NANOS2 (nanos C2HC-type zinc finger 2)

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Gene: NANOS2 (nanos C2HC-type zinc finger 2) Canis lupus familiaris

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Symbol:

NANOS2

Name:

nanos C2HC-type zinc finger 2

RGD ID:

12337878

Description:

ENCODES a protein that exhibits enzyme activator activity (inferred); metal ion binding (inferred); mRNA binding (inferred); INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH male infertility (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); P-body (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

nanos homolog 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	109,716,634 - 109,717,701 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	109,716,699 - 109,717,115 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	109,202,035 - 109,203,102 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	110,251,017 - 110,252,084 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	110,251,082 - 110,251,498 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	109,925,501 - 109,926,568 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	109,560,220 - 109,561,287 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	110,428,944 - 110,430,011 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

male infertility (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

germ-line stem cell population maintenance (IEA)

mRNA catabolic process (IEA)

mRNA destabilization (IEA)

negative regulation of meiotic nuclear division (IEA)

negative regulation of translation (IEA)

regulation of translation (IEA)

spermatogenesis (IEA,ISO)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

P-body (IEA)

perinuclear region of cytoplasm (IEA)

Molecular Function

enzyme activator activity (IEA)

metal ion binding (IEA)

mRNA binding (IEA)

protein binding (ISO)

RNA binding (IEA)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

NANOS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	109,716,634 - 109,717,701 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	109,716,699 - 109,717,115 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	109,202,035 - 109,203,102 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	110,251,017 - 110,252,084 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	110,251,082 - 110,251,498 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	109,925,501 - 109,926,568 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	109,560,220 - 109,561,287 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	110,428,944 - 110,430,011 (+)	NCBI		UU_Cfam_GSD_1.0

NANOS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	45,913,214 - 45,914,778 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	45,913,214 - 45,914,778 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	46,416,472 - 46,418,036 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	51,108,312 - 51,109,876 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	51,108,314 - 51,109,876	NCBI
Celera	19	43,221,499 - 43,223,063 (-)	NCBI		Celera
Cytogenetic Map	19	q13.32	NCBI
HuRef	19	42,844,824 - 42,846,388 (-)	NCBI		HuRef
CHM1_1	19	46,418,965 - 46,420,529 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	48,740,655 - 48,742,219 (-)	NCBI		T2T-CHM13v2.0

Nanos2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	18,721,449 - 18,722,887 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	18,721,325 - 18,722,887 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	18,987,524 - 18,988,962 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	18,987,400 - 18,988,962 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	19,572,873 - 19,574,311 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	18,146,046 - 18,147,484 (+)	NCBI		MGSCv36	mm8
Celera	7	16,399,407 - 16,400,845 (+)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	9.45	NCBI

Nanos2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	87,763,716 - 87,765,176 (+)	NCBI		GRCr8
mRatBN7.2	1	78,635,668 - 78,637,128 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	78,635,668 - 78,637,128 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	84,024,658 - 84,026,118 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	92,582,270 - 92,583,730 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	85,779,762 - 85,781,222 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	79,894,450 - 79,895,910 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	79,894,450 - 79,895,910 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	81,155,091 - 81,156,551 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	78,341,105 - 78,342,565 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	73,101,755 - 73,103,215 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Nanos2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955574	333,116 - 333,529 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955574	333,007 - 333,529 (-)	NCBI	ChiLan1.0	ChiLan1.0

NANOS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	52,077,294 - 52,086,515 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	53,948,686 - 53,957,908 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	42,922,655 - 42,924,679 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	51,458,466 - 51,460,116 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	51,459,529 - 51,459,945 (-)	Ensembl	panpan1.1		panPan2

Nanos2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	17,884,913 - 17,885,868 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936706	2,232,265 - 2,232,657 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936706	2,232,265 - 2,232,657 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NANOS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	52,219,418 - 52,219,834 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	52,218,889 - 52,219,834 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	47,481,251 - 47,481,667 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NANOS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	39,359,581 - 39,361,699 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	39,360,640 - 39,361,056 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	19,001,703 - 19,003,343 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nanos2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624832	7,309,334 - 7,310,645 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in NANOS2
13 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

endoderm	reproductive system	respiratory system
1	6	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038467805	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038528527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038592806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038656607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_541547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000037883 ⟹ ENSCAFP00000033519

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	1	109,716,699 - 109,717,115 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845008276 ⟹ ENSCAFP00845006510

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	1	110,251,082 - 110,251,498 (+)	Ensembl

RefSeq Acc Id:

XM_038467805 ⟹ XP_038323733

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	1	109,925,501 - 109,926,568 (+)	NCBI

RefSeq Acc Id:

XM_038528527 ⟹ XP_038384455

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	1	110,428,944 - 110,430,011 (+)	NCBI

RefSeq Acc Id:

XM_038592806 ⟹ XP_038448734

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	1	109,560,220 - 109,561,287 (+)	NCBI

RefSeq Acc Id:

XM_038656607 ⟹ XP_038512535

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	1	110,251,017 - 110,252,084 (+)	NCBI

RefSeq Acc Id:

XM_541547 ⟹ XP_541547

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	1	109,716,634 - 109,717,701 (+)	NCBI
Dog10K_Boxer_Tasha	1	109,202,035 - 109,203,102 (+)	NCBI

Sequence:

show sequence

CTGCCCACTGGCCCCAGAGCCCTGGCCTTCTTCCTCTAGCCACCCACCACCTCCGCCTGGGAGC
CATGCAGCTGCCAGCCTTCGACATGTGGAAGGACTACTTTAACCTGAGCAAGGTGGTGTTGGCA
CTGATCCAGAGTGGGGGGCAAAGGCCAGAGGCCCAAGGGAATGGGGAGCCGAGACCTGGGCCCC
AGCTGGGGCAGGATCAGGGTGTGGGAGGGCCGGGGGCCAGCCGAAGCCTGGCCACCCTGTGCAA
TTTCTGCAAGCACAATGGGGAATCGCGCCACGTCTACTCCTCACACCAGCTGAAGACCCCAGAG
GGTGTGGTGGTGTGCCCCATCCTGCGGCATTATGTGTGTCCCTTGTGCGGGGCCACCGGCGGCC
AGGCTCACACGCTCAAGTACTGTCCGCTCAACGGCGGCCAGCAGTCTCTGTACCGCCGCAGTGG
CCGCAATTCAGCTGGCCGCAAGGTCAAGCGCTGAGGATCAGGAGGTGCCTACCCCCCTTCTACC
CCCAACCCTCCTGGTTTGGTCCCTGCCTAGTCTCTGGACCCTCCCCCTGACTCACCCAGCCCTT
TGGAACTTCTGGCTCCCAGAGCTACATCCCTGCGGGATCCTGAAACAACAGGCTGCTGGGGAGC
CCCGCCAGCTCTGCCCCCCGGGGCCTCTCAGGCCTGGAGCTCTGTCCTGGGGGTGTCTGTGGAT
TCTTGGTGAGGCAGGACTGCTGCCCTCTGGACTGCAAGGCCTGGTGGCTCCTTCTGGACCACCG
TTTGTGGATCTTTAGTCTTTCTGGGGGCCAGTGTCACCAGCAGCCCCATGATCCCATTCCTGGT
GGACTTCTTGGATTATTGGACCTAGAGGACCCAGCGTGCTCTCCCAGGCCCAGCCTAAGAACTT
GGAGAGAGTGAACGAGACTGGCTTGGACACTCTAGCCCAAGAACATCAAGATGTGATTCTGACT
TGAGACCAGCTTTGTCCACCTGCTTCAGCCACCACATGTGAACTCATGGTTTCACCGTGGACTT
CCCTGGATTGTTCCTTCCCAGCCCGGGCAGCCCATCCACCGGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038323733	(Get FASTA)	NCBI Sequence Viewer
	XP_038384455	(Get FASTA)	NCBI Sequence Viewer
	XP_038448734	(Get FASTA)	NCBI Sequence Viewer
	XP_038512535	(Get FASTA)	NCBI Sequence Viewer
	XP_541547	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000033519.1
	ENSCAFP00030007104.1
	ENSCAFP00040012061.1
	ENSCAFP00845006510
	ENSCAFP00845006510.1

RefSeq Acc Id:	XP_541547 ⟸ XM_541547
- UniProtKB:	A0A8C0QJZ7 (UniProtKB/TrEMBL), A0A8C0JJU8 (UniProtKB/TrEMBL), A0A8I3MLE5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQLPAFDMWKDYFNLSKVVLALIQSGGQRPEAQGNGEPRPGPQLGQDQGVGGPGASRSLATLCN FCKHNGESRHVYSSHQLKTPEGVVVCPILRHYVCPLCGATGGQAHTLKYCPLNGGQQSLYRRSG RNSAGRKVKR hide sequence

Ensembl Acc Id:

ENSCAFP00000033519 ⟸ ENSCAFT00000037883

RefSeq Acc Id:

XP_038323733 ⟸ XM_038467805

RefSeq Acc Id:

XP_038448734 ⟸ XM_038592806

RefSeq Acc Id:	XP_038512535 ⟸ XM_038656607
- UniProtKB:	A0A8C0QJZ7 (UniProtKB/TrEMBL), A0A8C0JJU8 (UniProtKB/TrEMBL), A0A8I3MLE5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038384455 ⟸ XM_038528527
- UniProtKB:	A0A8C0JJU8 (UniProtKB/TrEMBL), A0A8C0QJZ7 (UniProtKB/TrEMBL), A0A8I3MLE5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845006510 ⟸ ENSCAFT00845008276

Protein Domains

Nanos-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000024541	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030004392	UniProtKB/TrEMBL
	ENSCAFG00040007490	UniProtKB/TrEMBL
	ENSCAFG00845004625	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000037883.2	UniProtKB/TrEMBL
	ENSCAFT00030008086.1	UniProtKB/TrEMBL
	ENSCAFT00040013932.1	UniProtKB/TrEMBL
	ENSCAFT00845008276	ENTREZGENE
	ENSCAFT00845008276.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.60.30	UniProtKB/TrEMBL
InterPro	Nanos/Xcar2	UniProtKB/TrEMBL
	Nanos_sf	UniProtKB/TrEMBL
	Znf_nanos-typ	UniProtKB/TrEMBL
KEGG Report	cfa:484432	UniProtKB/TrEMBL
NCBI Gene	NANOS2	ENTREZGENE
PANTHER	NANOS HOMOLOG 2	UniProtKB/TrEMBL
	PTHR12887	UniProtKB/TrEMBL
Pfam	zf-nanos	UniProtKB/TrEMBL
PROSITE	ZF_NANOS	UniProtKB/TrEMBL
UniProt	A0A8C0JJU8	ENTREZGENE
	A0A8C0QJZ7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3MLE5	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:43614	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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