| 70881 | Itih4 | inter-alpha-trypsin inhibitor heavy chain 4 | ENCODES a protein that exhibits peptidase inhibitor activity (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN acute-phase response (ortholog); response to cytokine (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis; Colonic Neoplasms; Invasive Pulmonary Aspergi llosis; FOUND IN extracellular space; cytoplasm (ortholog); plasma membrane (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,4-dinitrotoluene | 16 | 6086985 | 6102162 | Rat | 171 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 737492 | ITIH4 | inter-alpha-trypsin inhibitor heavy chain 4 | The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] | 3 | 52812962 | 52830672 | Human | 174 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737493 | Itih4 | inter alpha-trypsin inhibitor, heavy chain 4 | This gene encodes a member of the inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors with diverse functions as anti-apoptotic and matrix stabilizing molecules during development. This gene is predominantly expressed in the liver and the encoded protein was found to be a plasma kallikrein-sensitive glycoprotein. This gene is located in a cluster of related inter alpha trypsin inhibitor genes on chromosome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015] | 14 | 30608433 | 30623943 | Mouse | 174 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 9040693 | Itih4 | inter-alpha-trypsin inhibitor heavy chain 4 | INVOLVED IN acute-phase response (ortholog); response to cytokine (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Bacteremia (ortholog); Chronic Hepatitis B (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); plasma membrane (ortholog) | NW_004955430 | 2772064 | 2787912 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11902127 | ITIH4 | inter-alpha-trypsin inhibitor heavy chain 4 | ENCODES a protein that exhibits peptidase inhibitor activity (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN acute-phase response (inferred); hyaluronan metabolic process (inferred); response to cytokine (inferred); ASSOCIATED WITH amyotrophic lateral sclerosis (orth olog); Bacteremia (ortholog); Chronic Hepatitis B (ortholog); FOUND IN extracellular space (ortholog) | 3 | 52754664 | 52774867 | Bonobo | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12661168 | Itih4 | inter-alpha-trypsin inhibitor heavy chain 4 | ENCODES a protein that exhibits peptidase inhibitor activity (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN acute-phase response (inferred); hyaluronan metabolic process (inferred); response to cytokine (inferred); ASSOCIATED WITH amyotrophic lateral sclerosis (orth olog); Bacteremia (ortholog); Chronic Hepatitis B (ortholog); FOUND IN extracellular space (ortholog) | NW_004936473 | 3573282 | 3589345 | Squirrel | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625933821 | Itih4 | inter-alpha-trypsin inhibitor heavy chain 4 | INVOLVED IN acute-phase response (ortholog); response to cytokine (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Bacteremia (ortholog); Chronic Hepatitis B (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); plasma membrane (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922555 | Itih4 | inter-alpha-trypsin inhibitor heavy chain 4 | ENCODES a protein that exhibits peptidase inhibitor activity (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN acute-phase response (ortholog); response to cytokine (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Bacteremia (ortholog); Chronic Hep atitis B (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287814281 | itih4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18783815 | ITIH4 | inter-alpha-trypsin inhibitor heavy chain 4 | ENCODES a protein that exhibits calcium channel regulator activity (inferred); peptidase inhibitor activity (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN acute-phase response (inferred); chondrocyte differentiation (inferred); chondrocyte proliferation (inferred); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Bacteremia (ortholog); Chronic Hepatitis B (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12166456 | ITIH4 | inter-alpha-trypsin inhibitor heavy chain 4 | ENCODES a protein that exhibits peptidase inhibitor activity (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN acute-phase response (inferred); hyaluronan metabolic process (inferred); response to cytokine (inferred); ASSOCIATED WITH amyotrophic lateral sclerosis (orth olog); Bacteremia (ortholog); Chronic Hepatitis B (ortholog); FOUND IN extracellular space (ortholog) | | | | Dog | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14237275 | ITIH4 | inter-alpha-trypsin inhibitor heavy chain 4 | ENCODES a protein that exhibits peptidase inhibitor activity (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN acute-phase response; response to cytokine; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Bacteremia (ortholog); Chronic Hepatitis B (ortholog); F OUND IN extracellular space (ortholog); INTERACTS WITH dibromine | | | | Pig | 34 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 287814279 | itih4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6481341 | ITIH4-AS1 | ITIH4 antisense RNA 1 | | 3 | 52823935 | 52825314 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 16557796 | AC006254.1 | novel MUSTN1-ITIH4 readthrough | INVOLVED IN chondrocyte differentiation (inferred); chondrocyte proliferation (inferred); tissue regeneration (inferred); FOUND IN nucleus (inferred) | | | | Human | 5 | name | gene, protein-coding |
