ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) - Rat Genome Database

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Gene: ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) Chlorocebus sabaeus
Analyze
Symbol: ITIH4
Name: inter-alpha-trypsin inhibitor heavy chain 4
RGD ID: 18783815
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); hyaluronic acid binding (ortholog); INVOLVED IN acute-phase response (inferred); chondrocyte differentiation (inferred); chondrocyte proliferation (inferred); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Bacteremia (ortholog); Chronic Hepatitis B (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inter-alpha-trypsin inhibitor heavy chain family member 4; inter-alpha-trypsin inhibitor heavy chain H4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,194,979 - 14,216,180 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,195,701 - 14,213,603 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,684,251 - 152,702,173 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ITIH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,194,979 - 14,216,180 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,195,701 - 14,213,603 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,684,251 - 152,702,173 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ITIH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,812,962 - 52,830,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,812,962 - 52,830,688 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,846,978 - 52,864,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,822,046 - 52,839,734 (-)NCBINCBI36Build 36hg18NCBI36
Build 34352,822,045 - 52,839,734NCBI
Celera352,825,723 - 52,843,435 (-)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,908,665 - 52,926,377 (-)NCBIHuRef
CHM1_1352,799,205 - 52,816,916 (-)NCBICHM1_1
T2T-CHM13v2.0352,845,872 - 52,863,582 (-)NCBIT2T-CHM13v2.0
Itih4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,608,433 - 30,623,943 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,608,433 - 30,624,310 (+)EnsemblGRCm39 Ensembl
GRCm381430,886,476 - 30,901,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,886,476 - 30,902,353 (+)EnsemblGRCm38mm10GRCm38
MGSCv371431,699,678 - 31,715,169 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,715,522 - 29,730,858 (+)NCBIMGSCv36mm8
Celera1427,143,865 - 27,159,266 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
Itih4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,086,985 - 6,102,162 (+)NCBIGRCr8
mRatBN7.2166,080,539 - 6,095,710 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,080,539 - 6,095,708 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,091,889 - 6,107,055 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,237,346 - 7,252,512 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,099,223 - 6,114,442 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,970,367 - 6,985,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,970,342 - 6,985,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,896,782 - 6,912,274 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,319,608 - 6,334,782 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,319,608 - 6,334,777 (+)NCBI
Celera169,093,866 - 9,109,046 (-)NCBICelera
Cytogenetic Map16p16NCBI
Itih4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,770,373 - 2,789,131 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,772,064 - 2,787,912 (-)NCBIChiLan1.0ChiLan1.0
ITIH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,807,876 - 52,832,769 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,754,664 - 52,774,867 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,980,529 - 54,000,560 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,980,668 - 53,998,038 (-)Ensemblpanpan1.1panPan2
ITIH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2036,984,232 - 36,999,685 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,352,995 - 37,368,452 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,352,366 - 37,401,740 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.02037,125,001 - 37,140,491 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,402,544 - 37,418,024 (+)NCBIUU_Cfam_GSD_1.0
Itih4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,434,701 - 170,450,834 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,573,384 - 3,589,345 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,573,282 - 3,589,345 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITIH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,928,439 - 34,948,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,928,455 - 34,948,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,197,507 - 38,209,005 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Itih4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,397,744 - 4,411,406 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,397,704 - 4,411,562 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 36 17 60
Below cutoff 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000011185   ⟹   ENSCSAP00000009266
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2214,216,177 - 14,238,888 (-)Ensembl
RefSeq Acc Id: ENSCSAT00000011218   ⟹   ENSCSAP00000009297
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2214,195,701 - 14,213,603 (-)Ensembl
RefSeq Acc Id: XM_038003795   ⟹   XP_037859723
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666041152,684,251 - 152,702,173 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037859723 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009266.1
  ENSCSAP00000009297.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000009297   ⟸   ENSCSAT00000011218
RefSeq Acc Id: XP_037859723   ⟸   XM_038003795
- UniProtKB: A0A0D9RL08 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000009266   ⟸   ENSCSAT00000011185


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013113 Ensembl, UniProtKB/TrEMBL
  ENSCSAG00000013190 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011185.1 UniProtKB/TrEMBL
  ENSCSAT00000011218.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
InterPro ITI_HC_C UniProtKB/TrEMBL
  MUSTN1 UniProtKB/TrEMBL
  STIMATE/YPL162C UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene ITIH4 ENTREZGENE
PANTHER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER UniProtKB/TrEMBL
  INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4 UniProtKB/TrEMBL
  STORE-OPERATED CALCIUM ENTRY REGULATOR STIMATE UniProtKB/TrEMBL
  VACUOLAR MEMBRANE PROTEIN YPL162C UniProtKB/TrEMBL
Pfam ITI_HC_C UniProtKB/TrEMBL
  Mustang UniProtKB/TrEMBL
  STIMATE UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PROSITE VIT UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
SMART VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
UniProt A0A0D9RKX7_CHLSB UniProtKB/TrEMBL
  A0A0D9RL08 ENTREZGENE, UniProtKB/TrEMBL