NFS1 (NFS1 cysteine desulfurase) - Rat Genome Database

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Gene: NFS1 (NFS1 cysteine desulfurase) Sus scrofa
Analyze
Symbol: NFS1
Name: NFS1 cysteine desulfurase
RGD ID: 13848577
Description: ENCODES a protein that exhibits catalytic activity (inferred); cysteine desulfurase activity (inferred); iron-sulfur cluster binding (inferred); INVOLVED IN [4Fe-4S] cluster assembly (ortholog); molybdopterin cofactor metabolic process (ortholog); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH Combined Oxidative Phosphorylation Deficiency 52 (ortholog); FOUND IN cytosol (inferred); iron-sulfur cluster assembly complex (inferred); mitochondrial iron-sulfur cluster assembly complex (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cysteine desulfurase, mitochondrial; nitrogen fixation 1-like protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1739,000,644 - 39,029,185 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11739,000,659 - 39,029,179 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21744,351,262 - 44,379,781 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
NFS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1739,000,644 - 39,029,185 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11739,000,659 - 39,029,179 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21744,351,262 - 44,379,781 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382035,668,052 - 35,699,352 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2035,668,052 - 35,699,355 (-)EnsemblGRCh38hg38GRCh38
GRCh372034,255,974 - 34,287,274 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362033,720,025 - 33,750,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 342033,745,916 - 33,750,688NCBI
Celera2031,004,905 - 31,035,569 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2031,034,024 - 31,064,670 (-)NCBIHuRef
CHM1_12034,158,261 - 34,189,218 (-)NCBICHM1_1
T2T-CHM13v2.02037,389,027 - 37,420,327 (-)NCBIT2T-CHM13v2.0
Nfs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392155,965,557 - 155,986,134 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2155,965,559 - 155,986,106 (-)EnsemblGRCm39 Ensembl
GRCm382156,123,637 - 156,144,202 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2156,123,639 - 156,144,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv372155,949,373 - 155,969,922 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362155,815,090 - 155,835,626 (-)NCBIMGSCv36mm8
Celera2162,059,133 - 162,079,762 (-)NCBICelera
Cytogenetic Map2H1NCBI
Nfs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23144,637,309 - 144,659,660 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3144,637,309 - 144,659,666 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3148,503,081 - 148,525,423 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03157,120,353 - 157,142,693 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03154,859,878 - 154,882,218 (-)NCBIRnor_WKY
Rnor_6.03151,665,813 - 151,688,151 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,665,814 - 151,688,149 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl3152,200,936 - 152,222,647 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,030,431 - 158,052,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43146,528,820 - 146,551,156 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3143,359,073 - 143,381,415 (-)NCBICelera
Cytogenetic Map3q42NCBI
Nfs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542225,760,099 - 25,785,108 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542225,759,988 - 25,785,560 (+)NCBIChiLan1.0ChiLan1.0
NFS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12033,116,018 - 33,147,749 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02031,994,509 - 32,026,776 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NFS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12424,593,348 - 24,614,938 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2424,594,264 - 24,614,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2424,238,426 - 24,259,999 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02425,285,895 - 25,307,493 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2425,285,893 - 25,307,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12424,572,224 - 24,593,783 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02424,667,259 - 24,688,864 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02425,106,694 - 25,128,280 (-)NCBIUU_Cfam_GSD_1.0
Nfs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640173,590,462 - 173,613,116 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365615,136,692 - 5,158,266 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,592,304 - 56,617,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,592,308 - 56,617,469 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660872,935,798 - 2,960,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248423,736,411 - 3,774,014 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248423,736,352 - 3,774,456 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1 3 1 2 12 2 1
Low 9 3 4 11 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000007995   ⟹   ENSSSCP00000007781
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1739,000,644 - 39,029,185 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000052084   ⟹   ENSSSCP00000052905
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1739,000,644 - 39,029,185 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000088539   ⟹   ENSSSCP00000064488
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1739,003,269 - 39,029,173 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000089723   ⟹   ENSSSCP00000062847
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1739,000,660 - 39,027,896 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000098739   ⟹   ENSSSCP00000079137
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1739,009,932 - 39,027,896 (-)Ensembl
RefSeq Acc Id: NM_001136510   ⟹   NP_001129982
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11739,000,659 - 39,029,178 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005672887   ⟹   XP_005672944
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11739,000,659 - 39,029,179 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001129982 (Get FASTA)   NCBI Sequence Viewer  
  XP_005672944 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACI62524 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005672944   ⟸   XM_005672887
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001129982   ⟸   NM_001136510
- UniProtKB: B6UV57 (UniProtKB/TrEMBL),   A0A4X1TC78 (UniProtKB/TrEMBL),   F1S4V7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000064488   ⟸   ENSSSCT00000088539
RefSeq Acc Id: ENSSSCP00000062847   ⟸   ENSSSCT00000089723
RefSeq Acc Id: ENSSSCP00000007781   ⟸   ENSSSCT00000007995
RefSeq Acc Id: ENSSSCP00000052905   ⟸   ENSSSCT00000052084
RefSeq Acc Id: ENSSSCP00000079137   ⟸   ENSSSCT00000098739
Protein Domains
Aminotran_5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007307 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025035970 UniProtKB/TrEMBL
  ENSSSCG00030037503 UniProtKB/TrEMBL
  ENSSSCG00035069640 UniProtKB/TrEMBL
  ENSSSCG00040063126 UniProtKB/TrEMBL
  ENSSSCG00045012310 UniProtKB/TrEMBL
  ENSSSCG00050067154 UniProtKB/TrEMBL
  ENSSSCG00055015340 UniProtKB/TrEMBL
  ENSSSCG00060069014 UniProtKB/TrEMBL
  ENSSSCG00065056444 UniProtKB/TrEMBL
  ENSSSCG00070008008 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000007781 ENTREZGENE
  ENSSSCP00000007781.4 UniProtKB/TrEMBL
  ENSSSCP00000052905.2 UniProtKB/TrEMBL
  ENSSSCP00000062847.1 UniProtKB/TrEMBL
  ENSSSCP00000064488.1 UniProtKB/TrEMBL
  ENSSSCP00025021006.1 UniProtKB/TrEMBL
  ENSSSCP00025021010.1 UniProtKB/TrEMBL
  ENSSSCP00025021024.1 UniProtKB/TrEMBL
  ENSSSCP00025021038.1 UniProtKB/TrEMBL
  ENSSSCP00030023866.1 UniProtKB/TrEMBL
  ENSSSCP00030023875.1 UniProtKB/TrEMBL
  ENSSSCP00030023902.1 UniProtKB/TrEMBL
  ENSSSCP00030023913.1 UniProtKB/TrEMBL
  ENSSSCP00035039580.1 UniProtKB/TrEMBL
  ENSSSCP00035039615.1 UniProtKB/TrEMBL
  ENSSSCP00035039633.1 UniProtKB/TrEMBL
  ENSSSCP00035039641.1 UniProtKB/TrEMBL
  ENSSSCP00040037846.1 UniProtKB/TrEMBL
  ENSSSCP00040037910.1 UniProtKB/TrEMBL
  ENSSSCP00040038004.1 UniProtKB/TrEMBL
  ENSSSCP00040038077.1 UniProtKB/TrEMBL
  ENSSSCP00045014573.1 UniProtKB/TrEMBL
  ENSSSCP00045014590.1 UniProtKB/TrEMBL
  ENSSSCP00045014614.1 UniProtKB/TrEMBL
  ENSSSCP00045014633.1 UniProtKB/TrEMBL
  ENSSSCP00050039436.1 UniProtKB/TrEMBL
  ENSSSCP00050039443.1 UniProtKB/TrEMBL
  ENSSSCP00050039449.1 UniProtKB/TrEMBL
  ENSSSCP00050039456.1 UniProtKB/TrEMBL
  ENSSSCP00055024571.1 UniProtKB/TrEMBL
  ENSSSCP00055024636.1 UniProtKB/TrEMBL
  ENSSSCP00055024688.1 UniProtKB/TrEMBL
  ENSSSCP00055024741.1 UniProtKB/TrEMBL
  ENSSSCP00060040785.1 UniProtKB/TrEMBL
  ENSSSCP00060040791.1 UniProtKB/TrEMBL
  ENSSSCP00060040816.1 UniProtKB/TrEMBL
  ENSSSCP00060040847.1 UniProtKB/TrEMBL
  ENSSSCP00065033574.1 UniProtKB/TrEMBL
  ENSSSCP00065033579.1 UniProtKB/TrEMBL
  ENSSSCP00065033591.1 UniProtKB/TrEMBL
  ENSSSCP00065033595.1 UniProtKB/TrEMBL
  ENSSSCP00070012826.1 UniProtKB/TrEMBL
  ENSSSCP00070012835.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007995 ENTREZGENE
  ENSSSCT00000007995.4 UniProtKB/TrEMBL
  ENSSSCT00000052084.2 UniProtKB/TrEMBL
  ENSSSCT00000088539.1 UniProtKB/TrEMBL
  ENSSSCT00000089723.1 UniProtKB/TrEMBL
  ENSSSCT00025049117.1 UniProtKB/TrEMBL
  ENSSSCT00025049122.1 UniProtKB/TrEMBL
  ENSSSCT00025049174.1 UniProtKB/TrEMBL
  ENSSSCT00025049210.1 UniProtKB/TrEMBL
  ENSSSCT00030052306.1 UniProtKB/TrEMBL
  ENSSSCT00030052327.1 UniProtKB/TrEMBL
  ENSSSCT00030052377.1 UniProtKB/TrEMBL
  ENSSSCT00030052416.1 UniProtKB/TrEMBL
  ENSSSCT00035094234.1 UniProtKB/TrEMBL
  ENSSSCT00035094312.1 UniProtKB/TrEMBL
  ENSSSCT00035094353.1 UniProtKB/TrEMBL
  ENSSSCT00035094388.1 UniProtKB/TrEMBL
  ENSSSCT00040086326.1 UniProtKB/TrEMBL
  ENSSSCT00040086456.1 UniProtKB/TrEMBL
  ENSSSCT00040086640.1 UniProtKB/TrEMBL
  ENSSSCT00040086775.1 UniProtKB/TrEMBL
  ENSSSCT00045021175.1 UniProtKB/TrEMBL
  ENSSSCT00045021203.1 UniProtKB/TrEMBL
  ENSSSCT00045021240.1 UniProtKB/TrEMBL
  ENSSSCT00045021275.1 UniProtKB/TrEMBL
  ENSSSCT00050091589.1 UniProtKB/TrEMBL
  ENSSSCT00050091599.1 UniProtKB/TrEMBL
  ENSSSCT00050091616.1 UniProtKB/TrEMBL
  ENSSSCT00050091630.1 UniProtKB/TrEMBL
  ENSSSCT00055030853.1 UniProtKB/TrEMBL
  ENSSSCT00055030940.1 UniProtKB/TrEMBL
  ENSSSCT00055031014.1 UniProtKB/TrEMBL
  ENSSSCT00055031077.1 UniProtKB/TrEMBL
  ENSSSCT00060094291.1 UniProtKB/TrEMBL
  ENSSSCT00060094313.1 UniProtKB/TrEMBL
  ENSSSCT00060094383.1 UniProtKB/TrEMBL
  ENSSSCT00060094458.1 UniProtKB/TrEMBL
  ENSSSCT00065077263.1 UniProtKB/TrEMBL
  ENSSSCT00065077269.1 UniProtKB/TrEMBL
  ENSSSCT00065077291.1 UniProtKB/TrEMBL
  ENSSSCT00065077296.1 UniProtKB/TrEMBL
  ENSSSCT00070015502.1 UniProtKB/TrEMBL
  ENSSSCT00070015514.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro Aminotrans_V_dom UniProtKB/TrEMBL
  Aminotrans_V_PyrdxlP_BS UniProtKB/TrEMBL
  Cys_deSase_IscS UniProtKB/TrEMBL
  Cysteine_dSase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
KEGG Report ssc:100156145 UniProtKB/TrEMBL
NCBI Gene NFS1 ENTREZGENE
PANTHER PTHR11601:SF34 UniProtKB/TrEMBL
Pfam Aminotran_5 UniProtKB/TrEMBL
PIRSF NifS UniProtKB/TrEMBL
PROSITE AA_TRANSFER_CLASS_5 UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/TrEMBL
TIGRFAMs IscS UniProtKB/TrEMBL
UniProt A0A287B8T9_PIG UniProtKB/TrEMBL
  A0A4X1T9V1_PIG UniProtKB/TrEMBL
  A0A4X1TC78 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QGC5_PIG UniProtKB/TrEMBL
  A0A5G2R1T1_PIG UniProtKB/TrEMBL
  A0A8D0RRI8_PIG UniProtKB/TrEMBL
  A0A8D0RYH5_PIG UniProtKB/TrEMBL
  B6UV57 ENTREZGENE, UniProtKB/TrEMBL
  F1S4V7 ENTREZGENE
UniProt Secondary A0A288CFX5 UniProtKB/TrEMBL
  F1S4V7 UniProtKB/TrEMBL
VGNC ID VGNC:99724 ENTREZGENE