NFS1 (NFS1 cysteine desulfurase) - Rat Genome Database

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Gene: NFS1 (NFS1 cysteine desulfurase) Pan paniscus
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Symbol: NFS1
Name: NFS1 cysteine desulfurase
RGD ID: 11701118
Description: ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN [4Fe-4S] cluster assembly (ortholog); iron incorporation into metallo-sulfur cluster (ortholog); molybdopterin cofactor metabolic process (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH combined oxidative phosphorylation deficiency 52 (ortholog); glutathione synthetase deficiency (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cysteine desulfurase; cysteine desulfurase, mitochondrial; NFS1 nitrogen fixation 1 homolog; NFS1, cysteine desulfurase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22141,399,636 - 41,431,798 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12041,392,739 - 41,424,949 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,994,509 - 32,026,776 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12033,116,018 - 33,147,749 (-)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NFS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22141,399,636 - 41,431,798 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12041,392,739 - 41,424,949 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02031,994,509 - 32,026,776 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12033,116,018 - 33,147,749 (-)NCBIpanpan1.1PanPan1.1panPan2
NFS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382035,668,052 - 35,699,352 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2035,668,052 - 35,699,355 (-)EnsemblGRCh38hg38GRCh38
GRCh372034,255,974 - 34,287,274 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362033,720,025 - 33,750,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 342033,745,916 - 33,750,688NCBI
Celera2031,004,905 - 31,035,569 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2031,034,024 - 31,064,670 (-)NCBIHuRef
CHM1_12034,158,261 - 34,189,218 (-)NCBICHM1_1
T2T-CHM13v2.02037,389,027 - 37,420,327 (-)NCBIT2T-CHM13v2.0
Nfs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,965,569 - 155,986,106 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,965,559 - 155,986,106 (-)EnsemblGRCm39 Ensembl
GRCm382156,123,637 - 156,144,202 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2156,123,639 - 156,144,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv372155,949,373 - 155,969,922 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362155,815,090 - 155,835,626 (-)NCBIMGSCv36mm8
Celera2162,059,133 - 162,079,762 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map277.34NCBI
Nfs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83165,097,390 - 165,119,730 (-)NCBIGRCr8
mRatBN7.23144,637,309 - 144,659,660 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,637,309 - 144,659,666 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3148,503,081 - 148,525,423 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03157,120,353 - 157,142,693 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03154,859,878 - 154,882,218 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03151,665,813 - 151,688,151 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,665,814 - 151,688,149 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl3152,200,936 - 152,222,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,030,431 - 158,052,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43146,528,820 - 146,551,156 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3143,359,073 - 143,381,415 (-)NCBICelera
Cytogenetic Map3q42NCBI
Nfs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542225,760,099 - 25,785,108 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542225,759,988 - 25,785,560 (+)NCBIChiLan1.0ChiLan1.0
NFS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12424,593,348 - 24,614,938 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2424,594,264 - 24,614,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2424,238,426 - 24,259,999 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02425,285,895 - 25,307,493 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2425,285,893 - 25,307,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12424,572,224 - 24,593,783 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02424,667,259 - 24,688,864 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02425,106,694 - 25,128,280 (-)NCBIUU_Cfam_GSD_1.0
Nfs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640173,590,462 - 173,613,116 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365615,136,692 - 5,158,266 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1739,000,644 - 39,029,185 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11739,000,659 - 39,029,179 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21744,351,262 - 44,379,781 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,592,304 - 56,617,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,592,308 - 56,617,469 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660872,935,798 - 2,960,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248423,736,411 - 3,774,014 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248423,736,352 - 3,774,456 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_003831863   ⟹   XP_003831911
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22141,399,636 - 41,431,798 (-)NCBI
NHGRI_mPanPan12041,392,739 - 41,424,901 (-)NCBI
Mhudiblu_PPA_v02031,994,509 - 32,026,776 (-)NCBI
PanPan1.12033,116,018 - 33,147,747 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034947354   ⟹   XP_034803245
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22141,399,636 - 41,431,798 (-)NCBI
NHGRI_mPanPan12041,392,739 - 41,424,901 (-)NCBI
Mhudiblu_PPA_v02031,994,509 - 32,026,774 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003831911 (Get FASTA)   NCBI Sequence Viewer  
  XP_034803245 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000031547
  ENSPPAP00000031547.1
  ENSPPAP00000031555.1
  ENSPPAP00000031560.1
  ENSPPAP00000031563.1
  ENSPPAP00000031570.1
RefSeq Acc Id: XP_003831911   ⟸   XM_003831863
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BYF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034803245   ⟸   XM_034947354
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BPG6 (UniProtKB/TrEMBL)
Protein Domains
Aminotransferase class V


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038684 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000054412.1 UniProtKB/TrEMBL
  ENSPPAT00000054420.1 UniProtKB/TrEMBL
  ENSPPAT00000054425.1 UniProtKB/TrEMBL
  ENSPPAT00000054428.1 UniProtKB/TrEMBL
  ENSPPAT00000054435.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro Aminotrans_V_dom UniProtKB/TrEMBL
  Aminotrans_V_PyrdxlP_BS UniProtKB/TrEMBL
  Cys_deSase_IscS UniProtKB/TrEMBL
  Cysteine_dSase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_small UniProtKB/TrEMBL
KEGG Report pps:100988455 UniProtKB/TrEMBL
NCBI Gene NFS1 ENTREZGENE
PANTHER CYSTEINE DESULFURYLASE FAMILY MEMBER UniProtKB/TrEMBL
  PTHR11601:SF34 UniProtKB/TrEMBL
Pfam Aminotran_5 UniProtKB/TrEMBL
PIRSF NifS UniProtKB/TrEMBL
PROSITE AA_TRANSFER_CLASS_5 UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/TrEMBL
UniProt A0A2R9BPG2_PANPA UniProtKB/TrEMBL
  A0A2R9BPG6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BPH5_PANPA UniProtKB/TrEMBL
  A0A2R9BSZ0_PANPA UniProtKB/TrEMBL
  A0A2R9BYF7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 NFS1  NFS1 cysteine desulfurase    NFS1, cysteine desulfurase  Symbol and/or name change 5135510 APPROVED