PMID:20707993  
PMID:20833365   PMID:20965161   PMID:21115610   PMID:21267068   PMID:21504946   PMID:21621532   PMID:21674058   PMID:21873635   PMID:21991325   PMID:22071108   PMID:22102605   PMID:22190708  
PMID:22262692   PMID:22360967   PMID:22393026   PMID:22448252   PMID:23034635   PMID:23221368   PMID:23284137   PMID:23497137   PMID:24038201   PMID:24183939   PMID:24576537   PMID:24850856  
PMID:25142465   PMID:25344072   PMID:25416063   PMID:25605784   PMID:25725066   PMID:26120033   PMID:26589352   PMID:26609159   PMID:27072294   PMID:28118982   PMID:28128212   PMID:28162974  
PMID:28341395   PMID:28760667   PMID:29339164   PMID:29501710   PMID:29545285   PMID:30322389   PMID:30679547   PMID:31095680   PMID:32339196   PMID:32452519   PMID:32929012   PMID:33199444  
PMID:33199844   PMID:33912935   PMID:34278268   PMID:34401671   PMID:34494084   PMID:34686326   PMID:35394008   PMID:35426065   PMID:35705038   PMID:36796745   PMID:38355793  


Genomics

Comparative Map Data
Nanos2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39718,721,449 - 18,722,887 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl718,721,325 - 18,722,887 (+)EnsemblGRCm39 Ensembl
GRCm38718,987,524 - 18,988,962 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl718,987,400 - 18,988,962 (+)EnsemblGRCm38mm10GRCm38
MGSCv37719,572,873 - 19,574,311 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,146,046 - 18,147,484 (+)NCBIMGSCv36mm8
Celera716,399,407 - 16,400,845 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.45NCBI
NANOS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,913,214 - 45,914,778 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,913,214 - 45,914,778 (-)EnsemblGRCh38hg38GRCh38
GRCh371946,416,472 - 46,418,036 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,108,312 - 51,109,876 (-)NCBINCBI36Build 36hg18NCBI36
Build 341951,108,314 - 51,109,876NCBI
Celera1943,221,499 - 43,223,063 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,844,824 - 42,846,388 (-)NCBIHuRef
CHM1_11946,418,965 - 46,420,529 (-)NCBICHM1_1
T2T-CHM13v2.01948,740,655 - 48,742,219 (-)NCBIT2T-CHM13v2.0
Nanos2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,763,716 - 87,765,176 (+)NCBIGRCr8
mRatBN7.2178,635,668 - 78,637,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,635,668 - 78,637,128 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,024,658 - 84,026,118 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,582,270 - 92,583,730 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0185,779,762 - 85,781,222 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,894,450 - 79,895,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,894,450 - 79,895,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,155,091 - 81,156,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,341,105 - 78,342,565 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,101,755 - 73,103,215 (+)NCBICelera
Cytogenetic Map1q21NCBI
Nanos2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574333,116 - 333,529 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574333,007 - 333,529 (-)NCBIChiLan1.0ChiLan1.0
NANOS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22052,077,294 - 52,086,515 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,948,686 - 53,957,908 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,922,655 - 42,924,679 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,458,466 - 51,460,116 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,459,529 - 51,459,945 (-)Ensemblpanpan1.1panPan2
NANOS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,716,634 - 109,717,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,716,699 - 109,717,115 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,202,035 - 109,203,102 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,251,017 - 110,252,084 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,251,082 - 110,251,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,925,501 - 109,926,568 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,560,220 - 109,561,287 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,428,944 - 110,430,011 (+)NCBIUU_Cfam_GSD_1.0
Nanos2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,884,913 - 17,885,868 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367062,232,265 - 2,232,657 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367062,232,265 - 2,232,657 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NANOS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,219,418 - 52,219,834 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,218,889 - 52,219,834 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,481,251 - 47,481,667 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NANOS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,359,581 - 39,361,699 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl639,360,640 - 39,361,056 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607319,001,703 - 19,003,343 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nanos2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248327,309,334 - 7,310,645 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:339
Count of miRNA genes:265
Interacting mature miRNAs:293
Transcripts:ENSMUST00000063563
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse

Markers in Region
Nanos2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37719,573,137 - 19,573,629UniSTSGRCm37
Celera716,399,671 - 16,400,163UniSTS
Cytogenetic Map7A3UniSTS
cM Map7 UniSTS
UniSTS:489564  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38718,987,559 - 18,988,324UniSTSGRCm38
MGSCv37719,572,908 - 19,573,673UniSTSGRCm37
Celera716,399,442 - 16,400,207UniSTS
Cytogenetic Map7A3UniSTS
Nanos2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38718,987,788 - 18,988,280UniSTSGRCm38
MGSCv37719,573,137 - 19,573,629UniSTSGRCm37
Celera716,399,671 - 16,400,163UniSTS
Cytogenetic Map7A3UniSTS
cM Map7 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000063563   ⟹   ENSMUSP00000069765
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl718,721,325 - 18,722,887 (+)Ensembl
GRCm38.p6 Ensembl718,987,400 - 18,988,962 (+)Ensembl
RefSeq Acc Id: NM_194064   ⟹   NP_918953
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39718,721,449 - 18,722,887 (+)NCBI
GRCm38718,987,524 - 18,988,962 (+)ENTREZGENE
MGSCv37719,572,873 - 19,574,311 (+)RGD
Celera716,399,407 - 16,400,845 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_918953 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AFN66120 (Get FASTA)   NCBI Sequence Viewer  
  BAC82557 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000069765
  ENSMUSP00000069765.8
GenBank Protein P60322 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_918953   ⟸   NM_194064
- UniProtKB: F8VQ09 (UniProtKB/Swiss-Prot),   P60322 (UniProtKB/Swiss-Prot),   I6ZHM2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000069765   ⟸   ENSMUST00000063563
Protein Domains
Nanos-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60322-F1-model_v2 AlphaFold P60322 1-136 view protein structure

Promoters
RGD ID:6892020
Promoter ID:EPDNEW_M9461
Type:initiation region
Name:Nanos2_1
Description:Mus musculus nanos C2HC-type zinc finger 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38718,987,568 - 18,987,628EPDNEW
RGD ID:6841612
Promoter ID:MM_KWN:49011
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:NM_194064
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36719,573,246 - 19,573,746 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676627 AgrOrtholog
Ensembl Genes ENSMUSG00000051965 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000063563 ENTREZGENE
  ENSMUST00000063563.9 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.60.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Nanos/Xcar2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nanos_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_nanos-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:378430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2676627 ENTREZGENE
NCBI Gene 378430 ENTREZGENE
PANTHER NANOS HOMOLOG 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12887 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-nanos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nanos2 PhenoGen
PROSITE ZF_NANOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F8VQ09 ENTREZGENE
  I6ZHM2 ENTREZGENE, UniProtKB/TrEMBL
  NANO2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F8VQ09 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Nanos2  nanos C2HC-type zinc finger 2    nanos homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED