Itih4 (inter alpha-trypsin inhibitor, heavy chain 4) - Rat Genome Database

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Gene: Itih4 (inter alpha-trypsin inhibitor, heavy chain 4) Mus musculus
Analyze
Symbol: Itih4
Name: inter alpha-trypsin inhibitor, heavy chain 4
RGD ID: 737493
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process. Predicted to act upstream of or within acute-phase response. Located in cytoplasm and plasma membrane. Is expressed in several structures, including heart; intestine; liver; lung; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in intermediate coronary syndrome and myocardial infarction. Orthologous to human ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: inter-alpha-inhibitor heavy chain 4; ITI heavy chain H4; ITI-HC4; Itih; Itih-4; PK-120
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,608,433 - 30,623,943 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,608,433 - 30,624,310 (+)EnsemblGRCm39 Ensembl
GRCm381430,886,476 - 30,901,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,886,476 - 30,902,353 (+)EnsemblGRCm38mm10GRCm38
MGSCv371431,699,678 - 31,715,169 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,715,522 - 29,730,858 (+)NCBIMGSCv36mm8
Celera1427,143,865 - 27,159,266 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aluminium oxide  (EXP)
amiodarone  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gentamycin  (ISO)
indometacin  (ISO)
inulin  (EXP)
isoprenaline  (EXP)
L-ethionine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP)
nickel atom  (ISO)
nitrofen  (ISO)
olanzapine  (ISO)
omeprazole  (ISO)
ozone  (EXP)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
Triptolide  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Profiling of gender-specific rat plasma proteins associated with susceptibility or resistance to diet-induced obesity. Choi JW, etal., J Proteomics. 2012 Feb 2;75(4):1386-400. doi: 10.1016/j.jprot.2011.11.012. Epub 2011 Nov 20.
2. Proteomic demonstration of the recurrent presence of inter-alpha-inhibitor H4 heavy-chain during aspergillosis induced in an animal model. Desoubeaux G, etal., Int J Med Microbiol. 2014 May;304(3-4):327-38. doi: 10.1016/j.ijmm.2013.11.015. Epub 2013 Dec 1.
3. Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene. Fujita Y, etal., J Hum Genet. 2004;49(1):24-8. Epub 2003 Dec 6.
4. The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats. Ivancic MM, etal., Cancer Prev Res (Phila). 2014 Nov;7(11):1160-9. doi: 10.1158/1940-6207.CAPR-14-0056. Epub 2014 Sep 8.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats. Lubieniecka JM, etal., PLoS One. 2011 Apr 29;6(4):e19247. doi: 10.1371/journal.pone.0019247.
7. ITIH4, as an inflammation biomarker, mainly increases in bacterial bloodstream infection. Ma Y, etal., Cytokine. 2020 Dec 18;138:155377. doi: 10.1016/j.cyto.2020.155377.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma. Noh CK, etal., Clin Biochem. 2014 Sep;47(13-14):1257-61. doi: 10.1016/j.clinbiochem.2014.05.002. Epub 2014 May 14.
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. ITIH4 serum concentration increases during acute-phase processes in human patients and is up-regulated by interleukin-6 in hepatocarcinoma HepG2 cells. Pineiro M, etal., Biochem Biophys Res Commun. 1999 Sep 16;263(1):224-9.
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis. Tanaka H, etal., J Neurol. 2013 Jul;260(7):1782-97. doi: 10.1007/s00415-013-6877-3. Epub 2013 Feb 23.
18. Identification of potential urine proteins and microRNA biomarkers for the diagnosis of pulmonary tuberculosis patients. Wang J, etal., Emerg Microbes Infect. 2018 Apr 11;7(1):63. doi: 10.1038/s41426-018-0066-5.
Additional References at PubMed
PMID:3405219   PMID:9126497   PMID:9602042   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11438667   PMID:11803570   PMID:12477932   PMID:12819125   PMID:15939374   PMID:16141072  
PMID:16141073   PMID:16271702   PMID:18263735   PMID:21677750   PMID:21873635   PMID:22159717   PMID:24194600   PMID:26094694   PMID:26964679   PMID:27507650   PMID:28071719   PMID:28671696  
PMID:29987918   PMID:30958362   PMID:32325033   PMID:38190323  


Genomics

Comparative Map Data
Itih4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,608,433 - 30,623,943 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,608,433 - 30,624,310 (+)EnsemblGRCm39 Ensembl
GRCm381430,886,476 - 30,901,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,886,476 - 30,902,353 (+)EnsemblGRCm38mm10GRCm38
MGSCv371431,699,678 - 31,715,169 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,715,522 - 29,730,858 (+)NCBIMGSCv36mm8
Celera1427,143,865 - 27,159,266 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
ITIH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,812,962 - 52,830,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,812,962 - 52,830,688 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,846,978 - 52,864,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,822,046 - 52,839,734 (-)NCBINCBI36Build 36hg18NCBI36
Build 34352,822,045 - 52,839,734NCBI
Celera352,825,723 - 52,843,435 (-)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,908,665 - 52,926,377 (-)NCBIHuRef
CHM1_1352,799,205 - 52,816,916 (-)NCBICHM1_1
T2T-CHM13v2.0352,845,872 - 52,863,582 (-)NCBIT2T-CHM13v2.0
Itih4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,086,985 - 6,102,162 (+)NCBIGRCr8
mRatBN7.2166,080,539 - 6,095,710 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,080,539 - 6,095,708 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,091,889 - 6,107,055 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,237,346 - 7,252,512 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,099,223 - 6,114,442 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,970,367 - 6,985,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,970,342 - 6,985,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,896,782 - 6,912,274 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,319,608 - 6,334,782 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,319,608 - 6,334,777 (+)NCBI
Celera169,093,866 - 9,109,046 (-)NCBICelera
Cytogenetic Map16p16NCBI
Itih4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,770,373 - 2,789,131 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,772,064 - 2,787,912 (-)NCBIChiLan1.0ChiLan1.0
ITIH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,807,762 - 52,827,998 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,807,876 - 52,832,769 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,754,664 - 52,774,867 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,980,529 - 54,000,560 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,980,668 - 53,998,038 (-)Ensemblpanpan1.1panPan2
ITIH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2036,984,232 - 36,999,685 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,352,995 - 37,368,452 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,352,366 - 37,401,740 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.02037,125,001 - 37,140,491 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,402,544 - 37,418,024 (+)NCBIUU_Cfam_GSD_1.0
Itih4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,434,701 - 170,450,834 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,573,384 - 3,589,345 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,573,282 - 3,589,345 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITIH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,928,439 - 34,948,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,928,455 - 34,948,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,197,507 - 38,209,005 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITIH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,194,979 - 14,216,180 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,195,701 - 14,213,603 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,684,251 - 152,702,173 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itih4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,397,744 - 4,411,406 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,397,704 - 4,411,562 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itih4
427 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:698
Count of miRNA genes:270
Interacting mature miRNAs:292
Transcripts:ENSMUST00000006703, ENSMUST00000078490, ENSMUST00000120269, ENSMUST00000134988, ENSMUST00000168782
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
1301991Wta3_mweight adult 3 (mouse)Not determined14388747337887650Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined514347339143596Mouse
27226775Tibl7_mtibia length 7, 5 week (mouse)143032195748837457Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse

Markers in Region
Itih4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14BUniSTS
cM Map1411.75UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001159299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001289633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_018746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF023919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB809402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB872033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY788238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT025528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000006703   ⟹   ENSMUSP00000006703
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,608,459 - 30,623,905 (+)Ensembl
GRCm38.p6 Ensembl1430,886,502 - 30,901,948 (+)Ensembl
RefSeq Acc Id: ENSMUST00000078490   ⟹   ENSMUSP00000077580
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,608,459 - 30,623,801 (+)Ensembl
GRCm38.p6 Ensembl1430,886,502 - 30,901,844 (+)Ensembl
RefSeq Acc Id: ENSMUST00000120269   ⟹   ENSMUSP00000112798
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,608,433 - 30,624,310 (+)Ensembl
GRCm38.p6 Ensembl1430,886,476 - 30,902,353 (+)Ensembl
RefSeq Acc Id: ENSMUST00000168782   ⟹   ENSMUSP00000125920
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,608,478 - 30,623,803 (+)Ensembl
GRCm38.p6 Ensembl1430,886,521 - 30,901,846 (+)Ensembl
RefSeq Acc Id: ENSMUST00000227899
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1430,621,118 - 30,623,806 (+)Ensembl
GRCm38.p6 Ensembl1430,899,161 - 30,901,849 (+)Ensembl
RefSeq Acc Id: NM_001159299   ⟹   NP_001152771
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391430,608,433 - 30,623,943 (+)NCBI
GRCm381430,886,476 - 30,901,986 (+)NCBI
MGSCv371431,699,678 - 31,715,169 (+)RGD
Celera1427,143,849 - 27,159,269 (+)NCBI
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001289632   ⟹   NP_001276561
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391430,608,433 - 30,623,943 (+)NCBI
GRCm381430,886,476 - 30,901,986 (+)NCBI
Celera1427,143,849 - 27,159,269 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001289633   ⟹   NP_001276562
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391430,608,433 - 30,623,943 (+)NCBI
GRCm381430,886,476 - 30,901,986 (+)NCBI
Celera1427,143,849 - 27,159,269 (+)NCBI
Sequence:
RefSeq Acc Id: NM_018746   ⟹   NP_061216
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391430,608,433 - 30,623,943 (+)NCBI
GRCm381430,886,476 - 30,901,986 (+)NCBI
MGSCv371431,699,678 - 31,715,169 (+)RGD
Celera1427,143,849 - 27,159,269 (+)NCBI
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_061216   ⟸   NM_018746
- Peptide Label: isoform 1 precursor
- UniProtKB: Q91W60 (UniProtKB/Swiss-Prot),   Q8C7K5 (UniProtKB/Swiss-Prot),   Q8C7G9 (UniProtKB/Swiss-Prot),   Q505P8 (UniProtKB/Swiss-Prot),   O54882 (UniProtKB/Swiss-Prot),   Q9DBK8 (UniProtKB/Swiss-Prot),   A6X935 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001152771   ⟸   NM_001159299
- Peptide Label: isoform 2 precursor
- UniProtKB: E9PVD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276562   ⟸   NM_001289633
- Peptide Label: isoform 4 precursor
- UniProtKB: A0A2K6EDJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276561   ⟸   NM_001289632
- Peptide Label: isoform 3 precursor
- UniProtKB: E9Q5L2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000006703   ⟸   ENSMUST00000006703
RefSeq Acc Id: ENSMUSP00000125920   ⟸   ENSMUST00000168782
RefSeq Acc Id: ENSMUSP00000112798   ⟸   ENSMUST00000120269
RefSeq Acc Id: ENSMUSP00000077580   ⟸   ENSMUST00000078490
Protein Domains
VIT   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6X935-F1-model_v2 AlphaFold A6X935 1-942 view protein structure

Promoters
RGD ID:8681806
Promoter ID:EPDNEW_M18925
Type:initiation region
Name:Itih4_1
Description:Mus musculus inter alpha-trypsin inhibitor, heavy chain 4 , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381430,886,502 - 30,886,562EPDNEW
RGD ID:6825086
Promoter ID:MM_KWN:16073
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000120269,   NM_001159299,   OTTMUST00000065206,   UC007SVX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361431,699,456 - 31,699,956 (+)MPROMDB
RGD ID:6848639
Promoter ID:MM_TRO:2998
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   Spleen
Transcripts:MTR058619.14.601.1,   MTR058619.14.601.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361431,700,876 - 31,701,376 (+)MPROMDB
RGD ID:6848640
Promoter ID:MM_TRO:2999
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:MTR058619.14.601.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361431,709,306 - 31,709,806 (+)MPROMDB
RGD ID:6825087
Promoter ID:MM_KWN:16074
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000065208
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361431,711,406 - 31,712,807 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109536 AgrOrtholog
Ensembl Genes ENSMUSG00000021922 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000006703 ENTREZGENE
  ENSMUST00000006703.15 UniProtKB/TrEMBL
  ENSMUST00000078490 ENTREZGENE
  ENSMUST00000078490.14 UniProtKB/TrEMBL
  ENSMUST00000120269 ENTREZGENE
  ENSMUST00000120269.11 UniProtKB/Swiss-Prot
  ENSMUST00000168782 ENTREZGENE
  ENSMUST00000168782.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ITI_HC_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16427 UniProtKB/Swiss-Prot
MGD MGI:109536 ENTREZGENE
NCBI Gene 16427 ENTREZGENE
PANTHER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ITI_HC_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itih4 PhenoGen
PROSITE VIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART VIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2K6EDJ7 ENTREZGENE, UniProtKB/TrEMBL
  A6X935 ENTREZGENE
  E9PVD2 ENTREZGENE, UniProtKB/TrEMBL
  E9Q5L2 ENTREZGENE, UniProtKB/TrEMBL
  ITIH4_MOUSE UniProtKB/Swiss-Prot
  O54882 ENTREZGENE
  Q505P8 ENTREZGENE
  Q8C7G9 ENTREZGENE
  Q8C7K5 ENTREZGENE
  Q91W60 ENTREZGENE
  Q9DBK8 ENTREZGENE
UniProt Secondary O54882 UniProtKB/Swiss-Prot
  Q505P8 UniProtKB/Swiss-Prot
  Q8C7G9 UniProtKB/Swiss-Prot
  Q8C7K5 UniProtKB/Swiss-Prot
  Q91W60 UniProtKB/Swiss-Prot
  Q9DBK8 UniProtKB/Swiss-Prot