| 620912 | Nfs1 | NFS1 cysteine desulfurase | ENCODES a protein that exhibits cysteine desulfurase activity (ortholog); protein homodimerization activity (ortholog); sulfur carrier activity (ortholog); INVOLVED IN [2Fe-2S] cluster assembly (ortholog); [4Fe-4S] cluster assembly (ortholog); iron-sulfur cluster assembly (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; thiamine metabolic pathway; ASSOCIATED WITH combined oxidative phosphorylation deficiency 52 (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); mitochondrial [2Fe-2S] assembly complex (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol | 3 | 165097390 | 165119730 | Rat | 152 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 734360 | Nfs1 | nitrogen fixation gene 1 (S. cerevisiae) | Predicted to enable cysteine desulfurase activity and protein homodimerization activity. Involved in [4Fe-4S] cluster assembly and iron incorporation into metallo-sulfur cluster. Located in mitochondrial matrix and nucleus. Part of mitochondrial [2Fe-2S] assembly complex. Is expressed in several str uctures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 52. Orthologous to human NFS1 (NFS1 cysteine desulfurase). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 155965569 | 155986106 | Mouse | 147 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1350532 | NFS1 | NFS1 cysteine desulfurase | Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate m itochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010] | 20 | 35668052 | 35699352 | Human | 165 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8904964 | Nfs1 | NFS1 cysteine desulfurase | ENCODES a protein that exhibits cysteine desulfurase activity (ortholog); protein homodimerization activity (ortholog); sulfur carrier activity (ortholog); INVOLVED IN [2Fe-2S] cluster assembly (ortholog); [4Fe-4S] cluster assembly (ortholog); iron-sulfur cluster assembly (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH combined oxidative phosphorylation deficiency 52 (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); mitochondrial [2Fe-2S] assembly complex (ortholog) | NW_004955422 | 25759988 | 25785560 | Chinchilla | 35 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11701118 | NFS1 | NFS1 cysteine desulfurase | ENCODES a protein that exhibits protein homodimerization activity (ortholog); sulfur carrier activity (ortholog); INVOLVED IN [4Fe-4S] cluster assembly (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH combined oxidative phosphorylation deficie ncy 52 (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); mitochondrial matrix (ortholog) | 20 | 31994509 | 32026776 | Bonobo | 35 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12248422 | NFS1 | NFS1 cysteine desulfurase | ENCODES a protein that exhibits cysteine desulfurase activity (inferred); iron-sulfur cluster binding (inferred); metal ion binding (inferred); INVOLVED IN [4Fe-4S] cluster assembly (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH combined oxi dative phosphorylation deficiency 52 (ortholog); FOUND IN centrosome (inferred); cytosol (inferred); mitochondrial [2Fe-2S] assembly complex (inferred) | 24 | 24593348 | 24614938 | Dog | 41 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12604537 | Nfs1 | NFS1 cysteine desulfurase | ENCODES a protein that exhibits cysteine desulfurase activity (ortholog); protein homodimerization activity (ortholog); sulfur carrier activity (ortholog); INVOLVED IN [2Fe-2S] cluster assembly (ortholog); [4Fe-4S] cluster assembly (ortholog); iron-sulfur cluster assembly (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH combined oxidative phosphorylation deficiency 52 (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); mitochondrial [2Fe-2S] assembly complex (ortholog) | NW_004936561 | 5136692 | 5158266 | Squirrel | 35 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155253312 | nfs1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14377758 | NFS1 | | | | | | Yeast | | symbol | gene, null |
| 625886191 | Nfs1 | NFS1 cysteine desulfurase | ENCODES a protein that exhibits cysteine desulfurase activity (ortholog); protein homodimerization activity (ortholog); sulfur carrier activity (ortholog); INVOLVED IN [2Fe-2S] cluster assembly (ortholog); [4Fe-4S] cluster assembly (ortholog); iron-sulfur cluster assembly (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH combined oxidative phosphorylation deficiency 52 (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); mitochondrial [2Fe-2S] assembly complex (ortholog) | | | | Black Rat | 35 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 13848577 | NFS1 | NFS1 cysteine desulfurase | ENCODES a protein that exhibits cysteine desulfurase activity (inferred); iron-sulfur cluster binding (inferred); metal ion binding (inferred); INVOLVED IN [4Fe-4S] cluster assembly (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH combined oxi dative phosphorylation deficiency 52 (ortholog); FOUND IN centrosome (inferred); cytosol (inferred); mitochondrial [2Fe-2S] assembly complex (inferred) | | | | Pig | 41 | symbol , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14377759 | Nfs1 | | | | | | Fly | | symbol | gene, null |
| 18925024 | Nfs1 | NFS1 cysteine desulfurase | ENCODES a protein that exhibits protein homodimerization activity (ortholog); sulfur carrier activity (ortholog); INVOLVED IN [4Fe-4S] cluster assembly (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH combined oxidative phosphorylation deficie ncy 52 (ortholog); FOUND IN centrosome (ortholog); cytosol (ortholog); mitochondrial matrix (ortholog) | | | | Naked Mole-Rat | 35 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18754094 | NFS1 | NFS1 cysteine desulfurase | ENCODES a protein that exhibits cysteine desulfurase activity (inferred); iron-sulfur cluster binding (inferred); metal ion binding (inferred); INVOLVED IN [4Fe-4S] cluster assembly (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH combined oxi dative phosphorylation deficiency 52 (ortholog); FOUND IN cytosol (ortholog) | | | | Green Monkey | 42 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 155243655 | nfs1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1345825 | LYRM4 | LYR motif containing 4 | The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016] | 6 | 5031753 | 5260950 | Human | 95 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |