ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) - Rat Genome Database

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Gene: ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) Canis lupus familiaris
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Symbol: ITIH4
Name: inter-alpha-trypsin inhibitor heavy chain 4
RGD ID: 12166456
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); hyaluronic acid binding (ortholog); INVOLVED IN acute-phase response (inferred); hyaluronan metabolic process (inferred); negative regulation of endopeptidase activity (inferred); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Bacteremia (ortholog); Chronic Hepatitis B (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein); inter-alpha-trypsin inhibitor heavy chain family member 4; inter-alpha-trypsin inhibitor heavy chain H4; LOW QUALITY PROTEIN: inter-alpha-trypsin inhibitor heavy chain H4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2036,984,232 - 36,999,685 (+)NCBI
ROS_Cfam_1.02037,352,995 - 37,368,452 (+)NCBI
UNSW_CanFamBas_1.02037,125,001 - 37,140,491 (+)NCBI
UU_Cfam_GSD_1.02037,402,544 - 37,418,024 (+)NCBI


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
ITIH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2036,984,232 - 36,999,685 (+)NCBI
ROS_Cfam_1.02037,352,995 - 37,368,452 (+)NCBI
UNSW_CanFamBas_1.02037,125,001 - 37,140,491 (+)NCBI
UU_Cfam_GSD_1.02037,402,544 - 37,418,024 (+)NCBI
ITIH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl352,812,962 - 52,830,688 (-)EnsemblGRCh38hg38GRCh38
GRCh38352,812,962 - 52,830,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37352,846,978 - 52,864,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,822,046 - 52,839,734 (-)NCBINCBI36hg18NCBI36
Build 34352,822,045 - 52,839,734NCBI
Celera352,825,723 - 52,843,435 (-)NCBI
Cytogenetic Map3p21.1NCBI
HuRef352,908,665 - 52,926,377 (-)NCBIHuRef
CHM1_1352,799,205 - 52,816,916 (-)NCBICHM1_1
Itih4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,608,433 - 30,623,943 (+)NCBIGRCm39mm39
GRCm39 Ensembl1430,608,433 - 30,624,310 (+)Ensembl
GRCm381430,886,476 - 30,901,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,886,476 - 30,902,353 (+)EnsemblGRCm38mm10GRCm38
MGSCv371431,699,678 - 31,715,169 (+)NCBIGRCm37mm9NCBIm37
MGSCv361429,715,522 - 29,730,858 (+)NCBImm8
Celera1427,143,865 - 27,159,266 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
Itih4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2166,080,539 - 6,095,710 (+)NCBI
Rnor_6.0 Ensembl166,970,342 - 6,985,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0166,970,367 - 6,985,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0166,896,782 - 6,912,274 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,319,608 - 6,334,782 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1166,319,608 - 6,334,777 (+)NCBI
Celera169,093,866 - 9,109,046 (-)NCBICelera
Cytogenetic Map16p16NCBI
Itih4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,770,373 - 2,789,131 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,772,064 - 2,787,912 (-)NCBIChiLan1.0ChiLan1.0
ITIH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1353,980,529 - 54,000,560 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,980,668 - 53,998,038 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0352,754,664 - 52,774,867 (-)NCBIMhudiblu_PPA_v0panPan3
Itih4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,434,701 - 170,450,834 (-)NCBI
SpeTri2.0NW_0049364733,573,282 - 3,589,345 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITIH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,915,855 - 34,948,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,928,455 - 34,948,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,197,507 - 38,209,005 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITIH4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,194,979 - 14,216,180 (-)NCBI
ChlSab1.1 Ensembl2214,195,701 - 14,213,603 (-)Ensembl
Vero_WHO_p1.0NW_023666041152,684,251 - 152,702,173 (+)NCBI
Itih4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248224,397,704 - 4,411,562 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 15 6 2 6 2 6 9 4
Low 2 5 5 4 4 10 8 1 2
Below cutoff 2 2

Sequence


Reference Sequences
RefSeq Acc Id: XM_005642248   ⟹   XP_005642305
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2036,984,232 - 36,999,685 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022416574   ⟹   XP_022272282
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2036,984,232 - 36,999,685 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038427512   ⟹   XP_038283440
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02037,352,995 - 37,368,452 (+)NCBI
RefSeq Acc Id: XM_038427513   ⟹   XP_038283441
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02037,352,995 - 37,368,452 (+)NCBI
RefSeq Acc Id: XM_038427514   ⟹   XP_038283442
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02037,352,995 - 37,368,452 (+)NCBI
RefSeq Acc Id: XM_038566173   ⟹   XP_038422101
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02037,402,544 - 37,418,024 (+)NCBI
RefSeq Acc Id: XM_038630337   ⟹   XP_038486265
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02037,125,001 - 37,140,491 (+)NCBI
RefSeq Acc Id: XM_038630338   ⟹   XP_038486266
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02037,125,001 - 37,140,491 (+)NCBI
RefSeq Acc Id: XM_038630339   ⟹   XP_038486267
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02037,125,001 - 37,140,491 (+)NCBI
RefSeq Acc Id: XM_843672   ⟹   XP_848765
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2036,984,232 - 36,999,685 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_038486265   ⟸   XM_038630337
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038486267   ⟸   XM_038630339
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038486266   ⟸   XM_038630338
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038283440   ⟸   XM_038427512
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038283442   ⟸   XM_038427514
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038283441   ⟸   XM_038427513
- Peptide Label: isoform X2
RefSeq Acc Id: XP_005642305   ⟸   XM_005642248
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_848765   ⟸   XM_843672
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_022272282   ⟸   XM_022416574
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_038422101   ⟸   XM_038566173
- Peptide Label: isoform X3
Protein Domains
VIT   VWFA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000025533 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000035497 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000035513 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000039621 UniProtKB/TrEMBL
  ENSCAFT00000039632 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
InterPro ITI_HC_C UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene ITIH4 ENTREZGENE
Pfam ITI_HC_C UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PROSITE VIT UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
SMART VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
UniProt H9GWY1_CANLF UniProtKB/TrEMBL
  H9GWY3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:42147 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 ITIH4  inter-alpha-trypsin inhibitor heavy chain 4    inter-alpha-trypsin inhibitor heavy chain family member 4  Symbol and/or name change 5135510 APPROVED